Effects of the mycotoxin ochratoxin A and some of its metabolites on human kidney cell lines

Toxicology in Vitro

Volumn 17, Issue 4, 2003, Pages 441-448

  Muller G ^a   Burkert, B ^a   Rosner, H ^a   Kohler H ^a  

^a Fed Inst Hlth Protect CVM   (Germany)

Author keywords

CD46, CD55, CD59; Cell wall integrity; Complement regulating surface proteins; Kidney cell lines; Ochratoxin A, C; Proliferation

Indexed keywords

CD59 ANTIGEN; CELL SURFACE MARKER; CRUDE TOXIN; DECAY ACCELERATING FACTOR; MEMBRANE COFACTOR PROTEIN; MEMBRANE PROTEIN; MYCOTOXIN; OCHRATOXIN; TOXIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL COUNT; CELL LINE; CELL METABOLISM; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; EMBRYONAL CARCINOMA; GENOTOXICITY; HUMAN; HUMAN CELL; IMMUNOMODULATION; ISOLATION PROCEDURE; KIDNEY CARCINOMA; KIDNEY CELL; METABOLITE; STIMULATION;

EID: 0037805309     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(03)00053-5     Document Type: Article

References (52)

1. AOAC, 1990. Official Methods of Analysis: Ochratoxins in Barley. Part 2, No. 973.37, 1207.
2. Baudrimont I., Betbeder A.M., Creppy E.E. Reduction of the ochratoxin A-induced cytotoxicity in Vero cells by aspartame. Arch. Toxicol. 71:1997;290-298.
3. Beker D., Radic B. Fast determination of ochratoxin-A in serum by liquid chromatography - comparison with enzymic spectrofluorimetric method. J. Chromatogr. Biomed. Appl. 570:1991;441-445.
4. Benesic A., Mildenberger S., Gekle M. Nephritogenic ochratoxin A interferes with hormonal signalling in immortalized human kidney epithelial cells. Pflügers Arch. Eur. J. Physiol. 439:2000;278-287.
5. Berek L., Petri I.B., Mesterhazy A., Teren J., Molnar J. Effects of mycotoxins on human immune functions in vitro. Toxicology in Vitro. 15:2001;25-30.
6. Bondy G.S., Armstrong C.L. Cytotoxicity of nephrotoxic fungal toxins to kidney- derived LLC-PK1 and OK cell lines. Cell Biol. Toxicol. 14:1998;323-332.
7. Brana C., Benham C., Sundstrom L. A method for characterising cell death in vitro by combining propidium iodide staining with immunohistochemistry. Brain Res. Brain Res. Protoc. 10:2002;109-114.
8. Brasoveanu L.I., Altomonte M., Fonsatti E., Colizzi F., Coral S., Nicotra M.R., Cattarossi I., Cattelan A., Natali P.G., Maio M. Levels of cell membrane CD59 regulate the extent of complement-mediated lysis of human melanoma cells. Lab. Invest. 74:1996;33-42.
9. Creppy E.E. Human ochratoxicosis. J. Toxicol. Toxin Rev. 18:1999;277-293.
10. Curtui V.G., Gareis M.A., Usleber E., Märtlbauer E. Survey of Romanian slaughtered pigs for the occurrence of mycotoxins ochratoxin A and B, and zearalenone. Food Additives Contam. 18:2001;730-738.
11. Dörrenhaus A., Flieger A., Golka K., Schulze H., Albrecht M., Degen G.H., Föllmann W. Induction of unscheduled DNA synthesis in primary human urothelial cells by the mycotoxin ochratoxin A. Toxicol. Sci. 53:2000;271-277.
12. Dortant P.M., PetersVolleberg G.W.M., VanLoweren H., Marquardt R.R., Speijers G.J.A. Age-related differences in the toxicity of ochratoxin A in female rats. Food Chem. Toxicol. 39:2001;55-65.
13. Fink-Gremmels J., Jahn A., Blom M.J. Toxicity and metabolism of ochratoxin A. Natural Toxins. 3:1995;214-220.
14. Frank H.K. Risk Estimation for Ochratoxin A in European Countries. Mycotoxins, Endemic Nephropathy and Urinary Tract Tumors. IARC Scientific Publ. No. 115:1991;321-325.
15. Gekle M., Sauvant Ch., Schwerdt G., Silbernagel S. Tubulotoxic mechanisms of ochratoxin A. Kidney Blood Press Res. 21:1998;277-279.
16. Gekle M., Schwerdt G., Freudinger R., Mildenberger S., Wilflingseder D., Pollack V., Dander M., Schramek H. Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. J. Pharmacol. Exp. Ther. 293:2000;837-844.
17. Gorter A., Blok V.T., Haasnoot W.H., Ensink N.G., Daha M.R., Fleuren G.J. Expression of CD46, CD55, and CD59 on renal tumor cell lines and their role in preventing complement-mediated tumor cell lysis. Lab. Invest. 74:1996;1039-1049.
18. Heller M., Köhler H., Rosner H., Burkert B., Rohrmann B., Möller U., Thierbach S., Kielstein P., Müller G. Beeinflussung der Zytokinsekretion von Maus-Thymom-Zellen (EL-4) durch Ochratoxin. Mycotoxin Res. 16A:2000;194-198.
19. Hourcade D., Liszewski M.K., KrychGoldberg M., Atkinson J.P. Functional domains, structural variations and pathogen interactions of MCP, DAF and CR1. Immunopharmacol. 49:2000;103-116.
20. JECFA Safty Evaluation of Certain Mycotoxins in Food. WHO Food Additives Ser. 47; FAO - Food and Nutrition Paper74. 2001;WHO, Geneva. p. 366.
21. Krogh P., Gyrd-Hansen N., Hald B., Larsen S., Nielsen J.P., Smith M., Ivanoff Ch., Meisner H. Renal enzyme activities in experimental ochratoxin A-induced porcine nephropathy: diagnostic potential of phosphoenolpyrovate carboxykinase and gamma-glutamyl transpeptidase activity. J. Toxicol. Environ. Health. 23:1988;1-14.
22. Kuiper-Goodman T. Risk assessment of ochratoxin A:an update. Food Additives and Contaminants. 13(Suppl. (53)-(57)):1996.
23. Li S., Marquardt R.R., Frohlich A.A., Vitti T.G., Crow G. Pharmacokinetics of ochratoxin A and its metabolites in rats. Toxicol. Appl. Pharmacol. 145:1997;82-90.
24. Marshall N.J., Goodwin C.J., Holt S.J. A critical assessment of the use of microculture tetrazolium assays to measure cell growth and function. Growth Regulation. 5:1995;69-84.
25. Marin L.M., Murtha J., Dong W., Pestka J.J. Effects of mycotoxins on cytokine production and proliferation in EL-4 thymoma cells. J. Toxicol. Environ. Health. 48:1996;379-396.
26. McKeague A.L., Wilson D.J., Nelson J. Staurosporin-induced apoptosis and hydrogen peroxide-induced necrosis in two human breast cell lines. Br. J. Cancer. 13:2003;125-131.
27. van der Merwe K.J., Steyn P.S., Fourie L. Mycotoxins Part II. The constitution of ochratoxin A, B, and C, metabolites of Aspergillus ochraceus Wilk. J. Chem Soc. 5:1965;7083-7088.
28. Moon E.-Y., Rhee D.-K., Pyo S. In vitro suppressive effect of Aflatoxin B1 on murine peritoneal macrophage functions. Toxicology. 133:1999;171-179.
29. Moore J.H., Truelove B. Ochratoxin A. inhibition of mitochondrial respiration Science. 168:1970;1102-1103.
30. Müller G., Kielstein P., Köhler H., Berndt A., Rosner H. Studies of the influence of ochratoxin A on immune and defence reactions in the mouse model. Mycoses. 38:1995;85-91.
31. Müller G., Kielstein P., Rosner H., Berndt A., Heller M., Köhler H. Studies of the influence of ochratoxin A on immune and defence reactions in weaners. Mycoses. 42:1999;495-505.
32. Müller G., Rosner H., Rohrmann B., Erler W., Geschwend G., Gräfe U., Burkert B., Möller U., Diller R., Sachse K., Köhler H. Effects of mycotoxin ochratoxin A and some of its metabolites on the human cell line THP-1. Toxicology. 184:2003;69-82.
33. Nangaku M. Complement regulatory proteins in glomerular diseases. Kidney International. 54:1998;1419-1428.
34. O'Brien E., Heussner A.H., Dietrich D.R. Species-, sex-, and cell type-specific effects of ochratoxin A and B. Toxicol. Sci. 63:2001;256-264.
35. Page M., Bejaoui N., Cinq-Mars B., Lemieux P. Optimization of the tetrazolium-based colorimetric assay for the measurement of cell number and cytotoxicity. Int. J. Immunopharm. 10:1988;785-793.
36. Schwerdt G., Freudinger R., Silbernagel S., Gekle M. Ochratoxin A-binding proteins in rat organs and plasma and in different cell lines of the kidney. Toxicology. 135:1999;1-10.
37. Schwerdt G., Freudinger R., Mildenberger S., Silbernagel S., Gekle M. The nephrotoxin ochratoxin A induces apoptosis in cultured human proximal tubule cells. Cell Biol. Toxicol. 15:1999;405-415.
38. Scientific Cooperation on Questions Relating to Food Task 3.2.7. (SCOOP), 2001. Assessment of Dietary Intake of Ochratoxin A by the Population of EU Memberstate. Report 2001.
39. Shlosberg A., Elkin N., Malkinson M., Orgad U., Hanji V., Bogin E., Weisman Y., Meroz M., Bock R. Severe hepatopathy in geese and broilers associated with ochratoxin in their feed. Mycopathologia. 138:1997;71-76.
40. Stoev S.D., Stoeva J.K., Anguelov G., Hald B., Creppy E.E., Radic B. Hematological, biochemical and toxicological investigations in spontaneous cases with different frequency of porcine nephropathy in Bulgaria. J. Vet. Med. A. 45:1998;229.236.
41. Stoev S.D., Hald B., Mantle P.G. Porcine nephropathy in Bulgaria. a progressive syndrome of complex or uncertain (mycotoxin) aetiology Vet. Rec. 142:1998;190-194.
42. Stoev S.D., Goundasheva D., Mirtscheva T., Mantle P.G. Susceptibility to secondary bacterial infections in growing pigs as an ealy response in ochratoxicosis. Exp. Toxicol. Pathol. 52:2000;287-296.
43. Stoev S.D., Vitanov S., Anguelov G., Petkova-Bocharova T., Creppy E.E. Experimental mycotoxic nephropathy in pigs provoked by a diet containing ochratoxin A and penicillic acid. Vet. Res. Commun. 25:2001;205-223.
44. Stormer F.C. Ochratoxin A-a mycotoxin of concern. Handbook of applied mycology. Bhatnagar D., Lillehoj E.B., Arora D.K. Mycotoxins in Ecological Systems, vol. 5. 1992;403-432 Marcel Dekker, New York, Basel, Hong Kong.
45. Teodori L., Grabarek J., Smolewski P., Ghibelli L., Bergamaschi A., De Nicola M., Darzynkiewicz Z. Exposure of cells to static me#agnetic field accelerates loss of integrity of plasma membrane during apoptosis. Cytometry. 49:2002;113-118.
46. Varsano S., Rashkovsky L., Shapiro H., Radnay J. Cytokines modulate expression of cell-membrane complement inhibitory proteins in human lung cancer cell lines. Amer. J. Resp. Cell Molec. Biol. 19:1998;522-529.
47. Vrabcheva T., Usleber E., Dietrich R., Martlbauer E. Co- occurrence of ochratoxin A and citrinin in cereals from Bulgarian villages with a history of Balkan endemic nephropathy. J. Agric. Food Chem. 48:2000;2483-2488.
48. Wafa E.W., Yahya R.S., Sobh M.A., Eraky I., ElBaz H., ElGayar H.A., Betbeder A.M., Creppy E.E. Human ochratoxicosis and nephropathy in Egypt. a preliminary study Human Exper. Toxicol. 17:1998;124-129.
49. Wolff J., Bresch H., Cholmakow-Bodechtel C., Engel G., Erhardt S., Gareis M., Majerus P., Rosner H., Scheuer R. Belastung des Verbrauchers und der Lebensmittel mit Ochratoxin A. Abschluβbericht. 2000.
50. Wong S.S., Zhou H.R., Marin-Martinez M.L., Brooks K., Pestka J.J. Modulation of IL-1β, IL-6 and TNF-α secretion and mRNA expression by the trichothecene vomitoxin in the RAW 264.7 murine macrophage cell line. Food Chem. Toxicol. 36:1998;408-419.
51. Xiao H., Madhyastha R.R., Marquardt R.R., Li S., Jayantha S.L., Vodela K., Frohlich A.A., Kemppainen W. Toxicity of ochratoxin A, its opened lactone form and several of its analogs. structure- activity relationships Toxicol. Appl. Pharmacol. 137:1996;182-192.
52. Zimmerli B., Dick R. Ochratoxin A in table wine and grape-juice. occurence and risk assessment Food Add. Cont. 13:1996;655-668.