Briefs on insulin and innate immune response

Cellular Physiology and Biochemistry

Volumn 29, Issue 1-2, 2012, Pages 1-8

  Sunahara, Karen K S ^a   Sannomiya, Paulina ^a   Martins, Joilson O ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Akt; Alveolar macrophages; Cytokines; Diabetes Mellitus; Innate immune system; Insulin; Leukotrienes; MAPK; NF B; Phagocytosis; PKC; Sepsis

Indexed keywords

CYTOKINE; DNA; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; LEUKOTRIENE; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ALLOXAN DIABETES MELLITUS; ANTIINFLAMMATORY ACTIVITY; CELL METABOLISM; DIABETES MELLITUS; DIABETIC PATIENT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; GLUCOSE METABOLISM; GLYCEMIC CONTROL; HORMONE ACTION; HUMAN; HYPERGLYCEMIA; IMMUNE RESPONSE; IMMUNE SYSTEM; INFECTION; INFLAMMATION; INNATE IMMUNITY; INSULIN BLOOD LEVEL; INSULIN TREATMENT; LOW DRUG DOSE; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; REVIEW; SEPSIS; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; STRESS; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 84859861956     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000337579     Document Type: Review

References (64)

1. Shah BR, Hux JE: Quantifying the risk of infectious diseases for people with diabetes. Diabetes Care 2003;26:510-513. (Pubitemid 36929083)
2. Peleg AY, Weerarathna T, Mccarthy JS, Davis TM: Common infections in diabetes: pathogenesis, management and relationship to glycaemic control. Diabetes Metab Res Rev 2007;23:3-13. (Pubitemid 46152480)
3. Gregg EW, Gu Q, Cheng YJ, Narayan KM, Cowie CC: Mortality trends in men and women with diabetes, 1971 to 2000. Ann Intern Med 2007;147:149-155. (Pubitemid 351664594)
4. Kornum JB, Thomsen RW, Riis A, Lervang HH, Schonheyder HC, Sorensen HT: Diabetes, glycemic control, and risk of hospitalization with pneumonia: a population-based case-control study. Diabetes Care 2008;31:1541-1545.
5. Szkudelski T: The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 2001;50:537-546. (Pubitemid 34087272)
6. Lenzen S, Munday R: Thiol-group reactivity, hydrophilicity and stability of alloxan, its reduction products and its Nmethyl derivatives and a comparison with ninhydrin. Biochem Pharmacol 1991;42:1385-1391.
7. Gaulton GN, Schwartz JL, Eardley DD: Assessment of the diabetogenic drugs alloxan and streptozotocin as models for the study of immune defects in diabetic mice. Diabetologia 1985;28:769-775. (Pubitemid 16203780)
8. Anjos-Valotta EA, Martins JO, Oliveira MA, Casolari DA, Britto LR, Tostes RC, Fortes ZB, Sannomiya P: Inhibition of tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression in diabetic rats: role of insulin. Inflamm Res 2006;55:16-22. (Pubitemid 43142807)
9. De Oliveira Martins J, Meyer-Pflug AR, Alba-Loureiro TC, Melbostad H, Costa Da Cruz JW, Coimbra R, Curi R, Sannomiya P: Modulation of lipopolysaccharide-induced acute lung inflammation: Role of insulin. Shock 2006;25:260-266.
10. Martins JO, Zanoni FL, Martins DO, Coimbra R, Krieger JE, Jancar S, Sannomiya P. Insulin regulates cytokines and intercellular adhesion molecule-1 gene expression through nuclear factorkappaB activation in LPS-induced acute lung injury in rats. Shock 2009;31:404-409.
11. Panneerselvam S, Govindasamy S: Sodium molybdate improves the phagocytic function in alloxan-induced diabetic rats. Chem Biol Interact 2003;145:159-163. (Pubitemid 36398429)
12. Costa Rosa LF, Safi DA, Cury Y, Curi R: The effect of insulin on macrophage metabolism and function. Cell Biochem Funct 1996;14:33-42. (Pubitemid 26055414)
13. Serezani CH, Perrela JH, Russo M, Peters-Golden M, Jancar S: Leukotrienes are essential for the control of Leishmania amazonensis infection and contribute to strain variation in susceptibility. J Immunol 2006;177:3201-3208. (Pubitemid 44277838)
14. Wirth JJ, Kierszenbaum F: Stimulatory effects of leukotriene B4 on macrophage association with and intracellular destruction of Trypanosoma cruzi. J Immunol 1985;134:1989-1993. (Pubitemid 15128973)
15. Flamand L, Borgeat P, Lalonde R, Gosselin J: Release of anti-HIV mediators after administration of leukotriene B4 to humans. J Infect Dis 2004;189:2001-2009. (Pubitemid 38692279)
16. Peters-Golden M, Henderson WR Jr: Leukotrienes. N Engl J Med 2007;357:1841-1854.
17. Câmara NO, Martins JO, Landgraf RG, Jancar S: Emerging roles for eicosanoids in renal diseases. Curr Opin Nephrol Hypertens 2009;18:21-27.
18. Mancuso P, Standiford TJ, Marshall T, Peters-Golden M: 5-Lipoxygenase reaction products modulate alveolar macrophage phagocytosis of Klebsiella pneumoniae. Infect Immun 1998;66:5140-5146. (Pubitemid 29044602)
19. Serezani CH, Aronoff DM, Jancar S, Mancuso P, Peters-Golden M: Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase. Blood 2005;106:1067-1075. (Pubitemid 41076456)
20. Ferracini M, Martins JO, Campos MR, Anger DB, Jancar S: Impaired phagocytosis by alveolar macrophages from diabetic rats is related to the deficient coupling of LTs to the Fc gamma R signaling cascade. Mol Immunol 2010;47:1974-1980.
21. Roth DM, Smith JB, Lefer AM: Leukotriene production in isolated tissues of diabetic rats. Prostaglandins Leukot Med 1984;16:29-37. (Pubitemid 14012722)
22. Nimmerjahn F, Ravetch JV: Fcgamma receptors: old friends and new family members. Immunity 2006;24:19-28. (Pubitemid 43077197)
23. Cox D, Greenberg S: Phagocytic signaling strategies: Fc(gamma)receptor- mediated phagocytosis as a model system. Semin Immunol 2001;13:339-345. (Pubitemid 33121959)
24. Campos MR, Serezani CH, Peters-Golden M, Jancar S: Differential kinase requirement for enhancement of Fc gammaRmediated phagocytosis in alveolar macrophages by leukotriene B4 vs. D4. Mol Immunol 2009;46:1204-1211.
25. Serezani CH, Aronoff DM, Sitrin RG, Peters-Golden M: FcgammaR ligation leads to a complex with BLT1 in lipid rafts that enhance rat lung macrophage antimicrobial functions. Blood 2010;114:3316-3324.
26. Geerlings SE, Stolk RP, Camps MJL, Netten PM, Hoekstra JBL, Bouter KP, Bravenboer B, Collet JT, Jansz AR, Hoepelman AIM: Asymptomatic Bacteriuria may be considered a complication in women with diabetes. Diabetes Care 2000;23:744-749. (Pubitemid 30414186)
27. Geerlings SE, Hoepelman AL: Immune dysfunction in patients with diabetes mellitus. FEMS Immunol Med Microbiol 1999;26:259-265.
28. Alba-Loureiro TC, Munhoz CD, Martins JO, Cerchiaro GA, Scavone C, Curi R, Sannomiya P: Neutrophil function and metabolism in individuals with diabetes mellitus. Braz J Med Biol Res 2007;40:1037-1044. (Pubitemid 47232857)
29. Van Den Berghe G, Wouthers P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R: Intensive insulin therapy in critically ill patients. N Engl J Med 2001;345:1359-1367.
30. Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R: Intensive insulin therapy in the medical ICU. N Engl J Med 2006;354:449-461. (Pubitemid 43200296)
31. Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K, German Competence Network Sepsis (SepNet): Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008;358:125-139.
32. Inzucchi SE, Siegel MD: Glucose Control in the ICU -How Tight Is Too Tight? ? N Engl J Med 2009;360:1346-1349
33. Kham AH, Pessin JE: Insulin regulation of glucose of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia 2002;45:1475-1483.
34. Srivastava AK, Pandley SK: Potential mechanism(s) involved in the regulation of glycogen synthesis by insulin. Mol Cell Biochem 1998;182:135-141. (Pubitemid 28181656)
35. Ish-Shalom D, Christoffersen CT, Vorwerk P, Sacerdoti-Sierra N, Shymko RM, Naor D, De Meyts P: Mitogenic properties of insulin analogues mediated by the insulin receptor. Diabetologia 1997;40:S25-S31. (Pubitemid 27306919)
36. Mounier C, Posner BI: Transcriptional regulation by insulin: from the receptor to the gene. Can J Physiol Pharmacol 2006;84:713-724. (Pubitemid 44897892)
37. Finlay D, Patel S, Dickson LM, Shpiro N, Marquez R, Rhodes CJ, Sutherland C: Glycongen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element. BMC Mol Biol 2004;5:15.
38. Zhang J, Ou J, Bashmakov Y, Horton JD, Brown MS, Goldstein JL: Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes. Proc Natl Acad Sci USA 2001;98:3756-3761. (Pubitemid 32249844)
39. Martins JO, Ferracini M, Ravanelli N, Landgraf RG, Jancar S: Insulin inhibits LPS-induced signaling pathways in alveolar macrophages. Cell Physiol Biochem 2008;21:297-304. (Pubitemid 351591421)
40. Martins JO, Ferracini M, Ravanelli N, Landgraf RG, Jancar S: Insulin suppresses LPS-induced iNOS and COX-2 expression and NF-kappaB activation in alveolar macrophages. Cell Physiol Biochem 2008;22:279-286.
41. Kaytor EN, Zhu JL, Pao CI, Philips LS: Insulin-responsive nuclear proteins facilitate Sp1 interactions with the insulin-like growth factor-I gene. J Biol Chem 2001;276:36896-36901.
42. Fukuda H, Noguchi T, Iritani N: Transcriptional regulation of insulin receptor gene promoter in rat hepatocytes. Biochem Biophys Res Commun 2001;280:1274-1278. (Pubitemid 32917781)
43. Keane MP, Strieter RM: The importance of balanced pro-inflammatoty and antiinflammatory mechanisms in diffuse lung disease. Respir Res 2002;3:5-11.
44. Hug H, Sarre TF: Protein kinase C isoenzymes. Divergence in signal transduction? Biochem J 1993;291:329.
45. Liu JP: Protein kinase C and its substrates. Mol Cell Endocrinol 1996;116:1-29.
46. Martins JO: Can PKC™be a novel therapeutic target? J Leukoc Biol 2011;89:1-2.
47. Berry N, Nishizuka Y: Protein kinase C and T cell activation. Eur J Biochem 1990;189:205-214. (Pubitemid 20146001)
48. Kops GP, Burgering BM: Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling. J Mol Med 1999;77:656-665. (Pubitemid 29500958)
49. Martins JO, Campos CA, Cruz JW, Manzolli S, Alves VA, Vianna EO, Jancar S, Sannomiya P: Insulin modulates cytokine release and selectin expression in the early phase of allergic airway inflammation in diabetic rats. BMC Pulm Med 2010;10:39.
50. Martins JO, Ferracini M, Anger DB, Martins DO, Ribeiro LF Jr, Sannomiya P, Jancar S: Signaling pathways and mediators in LPS-induced lung inflammation in diabetic rats: role of insulin. Shock 2010;33:76-82.
51. Martins JO, Wittlin BM, Anger DBC, Martins DO, Sannomiya P, Jancar S: Early phase of allergic airway inflammation in diabetic rats: role of insulin on the signaling pathways and mediators. Cell Physiol Biochem 2010;26:739-748.
52. Cely CM, Arora P, Quartin AA, Kett DH, Schein RMH: Relationship of baseline glucose homeostasis to hyperglycemia during medical critical illness. Chest 2004;126:879-887. (Pubitemid 39258045)
53. Cavalher-Machado SC, Cuman RKN, Sartoretto JL, Martins JO, Tavares WL, Silva PMR, Martins MA, Sannomiya P: The allergic inflammatory reaction in neonatal streptozotocininduced diabetic rats: evidence of insulin resistance and microvascular dysfunction. Inflamm Res 2008;57:535-541.
54. Furuya DT, Poletto AC, Favaro RR, Martins JO, Zorn TM, Machado UF: Anti-inflammatory effect of atorvastatin ameliorates insulin resistance in monosodium glutamate-treated obese mice. Metabolism 2010;59:395-399.
55. Das UN: Current advances in sepsis and septic shock with particular emphasis on the role of insulin. Med Sci Monit 2003;9:RA181-192. (Pubitemid 37139596)
56. Hawiger J: Innate immunity and inflammation: A transcription paradigm. Immunol Res 2001;23:99-109. (Pubitemid 32575352)
57. Böhrer H, Qiu F, Zimmermann T, Zhang Y, Jilmer T, Mannel D, Bottiger BW, Stern DM, Waldherr R, Saeger HD, Ziegler R, Bierhaus A, Martin E, Nawroth PP: Role of NFkB in the mortality of sepsis. J Clin Invest 1997;100:972-985.
58. Traenckner EB, Wilk S, Baeuerle PA: A proteosome inhibitor prevents activation of NF-βB and stabilizes a newly prhosphorylated from of I-βBa that is still bound to NF-βB. EMBO J 1994;13:5433-5441. (Pubitemid 24351822)
59. Deree J, Martins JO, Melbostad H, Loomis WH, Coimbra R: Insights into the regulation of TNF-alpha production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition. Clinics 2008;63:321-328.
60. Dandona P, Aljada A, Mohanty P, Ghanim H, Hamouda W, Assian E, Ahmad S: Insulin inhibits intranuclear factor kB and stimulated IkB in mononuclear cells in obese subjects: Evidence for an Antiinflammatory effect? J Clin Endocrinol Metab 2001;86:3257-3265. (Pubitemid 32674120)
61. Jeschke MG, Klein D, Bolder U, Einspanier R: Insulin Attenuates the Systemic Inflammatory Response in Endotoxemic Rats. Endocrinology 2004;145:4084-4093. (Pubitemid 39120556)
62. Dandona P, Aljada A, Bandyopaddhyay A: Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 2004;25:4-7. (Pubitemid 38032801)
63. Aljada A, Ghanim H, Mohanty P, Kapur N, Dandona P: Insulin inhibits the proinflammatory transcriptio factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations. J Clin Endocrinol Metab 2002;87:1419-1422. (Pubitemid 36121118)
64. Musashi M, Ota S, Shiroshita N: The role of protein kinase C isoforms in cell proliferation and apoptosis. Int J Hematol 2000;72:12-19.