Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells

Blood

Volumn 119, Issue 9, 2012, Pages 2159-2170

  Giampietro, Costanza ^a   Taddei, Andrea ^a   Corada, Monica ^a   Sarra Ferraris, Gian Maria ^a   Alcalay, Myriam ^a   Cavallaro, Ugo ^a   Orsenigo, Fabrizio ^a   Lampugnani, Maria Grazia ^a,b   Dejana, Elisabetta ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CATENIN; FIBROBLAST GROWTH FACTOR; FORKHEAD TRANSCRIPTION FACTOR; NERVE CELL ADHESION MOLECULE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P120; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 84857719747     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-09-381012     Document Type: Article

References (49)

1. Nishimura T, Takeichi M. Remodeling of the adherens junctions during morphogenesis. Curr Top Dev Biol. 2009;89:33-54.
2. Halbleib JM, Nelson WJ. Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. Genes Dev. 2006;20(23):3199-3214. (Pubitemid 44904842)
3. Goodwin M, YapAS. Classical cadherin adhesion molecules: coordinating cell adhesion, signaling and the cytoskeleton. J Mol Histol. 2004;35(8-9):839-844. (Pubitemid 41404630)
4. Nyqvist D, Giampietro C, Dejana E. Deciphering the functional role of endothelial junctions by using in vivo models. EMBO Rep. 2008;9(8):742-747.
5. Lampugnani MG, Resnati M, Raiteri M, et al. A novel endothelial-specific membrane protein is a marker of cell-cell contacts. J Cell Biol. 1992; 118(6):1511-1522.
6. Carmeliet P, Lampugnani MG, Moons L, et al. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. 1999;98(2):147-157. (Pubitemid 29344903)
7. Vestweber D, Winderlich M, Cagna G, Nottebaum AF. Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player. Trends Cell Biol. 2009; 19(1):8-15.
8. Wheelock MJ, Johnson KR. Cadherins as modulators of cellular phenotype. Annu Rev Cell Dev Biol. 2003;19:207-235. (Pubitemid 37487348)
9. Dejana E. Endothelial cell-cell junctions: happy together. Nat Rev Mol Cell Biol. 2004;5(4):261-70. (Pubitemid 38480607)
10. Navarro P, Ruco L, Dejana E. Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization. J Cell Biol. 1998;140(6): 1475-1484. (Pubitemid 28152995)
11. Salomon D, Ayalon O, Patel-King R, Hynes RO, Geiger B. Extrajunctional distribution of N-cadherin in cultured human endothelial cells. J Cell Sci. 1992;102(Pt 1):7-17.
12. Gerhardt H, Wolburg H, Redies C. N-cadherin mediates pericytic- endothelial interaction during brain angiogenesis in the chicken. Dev Dyn. 2000;218(3):472-479. (Pubitemid 30461783)
13. Paik JH, Skoura A, Chae SS, et al. Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes Dev. 2004;18(19):2392-2403. (Pubitemid 39304686)
14. Luo Y, Radice GL. N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis. J Cell Biol. 2005;169(1):29-34. (Pubitemid 40562911)
15. Spagnuolo R, Corada M, Orsenigo F, et al. Gas1 is induced by VE-cadherin and vascular endothelial growth factor and inhibits endothelial cell apoptosis. Blood. 2004;103(8):3005-3012. (Pubitemid 38451673)
16. Crosby CV, Fleming PA, Argraves WS, et al. VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly. Blood. 2005;105(7):2771-2776. (Pubitemid 40446268)
17. Taddei A, Giampietro C, Conti A, et al. Endothelial adherens junctions control tight junctions by VE-cadherin- mediated upregulation of claudin-5. Nat Cell Biol. 2008;10(8):923-934.
18. Lampugnani MG, Zanetti A, Corada M, et al. Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J Cell Biol. 2003;161(4):793-804. (Pubitemid 36648762)
19. Reynolds AB. p120-catenin: Past and present. Biochim Biophys Acta. 2007;1773(1):2-7. (Pubitemid 44908717)
20. Ferreri DM, Minnear FL, Yin T, Kowalczyk AP, Vincent PA. N-cadherin levels in endothelial cells are regulated by monolayer maturity and p120 availability. Cell CommunAdhes. 2008;15(4):333-349.
21. Gentil-dit-Maurin A, Oun S, Almagro S, et al. Unraveling the distinct distributions of VE- and N-cadherins in endothelial cells: a key role for p120- catenin. Exp Cell Res. 2010;316(16):2587-2599.
22. Chiasson CM, Wittich KB, Vincent PA, Faundez V, Kowalczyk AP. p120-catenin inhibits VE-cadherin internalization through a Rho-independent mechanism. Mol Biol Cell. 2009;20(7):1970-1980.
23. Oas RG, Xiao K, Summers S, et al. p120-catenin is required for mouse vascular development. Circ Res. 2010;106(5):941-951.
24. Lampugnani MG, Zanetti A, Breviario F, et al. VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam. Mol Biol Cell. 2002;13(4):1175-1189. (Pubitemid 34309614)
25. Liebner S, Corada M, Bangsow T, et al. Wnt/beta-catenin signaling controls development of the bloodbrain barrier. J Cell Biol. 2008;183(3):409-417.
26. Corada M, Nyqvist D, Orsenigo F, et al. The Wnt/ beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev Cell. 2010;18(6):938-949.
27. Lopez D, Niu G, Huber P, Carter WB. Tumor-induced upregulation of Twist, Snail, and Slug represses the activity of the human VE-cadherin promoter. Arch Biochem Biophys. 2009;482(1-2):77-82.
28. Quasnichka H, Slater SC, Beeching CA, Boehm M, Sala-Newby GB, George SJ. Regulation of smooth muscle cell proliferation by beta-catenin/ T-cell factor signaling involves modulation of cyclin D1 and p21 expression. Circ Res. 2006; 99(12):1329-1337. (Pubitemid 44949668)
29. Maeda M, Johnson KR, Wheelock MJ. Cadherin switching: essential for behavioral but notmorphological changes during an epithelium-to-mesenchyme transition. J Cell Sci. 2005;118(Pt 5):873-887. (Pubitemid 40484880)
30. Zhang X, Gan L, Pan H, et al. Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. J Biol Chem. 2002;277(47): 45276-45284. (Pubitemid 36159133)
31. van Noort M, Meeldijk J, van der Zee R, Destree O, Clevers H. Wnt signaling controls the phosphorylation status of beta-catenin. J Biol Chem. 2002; 277(20):17901-17905. (Pubitemid 34967600)
32. Gerhardt H, Betsholtz C. Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res. 2003;314(1):15-23. (Pubitemid 37409909)
33. Tillet E, Vittet D, Feraud O, Moore R, Kemler R, Huber P. N-cadherin deficiency impairs pericyte recruitment, and not endothelial differentiation or sprouting, in embryonic stem cell-derived angiogenesis. Exp Cell Res. 2005;310(2):392-400. (Pubitemid 41457342)
34. Hellstrom M, Gerhardt H, Kalen M, et al. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol. 2001;153(3):543-553. (Pubitemid 34280141)
35. Nissen LJ, Cao R, Hedlund EM, et al. Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis. J Clin Invest. 2007;117(10):2766-2777. (Pubitemid 47529608)
36. Lavine KJ, White AC, Park C, et al. Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev. 2006;20(12):1651-1666. (Pubitemid 43901103)
37. Pintucci G, Yu PJ, Sharony R, et al. Induction of stromelysin-1 (MMP-3) by fibroblast growth factor- 2 (FGF-2) in FGF-2-/- microvascular endothelial cells requires prolonged activation of extracellular signal-regulated kinases-1 and -2 (ERK-1/2). J Cell Biochem. 2003;90(5):1015-1025. (Pubitemid 37467117)
38. Ohno T, Yoo MJ, Swanson ER, Hirano S, Ossoff RH, Rousseau B. Regenerative effects of basic fibroblast growth factor on extracellular matrix production in aged rat vocal folds. Ann Otol Rhinol Laryngol. 2009; 118(8):559-564.
39. Eswarakumar VP, Lax I, Schlessinger J. Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 2005;16(2):139-149. (Pubitemid 40616112)
40. Heuberger J, Birchmeier W. Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. Cold Spring Harb Perspect Biol. 2010;2(2):a002915.
41. Wheelock MJ, Shintani Y, Maeda M, Fukumoto Y, Johnson KR. Cadherin switching. J Cell Sci. 2008;121(Pt 6):727-735. (Pubitemid 351578108)
42. Cavallaro U. N-cadherin as an invasion promoter: a novel target for antitumor therapy? Curr Opin Investig Drugs. 2004;5(12):1274-1278. (Pubitemid 40074968)
43. George SJ, Beeching CA. Cadherin:catenin complex: a novel regulator of vascular smooth muscle cell behaviour. Atherosclerosis. 2006;188(1):1-11. (Pubitemid 44142546)
44. Kiefer F, Siekmann AF. The role of chemokines and their receptors in angiogenesis. Cell Mol Life Sci. 2011;68(17):2811-2830.
45. Speyer CL, Ward PA. Role of endothelial chemokines and their receptors during inflammation. J Invest Surg. 2011;24(1):18-27.
46. Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol. 2006; 7(5):359-371.
47. Suyama K, Shapiro I, Guttman M, Hazan RB. A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell. 2002;2(4):301-314. (Pubitemid 41043964)
48. Cavallaro U, Niedermeyer J, Fuxa M, Christofori G. N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling. Nat Cell Biol. 2001; 3(7):650-657. (Pubitemid 32624421)
49. Lampugnani MG, Corada M, Caveda L, et al. The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin). J Cell Biol. 1995;129(1):203-217.