Optimization of medium composition for the production of clavulanic acid by Streptomyces clavuligerus

Process Biochemistry

Volumn 40, Issue 3-4, 2005, Pages 1161-1166

  Wang, Yong Hua ^a   Yang, Bo ^b   Ren, Jie ^b   Dong, Mei Ling ^a   Liang, Dong ^a   Xu, An Long ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Clavulanic acid; Medium composition; Optimization; Streptomyces clavuligerus

Indexed keywords

CLAVULANIC ACIDS; OPTIMAL CONCENTRATION; RESPONSE SURFACE METHODOLOGY; STREPTOMUCES CLAVULIGERUS;

BIOCHEMISTRY; COMPOSITION; FUNGI; IRON COMPOUNDS; OPTIMIZATION;

ORGANIC ACIDS;

STREPTOMYCES; STREPTOMYCES CLAVULIGERUS;

EID: 9644262750     PISSN: 13595113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.procbio.2004.04.010     Document Type: Article

References (13)

1. Aharonowitz Y., Demain A.L. Catabolite regulation of cephalosporin production in Streptomyces clavuligerus. Antimicrob. Agents Chemother. 14:1978;159-164
2. Brown A.G., Butterworth D., Bole M., Hanscomb G., Hood J.D., Reading C., et al. Natrually occurring β-lactamase inhibitors with antibacterial activity. J. Antibiot. 29:1976;668-669
3. Reading C., Cole M. Clavulanic acid: a beta-lactamase-inhibiting beta-lactam from Streptomyces clavuligerus. Antimicrob. Agents Chemother. 5:1977;852-857
4. Rolinson G.N. Evolution of beta-lactamase inhibitors. Rev. Infect. Dis. 13:1991;S727-S732
5. Ives P.R., Bushell M.E. Manipulation of the physiology of clavulanic acid production in Streptomyces clavuligerus. Microbiology. 143:1997;3573-3579
6. Ester R.G., Alvaro Baptista-Neto C.B., Carlos O.H. Optimisation of medium composition for clavulanic acid production by Streptomyces clavuligerus. Biotechnol. Lett. 23:2001;157-161
7. Kuo-Cheng C., Yun-Huin L., Cheng-Min T., Chen-Hao H., Jer-Yiing H. Optimization of glycerol feeding for clavulanic acid production by Streptomyces clavuligerus with glycerol feeding. Biotechnol. Lett. 24:2002;455-458
8. Kirk S., Avogmpme-Rossa C.A., Bushell M.E. Growth limiting substrate affects antibiotic production and associated metabolic flues in Streptomyces clavuligerus. Biotechnol. Lett. 22:2000;1803-1809
9. Romero J., Liras P., Martin J.F. Dissociation of cephamycin and clavulanic acid biosynthesis in Streptomyces clavuligerus. Appl. Microbiol. Biotechnol. 20:1984;318-325
10. Paradkar A.S., Jensen S.E. Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus. J. Bacteriol. 177(5):1995;1307-1314
11. Kwon H.-J., Kim S.-U. Enhanced biosynthesis of clavulanic acid in Streptomyces clavuligerus due to oxidative challenge by redox-cycling agents. Appl. Microbiol. Biotechnol. 49:1998;77-83
12. Lebrihi A., Gemain P., Lefebvre G. Phosphate repression of cephamycin and clavulanic acid production by Streptomyces clavuligerus. Appl. Microbiol. Biotechnol. 26:1987;130-135
13. Foulstone M., Reading C. Assay of amoxicillin and clavulanic acid, the components of augmentin, in biological fluids with HPLC. Antimicrob. Agents Chemother. 22:1982;753-762