Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells

Biochemical and Biophysical Research Communications

Volumn 420, Issue 4, 2012, Pages 931-936

  Fujimoto, Yuri ^a   Nakagawa, Yoshimi ^a   Shingyouchi, Akiko ^a   Tokushige, Naoko ^a   Nakanishi, Noriko ^a   Satoh, Aoi ^a   Matsuzaka, Takashi ^a   Ishii, Kiyo aki ^a   Iwasaki, Hitoshi ^a   Kobayashi, Kazuto ^a   Yatoh, Shigeru ^a   Suzuki, Hiroaki ^a   Yahagi, Naoya ^a   Urayama, Osamu ^a   Yamada, Nobuhiro ^a   Shimano, Hitoshi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Adipocyte differentiation; Adipogenesis; Dicer; Lipid synthesis; MicroRNA

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; DICER; FAS ANTIGEN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SHORT HAIRPIN RNA;

ADENOVIRUS; ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION; LIPID STORAGE; LIPOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; DEAD-BOX RNA HELICASES; GENE EXPRESSION REGULATION; LIPIDS; MICE; PPAR GAMMA; RIBONUCLEASE III;

ADENOVIRIDAE;

EID: 84859817602     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.03.110     Document Type: Article

References (17)

1. Harris K.S., Zhang Z., McManus M.T., Harfe B.D., Sun X. Dicer function is essential for lung epithelium morphogenesis. Proc. Natl. Acad. Sci. USA 2006, 103:2208-2213.
2. Chen J.F., Murchison E.P., Tang R., Callis T.E., Tatsuguchi M., Deng Z., Rojas M., Hammond S.M., Schneider M.D., Selzman C.H., Meissner G., Patterson C., Hannon G.J., Wang D.Z. Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc. Natl. Acad. Sci. USA 2008, 105:2111-2116.
3. Inoue N., Yahagi N., Yamamoto T., Ishikawa M., Watanabe K., Matsuzaka T., Nakagawa Y., Takeuchi Y., Kobayashi K., Takahashi A., Suzuki H., Hasty A.H., Toyoshima H., Yamada N., Shimano H. Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance. J. Biol. Chem. 2008, 283:21220-21229.
4. Rosen E.D., Spiegelman B.M. Molecular regulation of adipogenesis. Annu. Rev. Cell Dev. Biol. 2000, 16:145-171.
5. Nakanishi N., Nakagawa Y., Tokushige N., Aoki N., Matsuzaka T., Ishii K., Yahagi N., Kobayashi K., Yatoh S., Takahashi A., Suzuki H., Urayama O., Yamada N., Shimano H. The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice. Biochem. Biophys. Res. Commun. 2009, 385:492-496.
6. Romao J.M., Jin W., Dodson M.V., Hausman G.J., Moore S.S., Guan le L. MicroRNA regulation in mammalian adipogenesis. Exp. Biol. Med. (Maywood). 2011, 236:997-1004.
7. McGregor R.A., Choi M.S. MicroRNAs in the regulation of adipogenesis and obesity. Curr. Mol. Med. 2011, 11:304-316.
8. Xie H., Lim B., Lodish H.F. MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes 2009, 58:1050-1057.
9. Kim S.Y., Kim A.Y., Lee H.W., Son Y.H., Lee G.Y., Lee J.W., Lee Y.S., Kim J.B. MiR-27a is a negative regulator of adipocyte differentiation via suppressing PPARgamma expression. Biochem. Biophys. Res. Commun. 2010, 392:323-328.
10. Mudhasani R., Imbalzano A.N., Jones S.N. An essential role for Dicer in adipocyte differentiation. J. Cell Biochem. 2010, 110:812-816.
11. Nakagawa Y., Shimano H., Yoshikawa T., Ide T., Tamura M., Furusawa M., Yamamoto T., Inoue N., Matsuzaka T., Takahashi A., Hasty A.H., Suzuki H., Sone H., Toyoshima H., Yahagi N., Yamada N. TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes. Nat. Med. 2006, 12:107-113.
12. Nakae J., Kitamura T., Kitamura Y., Biggs W.H., Arden K.C., Accili D. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev. Cell 2003, 4:119-129.
13. Gerin I., Bommer G.T., McCoin C.S., Sousa K.M., Krishnan V., MacDougald O.A. Roles for miRNA-378/378* in adipocyte gene expression and lipogenesis. Am. J. Physiol. Endocrinol. Metab. 2010, 299:E198-206.
14. Cummins J.M., He Y., Leary R.J., Pagliarini R., Diaz L.A., Sjoblom T., Barad O., Bentwich Z., Szafranska A.E., Labourier E., Raymond C.K., Roberts B.S., Juhl H., Kinzler K.W., Vogelstein B., Velculescu V.E. The colorectal microRNAome. Proc. Natl. Acad. Sci. USA 2006, 103:3687-3692.
15. Krutzfeldt J., Stoffel M. MicroRNAs: a new class of regulatory genes affecting metabolism. Cell Metab. 2006, 4:9-12.
16. Mudhasani R., Zhu Z., Hutvagner G., Eischen C.M., Lyle S., Hall L.L., Lawrence J.B., Imbalzano A.N., Jones S.N. Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. J. Cell Biol. 2008, 181:1055-1063.
17. Lin Q., Gao Z., Alarcon R.M., Ye J., Yun Z. A role of miR-27 in the regulation of adipogenesis. FEBS. J. 2009, 276:2348-2358.