Modulation of anxiety-like behavior in sildenafil citrate-treated mice placed in an elevated plus-maze

Basic and Clinical Neuroscience

Volumn 2, Issue 4, 2011, Pages 53-57

  Shahidi, Siamak ^a   Hashemi Firouzi, Nasrin ^b   Mahmoodi, Minoo ^b  

^a HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

Acute; Anxiety; Elevated plus maze; Mice; Sildenafil

Indexed keywords

CYCLIC GMP; NITRIC OXIDE; PHOSPHODIESTERASE V; SILDENAFIL;

ACUTE DRUG ADMINISTRATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG MEGADOSE; ELEVATED PLUS MAZE; LOW DRUG DOSE; MALE; MAZE TEST; MOUSE; NONHUMAN; TRANQUILIZING ACTIVITY;

EID: 84859783977     PISSN: 2008126X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Boccia, M.M., Blake, M.G., Krawczykm M.C., Baratti, C.M. (2011). Sildenafil, a selective phosphodiesterase type 5 inhibitor, enhances memory reconsolidation of an inhibitory avoidance task in mice. Behavior brain research, 220(2), 319- 324.
2. Calixto, A.V., Duarte, F.S., Duzzioni, M., Nascimento Häckl, L.P., Faria, M.S., De Lima, T.C. (2010). Role of ventral hippocampal nitric oxide/cGMP pathway in anxiety-related behaviors in rats submitted to the elevated T-maze. Behavior Brain Research, 207(1), 112-117.
3. Czech, D.A., Jacobson, E., LeSueur-Reed, K.T., Kazel, M.R. (2003). Putative anxiety-linked effects of the nitric oxide synthase inhibitor LNAME in three murine exploratory behavior models. Pharmacology Biochemistry and Behavior, 75(4), 741-748.
4. De Oliveira, C.L., Del Bel, E.A., Guimarãaes, F.S. (1997). Effects of L-NOARG on plus-maze performance in rats. Pharmacology Biochemistry and Behavior, 56(1), 55-59.
5. Garthwaite, J., Boulton, C.L. (1995). Nitric oxide signaling in the central nervous system. Annual Review of Physiology, 995(57), 683-706.
6. Gilhotra, N., Dhingra, D. (2009). Involvement of NO-cGMP pathway in anti-anxiety effect of aminoguanidine in stressed mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33(8), 1502-1507.
7. Goldstein, I., Lue, T.F., Padma-Nathan, H., Rosen, R.C., Steers, W.D., Wicker, P.A. (1998). Oral sildenafil in the treatment of erectile dysfunction. New England Journal of Medicine, 338(20), 1397-1404.
8. Hotchkiss, AK., Pyter, L.M., Gatien, M.L., Wen, J.C., Milman, H.A., Nelson, R.J. (2005). Aggressive behavior increases after termination of chronic sildenafil treatment in mice. Physiology & Behavior, 83(5), 683- 688.
9. Kurt, M., Bilge, S.S., Aksoz, E., Kukula, O., Celik, S., Kesim, Y. (2004). Effect of sildenafil on anxiety in the plus-maze test in mice. Polish Journal of Pharmacology, 56(3), 353-357.
10. Li, S., Chung, E., Quock, R. (2004). Role of cyclic GMP in nitrousoxide- induced anxiolytic-like behavior in the mouse light-dark exploration test. Behavioral Neuroscience, 118(3), 648-652.
11. McCullough, AR. (2002). Four-Year Review of Sildenafil Citrate. Reviews in Urology, 4(3), 26-38.
12. Milman, H.A., Arnold, S.B. (2002). Neurologic, psychological, and aggressive disturbances with sildenafil. The Annals of Pharmacotherapy, 36(7-8), 1129-1134.
13. Pokk, P., Vali, M. (2002). The effects of the nitric oxide synthase inhibitors on the behavior of small-platform stressed mice in the plus-maze test. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 26(2), 241-247.
14. Prickaerts, J., Vanstaveren, W.C., Sik, A., Markerink-Vanittersum, M., Niewohner, U., Vanderstaay., et al. (2002). Effects of two selective phosphodiesterase type 5 inhibitors, sildenafil and vardenafil, on object recognition memory and hippocampal cyclic GMP levels in the rat. Neuroscience, 113(2), 351-361.
15. Riazi, K., Roshanpour, M., Rafiei-Tabatabaei, N., Homayoun, H., Ebrahimi, F., Dehpour, A.R. (2006). The proconvulsant effect of sildenafil in mice: role of nitric oxide-cGMP pathway. British Journal of Pharmacology, 147(8), 935-943.
16. Solís, A. A., Bethancourt, J.A., Britton, G.B. (2008). Chronic sildenafil (Viagra) administration reduces anxiety in intact and castrated male rats. Psicothema, 20(4), 812-817.
17. Snyder, S.H., Bredt, D.S. (1991). Nitric oxide as a neuronal messenger. Trends in Pharmacological Sciences, 12(4), 125-128.
18. Ulhayathas, S., Karuppagounder, S.S., Thrash, B.M., Parameshwaran, K., Suppiramaniam, V., Dhanasekaran, M. (2007). Versatile effects of sildenafil: recent pharmacological applications. Pharmacological Reports, 59(2), 150-163.
19. Vale, A.L., Green, S., Montgomery, A.M., Shafi, S. (1998). The nitric oxide synthesis inhibitor L-NAME produces anxiogenic-like effects in the rat elevated plus-maze test, but not in the social interaction test. Journal of Psychopharmacology, 12(3), 268-272.
20. Volke, V., Vasar, E. (1997). Phosphodiesterase type 5 inhibitor sildenafil has anxiogenic-like properties in mouse light-dark compartment test. 15th ECNP Congress Barcelona Spain 6.023
21. Volke, V., Wegener, G., & Vasar, E. (2003). Augmentation of the NO-cGMP cascade induces anxiogenic-like effect in mice. Journal of Physiology and Pharmacology, 54(4), 653-660.
22. Workman, J.L., Trainor, B.C., Finy, M.S., Nelson, R.J. (2008). Inhibition of neuronal nitric oxide reduces anxiety-like responses to pair housing. Behavior Brain Research, 187(1), 109-115.
23. Zhang, R., Wang, Y., Zhang, L., Zhang, Z., Tsang, W., Lu, M., Zhang, L., Chopp, M. (2002). Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke, 33(11), 2675-2680.