Comparison of pharmacokinetic interactions and physiologically based pharmacokinetic modelling of PCB 153 and PCB 126 in nonpregnant mice, lactating mice, and suckling pups

Toxicological Sciences

Volumn 65, Issue 1, 2002, Pages 26-34

  Lee, Sun Ku ^a   Ou, Ying C ^a,b   Yang, Raymond S H ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b OTSUKA PHARMACEUTICAL DEVELOPMENT AND COMMERCIALIZATION INC   (United States)

Author keywords

Diffusion permeation constant; Fat content; Lactational transfer; Mixture; PBPK modeling; PCB; Pharmacokinetic interactions

Indexed keywords

2,2',4,4',5,5' HEXACHLOROBIPHENYL; 3,3',4,4',5 PENTACHLOROBIPHENYL; FAT; POLYCHLORINATED BIPHENYL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CHEMICAL INTERACTION; CONTROLLED STUDY; DIFFUSION COEFFICIENT; FAT CONTENT; GAS CHROMATOGRAPHY; LACTATION; LIVER LEVEL; MOUSE; NEUROTOXICITY; NONHUMAN; PERINATAL DRUG EXPOSURE; PLACENTAL TRANSFER; QUANTITATIVE ASSAY; SUCKLING; TISSUE LEVEL; TOXICOKINETICS;

ADIPOSE TISSUE; ANIMALS; BODY WEIGHT; DRUG INTERACTIONS; ESTROGEN ANTAGONISTS; FEMALE; LACTATION; LIVER; MATERNAL EXPOSURE; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MULTIPLE CHEMICAL SENSITIVITY; POLYCHLORINATED BIPHENYLS; PREGNANCY; TIME FACTORS; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0036149778     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/65.1.26     Document Type: Article

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