Measurement of binding of basic drugs to acidic phospholipids using surface plasmon resonance and incorporation of the data into mechanistic tissue composition equations to predict steady-state volume of distribution

Drug Metabolism and Disposition

Volumn 39, Issue 10, 2011, Pages 1789-1793

  Small, Helen ^a   Gardner, Iain ^a   Jones, Hannah M ^a   Davis, John ^a   Rowland, Malcolm ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 DIMETHYLAMINOMETHYL 4 (4 METHYLSULFANYLPHENOXY)BENZENESULFONAMIDE; AMLODIPINE; BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE; LIPOSOME; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE; PLASMA PROTEIN; PROPRANOLOL; UK 390957; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BINDING AFFINITY; CALCULATION; CONTROLLED STUDY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; HUMAN; INTERMETHOD COMPARISON; PREDICTION; PRIORITY JOURNAL; STEADY STATE; SURFACE PLASMON RESONANCE; TISSUE DISTRIBUTION;

AMLODIPINE; HYDROGEN-ION CONCENTRATION; LIPOSOMES; MODELS, CHEMICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PHOSPHATIDYLSERINES; PROPRANOLOL; PROTEIN BINDING; SULFONAMIDES; SURFACE PLASMON RESONANCE; TISSUE DISTRIBUTION;

EID: 80053170084     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.040253     Document Type: Article

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