Context surrounding processing sites is crucial in determining cleavage rate of a subset of processing sites in HIV-1 gag and gag-pro-pol polyprotein precursors by viral protease

Journal of Biological Chemistry

Volumn 287, Issue 16, 2012, Pages 13279-13290

  Lee, Sook Kyung ^a   Potempa, Marc ^a   Kolli, Madhavi ^b   Özen, Ayşegül ^b   Schiffer, Celia A ^b   Swanstrom, Ronald ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CLEAVAGE RATES; CLEAVAGE SITES; COMPLEX SUBSTRATES; CONTEXT INDEPENDENT; HIV-1 PROTEASE; HUMAN IMMUNODEFICIENCY VIRUS TYPE-1; INFECTIOUS PARTICLES; N-TERMINAL DOMAINS; POLYPROTEINS; PROCESSING RATES; PROTEASE ASSAY; SCISSILE BOND; VIRAL PROTEASE; WILD TYPES;

VIRUSES;

SUBSTRATES;

CAPSID PROTEIN; GAG PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE; MATRIX PROTEIN; MULTIDRUG RESISTANCE PROTEIN; POLYPROTEIN; PROLINE; PROTEIN PRECURSOR; PROTEIN VARIANT; SPACER PEPTIDE 1; SPACER PEPTIDE 2; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CHIMERA; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FOLDING; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV LONG TERMINAL REPEAT; HIV PROTEASE; HIV-1; POL GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; SUBSTRATE SPECIFICITY; VIRION; VIRUS ASSEMBLY;

HUMAN IMMUNODEFICIENCY VIRUS 1; MIRIDAE;

EID: 84859762033     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.339374     Document Type: Article

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