-
1
-
-
67650092919
-
LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
-
19520913 10.1126/science.1168974
-
N Zelcer C Hong R Boyadjian P Tontonoz 2009 LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor Science 325 100 104 19520913 10.1126/science.1168974
-
(2009)
Science
, vol.325
, pp. 100-104
-
-
Zelcer, N.1
Hong, C.2
Boyadjian, R.3
Tontonoz, P.4
-
4
-
-
0037785185
-
Cardiovascular disease
-
DOI 10.1056/NEJMra035098
-
EG Nabel 2003 Cardiovascular disease N Engl J Med 349 60 72 12840094 10.1056/NEJMra035098 (Pubitemid 36765105)
-
(2003)
New England Journal of Medicine
, vol.349
, Issue.1
, pp. 60-72
-
-
Nabel, E.G.1
-
5
-
-
0033549840
-
Drug treatment of lipid disorders
-
DOI 10.1056/NEJM199908123410707
-
RH Knopp 1999 Drug treatment of lipid disorders N Engl J Med 341 498 511 10441607 10.1056/NEJM199908123410707 (Pubitemid 29372891)
-
(1999)
New England Journal of Medicine
, vol.341
, Issue.7
, pp. 498-511
-
-
Knopp, R.H.1
-
6
-
-
56749106312
-
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
-
JUPITER Study Group. 18997196 10.1056/NEJMoa0807646
-
PM Ridker E Danielson FAH Fonseca J Genest AM Gotto Jr JJ Kastelein W Koenig P Libby AJ Lorenzatti JG MacFadyen BG Nordestgaard J Shepherd JT Willerson RJ Glynn JUPITER Study Group 2008 Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein N Engl J Med 359 2195 2207 18997196 10.1056/NEJMoa0807646
-
(2008)
N Engl J Med
, vol.359
, pp. 2195-2207
-
-
Ridker, P.M.1
Danielson, E.2
Fonseca, F.A.H.3
Genest, J.4
Gotto Jr, A.M.5
Kastelein, J.J.6
Koenig, W.7
Libby, P.8
Lorenzatti, A.J.9
MacFadyen, J.G.10
Nordestgaard, B.G.11
Shepherd, J.12
Willerson, J.T.13
Glynn, R.J.14
-
7
-
-
67649834099
-
Inhibition of PCSK9: A powerful weapon for achieving ideal LDL cholesterol levels
-
19506257 10.1073/pnas.0904560106
-
D Steinberg JL Witztum 2009 Inhibition of PCSK9: A powerful weapon for achieving ideal LDL cholesterol levels Proc Natl Acad Sci USA 106 9546 9547 19506257 10.1073/pnas.0904560106
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 9546-9547
-
-
Steinberg, D.1
Witztum, J.L.2
-
8
-
-
30344473341
-
Protein sensors for membrane sterols
-
DOI 10.1016/j.cell.2005.12.022, PII S0092867405014637
-
JL Goldstein RA DeBose-Boyd MS Brown 2006 Protein sensors for membrane sterols Cell 124 35 46 16413480 10.1016/j.cell.2005.12.022 (Pubitemid 43069308)
-
(2006)
Cell
, vol.124
, Issue.1
, pp. 35-36
-
-
Goldstein, J.L.1
DeBose-Boyd, R.A.2
Brown, M.S.3
-
9
-
-
34547108600
-
Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation
-
DOI 10.1074/jbc.M702027200
-
DW Zhang TA Lagace R Garuti Z Zhao M McDonald JD Horton JC Cohen HH Hobbs 2007 Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation J Biol Chem 282 18602 18612 17452316 10.1074/jbc.M702027200 (Pubitemid 47100234)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.25
, pp. 18602-18612
-
-
Zhang, D.-W.1
Lagace, T.A.2
Garuti, R.3
Zhao, Z.4
McDonald, M.5
Horton, J.D.6
Cohen, J.C.7
Hobbs, H.H.8
-
10
-
-
40949136906
-
PCSK9: An enigmatic protease
-
18280815
-
D Lopez 2008 PCSK9: an enigmatic protease Biochim Biophys Acta 1781 184 191 18280815
-
(2008)
Biochim Biophys Acta
, vol.1781
, pp. 184-191
-
-
Lopez, D.1
-
11
-
-
48249115641
-
Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion
-
18631360 10.1111/j.1742-4658.2008.06553.x
-
J Cameron ∅L Holla KE Berge MA Kulseth T Ranheim TP Leren JK Laerdahl 2008 Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion FEBS J 275 4121 4133 18631360 10.1111/j.1742-4658.2008.06553.x
-
(2008)
FEBS J
, vol.275
, pp. 4121-4133
-
-
Cameron, J.1
Berge, K.E.2
Kulseth, M.A.3
Ranheim, T.4
Leren, T.P.5
Laerdahl, J.K.6
-
13
-
-
51349161358
-
Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor
-
18753623 10.1073/pnas.0806312105
-
DW Zhang R Garuti WJ Tang JC Cohen HH Hobbs 2008 Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor Proc Natl Acad Sci USA 105 13045 13050 18753623 10.1073/pnas.0806312105
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 13045-13050
-
-
Zhang, D.W.1
Garuti, R.2
Tang, W.J.3
Cohen, J.C.4
Hobbs, H.H.5
-
14
-
-
67649834056
-
A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates
-
19443683 10.1073/pnas.0903849106
-
JC Chan DE Piper Q Cao D Liu C King W Wang J Tang Q Liu J Higbee Z Xia Y Di S Shetterly Z Arimura H Salomonis WG Romanow ST Thibault R Zhang P Cao XP Yang T Yu M Lu MW Retter G Kwon K Henne O Pan MM Tsai B Fuchslocher E Yang L Zhou KJ Lee M Daris J Sheng Y Wang WD Shen WC Yeh M Emery NP Walker B Shan M Schwarz SM Jackson 2009 A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates Proc Natl Acad Sci USA 106 9820 9825 19443683 10.1073/pnas.0903849106
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 9820-9825
-
-
Chan, J.C.1
Piper, D.E.2
Cao, Q.3
Liu, D.4
King, C.5
Wang, W.6
Tang, J.7
Liu, Q.8
Higbee, J.9
Xia, Z.10
Di, Y.11
Shetterly, S.12
Arimura, Z.13
Salomonis, H.14
Romanow, W.G.15
Thibault, S.T.16
Zhang, R.17
Cao, P.18
Yang, X.P.19
Yu, T.20
Lu, M.21
Retter, M.W.22
Kwon, G.23
Henne, K.24
Pan, O.25
Tsai, M.M.26
Fuchslocher, B.27
Yang, E.28
Zhou, L.29
Lee, K.J.30
Daris, M.31
Sheng, J.32
Wang, Y.33
Shen, W.D.34
Yeh, W.C.35
Emery, M.36
Walker, N.P.37
Shan, B.38
Schwarz, M.39
Jackson, S.M.40
more..
-
15
-
-
33644651160
-
Liver X receptors as integrators of metabolic and inflammatory signaling
-
DOI 10.1172/JCI27883
-
N Zelcer P Tontonoz 2006 Liver X receptors as integrators of metabolic and inflammatory signaling J Clin Invest 116 607 614 16511593 10.1172/JCI27883 (Pubitemid 43326865)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.3
, pp. 607-614
-
-
Zelcer, N.1
Tontonoz, P.2
-
16
-
-
46149098344
-
LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response
-
DOI 10.1016/j.cell.2008.04.052, PII S0092867408006946
-
SJ Bensinger MN Bradley SB Joseph N Zelcer EM Janssen MA Hausner R Shih JS Parks PA Edwards BD Jamieson P Tontonoz 2008 LXR signaling couples sterol metabolism to proliferation in the acquired immune response Cell 134 97 111 18614014 10.1016/j.cell.2008.04.052 (Pubitemid 351905740)
-
(2008)
Cell
, vol.134
, Issue.1
, pp. 97-111
-
-
Bensinger, S.J.1
Bradley, M.N.2
Joseph, S.B.3
Zelcer, N.4
Janssen, E.M.5
Hausner, M.A.6
Shih, R.7
Parks, J.S.8
Edwards, P.A.9
Jamieson, B.D.10
Tontonoz, P.11
-
17
-
-
58849094584
-
Minireview: Liver X receptor beta: Emerging roles in physiology and diseases
-
19074550 10.1210/me.2008-0398
-
C Gabbi M Warner JA Gustafsson 2009 Minireview: liver X receptor beta: emerging roles in physiology and diseases Mol Endocrinol 23 129 136 19074550 10.1210/me.2008-0398
-
(2009)
Mol Endocrinol
, vol.23
, pp. 129-136
-
-
Gabbi, C.1
Warner, M.2
Gustafsson, J.A.3
-
18
-
-
0033579439
-
MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth
-
DOI 10.1074/jbc.274.51.36288
-
P-A Olsson L Korhonen EA Mercer D Lindholm 1999 MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth J Biol Chem 274 36288 36292 10593918 10.1074/jbc.274.51.36288 (Pubitemid 30005229)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.51
, pp. 36288-36392
-
-
Olsson, P.-A.1
Korhonen, L.2
Mercer, E.A.3
Lindholm, D.4
-
19
-
-
65149104670
-
Merlin and the ERM proteins-regulators of receptor distribution and signaling at the cell cortex
-
19345106 10.1016/j.tcb.2009.02.006
-
AI McClatchey RG Fehon 2009 Merlin and the ERM proteins-regulators of receptor distribution and signaling at the cell cortex Trends Cell Biol 19 198 206 19345106 10.1016/j.tcb.2009.02.006
-
(2009)
Trends Cell Biol
, vol.19
, pp. 198-206
-
-
McClatchey, A.I.1
Fehon, R.G.2
-
20
-
-
0141794468
-
Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR
-
DOI 10.1016/S0014-5793(03)01010-X
-
BC Bornhauser C Johansson D Lindholm 2003 Functional activities and cellular localisation of the ezrin.radixin, moesin (ERM) and RING-Zinc finger domains in MIR FEBS Lett 553 195 199 14550572 10.1016/S0014-5793(03)01010-X (Pubitemid 37206350)
-
(2003)
FEBS Letters
, vol.553
, Issue.1-2
, pp. 195-199
-
-
Bornhauser, B.C.1
Johansson, C.2
Lindholm, D.3
-
21
-
-
0034731293
-
Neuronal expression of the ERM-like protein MIR in rat brain and its localization to human chromosome 6
-
DOI 10.1006/bbrc.2000.4028
-
P-A Olsson BC Bornhauser L Korhonen D Lindholm 2000 Neuronal expression of the ERM-like protein MIR in rat brain and its localisation to human chromosome 6 Biochem Biophys Res Commun 279 879 883 11162443 10.1006/bbrc.2000.4028 (Pubitemid 32042870)
-
(2000)
Biochemical and Biophysical Research Communications
, vol.279
, Issue.3
, pp. 879-883
-
-
Olsson, P.-A.1
Bornhauser, B.C.2
Korhonen, L.3
Lindholm, D.4
-
22
-
-
0042818023
-
MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain
-
DOI 10.1074/jbc.M306271200
-
BC Bornhauser P-A Olsson D Lindholm 2003 MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain J Biol Chem 278 35412 35420 12826659 10.1074/jbc.M306271200 (Pubitemid 37102310)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.37
, pp. 35412-35420
-
-
Bornhauser, B.C.1
Olsson, P.-A.2
Lindholm, D.3
-
23
-
-
21144454239
-
MSAP enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain
-
DOI 10.1007/s00018-005-5055-x
-
BC Bornhauser D Lindholm 2005 MSAP enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain Cell Mol Life Sci 62 1260 1266 15905959 10.1007/s00018-005-5055-x (Pubitemid 40880129)
-
(2005)
Cellular and Molecular Life Sciences
, vol.62
, Issue.11
, pp. 1260-1266
-
-
Bornhauser, B.C.1
Lindholm, D.2
-
25
-
-
44649101850
-
Atypical ubiquitin chains: New molecular signals. 'Protein Modifications: Beyond the Usual Suspects' Review Series
-
DOI 10.1038/embor.2008.93, PII EMBOR200893
-
F Ikeda I Dikic 2008 Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series EMBO Rep 9 536 542 18516089 10.1038/embor.2008.93 (Pubitemid 351772916)
-
(2008)
EMBO Reports
, vol.9
, Issue.6
, pp. 536-542
-
-
Ikeda, F.1
Dikic, I.2
-
27
-
-
44149090296
-
Role of platelet-derived growth factors in physiology and medicine
-
DOI 10.1101/gad.1653708
-
J Andrae R Gallini C Betsholtz 2008 Role of platelet-derived growth factors in physiology and medicine Genes Dev 22 1276 1312 18483217 10.1101/gad.1653708 (Pubitemid 351717519)
-
(2008)
Genes and Development
, vol.22
, Issue.10
, pp. 1276-1312
-
-
Andrae, J.1
Gallini, R.2
Betsholtz, C.3
-
28
-
-
0037432766
-
LRP: Role in vascular wall integrity and protection from atherosclerosis
-
DOI 10.1126/science.1082095
-
P Boucher M Gotthardt WP Li RG Anderson J Herz 2003 LRP: Role in vascular wall integrity and protection from atherosclerosis Science 300 329 332 12690199 10.1126/science.1082095 (Pubitemid 36433724)
-
(2003)
Science
, vol.300
, Issue.5617
, pp. 329-332
-
-
Boucher, P.1
Gotthardt, M.2
Li, W.-P.3
Anderson, R.G.W.4
Herz, J.5
|