PKB/Akt partners with Dab2 in albumin endocytosis

American Journal of Physiology - Renal Physiology

Volumn 302, Issue 8, 2012, Pages

  Koral, Kelly ^a   Erkan, Elif ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Apoptosis; Proteinuria; Proximal tubule

Indexed keywords

ADAPTOR PROTEIN; ALBUMIN; DISABLED 2 PROTEIN; MEGALIN; PROLINE RICH PROTEIN; PROTEIN KINASE B; RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENDOCYTOSIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KIDNEY TUBULE CELL; NONHUMAN; PRIORITY JOURNAL; PROLINE RICH PROTEIN DOMAIN; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT;

EID: 84859750844     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00289.2011     Document Type: Article

References (54)

1. Ahmed NN, Grimes HL, Bellacosa A, Chan TO, Tsichlis PN. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc Natl Acad Sci USA 94: 3627-3632, 1997.
2. Brazil DP, Hemmings BA. Ten years of protein kinase B signaling: a hard Akt to follow. Trends Biochem Sci 26: 657-664, 2001.
3. Caruso-Neves C, Pinheiro AA, Cai H, Souza-Menezes J, Guggino WB. PKB and megalin determine the survival or death of renal proximal tubule cells. Proc Natl Acad Sci USA 103: 18810-18815, 2006.
4. Chatrit D, Barzilay L, Horn G, Bielik T, Smorodinsky NI, Ehrlich M. Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis. J Biol Chem 286: 5392-5403, 2011.
5. Christ A, Terryn S, Schmidt V, Christensen EI, Huska MR, Andrade- Navarro MA, Hubner N, Devuyst O, Hammes A, Willnow TE. The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo. Kidney Int 78: 473-477, 2010.
6. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. Akt phosphorylation of BAD couples survival signals to the cellintrinsic death machinery. Cell 91: 231-241, 1997.
7. Eddy AA, Giachelli CM. Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria. Kidney Int 47: 1546-1557, 1995.
8. Eddy AA. Interstitial nephritis induced by protein-overload proteinuria. Am J Pathol 135: 719-733, 1989.
9. Erkan E, De Leon M, Devarajan P. Albumin overload induces apoptosis in LLC-PK1 cells. Am J Physiol Renal Physiol 280: F1107-F1114, 2001.
10. Erkan E, Garcia CD, Patterson LT, Mishra J, Mitsnefes MM, Kaskel FJ, Devarajan P. Induction of renal tubular cell apoptosis in focal segmental glomerulosclerosis: roles of proteinuria and Fas-dependent pathways. J Am Soc Nephrol 16: 398-407, 2005.
11. Erkan E, Devarajan P, Schwartz GJ. Mitochondria are the major targets in albumin-induced apoptosis in proximal tubule cells. J Am Soc Nephrol 18: 1199-1208, 2007.
12. Gaidarov I, Smith ME, Domin J, Keen JH. The class II phosphoinositide 3-kinase C2 α ́ is activated by clathrin and regulates clathrin-mediated membrane trafficking. Mol Cell 7: 443-449, 2001.
13. Gaidarov I, Zhao Y, Keen JH. Individual phosphoinositide 3-kinase C2 α ́ domain activities independently regulate clathrin function. J Biol Chem 280: 40766-40772, 2005.
14. Gallagher H, Oleinikov AV, Fenske C, Newman DJ. The adaptor disabled-2 binds to the third psi xNPxY sequence on the cytoplasmic tail of megalin. Biochimie 86: 179-182, 2004.
15. Gardai SJ, Hildeman DA, Frankel SK, Whitlock BB, Frasch SC, Borregaard N, Marrack P, Bratton DL, Henson PM. Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem 279: 21085-21095, 2004.
16. Gekle M. Renal albumin handling: a look at the dark side. Kidney Int 71: 479-481, 2007.
17. Haucke V. Phosphoinositide regulation of clathrin-mediated endocytosis. Biochem Soc Trans 33: 1285-1289, 205.
18. Inoue A, Sato O, Homma K, Ikebe M. DOC-2/DAB2 is the binding partner of myosin VI. Biochem Biophys Res Commun 290: 300-307, 2002.
19. Jiang BH, Aoki M, Zhenh JZ, Li J, Vogt PK. Myogenic signaling of phosphotidylinositol 3 kinase requires the serine-threonine kinase Akt/ protein kinase B. Proc Natl Acad Sci USA 96: 2077-2081, 1999.
20. Kim D, Sun M, He L, Zhou QH, Chen J, Sun XM, Bepler G, Sebti SM, Cheng JQ. A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J Biol Chem 285: 8383-8394, 2010.
21. Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, O'Connell JR, Li M, Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang SJ, Johnson AD, Dehghan A, Teumer A, Paré G, Atkinson EJ, Zeller T, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, Tönjes A, Hayward C, Aspelund T, Eiriksdottir G, Launer LJ, Harris TB, Rampersaud E, Mitchell BD, Arking DE, Boerwinkle E, Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer IH, Haritunians T, Lumley T, Siscovick D, Psaty BM, Zillikens MC, Oostra BA, Feitosa M, Province M, de Andrade M, Turner ST, Schillert A, Ziegler A, Wild PS, Schnabel RB, Wilde S, Munzel TF, Leak TS, Illig T, Klopp N, Meisinger C, Wichmann HE, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Schreiber S, Aulchenko YS, Felix JF, Rivadeneira F, Uitterlinden AG, Hofman A, Imboden M, Nitsch D, Brandstätter A, Kollerits B, Kedenko L, Mägi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, Völzke H, Kroemer HK, Nauck M, Völker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM, Kardia SL, Blankenberg S, Liu Y, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Shlipak MG, van Duijn CM, Borecki I, Krämer BK, Rudan I, Gyllensten U, Wilson JF, Witteman JC, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM, Fox CS. New lociassociated with kidney function and chronic kidney disease. Nat Genet 42: 376-384, 2010.
22. Lee IH, Dinudom A, Sanchez-Perez A, Kumar S, Cook DI. Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J Biol Chem 282: 29866-29873, 2007.
23. Li Y, Lu W, Marzolo MP, Bu G. Differential functions of members of the low density lipoprotein receptor family suggested by their distinct endocytosis rates. J Biol Chem 276: 18000-18006, 2001.
24. Lu B, Wang L, Stehlik C, Medan D, Huang C, Chen F, Shi X, Rojanasakul Y. Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells. J Immunol 176: 6785-6793, 2006.
25. Maurer ME, Cooper JA. Endocytosis of megalin by visceral endoderm cells requires Dab2 adaptor protein. J Cell Sci 118: 5345-5355, 2005.
26. Mishra SK, Keyel PA, Hawryluk MJ, Agostinelli NR, Watkins SC, Traub LM. Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor. EMBO J 21: 4915-4926, 2002.
27. Morris SM, Tallquist MD, Rock CO, Cooper JA. Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J 21: 1555-1564, 2002.
28. Nagai J, Christensen EI, Morris SM, Willnow TE, Cooper JA, Nielsen R. Mutually dependent localization of megalin and Dab2 in the renal proximal tubule. Am J Physiol Renal Physiol 289: F569-F576, 2005.
29. Nagai M, Meerloo T, Takeda T, Farquhar MG. The adaptor protein ARH escorts megalin to and through endosomes. Mol Biol Cell 14: 4984-4996, 2003.
30. Nechushtan A, Smith CL, Hsu YT, Youle RJ. Conformation of the Bax C-terminus regulates subcellular location and cell death. EMBO J 18: 2330-2341, 1999.
31. Oleinikov AV, Zhao J, Makker SP. Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin. Biochem J 347: 613-621, 2000.
32. Racussen LC, Monteil C, Sgrignoli A, Lucskay M, Marouillat S, Rhim JGS, Morin JP. Cell lines with extended in vitro growth potential from human renal proximal tubule: characterization, response to inducers, and comparison with established cell lines. J Lab Clin Med 129: 318-329, 1997.
33. Remuzzi G, Chiurchiu C, Ruggenenti P. Proteinuria predicting outcome in renal disease: nondiabetic nephropathies (REIN). Kidney Int Suppl 92: S90-S96, 2004.
34. Remuzzi G. Renal protection: progression, regression, remission from nephropathy beyond blood pressure control. Int J Clin Pract Suppl 110: 9-15, 2000.
35. Stiles BL. PI-3-K and Akt: onto the mitochondria. Adv Drug Deliv Rev 61: 1276-1282, 2009.
36. Takeda T, Yamazaki H, Farquhar MG. Identification of an apical sorting determinant in the cytoplasmic tail of megalin. Am J Physiol Cell Physiol 284: C1105-C1113, 2003.
37. Thomas GL, Yang B, Wagner BE, Savill J, El Nahas AM. Cellular apoptosis and proliferation in experimental renal fibrosis. Nephrol Dial Transplant 13: 2216-2226, 1998.
38. Tojo A, Endou H. Intrarenal handling of proteins in rats using fractional micropuncture technique. Am J Physiol Renal Fluid Electrolyte Physiol 263: F601-F606, 1992.
39. Traub LM. Clathrin couture: fashioning distinctive membrane coats at the cell surface. PLoS Biol 7: 1-5, 2009.
40. Tseng CP, Ely BD, Pong RC, Wang Z, Zhou J, Hsieh JT. The role of DOC/Dab2 protein phosphorylation in the inhibition of Ap-1 activity. J Biol Chem 274: 31981-31986, 1999.
41. Woost PG, Orosz DE, Jin W, Frisa PS, Jacobberger JW, Douglas JG, Hopfer U. Immortalization and characterization of proximal tubule cells derived from kidneys of spontaneously hypertensive and normotensive rats. Kidney Int 50: 125-134, 1996.
42. Xie D, Gore C, Zhou J, Pong RC, Zhang H, Yu L, Vesella RL, Min W, Hsieh JT. Dab2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis. Proc Natl Acad Sci USA 106: 19878-19883, 2009.
43. Xu X, Yi T, Tang B, Lambeth JD. Disabled-2 (Dab2) is an SH3 domainbinding partner of Grb2. Oncogene 16: 1561-1569, 1998.
44. Yamaguchi H, Wang HG. The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change. Oncogene 20: 7779-7786, 2001.
45. Yang B, Johnson TS, Thomas GL, Watson PF, Wagner B, Skill NJ, Haylor JL, Nahas AM. Expression of apoptosis-related genes and proteins in experimental chronic renal scarring. J Am Soc Nephrol 12: 275-288, 2001.
46. Yang L, Dan HC, Sun M, Liu Q, Sun X, Feldman RI, Hamilton AD, Polokoff M, Nicosia SV, Herlyn M, Sebti SM, Cheng JQ. Akt/Protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling antitumor activity in cancer cells overexpressing Akt. Cancer Res 64: 4394-4399, 2004.
47. Yang ZZ, Tschopp O, Baudry A, Dummler B, Hynx D, Hemmings BA. Physiological functions of protein kinase B/Akt. Biochem Soc Trans 32: 350-354, 2004.
48. Yu C, Feng W, Wei Z, Miyanoiri Y, Wen W, Zhao Y, Zhang M. Myosin VI undergoes cargo-mediated dimerization. Cell 138: 537-548, 2009.
49. Yuseff MI, Farfan P, Bu G, Marzolo MP. A cytoplasmic PPPSP motif determines megalin's phosphorylation and regulates receptor's recycling and surface expression. Traffic 8: 1215-1230, 2007.
50. Zhai XY, Nielsen R, Birn H, Drumm K, Mildenberger S, Freudinger R, Moestrup SK, Verroust PJ, Christensen EL, Gekle M. Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney. Kidney Int 58: 1523-1533, 2000.
51. Zhou J, Hsieh J. The inhibitory role of DOC-2/DAB2 in growth factor receptor-mediated signal cascade. DOC-2/DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2. J Biol Chem 276: 27793-27798, 2001.
52. Zoja C, Donadelli R, Colleoni S, Figliuzzi M, Bonazzola S, Morigi M, Remuzzi G. Protein overload stimulates RANTES production by proximal tubular cells depending on NF-κB activation. Kidney Int 53: 1608-1615, 1998.
53. Zoja C, Morigi M, Figliuzzi M, Bruzzi I, Oldroyd S, Benigni A, Ronco P, Remuzzi G. Proximal tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins. Am J Kidney Dis 26: 934-941, 1995.
54. Zou Z, Chung B, Nguyen T, Mentone S, Thomsom B, Biemesderfer D. Linking receptor-mediated endocytosis and cell signaling: evidence for regulated intramembrane proteolysis of megalin in proximal tubule. J Biol Chem 279: 34302-34310, 2004.