Identification of an apical sorting determinant in the cytoplasmic tail of megalin

American Journal of Physiology - Cell Physiology

Volumn 284, Issue 5 53-5, 2003, Pages

  Takeda, Tetsuro ^a   Yamazaki, Hajime ^a   Farquhar, Marilyn G ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chimeric minireceptors; Endocytosis; Low density lipoprotein receptor related protein; Madin Darby canine kidney cells; NPXY sorting signals

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MEGALIN;

ANIMAL CELL; ANIMAL TISSUE; APICAL MEMBRANE; APICAL SORTING DETERMINANT; ARTICLE; BIOTINYLATION; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL POLARITY; CELL STRAIN; CELL SURFACE; CHIMERA; CONTROLLED STUDY; CYTOPLASM; DELETION MUTANT; DILEUCINE MOTIF; ENDOCYTOSIS; ENDOSOME; EPITHELIUM CELL; FILTRATION; GENE EXPRESSION REGULATION; IMMUNOFLUORESCENCE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; MULTIGENE FAMILY; NONHUMAN; NPXY MOTIF; PDZ BINDING MOTIF; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN TARGETING; RAT; RECEPTOR GENE; SH3 MOTIF; YXXO MOTIF;

ANIMALIA;

EID: 0037404459     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.00514.2002     Document Type: Article

References (40)

1. Brown DA and Rose JK. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68: 533-544, 1992.
2. Bu G and Rennke S. Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein. J Biol Chem 271: 22218-22224, 1996.
3. Christensen EI and Willnow TE. Essential role of megalin in renal proximal tubule for vitamin homeostasis. J Am Soc Nephrol 10: 2224-2236, 1999.
4. Czekay RP, Orlando RA, Woodward L, Lundstrom M, and Farquhar MG. Endocytic trafficking of megalin/RAP complexes: dissociation of the complexes in late endosomes. Mol Biol Cell 8: 517-532, 1997.
5. Farquhar MG, Kerjaschki D, Lundstrom M, and Orlando RA. gp330 and RAP: the Heymann nephritis antigenic complex. Ann NY Acad Sci 737: 96-113, 1994.
6. Finer MH, Dull TJ, Qin L, Farson D, and Roberts MR. kat: a high-efficiency retroviral transduction system for primary human T lymphocytes. Blood 83: 43-50, 1994.
7. Folsch H, Ohno H, Bonifacino JS, and Mellman I. A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells. Cell 99: 189-198, 1999.
8. Folsch H, Pypaert M, Schu P, and Mellman I. Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells. J Cell Biol 152: 595-606, 2001.
9. Goldstein JL, Brown MS, Anderson RG, Russell DW, and Schneider WJ. Receptor-mediated endocytosis: concepts emerging from the LDL receptor system. Annu Rev Cell Biol 1: 1-39, 1985.
10. Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, and Herz J. Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J Biol Chem 275: 25616-25624, 2000.
11. Heilker R, Spiess M, and Crottet P. Recognition of sorting signals by clathrin adaptors. Bioessays 21: 558-567, 1999.
12. Herz J, Hamann U, Rogne S, Myklebost O, Gausepohl H, and Stanley KK. Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDLreceptor suggest a physiological role as lipoprotein receptor. EMBO J 7: 4119-4127, 1988.
13. Ikonen E and Simons K. Protein and lipid sorting from the trans-Golgi network to the plasma membrane in polarized cells. Semin Cell Dev Biol 9: 503-509, 1998.
14. Kerjaschki D and Farquhar MG. The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci USA 79: 5557-5581, 1982.
15. Krieger M and Herz J. Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP). Annu Rev Biochem 63: 601-637, 1994.
16. Le Bivic A, Sambuy Y, Mostov K, and Rodriguez-Boulan E. Vectorial targeting of an endogenous apical membrane sialoglycoprotein and uvomorulin in MDCK cells. J Cell Biol 110: 15331539, 1990.
17. Matter K. Epithelial polarity: sorting out the sorters. Curr Biol 10: R39-R42, 2000.
18. Matter K, Yamamoto EM, and Mellman I. Structural requirements and sequence motifs for polarized sorting and endocytosis of LDL and Fc receptors in MDCK cells. J Cell Biol 126: 991-1004, 1994.
19. Mostov KE, Verges M, and Altschuler Y. Membrane traffic in polarized epithelial cells. Curr Opin Cell Biol 12: 483-490, 2000.
20. Muth TR, Ahn J, and Caplan MJ. Identification of sorting determinants in the C-terminal cytoplasmic tails of the gammaaminobutyric acid transporters GAT-2 and GAT-3. J Biol Chem 273: 25616-25627, 1998.
21. Nelson WJ and Yeaman C. Protein trafficking in the exocytic pathway of polarized epithelial cells. Trends Cell Biol 11: 483-486, 2001.
22. Ohno H, Stewart J, Fournier MC, Bosshart H, Rhee I, Miyatake S, Saito T, Gallusser A, Kirchhausen T, and Bonifacino JS. Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science 269: 1872-1875, 1995.
23. Oleinikov AV, Zhao J, and Makker SP. Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin. Biochem J 347: 613-621, 2000.
24. Orlando RA and Farquhar MG. Functional domains of the receptor-associated protein (RAP). Proc Natl Acad Sci USA 91: 3161-3165, 1994.
25. Orlando RA, Rader K, Authier F, Yamazaki H, Posner BI, Bergeron JJ, and Farquhar MG. Megalin is an endocytic receptor for insulin. J Am Soc Nephrol 9: 1759-1766, 1998.
26. Patrie KM, Drescher AJ, Goyal M, Wiggins RC, and Margolis B. The membrane-associated guanylate kinase protein magi-1 binds megalin and is present in glomerular podocytes. J Am Soc Nephrol 12: 667-677, 2001.
27. Rader K, Orlando RA, Lou X, and Farquhar MG. Characterization of ANKRA, a novel ankyrin repeat protein that interacts with the cytoplasmic domain of megalin. J Am Soc Nephrol 11: 2167-2178, 2000.
28. Rapoport I, Chen YC, Cupers P, Shoelson SE, and Kirchhausen T. Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site. EMBO J 17: 2148-2155, 1998.
29. Rodriguez-Boulan E and Gonzalez A. Glycans in post-Golgi apical targeting: sorting signals or structural props? Trends Cell Biol 9: 291-294, 1999.
30. Saito A, Pietromonaco S, Loo AK, and Farquhar MG. Complete cloning and sequencing of rat gp330/"megalin"; a distinctive member of the low density lipoprotein receptor gene family. Proc Natl Acad Sci USA 91: 9725-9729, 1994.
31. Saito A, Yamazaki H, Rader K, Nakatani A, Ullrich R, Kerjaschki D, Orlando RA, and Farquhar MG. Mapping rat megalin: the second cluster of ligand binding repeats contains a 46-amino acid pathogenic epitope involved in the formation of immune deposits in Heymann nephritis. Proc Natl Acad Sci USA 93: 8601-8605, 1996.
32. Sargiacomo M, Lisanti M, Graeve L, Le Bivic A, and Rodriguez-Boulan E. Integral and peripheral protein composition of the apical and basolateral membrane domains in MDCK cells. J Membr Biol 107: 277-286, 1989.
33. Scheiffele P, Peranen J, and Simons K. N-glycans as apical sorting signals in epithelial cells. Nature 378: 96-98, 1995.
34. Short DB, Trotter KW, Reczek D, Kreda SM, Bretscher A, Boucher RC, Stutts MJ, and Milgram SL. An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton. J Biol Chem 273: 19797-19801, 1998.
35. Simons K and Ikonen E. Functional rafts in cell membranes. Nature 387: 569-572, 1997.
36. Takeda T, Go WY, Orlando RA, and Farquhar MG. Expression of podocalyxin inhibits cell-cell adhesion and modifies junctional properties in Madin-Darby canine kidney cells. Mol Biol Cell 11: 3219-3232, 2000.
37. Trommsdorff M, Borg JP, Margolis B, and Herz J. Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J Biol Chem 273: 33556-33560, 1998.
38. Yamazaki H, Ullrich R, Exner M, Saito A, Orlando RA, Kerjaschki D, and Farquhar MG. All four putative ligandbinding domains in megalin contain pathogenic epitopes capable of inducing passive Heymann nephritis. J Am Soc Nephrol 9: 1638-1644, 1998.
39. Yeaman C, Grindstaff KK, and Nelson WJ. New perspectives on mechanisms involved in generating epithelial cell polarity. Physiol Rev 79: 73-98, 1999.
40. Zheng G, Bachinsky DR, Stamenkovic I, Strickland DK, Brown D, Andres G, and McCluskey RT. Organ distribution in rats of two members of the low density lipoprotein receptor gene family, gp330 and LRP/alpa 2MR, and the receptor-associated protein (RAP). J Histochem Cytochem 42: 531-542, 1994.