Functional consequence of covalent reaction of phosphoenolpyruvate with UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA)

Journal of Biological Chemistry

Volumn 287, Issue 16, 2012, Pages 12657-12667

  Zhu, Jin Yi ^a   Yang, Yan ^a   Han, Huijong ^a   Betzi, Stephane ^a   Olesen, Sanne H ^a   Marsilio, Frank ^a   Schönbrunn, Ernst ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE RESIDUES; BIOCHEMICAL STUDIES; COVALENT MODIFICATIONS; COVALENT REACTION; COVALENTLY BOUND; DRUG DISCOVERY; DUAL FUNCTION; ENTEROBACTER CLOACAE; FEEDBACK REGULATION; FOSFOMYCIN; IN-VITRO; INSTANTANEOUS REACTION; PHOSPHOENOLPYRUVATES; REACTION CYCLES;

BIOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

ANTIBIOTICS;

PEPTIDOGLYCAN; PHOSPHOENOLPYRUVATE; TRANSFERASE; UDP N ACETYLGLUCOSAMINE 1 CARBOXYVINYLTRANSFERASE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGALACTOSAMINE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; CATALYSIS; CHEMICAL REACTION; COMPLEX FORMATION; COVALENT BOND; CRYSTAL STRUCTURE; FEEDBACK SYSTEM; IN VITRO STUDY; PRIORITY JOURNAL;

ALKYL AND ARYL TRANSFERASES; CRYSTALLOGRAPHY, X-RAY; DNA ADDUCTS; ENTEROBACTER CLOACAE; ENZYME ACTIVATION; ESCHERICHIA COLI; MURAMIC ACIDS; PHOSPHOENOLPYRUVATE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

ENTEROBACTER CLOACAE;

EID: 84859749022     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.342725     Document Type: Article

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