Role of the loop containing residue 115 in the induced-fit mechanism of the bacterial cell wall biosynthetic enzyme MurA

Biochemistry

Volumn 39, Issue 9, 2000, Pages 2164-2173

  Schönbrunn, Ernst ^a,b   Eschenburg, Susanne ^c   Krekel, Florian ^a   Luger, Karolin ^b   Amrhein, Nikolaus ^a  

^a ETH ZURICH   (Switzerland)

^b Veterinary Dentistry and Oral Surgery   (United States)

^c MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; CYSTEINE; FOSFOMYCIN; MUTANT PROTEIN; PHOSPHOENOLPYRUVATE; SERINE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE;

ARTICLE; BACTERIAL CELL WALL; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENTEROBACTER CLOACAE; ENZYME BINDING; ENZYME INACTIVATION; ENZYME KINETICS; ENZYME MECHANISM; HYDROGEN BOND; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ALKYL AND ARYL TRANSFERASES; AMINO ACID SUBSTITUTION; CATALYSIS; CELL WALL; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; ENTEROBACTER CLOACAE; ENZYME ACTIVATION; ENZYME INHIBITORS; FOSFOMYCIN; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; SERINE; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS;

BACTERIA (MICROORGANISMS); ENTEROBACTER CLOACAE;

EID: 0040805973     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991091j     Document Type: Article

References (22)

1. Walsh, C. T., Benson, T. E., Kim, D. H., and Lees, W. J. (1996) Chem. Biol. 3, 83-91.
2. Kahan, F. M., Kahan, J. S., Cassidy, P. J., and Kropp, H. (1974) Ann. N. Y. Acad. Sci. 235, 364-385.
3. Steinrücken, H. C., and Amrhein, N. (1980) Biochem. Biophys. Res. Commun. 94, 1207-1212.
4. Wanke, C., and Amrhein, N. (1993) Eur. J. Biochem. 218, 861-870.
5. Marquardt, J. L., Brown, D. E., Lane, W. S., Haley, T. M., Ichikawa, Y., Wong, C.-H., and Walsh, C. T. (1994) Biochemistry 33, 10646-10651.
6. Kim, D. H., Lees, W. J., Kempsell, K. E., Lane, W. S., Duncan, K., and Walsh, C. T. (1996) Biochemistry 35, 4923-4928.
7. Schönbrunn, E., Sack, S., Eschenburg, S., Perrakis, A., Krekel, F., Amrhein, N., and Mandelkow, E. (1996) Structure (London) 4, 1065-1075.
8. Skarzynski, T., Mistry, A., Wonacott, A., Hutchinson, S. E., Kelly, V. A., and Duncan, K. (1996) Structure (London) 4, 1465-1474.
9. Skarzynski, T., Kim, D. H., Lees, W. J., Walsh, C. T., and Duncan, K. (1998) Biochemistry 37, 2572-2577.
10. Schönbrunn, E., Svergun, D. I., Amrhein, N., and Koch, M. H. J. (1998) Eur. J. Biochem. 253, 406-412.
11. Wanke, C., Falchetto, R., and Amrhein, N. (1992) FEBS Lett. 301, 271-276.
12. Krekel, F. (1998) Dissertation ETH Zürich, Switzerland.
13. Schloss, J. V. (1989) in Target sites of herbicide action (Böger, P., and Sandmann, G., Eds.) pp 165-245, CRC Press, Boca Raton, FL.
14. Benson, T. E., Marquardt, J. L., Marquardt, A. C., Etzkorn, F. A., and Walsh, C. T. (1993) Biochemistry 33, 2024-2030.
15. Sack, S., Dauter, Z., Wanke, C., Amrhein, N., Mandelkow, E., and Schönbrunn, E. (1996) J. Struct. Biol. 117, 73-76.
16. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326.
17. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, W., Jiang, J.-S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr., Sect. D 54, 905-921.
18. Jones, T. A., Zou, J.-Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr., Sect. A 47, 110-119.
19. Collaborative Computational Project, No. 4 (1994) Acta Crystallogr., Sect. D 50, 760-763.
20. Hooft, R. W. W., Vriend, G., Sander, C., and Abola, E. E. (1996) Nature 381, 272.
21. Shuttleworth, W. A., Pohl, M. E., Helms, G. L., Jakeman, D. L., and Evans, J. N. S. (1999). Biochemistry 38, 296-302.
22. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.