Evidence of kinetic control of ligand binding and staged product release in MurA (Enolpyruvyl UDP-GlcNAc synthase)-catalyzed reactions

Biochemistry

Volumn 48, Issue 49, 2009, Pages 11715-11723

  Jackson, Sean G ^a,b   Zhang, Fuzhong ^a   Chindemi, Paul ^a   Junop, Murray S ^a,b   Berti, Paul J ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CATALYTIC SITES; CATALYZED REACTIONS; COCRYSTAL STRUCTURE; ION PAIRS; KINETIC CONTROL; KINETIC EVIDENCE; LIGAND BINDING; N-ACETYLMURAMIC ACID; ONE STEP; PEPTIDOGLYCANS; POTENT INHIBITOR; PRODUCT RELEASE; SIDE CHAINS; SYNTHASES; TETRAHEDRAL INTERMEDIATES;

BIOCHEMISTRY; ENZYMES; HYDROGEN BONDS; INTERNET PROTOCOLS; IONS; LIGANDS;

BINDING SITES;

MURA(ENOLPYRUVYL UDP GLCNAC SYNTHASE) CATALYZED; PHOSPHITE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLMURAMIC ACID;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHOREOGRAPHY; CONFORMATION; CRYSTAL STRUCTURE; HYDROGEN BOND; KINETICS; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL;

ALKYL AND ARYL TRANSFERASES; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; ESCHERICHIA COLI PROTEINS; FOSFOMYCIN; KINETICS; LIGANDS; PHOSPHOENOLPYRUVATE; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 71549121352     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901524q     Document Type: Article

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