A novel inhibitor that suspends the induced fit mechanism of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA)

Journal of Biological Chemistry

Volumn 280, Issue 14, 2005, Pages 14070-14075

  Eschenburg, Susanne ^b   Priestman, Melanie A ^a   Abdul Latif, Farid A ^e   Delachaume, Carole ^d   Fassy, Florence ^c   Schönbrunn, Ernst ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^c SANOFI   (France)

^d Novexel   (France)

^e Aventis Combinatorial Technol Ctr   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CATALYSIS; CELL MEMBRANES; ENZYME INHIBITION; FLUORESCENCE; ORGANIC ACIDS;

BACTERIAL CELLS; FOSFOMYCIN; MURA (UDP-N-ACETYLGLUCOSOMINE ENOLPYRUVYL TRANSFERASE, EC 2.5.1.7); UDP-N ACETYLGLUCOSOMINE;

ENZYMES;

ANTHRANILIC ACID DERIVATIVE; BACTERIAL ENZYME; PROLINE; T 6361; T 6362; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE ENOLPYRUVYLTRANSFERASE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; ENZYME MECHANISM; ENZYME STRUCTURE; FLUORESCENCE; HIGH THROUGHPUT SCREENING; NONHUMAN; PRIORITY JOURNAL;

ALKYL AND ARYL TRANSFERASES; ANTI-BACTERIAL AGENTS; ASPARTIC ACID; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MICROBIAL; ENTEROBACTER CLOACAE; ENZYME INHIBITORS; FOSFOMYCIN; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHALENESULFONATES; PROTEIN STRUCTURE, TERTIARY;

EID: 17144418885     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M414412200     Document Type: Article

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