The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP- N -acetylglucosamine 1- carboxyvinyltransferase (MurA)

Biochemistry

Volumn 49, Issue 19, 2010, Pages 4276-4282

  Schönbrunn, Ernst ^a   Han, Huijong ^a   Yang, Yan ^a   Olesen, Sanne H ^a   Becker, Andreas ^a   Betzi, Stephane ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ANTIBIOTIC FOSFOMYCIN; ANTIBIOTIC PROPERTY; ASPERGILLUS TERREUS; BACTERIAL CELLS; BINARY STATE; BIOSYNTHETIC ENZYMES; COVALENT MODIFICATIONS; DEAD-END COMPLEX; ENTEROBACTER; ENZYME CONFORMATIONS; FOSFOMYCIN; IN-VITRO; INACTIVATION EFFICIENCY; KINETIC CHARACTERIZATION; MOLECULAR TARGETS; N-ACETYLGLUCOSAMINE; NONCOVALENT BINDING; RATE CONSTANT K; STRUCTURAL CHARACTERISTICS; TERREIC ACID; THIOL GROUPS;

ANTIBIOTICS; BACTERIOLOGY; BINDING ENERGY; BIOSYNTHESIS; CELL MEMBRANES; CRYSTAL STRUCTURE; ENZYMES; ESCHERICHIA COLI; INTERNET PROTOCOLS; RATE CONSTANTS; WALLS (STRUCTURAL PARTITIONS);

ACIDS;

CYSTEINE; FOSFOMYCIN; NUCLEOPHILE; QUININE DERIVATIVE; QUINONE DERIVATIVE; TERREIC ACID; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE;

ARTICLE; ASPERGILLUS TERREUS; BACTERIAL CELL WALL; BIOSYNTHESIS; CRYSTAL STRUCTURE; ENTEROBACTER CLOACAE; ENZYME CONFORMATION; ESCHERICHIA COLI; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL;

ALKYL AND ARYL TRANSFERASES; BINDING SITES; CATALYTIC DOMAIN; CELL WALL; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; QUINONES;

ASPERGILLUS TERREUS; BACTERIA (MICROORGANISMS); ENTEROBACTER CLOACAE; ESCHERICHIA COLI; FUNGI;

EID: 77952329483     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100365b     Document Type: Article

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