-
1
-
-
0035123904
-
Kynurenines in the CNS: from endogenous obscurity to therapeutic importance
-
Stone TW. Kynurenines in the CNS: from endogenous obscurity to therapeutic importance. Prog Neurobiol. 2001;64:185-218.
-
(2001)
Prog Neurobiol
, vol.64
, pp. 185-218
-
-
Stone, T.W.1
-
2
-
-
0036943254
-
Purines and neuroprotection
-
Stone TW. Purines and neuroprotection. Adv Exp Med Biol. 2002;513:249-80.
-
(2002)
Adv Exp Med Biol
, vol.513
, pp. 249-280
-
-
Stone, T.W.1
-
3
-
-
0030347242
-
The kynurenine pathway and neurologic disease Therapeutic strategies
-
Heyes MP. The kynurenine pathway and neurologic disease. Therapeutic strategies. Adv Exp Med Biol. 1996;398:125-9.
-
(1996)
Adv Exp Med Biol
, vol.398
, pp. 125-129
-
-
Heyes, M.P.1
-
4
-
-
4944258716
-
The role of inflammation in Alzheimer's disease
-
Tuppo EE, Arias HR. The role of inflammation in Alzheimer's disease. Int J Biochem Cell Biol. 2005;37:289-305.
-
(2005)
Int J Biochem Cell Biol
, vol.37
, pp. 289-305
-
-
Tuppo, E.E.1
Arias, H.R.2
-
5
-
-
11144230769
-
Neuroglial activation and neuroinflammation in the brain of patients with autism
-
Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol. 2005;57:67-81.
-
(2005)
Ann Neurol
, vol.57
, pp. 67-81
-
-
Vargas, D.L.1
Nascimbene, C.2
Krishnan, C.3
Zimmerman, A.W.4
Pardo, C.A.5
-
6
-
-
0034176154
-
Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection
-
Stone TW. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. Trends Pharmacol Sci. 2000;21: 149-54.
-
(2000)
Trends Pharmacol Sci
, vol.21
, pp. 149-154
-
-
Stone, T.W.1
-
7
-
-
0035239223
-
Endogenous neurotoxins from Tryptophan
-
Stone TW. Endogenous neurotoxins from Tryptophan. Toxicon. 2001;39: 61-73.
-
(2001)
Toxicon
, vol.39
, pp. 61-73
-
-
Stone, T.W.1
-
8
-
-
0037025273
-
The pharmacological manipulation of glutamate receptors and neuroprotection
-
Stone TW, Addae JI. The pharmacological manipulation of glutamate receptors and neuroprotection. Eur J Pharmacol. 2002;447:285-96.
-
(2002)
Eur J Pharmacol
, vol.447
, pp. 285-296
-
-
Stone, T.W.1
Addae, J.I.2
-
9
-
-
35449003309
-
Tryptophan, adenosine, neurodegeneration and neuroprotection
-
Stone TW, Forrest CM, Mackay GM, Stoy N, Darlington LG. Tryptophan, adenosine, neurodegeneration and neuroprotection. Metab Brain Dis. 2007.
-
(2007)
Metab Brain Dis
-
-
Stone, T.W.1
Forrest, C.M.2
Mackay, G.M.3
Stoy, N.4
Darlington, L.G.5
-
10
-
-
0042975281
-
Tryptophan metabolites and brain disorders
-
Stone TW, Mackay GM, Forrest CM, Clark CJ, Darlington LG. Tryptophan metabolites and brain disorders. Clin Chem Lab Med. 2003;41:852-9.
-
(2003)
Clin Chem Lab Med
, vol.41
, pp. 852-859
-
-
Stone, T.W.1
Mackay, G.M.2
Forrest, C.M.3
Clark, C.J.4
Darlington, L.G.5
-
11
-
-
0036378826
-
Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease
-
Guillemin GJ, Brew BJ. Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease. Redox Rep. 2002;7:199-206.
-
(2002)
Redox Rep
, vol.7
, pp. 199-206
-
-
Guillemin, G.J.1
Brew, B.J.2
-
12
-
-
35948955851
-
-
In International Congress Series (Takai K, ed.^editors.)
-
Guillemin GJ, Brew BJ, Noonan CE, Knight TG, Smythe GA, Cullen KM. Mass spectrometric detection of quinolinic acid in microdissected Alzheimer's disease plaques. In International Congress Series (Takai K, ed.^editors.). 2007;404-8.
-
(2007)
Mass spectrometric detection of quinolinic acid in microdissected Alzheimer's disease plaques
, pp. 404-408
-
-
Guillemin, G.J.1
Brew, B.J.2
Noonan, C.E.3
Knight, T.G.4
Smythe, G.A.5
Cullen, K.M.6
-
13
-
-
0034647059
-
Early kynurenergic impairment in Huntington's Disease and in a transgenic animal model
-
Guidetti P, Hemachandra Reddy P, Tagle DA, Schwarcz R. Early kynurenergic impairment in Huntington's Disease and in a transgenic animal model. Neurosci Lett. 2000;283:233-5.
-
(2000)
Neurosci Lett
, vol.283
, pp. 233-235
-
-
Guidetti, P.1
Hemachandra Reddy, P.2
Tagle, D.A.3
Schwarcz, R.4
-
14
-
-
1042268020
-
3-Hydroxykynurenine and quinolinate: pathogenic synergism in early grade Huntington's disease?
-
Guidetti P, Schwarcz R. 3-Hydroxykynurenine and quinolinate: pathogenic synergism in early grade Huntington's disease? Adv Exp Med Biol. 2003;527:137-45.
-
(2003)
Adv Exp Med Biol
, vol.527
, pp. 137-145
-
-
Guidetti, P.1
Schwarcz, R.2
-
15
-
-
33744781601
-
Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis
-
Guillemin GJ, Meininger V, Brew BJ. Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis. Neurodegener Dis. 2005;2:166-76.
-
(2005)
Neurodegener Dis
, vol.2
, pp. 166-176
-
-
Guillemin, G.J.1
Meininger, V.2
Brew, B.J.3
-
16
-
-
0002473245
-
Quinolinic acid production by macrophages infected with demented and non-demented isolates of HIV
-
Brew BJ, Pemberton L, Evans L, Heyes M. Quinolinic acid production by macrophages infected with demented and non-demented isolates of HIV. Clin Neuropathol. 1993;12:S1.
-
(1993)
Clin Neuropathol
, vol.12
-
-
Brew, B.J.1
Pemberton, L.2
Evans, L.3
Heyes, M.4
-
17
-
-
27344457006
-
Quinolinic acid selectively induces apoptosis of human astocytes: Potential role in AIDS dementia complex
-
Guillemin GJ, Wang L, Brew BJ. Quinolinic acid selectively induces apoptosis of human astocytes: Potential role in AIDS dementia complex. Journal of Neuroinflammation. 2005;2:16.
-
(2005)
Journal of Neuroinflammation
, vol.2
, pp. 16
-
-
Guillemin, G.J.1
Wang, L.2
Brew, B.J.3
-
18
-
-
0035544420
-
IFN-beta1 induces kynurenine pathway metabolism in human macrophages: Potential implications for multiple sclerosis treatment
-
Guillemin GJ, Kerr SJ, Pemberton LA, et al. IFN-beta1 induces kynurenine pathway metabolism in human macrophages: Potential implications for multiple sclerosis treatment. Journal of Interferon and Cytokine Research. 2001;21:1097-101.
-
(2001)
Journal of Interferon and Cytokine Research
, vol.21
, pp. 1097-1101
-
-
Guillemin, G.J.1
Kerr, S.J.2
Pemberton, L.A.3
-
19
-
-
0036690151
-
Endogenous kynurenines as targets for drug discovery and development
-
Stone TW, Darlington LG. Endogenous kynurenines as targets for drug discovery and development. Nat Rev Drug Discov. 2002;1:609-20.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 609-620
-
-
Stone, T.W.1
Darlington, L.G.2
-
20
-
-
0034661001
-
Tryptophan metabolism through kynurenine pathway in rat brain and liver slices
-
Dale WE, Dang Y, Brown O. Tryptophan metabolism through kynurenine pathway in rat brain and liver slices. Free Radic Biol Med. 2000;29:191-8.
-
(2000)
Free Radic Biol Med
, vol.29
, pp. 191-198
-
-
Dale, W.E.1
Dang, Y.2
Brown, O.3
-
21
-
-
67651228062
-
Effects of Kynurenine pathway metabolites on intracellular NAD? synthesis and cell death in human primary astrocytes and neurons
-
Braidy N, Grant R, Brew BJ, Adams S, Jayasena T, Guillemin GJ. Effects of Kynurenine pathway metabolites on intracellular NAD? synthesis and cell death in human primary astrocytes and neurons. IJTR. 2009;2:61-9.
-
(2009)
IJTR
, vol.2
, pp. 61-69
-
-
Braidy, N.1
Grant, R.2
Brew, B.J.3
Adams, S.4
Jayasena, T.5
Guillemin, G.J.6
-
22
-
-
69149084827
-
Manipulation of indoleamine 2 3 dioxygenase; a novel therapeutic target for treatment of diseases
-
Tan PH, Bharath AK. Manipulation of indoleamine 2,3 dioxygenase; a novel therapeutic target for treatment of diseases. Exp Opin Ther Targ. 2009;13: 987-1012.
-
(2009)
Exp Opin Ther Targ
, vol.13
, pp. 987-1012
-
-
Tan, P.H.1
Bharath, A.K.2
-
23
-
-
77749242786
-
Cortical kynurenine pathway metabolism: a novel target for cognitive enhancement in schizophrenia
-
Wonodi I, Schwarcz R. Cortical kynurenine pathway metabolism: a novel target for cognitive enhancement in schizophrenia. Schiz Bull. 2010;36: 211-8.
-
(2010)
Schiz Bull
, vol.36
, pp. 211-218
-
-
Wonodi, I.1
Schwarcz, R.2
-
24
-
-
70349754448
-
Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons
-
Braidy N, Grant R, Adams S, Brew BJ, Guillemin G. Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons. Neurotox Res. 2009;16:77-86.
-
(2009)
Neurotox Res
, vol.16
, pp. 77-86
-
-
Braidy, N.1
Grant, R.2
Adams, S.3
Brew, B.J.4
Guillemin, G.5
-
25
-
-
0031930117
-
Murine glial cells regenerate NAD, after peroxideinduced depletion, using either nicotinic acid, nicotinamide, or quinolinic acid as substrates
-
Grant RS, Kapoor V. Murine glial cells regenerate NAD, after peroxideinduced depletion, using either nicotinic acid, nicotinamide, or quinolinic acid as substrates. J Neurochem. 1998;70:1759-63.
-
(1998)
J Neurochem
, vol.70
, pp. 1759-1763
-
-
Grant, R.S.1
Kapoor, V.2
-
26
-
-
0022634961
-
Metabolic consequences of DNA damage: DNA damage induces alterations in glucose metabolism by activation of Poly(ADP-ribose) polymerase
-
Berger SJ, Sudar DC, Berger NA. Metabolic consequences of DNA damage: DNA damage induces alterations in glucose metabolism by activation of Poly(ADP-ribose) polymerase. Biochem Biophys Res Commun. 1986;134: 227-32.
-
(1986)
Biochem Biophys Res Commun
, vol.134
, pp. 227-232
-
-
Berger, S.J.1
Sudar, D.C.2
Berger, N.A.3
-
27
-
-
18544375428
-
Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: focus on cell death and transcriptional regulation
-
Erdelyi K, Bakondi E, Gergely P, Szabo C, Virag L. Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: focus on cell death and transcriptional regulation. Cell Mol Life Sci. 2005; 62:751-9.
-
(2005)
Cell Mol Life Sci
, vol.62
, pp. 751-759
-
-
Erdelyi, K.1
Bakondi, E.2
Gergely, P.3
Szabo, C.4
Virag, L.5
-
28
-
-
0038449141
-
PARP-1, a determinant of cell survival in response to DNA damage
-
Bouchard V, Rouleau M, Poirier GG. PARP-1, a determinant of cell survival in response to DNA damage. Experimental Hematology. 2003;31:446-54.
-
(2003)
Experimental Hematology
, vol.31
, pp. 446-454
-
-
Bouchard, V.1
Rouleau, M.2
Poirier, G.G.3
-
29
-
-
40849135481
-
The Sirtuin family: Therapeutic targets to treat diseases of aging
-
Milne J, Denu JM. The Sirtuin family: Therapeutic targets to treat diseases of aging. Curr Pharm Des. 2008;12:11-7.
-
(2008)
Curr Pharm Des
, vol.12
, pp. 11-17
-
-
Milne, J.1
Denu, J.M.2
-
30
-
-
33845327501
-
SIRT1: linking adaptive cellular responses to agingassociated changes in organismal physiology
-
Anastasiou D, Krek W. SIRT1: linking adaptive cellular responses to agingassociated changes in organismal physiology. Physiology (Bethesda). 2006; 21:404-10.
-
(2006)
Physiology (Bethesda)
, vol.21
, pp. 404-410
-
-
Anastasiou, D.1
Krek, W.2
-
31
-
-
23044462498
-
Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus
-
Guillemin GJ, Brew BJ, Noonan CE, Takikawa O, Cullen KM. Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus. Neuropathol Appl Neurobiol. 2005;31:395-404.
-
(2005)
Neuropathol Appl Neurobiol
, vol.31
, pp. 395-404
-
-
Guillemin, G.J.1
Brew, B.J.2
Noonan, C.E.3
Takikawa, O.4
Cullen, K.M.5
-
32
-
-
0034894035
-
Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection
-
Guillemin GJ, Kerr SJ, Smythe GA, et al. Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection. J Neurochem. 2001;78:1-13.
-
(2001)
J Neurochem
, vol.78
, pp. 1-13
-
-
Guillemin, G.J.1
Kerr, S.J.2
Smythe, G.A.3
-
33
-
-
0015888084
-
An improved cycling assay for nicotinamide adenine dinucleotide
-
Bernofsky C, Swan M. An improved cycling assay for nicotinamide adenine dinucleotide. Anal Biochem. 1973;53:452-8.
-
(1973)
Anal Biochem
, vol.53
, pp. 452-458
-
-
Bernofsky, C.1
Swan, M.2
-
34
-
-
0023221068
-
Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
-
Koh JY, Choi DW. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J Neurosci Methods. 1987;20:83-90.
-
(1987)
J Neurosci Methods
, vol.20
, pp. 83-90
-
-
Koh, J.Y.1
Choi, D.W.2
-
35
-
-
0023013615
-
Tryptophan degradation in mice initiated by indoleamine 2 3-dioxygenase
-
Takikawa O, Yoshida R, Kido R, Hayaishi O. Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase. J Biol Chem. 1986;261: 3648-53.
-
(1986)
J Biol Chem
, vol.261
, pp. 3648-3653
-
-
Takikawa, O.1
Yoshida, R.2
Kido, R.3
Hayaishi, O.4
-
36
-
-
67651243648
-
The excitotoxin quinolinic acid induces tau phosphorylation in human neurons
-
Rahman A, Ting K, Cullen KM, Brew BJ, Braidy N, Guillemin GJ. The excitotoxin quinolinic acid induces tau phosphorylation in human neurons. PLOSONE. 2009;4:e6344.
-
(2009)
PLOSONE
, vol.4
-
-
Rahman, A.1
Ting, K.2
Cullen, K.M.3
Brew, B.J.4
Braidy, N.5
Guillemin, G.J.6
-
37
-
-
0017184389
-
A rapid and sensitive method for quantitation of microgram quantities of protein utilising the principle of protein-dye binding
-
Bradford MM. A rapid and sensitive method for quantitation of microgram quantities of protein utilising the principle of protein-dye binding. Anal Biochem. 1976;53:452-8.
-
(1976)
Anal Biochem
, vol.53
, pp. 452-458
-
-
Bradford, M.M.1
-
38
-
-
38949185264
-
Modulation of sirtuins: new targets for antiageing
-
Pallas M, Verdaguer E, Tajes M, Gutierrez-Cuesta J, Camins A. Modulation of sirtuins: new targets for antiageing. Recent Patents CNS Drug Discov. 2008;3:61-9.
-
(2008)
Recent Patents CNS Drug Discov
, vol.3
, pp. 61-69
-
-
Pallas, M.1
Verdaguer, E.2
Tajes, M.3
Gutierrez-Cuesta, J.4
Camins, A.5
-
39
-
-
37549068090
-
+/NADPH in cellular functions and cell death: regulation and biological consequences
-
+/NADPH in cellular functions and cell death: regulation and biological consequences. Antioxid Redox Signal. 2008;10:179-205.
-
(2008)
Antioxid Redox Signal
, vol.10
, pp. 179-205
-
-
Ying, W.1
-
41
-
-
55249118587
-
+ anabolism: Therapeutic potential for oxidative stress in ageing and Alzheimer's disease
-
+ anabolism: Therapeutic potential for oxidative stress in ageing and Alzheimer's disease. Neurotox Res. 2007;13:173-84.
-
(2007)
Neurotox Res
, vol.13
, pp. 173-184
-
-
Braidy, N.1
Guillemin, G.2
Grant, R.3
-
42
-
-
0033915898
-
IDO induction in IFN-gamma activated astroglia: a role in improving cell viability during oxidative stress
-
Grant RS, Naif H, Espinosa M, Kapoor V. IDO induction in IFN-gamma activated astroglia: a role in improving cell viability during oxidative stress. Redox Rep. 2007;5:101-4.
-
(2007)
Redox Rep
, vol.5
, pp. 101-104
-
-
Grant, R.S.1
Naif, H.2
Espinosa, M.3
Kapoor, V.4
-
43
-
-
84859770335
-
Kynurenine pathway metabolism is involved in the maintenance of the intracellular NAD+ concentration in human primary astrocytes
-
Grant R. Kynurenine pathway metabolism is involved in the maintenance of the intracellular NAD+ concentration in human primary astrocytes. IJTR. 2010;3:151-6.
-
(2010)
IJTR
, vol.3
, pp. 151-156
-
-
Grant, R.1
-
45
-
-
36849077601
-
Bechmann I. IDO expression in the brain: a double-edged sword
-
Kwidzinski E, Bechmann I. IDO expression in the brain: a double-edged sword. J Mol Med. 2007.
-
(2007)
J Mol Med
-
-
Kwidzinski, E.1
-
46
-
-
0036341332
-
Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis
-
Sakurai K, Zou JP, Tschetter JR, Ward JM, GM S. Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2002;129:186-96.
-
(2002)
J Neuroimmunol
, vol.129
, pp. 186-196
-
-
Sakurai, K.1
Zou, J.P.2
Tschetter, J.R.3
Ward, J.M.4
Gm, S.5
-
47
-
-
0021791302
-
Characterization of quinolinic acid phosphoribosyltransferase in human blood and observations in Huntington's disease
-
Foster AC, Schwarcz R. Characterization of quinolinic acid phosphoribosyltransferase in human blood and observations in Huntington's disease. J Neurochem. 1985;45:199-205.
-
(1985)
J Neurochem
, vol.45
, pp. 199-205
-
-
Foster, A.C.1
Schwarcz, R.2
-
48
-
-
11144314849
-
Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons
-
Guillemin GJ, Smythe G, Takikawa O, Brew BJ. Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons. Glia. 2005;49:15-23.
-
(2005)
Glia
, vol.49
, pp. 15-23
-
-
Guillemin, G.J.1
Smythe, G.2
Takikawa, O.3
Brew, B.J.4
-
49
-
-
84859736443
-
Transcriptional targets of sirtuins in the coordination of mammalian physiology
-
Fiege J, Auwerx J. Transcriptional targets of sirtuins in the coordination of mammalian physiology. Curr Opin Cell Biol. 2005:20.
-
(2005)
Curr Opin Cell Biol
, pp. 20
-
-
Fiege, J.1
Auwerx, J.2
-
50
-
-
26244436281
-
Evolutionary conserved and nonconserved cellular localisations and functions of human SIRT proteins
-
Michishita E, Park J, Burneskis J, Barrett J, Horikawa I. Evolutionary conserved and nonconserved cellular localisations and functions of human SIRT proteins. Mol Biol Chem. 2005;16:4623-35.
-
(2005)
Mol Biol Chem
, vol.16
, pp. 4623-4635
-
-
Michishita, E.1
Park, J.2
Burneskis, J.3
Barrett, J.4
Horikawa, I.5
|