Insulin therapy restores impaired function and expression of P-glycoprotein in blood-brain barrier of experimental diabetes

Biochemical Pharmacology

Volumn 75, Issue 8, 2008, Pages 1649-1658

  Liu, Haiyan ^a   Liu, Xiaodong ^a   Jia, Lee ^b   Liu, Yuchun ^a   Yang, Huiwen ^a   Wang, Guangji ^a   Xie, Lin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Blood brain barrier; Diabetes mellitus; Insulin; mdr1a mdr1b mRNA; P glycoprotein

Indexed keywords

GLYCOPROTEIN P; INSULIN; MESSENGER RNA; RHODAMINE 123; STREPTOZOCIN; VINCRISTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; BRAIN CORTEX; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; ENDOTHELIUM CELL; GENE; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; INSULIN TREATMENT; MALE; MDR1A GENE; MDR1B GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STREPTOZOCIN DIABETES; WESTERN BLOTTING;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BLOOD GLUCOSE; BLOOD-BRAIN BARRIER; CELLS, CULTURED; CEREBRAL CORTEX; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIAL CELLS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; P-GLYCOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; VINCRISTINE;

EID: 40949164610     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.01.004     Document Type: Article

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