Differential expression of multidrug resistance genes in naïve rat brain

Neuroscience Letters

Volumn 339, Issue 1, 2003, Pages 33-36

  Kwan, Patrick ^a   Sills, Graeme J ^a   Butler, Elaine ^a   Gant, Timothy W ^b   Brodie, Martin J ^a  

^a WESTERN INFIRMARY   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Brain; Multidrug resistance; P glycoprotein; Quantitative reverse transcriptase polymerase chain reaction; Rat

Indexed keywords

GLYCOPROTEIN P;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; BRAIN REGION; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENETIC CODE; HIPPOCAMPUS; MALE; MULTIDRUG RESISTANCE GENE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE GENETICS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0037435393     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)01453-2     Document Type: Article

References (20)

1. Dombrowski S.M., Desai S.Y., Marroni M., Cucullo C., Goodrich K., Bingaman W., Mayberg M.R., Bengez L., Janigro D. Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia. 42:2001;1501-1506.
2. Kwan P., Brodie M.J. Early identification of refractory epilepsy. N. Engl. J. Med. 342:2000;314-319.
3. Kwan P., Sills G.J., Butler E., Gant T.W., Meldrum B.S., Brodie M.J. Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain following a single audiogenic seizure. Epilepsia. 43:2002;1318-1323.
4. Lazarowski A., Sevlever G., Taratuto A., Massaro M., Rabinowicz A. Tuberous sclerosis associated with MDR1 gene expression and drug-resistant epilepsy. Pediatr. Neurol. 21:1999;731-734.
5. Ling V. Multidrug resistance: molecular mechanisms and clinical relevance. Cancer Chemother. Pharmacol. 40:1997;S3-S8.
6. Potschka H., Fedrowitz M., Löscher W. P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain. NeuroReport. 12:2001;3557-3560.
7. Potschka H., Fedrowitz M., Löscher W. P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats. Neurosci. Lett. 327:2002;173-176.
8. Potschka H., Löscher W. In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats. Epilepsia. 42:2001;1231-1240.
9. Regina A., Koman A., Piciotti M., ElHafny B., Center M.S., Bergmann R., Couraud P.-O., Roux F. Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells. J. Neurochem. 71:1998;705-715.
10. Rizzi M., Caccia S., Guiso G., Richichi C., Gorter J.A., Aronica E., Aliprandi M., Bagnati R., Fanelli R., D'Incalci M., Samanin R., Vezzani A. Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance. J. Neurosci. 22:2002;5833-5839.
11. Schinkel A.H. P-Glycoprotein, a gatekeeper in the blood-brain barrier. Adv. Drug Deliv. Res. 36:1999;179-194.
12. Schinkel A.H., Wagenaar E., Mol C.A.A.M., van Deemter L. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J. Clin. Invest. 97:1996;2517-2524.
13. Schinkel A.H., Mayer U., Wagenaar E., Mol C.A.A.M., van Deemter L., Smit J.J.M., van der Valk M.A., Voordouw A.C., Spits H., van Tellingen O., Zijlmans J.M.J.M., Fibbe W.E., Borst P. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc. Natl. Acad. Sci. USA. 94:1997;4028-4033.
14. Seegers U., Potschka H., Löscher W. Expression of the multidrug transporter P-glycoprotein in brain capillary endothelial cells and brain parenchyma of amygdala-kindled rats. Epilepsia. 43:2002;675-684.
15. Sills G.J., Kwan P., Butler E., de Lange E.C.M., van den Berg D.-J., Brodie M.J. P-glycoprotein-mediated efflux of antiepileptic drugs; preliminary studies in mdr1a knockout mice. Epilepsy Behav. 3:2002;427-432.
16. Sisodiya S.M., Heffernan J., Squier M.V. Over-expression of P-glycoprotein in malformations of cortical development. NeuroReport. 10:1999;3437-3441.
17. Stephen L.J., Kwan P., Brodie M.J. Does the cause of localisation-related epilepsy influence the response to antiepileptic drug treatment? Epilepsia. 42:2001;357-362.
18. Tishler D.M., Weinberg K.I., Hinton D.R., Barbaro N., Annett G.M., Raffel C. MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia. 36:1995;1-6.
19. Zhang F., Riley J., Gant T.W. Use of internally controlled reverse transcriptase-polymerase chain reaction for absolute quantitation of individual multidrug resistant gene transcripts in tissue samples. Electrophoresis. 17:1996;255-260.
20. Zhang L., Ong W.Y., Lee T. Induction of P-glycoprotein expression in astrocytes following intracerebroventricular kainate injections. Exp. Brain Res. 126:1999;509-516.