Mapping of c-fos gene expression in the brain during morphine dependence and precipitated withdrawal, and phenotypic identification of the striatal neurons involved

European Journal of Neuroscience

Volumn 12, Issue 12, 2000, Pages 4475-4486

  Georges, F ^a   Stinus, L ^a   Le Moine, C ^a  

^a CNRS   (France)

Author keywords

Dopamine opioid interactions; In situ hybridization; Mesostriatal system; Opiate dependence; Rat

Indexed keywords

DOPAMINE 1 RECEPTOR; MESSENGER RNA; NALTREXONE; OPIATE RECEPTOR; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; GLOBUS PALLIDUS; IN SITU HYBRIDIZATION; MALE; MORPHINE ADDICTION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; NORADRENERGIC NERVE; NUCLEUS ACCUMBENS; ONCOGENE C FOS; PHENOTYPE; PRIORITY JOURNAL; PUTAMEN; RAT; WITHDRAWAL SYNDROME;

ANIMALS; BRAIN; CORPUS STRIATUM; DRUG IMPLANTS; GENE EXPRESSION REGULATION; GENES, FOS; MALE; MORPHINE; MORPHINE DEPENDENCE; NALTREXONE; NEURONS; ORGAN SPECIFICITY; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SUBSTANCE WITHDRAWAL SYNDROME; TRANSCRIPTION, GENETIC;

EID: 0034523717     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816X.2000.01334.x     Document Type: Article

References (73)

1. Profound depression of mesolimbic dopamine release after morphine withdrawal in dependent rats
2. Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine
3. Molecular and neuranatomical properties of the endogenous opioid system: Implications for treatment of opiate addiction
4. Systemic morphine-induced Fos protein in the rat striatum and nucleus accumbens is regulated by mu opioid receptors in the substantia nigra and ventral tegmental area
5. Total neurochemical lesion of noradrenergic neurons of the locus coeruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence the ability of clonidine to reverse opiate withdrawal
6. Differential effects of μ and κ opioid antagonists on Fos-like immunoreactivity in extended amygdala
7. Distribution of c-fos in guinea-pig brain following morphine withdrawal
8. Interactions between endogenous opioids and dopamine: Implications for reward and aversion
9. Precipitated morphine withdrawal stimulates multiple activator protein-1 signaling pathways in rat brain
10. Withdrawal from morphine or amphetamine: Different effects on dopamine in the ventral-medial striatum studied with microdialysis
11. Psychomotor stimulant- and opiate-induced c-fos mRNA expression patterns in the rat forebrain: Comparisons between acute drug treatment and a drug challenge in sensitized animals
12. Isolation and characterization of the c-fos (rat) cDNA and analysis of posttranslational modification in vitro
13. Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion
14. Neurobiology of opiate abuse
15. Identification of brain regions that are markedly activated by morphine in tolerant but not in naive rats
16. Chronic morphine exposure and spontaneous withdrawal are associated with modifications of dopamine receptor and neuropeptide gene expression in the rat striatum
17. Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: An in situ hybridization histochemistry and fluorescent retrograde tracing study
18. D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
19. Different effects of opiate withdrawal on dopamine turnover, uptake, and release in the striatum and nucleus accumbens
20. Clonidine and opiate withdrawal
21. Prolonged tolerance, dependence and abstinence following subcutaneous morphine pellet implantation in the rat
22. Neurotransmitters and neuromodulators in the basal ganglia
23. Involvement of D2 dopamine receptors in the nucleus accumbens in the opiate withdrawal syndrome
24. Induction of the c-fos proto-oncogene during opiate withdrawal in the locus coeruleus and other regions of rat brain
25. Differential regulation, by MK-801, of dopamine receptor gene expression in rat nigrostriatal and mesocorticolimbic systems
26. Suppression of corticotropin-releasing factor in the amygdala attenuates aversive consequences of morphine withdrawal
27. Morphine-stimulated metabolism of striatal and limbic dopamine is dissimilarly sensitized in rats upon withdrawal from chronic morphine treatment
28. Role of corticotropin-releasing factor receptor-1 in opiate withdrawal
29. Opioids excite dopamine neurons by hyperpolarization of local interneurons
30. Drugs of abuse: Anatomy, pharmacology and function of reward pathways
31. Cellular and molecular mechanisms of drug dependence
32. Neural substrates of opiate withdrawal
33. The neurobiology of drug addiction
34. Chronic treatment with dizocilpine maleate increases the number of striatal neurons expressing the D2 receptor gene
35. Quantitative in situ hybridization using radioactive probes to study gene expression in heterocellular systems
36. D1 and D2 dopamine receptor gene expression in the rat striatum: Sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum
37. Dopamine-adenosine interactions in the striatum and the globus pallidus: Inhibition of striatopallidal neurons through either D2 or A2A receptors enhances D1 receptor-mediated effects on c-fos expression
38. Morphine induces c-fos and junB in striatum and nucleus accumbens via D1 and N-methyl-D-aspartate receptors
39. Destruction of the locus coeruleus decreases physical signs of opiate withdrawal
40. Role of different brain structures in the expression of the physical morphine withdrawal syndrome
41. Anatomy of CNS opioid receptors
42. Delayed application of MK-801 attenuates development of morphine tolerance in rats
43. Electrophysiological evidence for excitation of rat ventral tegmental area dopamine neurons by morphine
44. Chronic administration of NMDA antagonists induces D2 receptor synthesis in rat striatum
45. Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation
46. Multiple D2 dopamine receptors produced by alternative RNA splicing
47. Catecholamin innervation of the basal forebrain. I. The septal area
48. Coordinate expression of c-fos and jun B is induced in the rat striatum by cocaine
49. Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning
50. Molecular mechanisms of drug addiction
51. Molecular and cellular basis of addiction
52. Induction of chronic Fos-related antigens in rat brain by chronic morphine administration
53. Monoamine innervation of bed nucleus of stria terminalis: An electron microscopic investigation
54. Dopamine microdialysis in the nucleus accumbens during acute and chronic morphine, naloxone-precipitated withdrawal and clonidine treatment
55. The role of the locus coeruleus and N-methyl-D-aspartic acid (NMDA) and AMPA receptors in opiate withdrawal
56. A selective AMPA antagonist, LY293558, supresses morphine withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal
57. Marked inhibition of mesolimbic dopamine release: A common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats
58. Glucocorticoid receptor activation potentiates the morphine-induced adaptive increase in dopamine D-1 receptor efficacy in gamma- aminobutyric acid neurons of rat striatum/ nucleus accumbens
59. Effect of precipitated withdrawal on extracellular glutamate and aspartate in the nucleus accumbens of chronically morphine-treated rats: An in vivo microdialysis study
60. Endogenous kappa-opioid systems in opiate withdrawal: Role in aversion and accompanying changes in mesolimbic dopamine release
61. The effects of opioid peptides on dopamine release in the nucleus accumbens: An in vivo microdialysis study
62. Opposite tonic modulation by dopamine and adenosine on c-fos expression in striatopallidal neurons
63. The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-beta-hydroxylase as a marker
64. Glutamate antagonists prevent morphine withdrawal in mice and guinea pigs
65. Direct evidence for a role of glutamate in the expression of the opioid withdrawal syndrome
66. Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801
67. The selective mGlu2/3 receptor agonist LY354740 attenuates morphine-withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal
68. Expression of Fos-related Antigens in the nucleus accumbens during opiate withdrawal and their attenuation by a D2 dopamine receptor agonist
69. A psychomotor stimulant theory of addiction
70. Brain dopamine and reward
71. Pharmacokinetics and pharmacodynamics of subcutaneous morphine pellets in the rat
72. Rat brain preproenkephalin mRNA. cDNA cloning, primary structure, and distribution in the central nervous system