Genetic deletion of dectin-1 does not affect the course of murine experimental colitis

BMC Gastroenterology

Volumn 12, Issue , 2012, Pages

  Heinsbroek, Sigrid E M ^a,c   Oei, Anneke ^a   Roelofs, Joris J T H ^a   Dhawan, Shobhit ^a   te Velde, Anje ^a   Gordon, Siamon ^b   de Jonge, Wouter J ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Colitis; Dectin 1; Fungi; Innate immunity; Intestine; Macrophages

Indexed keywords

DECTIN 1; DEXTRAN SULFATE; INTERLEUKIN 10; LECTIN; LIPOPOLYSACCHARIDE; LIPOTEICHOIC ACID; TEICHOIC ACID; TUMOR NECROSIS FACTOR ALPHA; ZYMOSAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LEVEL; COLITIS; CONTROLLED STUDY; CYTOKINE RESPONSE; DISEASE COURSE; DISEASE SEVERITY; FECES ANALYSIS; GENE DELETION; GENETIC ASSOCIATION; HELICOBACTER HEPATICUS; IMMUNOCOMPETENT CELL; IN VITRO STUDY; INTESTINE FLORA; MACROPHAGE; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; FECES; GENETICS; IMMUNOLOGY; LARGE INTESTINE; METABOLISM; METAGENOME; MICROBIOLOGY; RHODOTORULA;

ANIMALS; COLITIS; DEXTRAN SULFATE; FECES; HELICOBACTER HEPATICUS; INTERLEUKIN-10; INTESTINE, LARGE; LECTINS, C-TYPE; LIPOPOLYSACCHARIDES; MACROPHAGES; METAGENOME; MICE; MICE, INBRED C57BL; RHODOTORULA; TEICHOIC ACIDS; TUMOR NECROSIS FACTOR-ALPHA; ZYMOSAN;

EID: 84859723328     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-12-33     Document Type: Article

References (51)

1. Cario E. Toll-like receptors in inflammatory bowel diseases: a decade later. Inflamm Bowel Dis 2010, 16:1583-1597. 10.1002/ibd.21282, 2958454, 20803699.
2. Werts C, Rubino S, Ling A, Girardin SE, Philpott DJ. Nod-like receptors in intestinal homeostasis, inflammation, and cancer. J Leukoc Biol 2011, 90:471-482. 10.1189/jlb.0411183, 21653239.
3. Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, et al. Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest 2007, 117:3909-3921. 2075480, 18008007.
4. Fukata M, Michelsen KS, Eri R, Thomas LS, Hu B, Lukasek K, et al. Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol 2005, 288:G1055-G1065. 10.1152/ajpgi.00328.2004, 15826931.
5. Araki A, Kanai T, Ishikura T, Makita S, Uraushihara K, Iiyama R, et al. MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis. J Gastroenterol 2005, 40:16-23. 10.1007/s00535-004-1492-9, 15692785.
6. Lowe EL, Crother TR, Rabizadeh S, Hu B, Wang H, Chen S, et al. Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. PLoS One 2010, 5:e13027. 10.1371/journal.pone.0013027, 2946405, 20885960.
7. Watanabe T, Asano N, Murray PJ, Ozato K, Tailor P, Fuss IJ, et al. Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J Clin Invest 2008, 118:545-559. 2176188, 18188453.
8. Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 2010, 32:379-391. 10.1016/j.immuni.2010.03.003, 2982187, 20303296.
9. Rakoff-Nahoum S, Hao L, Medzhitov R. Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity 2006, 25:319-329. 10.1016/j.immuni.2006.06.010, 16879997.
10. Franchimont D, Vermeire S, El HH, Pierik M, Van SK, Gustot T, et al. Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis. Gut 2004, 53:987-992. 10.1136/gut.2003.030205, 1774122, 15194649.
11. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001, 411:599-603. 10.1038/35079107, 11385576.
12. Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001, 411:603-606. 10.1038/35079114, 11385577.
13. Villani AC, Lemire M, Fortin G, Louis E, Silverberg MS, Collette C, et al. Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nat Genet 2009, 41:71-76. 10.1038/ng.285, 2728932, 19098911.
14. Simon GL, Gorbach SL. Intestinal flora in health and disease. Gastroenterology 1984, 86:174-193.
15. Osorio F, Reis e Sousa C. Myeloid C-type lectin receptors in pathogen recognition and host defense. Immunity 2011, 34:651-664. 10.1016/j.immuni.2011.05.001, 21616435.
16. Walker LJ, Aldhous MC, Drummond HE, Smith BR, Nimmo ER, Arnott ID, et al. Anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease are associated with disease severity but not NOD2/CARD15 mutations. Clin Exp Immunol 2004, 135:490-496. 10.1111/j.1365-2249.2003.02392.x, 1808965, 15008984.
17. Dotan I, Fishman S, Dgani Y, Schwartz M, Karban A, Lerner A, et al. Antibodies against laminaribioside and chitobioside are novel serologic markers in Crohn's disease. Gastroenterology 2006, 131:366-378. 10.1053/j.gastro.2006.04.030, 16890590.
18. Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, et al. Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells. J Immunol 2007, 179:3463-3471.
19. Brown GD, Herre J, Williams DL, Willment JA, Marshall AS, Gordon S. Dectin-1 mediates the biological effects of beta-glucans. J Exp Med 2003, 197:1119-1124. 10.1084/jem.20021890, 2193964, 12719478.
20. Rogers NC, Slack EC, Edwards AD, Nolte MA, Schulz O, Schweighoffer E, et al. Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 2005, 22:507-517. 10.1016/j.immuni.2005.03.004, 15845454.
21. Herre J, Marshall AS, Caron E, Edwards AD, Williams DL, Schweighoffer E, et al. Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages. Blood 2004, 104:4038-4045. 10.1182/blood-2004-03-1140, 15304394.
22. Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med 2003, 197:1107-1117. 10.1084/jem.20021787, 2193968, 12719479.
23. LeibundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, et al. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 2007, 8:630-638. 10.1038/ni1460, 17450144.
24. Osorio F, LeibundGut-Landmann S, Lochner M, Lahl K, Sparwasser T, Eberl G, et al. DC activated via dectin-1 convert Treg into IL-17 producers. Eur J Immunol 2008, 38:3274-3281. 10.1002/eji.200838950, 2699423, 19039774.
25. Reid DM, Montoya M, Taylor PR, Borrow P, Gordon S, Brown GD, et al. Expression of the {beta}-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions. J Leukoc Biol 2004, 76:86-94. 10.1189/jlb.0104031, 15107454.
26. de Vries HS, Plantinga TS, van Krieken JH, Stienstra R, van Bodegraven AA, Festen EA, et al. Genetic association analysis of the functional c.714 T > G polymorphism and mucosal expression of dectin-1 in inflammatory bowel disease. PLoS One 2009, 4:e7818. 10.1371/journal.pone.0007818, 2771910, 19915667.
27. Kullberg MC, Jankovic D, Feng CG, Hue S, Gorelick PL, McKenzie BS, et al. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J Exp Med 2006, 203:2485-2494. 10.1084/jem.20061082, 2118119, 17030948.
28. Kullberg MC, Jankovic D, Feng CG, Hue S, Gorelick PL, McKenzie BS, et al. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J Exp Med 2006, 203:2485-2494. 10.1084/jem.20061082, 2118119, 17030948.
29. Heinsbroek SE, Taylor PR, Martinez FO, Martinez-Pomares L, Brown GD, Gordon S. Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis. PLoS Pathog 2008, 4:e1000218. 10.1371/journal.ppat.1000218, 2583056, 19043561.
30. Christensen HR, Frokiaer H, Pestka JJ. Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. J Immunol 2002, 168:171-178.
31. Lammers KM, Brigidi P, Vitali B, Gionchetti P, Rizzello F, Caramelli E, et al. Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cells. FEMS Immunol Med Microbiol 2003, 38:165-172. 10.1016/S0928-8244(03)00144-5, 13129651.
32. Khatib R, Riederer KM, Ramanathan J, Baran J. Faecal fungal flora in healthy volunteers and inpatients. Mycoses 2001, 44:151-156. 10.1046/j.1439-0507.2001.00639.x, 11486452.
33. Galan-Sanchez F, Garcia-Martos P, Rodriguez-Ramos C, Marin-Casanova P, Mira-Gutierrez J. Microbiological characteristics and susceptibility patterns of strains of Rhodotorula isolated from clinical samples. Mycopathologia 1999, 145:109-112. 10.1023/A:1007059005753, 10685444.
34. Miceli MH, Diaz JA, Lee SA. Emerging opportunistic yeast infections. Lancet Infect Dis 2011, 11:142-151. 10.1016/S1473-3099(10)70218-8, 21272794.
35. Wirtz S, Neurath MF. Mouse models of inflammatory bowel disease. Adv Drug Deliv Rev 2007, 59:1073-1083. 10.1016/j.addr.2007.07.003, 17825455.
36. Fox JG, Ge Z, Whary MT, Erdman SE, Horwitz BH. Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer. Mucosal Immunol 2011, 4:22-30. 10.1038/mi.2010.61, 20944559.
37. Williams AM, Probert CS, Stepankova R, Tlaskalova-Hogenova H, Phillips A, Bland PW. Effects of microflora on the neonatal development of gut mucosal T cells and myeloid cells in the mouse. Immunology 2006, 119:470-478. 10.1111/j.1365-2567.2006.02458.x, 2265821, 16995882.
38. Morland B, Smievoll AI, Midtvedt T. Comparison of peritoneal macrophages from germfree and conventional mice. Infect Immun 1979, 26:1129-1136. 414738, 393629.
39. Morland B, Midtvedt T. Phagocytosis, peritoneal influx, and enzyme activities in peritoneal macrophages from germfree, conventional, and ex-germfree mice. Infect Immun 1984, 44:750-752. 263691, 6233226.
40. Drummond RA, Brown GD. The role of Dectin-1 in the host defence against fungal infections. Curr Opin Microbiol 2011, 14:392-399. 10.1016/j.mib.2011.07.001, 21803640.
41. Standaert-Vitse A, Sendid B, Joossens M, Francois N, Vandewalle-El KP, Branche J, et al. Candida albicans colonization and ASCA in familial Crohn's disease. Am J Gastroenterol 2009, 104:1745-1753. 10.1038/ajg.2009.225, 19471251.
42. Standaert-Vitse A, Jouault T, Vandewalle P, Mille C, Seddik M, Sendid B, et al. Candida albicans Is an Immunogen for Anti-Saccharomyces cerevisiae Antibody Markers of Crohn's Disease. Gastroenterology 2006, 130:1764-1775. 10.1053/j.gastro.2006.02.009, 16697740.
43. Taylor PR, Tsoni SV, Willment JA, Dennehy KM, Rosas M, Findon H, et al. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol 2007, 8:31-38. 10.1038/ni1408, 1888731, 17159984.
44. Jawhara S, Thuru X, Standaert-Vitse A, Jouault T, Mordon S, Sendid B, et al. Colonization of mice by Candida albicans is promoted by chemically induced colitis and augments inflammatory responses through galectin-3. J Infect Dis 2008, 197:972-980. 10.1086/528990, 18419533.
45. Dieleman LA, Ridwan BU, Tennyson GS, Beagley KW, Bucy RP, Elson CO. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 1994, 107:1643-1652.
46. Wang JE, Warris A, Ellingsen EA, Jorgensen PF, Flo TH, Espevik T, et al. Involvement of CD14 and toll-like receptors in activation of human monocytes by Aspergillus fumigatus hyphae. Infect Immun 2001, 69:2402-2406. 10.1128/IAI.69.4.2402-2406.2001, 98172, 11254600.
47. Netea MG, Van Der Graaf CA, Vonk AG, Verschueren I, Van der Meer JW, Kullberg BJ. The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis. J Infect Dis 2002, 185:1483-1489. 10.1086/340511, 11992285.
48. Ezekowitz RA, Sastry K, Bailly P, Warner A. Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. J Exp Med 1990, 172:1785-1794. 10.1084/jem.172.6.1785, 2188777, 2258707.
49. Sato K, Yang X, Yudate T, Chung JS, Wu J, Luby-Phelps K, et al. Dectin-2 Is a Pattern Recognition Receptor for Fungi That Couples with the Fc Receptor {gamma} Chain to Induce Innate Immune Responses. J Biol Chem 2006, 281:38854-38866. 10.1074/jbc.M606542200, 17050534.
50. Cambi A, Gijzen K, de Vries JM, Torensma R, Joosten B, Adema GJ, et al. The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells. Eur J Immunol 2003, 33:532-538. 10.1002/immu.200310029, 12645952.
51. Taylor PR, Brown GD, Herre J, Williams DL, Willment JA, Gordon S. The Role of SIGNR1 and the {beta}-Glucan Receptor (Dectin-1) in the Nonopsonic Recognition of Yeast by Specific Macrophages. J Immunol 2004, 172:1157-1162.