Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, induces mitochondrial apoptosis in K562 cells and inhibits topoisomerase I in vitro

Toxicology Letters

Volumn 211, Issue 2, 2012, Pages 126-134

  Liu, Ming ^a   Zhang, Wei ^b   Wei, Jianteng ^a   Qiu, Lin ^c   Lin, Xiukun ^a  

^a INSTITUTE OF OCEANOLOGY   (China)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

^c Chinese Academy of Sciences   (China)

Author keywords

Apoptosis; Bis(2,3 dibromo 4,5 dihydroxybenzyl) ether; Minor groove binding; Topoisomerase I inhibition

Indexed keywords

ANTINEOPLASTIC AGENT; BIS(2,3 DIBROMO 4,5 DIHYDROXYBENZYL)ETHER; CASPASE 3; CASPASE 9; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; ETHIDIUM BROMIDE; MARINE TOXIN; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SURVIVIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL VIABILITY; COLORECTAL CARCINOMA; CYTOTOXICITY; DRUG STRUCTURE; ENZYME INHIBITION; FEMALE; FLUORESCENCE; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ADENOCARCINOMA; MITOCHONDRION; MYELOID LEUKEMIA; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL SURVIVAL; DNA TOPOISOMERASES, TYPE I; ETHERS; FLOW CYTOMETRY; HUMANS; K562 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MODELS, MOLECULAR; PHENOLS; REACTIVE OXYGEN SPECIES; TOPOISOMERASE I INHIBITORS;

ALGAE;

EID: 84859722292     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.03.771     Document Type: Article

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