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Volumn 35, Issue 4, 2012, Pages 379-386

Advances in WNK signaling of salt and potassium metabolism: Clinical implications

Author keywords

Angiotensin II; Electrolytes; Hypertension; Potassium; Sodium

Indexed keywords

ALDOSTERONE; ANGIOTENSIN II; PHOSPHOTRANSFERASE; POTASSIUM; PROTEIN KINASE WNK1; PROTEIN KINASE WNK3; PROTEIN KINASE WNK4; PROTEIN SERINE THREONINE KINASE; SODIUM; SODIUM CHLORIDE; UNCLASSIFIED DRUG; WATER;

EID: 84859642327     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000337479     Document Type: Review
Times cited : (21)

References (58)
  • 2
    • 78751654853 scopus 로고    scopus 로고
    • The WNKs: Atypical protein kinases with pleiotropic actions
    • McCormick JA, Ellison DH: The WNKs: atypical protein kinases with pleiotropic actions. Physiol Rev 2011; 91: 177-219.
    • (2011) Physiol. Rev. , vol.91 , pp. 177-219
    • McCormick, J.A.1    Ellison, D.H.2
  • 4
    • 0036328423 scopus 로고    scopus 로고
    • Pseudohypoaldosteronism type II: Marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density
    • DOI 10.1210/jc.87.7.3248
    • Mayan H, Vered I, Mouallem M, Tzadok- Witkon M, Pauzner R, Farfel Z: Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density. J Clin Endocrinol Metab 2002; 87: 3248-3254. (Pubitemid 34816373)
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , Issue.7 , pp. 3248-3254
    • Mayan, H.1    Vered, I.2    Mouallem, M.3    Tzadok-Witkon, M.4    Pauzner, R.5    Farfel, Z.6
  • 5
    • 0022571505 scopus 로고
    • The syndrome of hypertension and hyperkalaemia without renal failure: Long term correction by thiazide diuretic
    • Gordon RD, Hodsman GP: The syndrome of hypertension and hyperkalaemia without renal failure: long term correction by thiazide diuretic. Scott Med J 1986; 31: 43-44. (Pubitemid 16131291)
    • (1986) Scottish Medical Journal , vol.31 , Issue.1 , pp. 43-44
    • Gordon, R.D.1    Hodsman, G.P.2
  • 6
    • 70349651260 scopus 로고    scopus 로고
    • + -Cl - cotransporter: Molecular biology, functional properties, and regulation by WNKs
    • + -Cl - cotransporter: molecular biology, functional properties, and regulation by WNKs. Am J Physiol Renal Physiol 2009; 297:F838-F848.
    • (2009) Am. J. Physiol. Renal. Physiol. , vol.297
    • Gamba, G.1
  • 10
    • 0028819663 scopus 로고
    • Expression of the thiazide-sensitive Na-Cl cotransporter by rabbit distal convoluted tubule cells
    • Bachmann S, Velázquez H, Obermuller N, Reily RF, Moser D, Ellison DH: Expression of the thiazide-sensitive Na-Cl cotransporter by rabbit distal convoluted tubule cells. J Clin invest 1995; 96: 2510-2514.
    • (1995) J Clin invest , vol.96 , pp. 2510-2514
    • Bachmann, S.1    Velázquez, H.2    Obermuller, N.3    Reily, R.F.4    Moser, D.5    Ellison, D.H.6
  • 12
    • 79955159268 scopus 로고    scopus 로고
    • Aldosterone paradox: Differential regulation of ion transport in distal nephron
    • Arroyo JP, Ronzaud C, Lagnaz D, Staub O, Gamba G: Aldosterone paradox: differential regulation of ion transport in distal nephron. Physiology (Bethesda) 2011; 26: 115-123.
    • (2011) Physiology (Bethesda , vol.26 , pp. 115-123
    • Arroyo, J.P.1    Ronzaud, C.2    Lagnaz, D.3    Staub, O.4    Gamba, G.5
  • 13
    • 0033963206 scopus 로고    scopus 로고
    • Mammalian distal tubule: Physiology, pathophysiology, and molecular anatomy
    • Reilly RF, Ellison DH: Mammalian distal tubule: physiology, pathophysiology, and molecular anatomy. Physiol Rev 2000; 80: 277-313. (Pubitemid 30060566)
    • (2000) Physiological Reviews , vol.80 , Issue.1 , pp. 277-313
    • Reilly, R.F.1    Ellison, D.H.2
  • 17
    • 0037376254 scopus 로고    scopus 로고
    • Sodium and calcium transport pathways along the mammalian distal nephron: From rabbit to human
    • Loffing J, Kaissling B: Sodium and calcium transport pathways along the mammalian distal nephron: from rabbit to human. Am J Physiol Renal Physiol 2003; 284:F628-F643. (Pubitemid 36336969)
    • (2003) American Journal of Physiology - Renal Physiology , vol.284 , Issue.4
    • Loffing, J.1    Kaissling, B.2
  • 19
    • 12944294332 scopus 로고    scopus 로고
    • Molecular diversity and regulation of renal potassium channels
    • DOI 10.1152/physrev.00051.2003
    • Hebert SC, Desir G, Giebisch G, Wang W: Molecular diversity and regulation of renal potassium channels. Physiol Rev 2005; 85: 319-371. (Pubitemid 40173996)
    • (2005) Physiological Reviews , vol.85 , Issue.1 , pp. 319-371
    • Hebert, S.C.1    Desir, G.2    Giebisch, G.3    Wang, W.4
  • 20
    • 78049482361 scopus 로고    scopus 로고
    • BK channels and a new form of hypertension
    • Grimm PR, Sansom SC: BK channels and a new form of hypertension. Kidney Int 2010; 78: 956-962.
    • (2010) Kidney Int. , vol.78 , pp. 956-962
    • Grimm, P.R.1    Sansom, S.C.2
  • 22
    • 0032880883 scopus 로고    scopus 로고
    • Sodium transport-related proteins in the mammalian distal nephron - Distribution, ontogeny and functional aspects
    • DOI 10.1007/s004290050294
    • Bachmann S, Bostanjoglo M, Schmitt R, Ellison DH: Sodium transport-related proteins in the mammalian distal nephron - distribution, ontogeny and functional aspects. Anat Embryol (Berl) 1999; 200: 447-468. (Pubitemid 29467309)
    • (1999) Anatomy and Embryology , vol.200 , Issue.5 , pp. 447-468
    • Bachmann, S.1    Bostanjoglo, M.2    Schmitt, R.3    Ellison, D.H.4
  • 23
    • 0037184942 scopus 로고    scopus 로고
    • Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)
    • DOI 10.1074/jbc.M208108200
    • Piechotta K, Lu J, Delpire E: Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alaninerich kinase (SPAK) and oxidative stress response 1 (OSR1). J Biol Chem 2002; 277: 50812-50819. (Pubitemid 36042246)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.52 , pp. 50812-50819
    • Piechotta, K.1    Lu, J.2    Delpire, E.3
  • 24
    • 26844532768 scopus 로고    scopus 로고
    • The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases
    • DOI 10.1042/BJ20051180
    • Vitari AC, Deak M, Morrice NA, Alessi DR: The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome, phosphorylate and active SPAK and OSR1 protein kinases. Biochem J 2005; 391: 17-24. (Pubitemid 41445471)
    • (2005) Biochemical Journal , vol.391 , Issue.1 , pp. 17-24
    • Vitari, A.C.1    Deak, M.2    Morrice, N.A.3    Alessi, D.R.4
  • 26
    • 77958022519 scopus 로고    scopus 로고
    • Effects of dietary K on cell-surface expression of renal ion channels and transporters
    • Frindt G, Palmer LG: Effects of dietary K on cell-surface expression of renal ion channels and transporters. Am J Physiol Renal Physiol 2010; 299:F890-F897.
    • (2010) Am. J. Physiol. Renal. Physiol. , vol.299
    • Frindt, G.1    Palmer, L.G.2
  • 29
    • 0026011281 scopus 로고
    • Diuretics
    • Rose BD: Diuretics. Kidney Int 1991; 39: 336-352.
    • (1991) Kidney Int. , vol.39 , pp. 336-352
    • Rose, B.D.1
  • 32
    • 35549003692 scopus 로고    scopus 로고
    • Mechanisms of Disease: WNK-ing at the mechanism of salt-sensitive hypertension
    • DOI 10.1038/ncpneph0638, PII NCPNEPH0638
    • Huang CL, Kuo E: Mechanisms of disease: WNK-ing at the mechanism of salt-sensitive hypertension. Nat Clin Pract Nephrol 2007; 3: 623-630. (Pubitemid 350012824)
    • (2007) Nature Clinical Practice Nephrology , vol.3 , Issue.11 , pp. 623-630
    • Huang, C.-L.1    Kuo, E.2
  • 38
    • 85027955816 scopus 로고    scopus 로고
    • Angiotensin II induces phosphorylation of the thiazide- sensitive sodium chloride cotransporter independent of aldosterone
    • van der LN, Lim CH, Fenton RA, Meima ME, Jan Danser AH, Zietse R, Hoorn EJ: Angiotensin II induces phosphorylation of the thiazide- sensitive sodium chloride cotransporter independent of aldosterone. Kidney Int 2011; 79: 66-76.
    • (2011) Kidney Int. , vol.79 , pp. 66-76
    • Van Der, L.N.1    Lim, C.H.2    Fenton, R.A.3    Meima, M.E.4    Jan Danser, A.H.5    Zietse, R.6    Hoorn, E.J.7
  • 39
    • 67649850599 scopus 로고    scopus 로고
    • Enhanced distal nephron sodium reabsorption in chronic angiotensin II-infused mice
    • Zhao D, Seth DM, Navar LG: Enhanced distal nephron sodium reabsorption in chronic angiotensin II-infused mice. Hypertension 2009; 54: 120-126.
    • (2009) Hypertension , vol.54 , pp. 120-126
    • Zhao, D.1    Seth, D.M.2    Navar, L.G.3
  • 41
    • 79551535153 scopus 로고    scopus 로고
    • Angiotensin II diminishes the effect of SGK1 on the WNK4-mediated inhibition of ROMK1 channels
    • Yue P, Sun P, Lin DH, Pan C, Xing W, Wang W: Angiotensin II diminishes the effect of SGK1 on the WNK4-mediated inhibition of ROMK1 channels. Kidney Int 2011; 79: 423-431.
    • (2011) Kidney Int. , vol.79 , pp. 423-431
    • Yue, P.1    Sun, P.2    Lin, D.H.3    Pan, C.4    Xing, W.5    Wang, W.6
  • 42
    • 79952354204 scopus 로고    scopus 로고
    • Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1
    • Cheng CJ, Huang CL: Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1. J Am Soc Nephrol 2011; 22: 460-471.
    • (2011) J. Am. Soc. Nephrol. , vol.22 , pp. 460-471
    • Cheng, C.J.1    Huang, C.L.2
  • 46
    • 66449106203 scopus 로고    scopus 로고
    • + homeostasis by kidney- specific WNK1 kinase
    • + homeostasis by kidney- specific WNK1 kinase. J Biol Chem 2009; 284: 12198-12206.
    • (2009) J. Biol. Chem. , vol.284 , pp. 12198-12206
    • Liu, Z.1    Wang, H.R.2    Huang, C.L.3
  • 48
    • 79551604642 scopus 로고    scopus 로고
    • Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models
    • Liu Z, Xie J, Wu T, Truong T, Auchus RJ, Huang CL: Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models. Hum Mol Genet 2011; 20: 855-866.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 855-866
    • Liu, Z.1    Xie, J.2    Wu, T.3    Truong, T.4    Auchus, R.J.5    Huang, C.L.6
  • 51
    • 36048938340 scopus 로고    scopus 로고
    • The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex
    • DOI 10.1172/JCI32033
    • Yang CL, Zhu X, Ellison DH: The thiazidesensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. J Clin Invest 2007; 117: 3403-3411. (Pubitemid 350096996)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.11 , pp. 3403-3411
    • Yang, C.-L.1    Zhu, X.2    Ellison, D.H.3
  • 52
    • 29144500339 scopus 로고    scopus 로고
    • Ubiquitylation of ion channels
    • DOI 10.1152/physiol.00033.2005
    • Abriel H, Staub O: Ubiquitylation of ion channels. Physiology (Bethesda) 2005; 20: 398-407. (Pubitemid 41812423)
    • (2005) Physiology , Issue.6 , pp. 398-407
    • Abriel, H.1    Staub, O.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.