Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1

Journal of the American Society of Nephrology

Volumn 22, Issue 3, 2011, Pages 460-471

  Cheng, Chih Jen ^a,b   Huang, Chou Long ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

DYNAMIN; INSULIN; INTERSECTIN; PHOSPHATIDYLINOSITOL 3 KINASE; POTASSIUM CHANNEL; PROTEIN KINASE B; PROTEIN KINASE WNK1; RENAL OUTER MEDULLARY POTASSIUM CHANNEL; SMALL INTERFERING RNA; SOMATOMEDIN C; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; BIOTINYLATION; CELL STRAIN HEK293; ENDOCYTOSIS; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

EID: 79952354204     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010060681     Document Type: Article

References (38)

1. Ho K, Nichols CG, Lederer WJ, Lytton J, Vassilev PM, Kanazirska MV, Hebert SC: Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature 362: 31-38, 1993 (Pubitemid 23087286)
2. Rodan AR, Huang CL: Distal potassium handling based on flow modulation of maxi-K channel activity. Curr Opin Nephrol Hypertens 18: 350-355, 2009
3. Zeng WZ, Babich V, Ortega B, Quigley R, White SJ, Welling PA, Huang CL: Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesicles. Am J Physiol Renal Physiol 283: F630-F639, 2002 (Pubitemid 35033949)
4. Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH: WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem 275: 16795-16801, 2000 (Pubitemid 30398913)
5. Wilson FH, Disse-Nicode'me S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP: Human hypertension caused by mutations in WNK kinases. Science 293: 1107-1112, 2001
6. Verissimo F, Jordan P: WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. Oncogene 20: 5562-5569, 2001 (Pubitemid 32889495)
7. Vitari AC, Deak M, Morrice NA, Alessi DR: The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J 391: 17-24, 2005 (Pubitemid 41445471)
8. Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H: WNK1 regulates phosphorylation of cation-chloride- coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem 280: 42685-42693, 2005 (Pubitemid 43049227)
9. Xu BE, Stippec S, Chu PY, Lazrak A, Li XJ, Lee BH, English JM, Ortega B, Huang CL, Cobb MH: WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci USA 102: 10315-10320, 2005 (Pubitemid 41023368)
10. Yang CL, Angell J, Mitchell R, Ellison DH: WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest 111: 1039-1045, 2003 (Pubitemid 36397480)
11. He G, Wang HR, Huang SK, Huang CL: Intersectin links WNK kinases to endocytosis of ROMK1. J Clin Invest 117: 1078-1087, 2007 (Pubitemid 46556764)
12. Vitari AC, Deak M, Collins BJ, Morrice N, Prescott AR, Phelan A, Humphreys S, Alessi DR: WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate. Biochem J 378: 257-268, 2004 (Pubitemid 38299565)
13. Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP: Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells. J Biol Chem 280: 21622-21628, 2005 (Pubitemid 40805731)
14. Xu BE, Stippec S, Lazrak A, Huang CL, Cobb MH: WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. J Biol Chem 280: 34218-34223, 2005 (Pubitemid 41443147)
15. Lee IH, Dinudom A, Sanchez-Perez A, Kumar S, Cook DI: Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J Biol Chem 282: 29866-29873, 2007 (Pubitemid 350035273)
16. Ahmed M, Gannon MC, Nuttall FQ: Postprandial plasma glucose, insulin, glucagon and triglyceride responses to a standard diet in normal subjects. Diabetologia 12: 61-67, 1976
17. Rechler MM, Nissley SP: The nature and regulation of the receptors for insulin-like growth factors. Annu Rev Physiol 47: 425-442, 1985 (Pubitemid 15142390)
18. Zapf J, Walter H, Froesch ER: Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia. J Clin Invest 68: 1321-1330, 1981 (Pubitemid 12235034)
19. Pearce LR, Komander D, Alessi DR: The nuts and bolts of AGC protein kinases. Nat Rev Mol Cell Biol 11: 9-22, 2010
20. Kobayashi T, Cohen P: Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Biochem J 15: 319-328, 1999 (Pubitemid 29209961)
21. Lazrak A, Liu Z, Huang CL: Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc Natl Acad Sci USA 103: 1615-1620, 2006 (Pubitemid 43191213)
22. Kahle KT, Wilson FH, Leng Q, Lalioti MD, O'Connell AD, Dong K, Rapson AK, MacGregor GG, Giebisch G, Hebert SC, Lifton RP: WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion. Nat Genet 35: 372-376, 2003 (Pubitemid 37486922)
23. Yoo D, Kim BY, Campo C, Nance L, King A, Maouyo D, Welling PA: Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. J Biol Chem 278: 23066-23075, 2003 (Pubitemid 36830372)
24. O'Reilly M, Marshall E, Speirs HJ, Brown RW: WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain. J Am Soc Nephrol 14: 2447-2456, 2003
25. Flyvbjerg A, Marshall SM, Frystyk J, Rasch R, Bornfeldt KE, Arnqvist H, Jensen PK, Pallesen G, Orskov H: Insulin-like growth factor I in initial renal hypertrophy in potassium-depleted rats. Am J Physiol 262: F1023-F1031, 1992
26. Giordano M, DeFronzo RA: Acute effect of human recombinant insulin-like growth factor-1 on renal function in humans. Nephron 71: 10-15, 1995
27. Svensson J, Tivesten A, Sjögren K, Isaksson O, Bergström G, Mohan S, Mölne J, Isgaard J, Ohlsson C: Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression. J Endocrinol 193: 359-366, 2007 (Pubitemid 47033745)
28. Li D, Wei Y, Babilonia E, Wang Z, Wang WH: Inhibition of phosphatidylinositol 3-kinase stimulates activity of the small-conductance K channel in the CCD. Am J Physiol Renal Physiol 290: F806-F812, 2006 (Pubitemid 43724940)
29. + concentration. Am J Physiol Cell Physiol 290: C1355-C1363, 2006
30. DeFronzo RA, Cooke CR, Andres R, Faloona GR, Davis PJ: The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man. J Clin Invest 55: 845-855, 1975
31. DeFronzo RA, Goldberg M, Agus ZS: The effects of glucose and insulin on renal electrolyte transport. J Clin Invest 58: 83-90, 1976
32. Furuya H, Tabei K, Muto S, Asano Y: Effect of insulin on potassium secretion in rabbit cortical collecting ducts. Am J Physiol 262: F30-F35, 1992
33. + homeostasis. Proc Natl Acad Sci USA 104: 4025-4029, 2007
34. + elimination in the sgk1-knockout mouse. J Am Soc Nephrol 15: 885-891, 2004
35. Grahammer F, Artunc F, Sandulache D, Rexhepaj R, Friedrich B, Risler T, McCormick JA, Dawson K, Wang J, Pearce D, Wulff P, Kuhl D, Lang F: Renal function of gene-targeted mice lacking both SGK1 and SGK3. Am J Physiol Regul Integr Comp Physiol 290: R945-R950, 2006
36. McCormick JA, Bhalla V, Pao AC, Pearce D: SGK1: A rapid aldosterone-induced regulator of renal sodium reabsorption. Physiology 20: 134-139, 2005 (Pubitemid 40627554)
37. + transport. Proc Natl Acad Sci USA 101: 17434-17439, 2004
38. Chen W, Chen Y, Xu BE, Juang YC, Stippec S, Zhao Y, Cobb MH: Regulation of a third conserved phosphorylation site in SGK1. J Biol Chem 284: 3453-3460, 2009