Infant leukaemia biology, aetiology and treatment

Leukemia

Volumn 10, Issue 2, 1996, Pages 372-377

  Greaves, M F ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; CYTARABINE; DOXORUBICIN; IMMUNOTOXIN; METHOTREXATE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; ZINC FINGER PROTEIN;

B LYMPHOCYTE; BONE MARROW TRANSPLANTATION; CHINESE MEDICINE; CHROMOSOME 11Q; CONFERENCE PAPER; DRUG CLEARANCE; FETUS WASTAGE; GENE DELETION; GENE REARRANGEMENT; HUMAN; INCIDENCE; INFANT; INTRON; LD 50; LEUKEMIA; LEUKEMIA REMISSION; MONOCYTE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DOMAIN; SURVIVAL; TRANSCRIPTION REGULATION;

EID: 0029930974     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (32)

1. Bernard OA, Berger R. Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. Genes Chromos Cancer 1995; 13: 75-85.
2. Canaani E, Nowell PC, Croce CM. Molecular genetics of 11q23 chromosome translocations. Adv Cancer Res 1995; 66: 213-234.
3. Chaplin T et al. A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia. Blood 1995; 85: 1435-1441.
4. Chaplin T et al. The t(10;11) translocation in AML(M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene. Blood 1995; 86: 2073-2076.
5. Chen C-S et al. The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia. Blood 1993; 82: 1080-1085.
6. Chen C-S et al. Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome. Blood 1993; 81: 2386-2393.
7. Chessells JM et al. Acute lymphoblastic leukaemia in infancy: experience in MRC UKALL trials. Leukemia 1994; 8: 1275-1279.
8. Cimino G et al. ALL-1 gene rearrangements in acute myeloid leukemia: association with M4-M5 French-American-British classification subtypes and young age. Cancer Res 1995; 55: 1625-1628.
9. Cimino G et al. Prognostic relevance of ALL-1 rearrangements in infant acute leukemias. Leukemia 1995; 9: 391-395.
10. Cleary ML. A promiscuous oncogene in acute leukemia. New Engl J Med 1993; 329: 958-960.
11. Cnattingius S et al. Prenatal and neonatal risk factors for childhood lymphatic leukemia. J Natl Cancer Inst 1995; 87: 908-914.
12. Domer PH et al. Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product. Proc Natl Acad Sci USA 1993; 90: 7884-7888.
13. Ford AM et al. In utero rearrangements in the trithorax-related oncogene in infant leukaemias. Nature 1993; 363: 358-360.
14. Heerema NA et al. Cytogenetic features of infants less than 12 months of age at diagnosis of acute lymphoblastic leukemia: impact of the 11q23 breakpooint on outcome. a report of the Children's Cancer Group. Blood 1994; 83: 2274-2284.
15. Hilden JM et al. Molecular analysis of infant ALL:MLL gene rearrangement and RT-PCR for t(4;11)(q21;q23). Blood (in press)
16. Leiper AD, Chessells JM. Acute lymphoblastic leukaemia under 2 years. Arch Dis Childhood 1986; 61: 1007-1012.
17. Manabe A et al. Interleukin-4 induces programmed cell death (apoptosis) in cases of high-risk acute lymphoblastic leukemia. Blood 1994; 83: 1731-1737.
18. Martinez-Climent JA et al. Detection of 11q23/MLL rearrangements in infant leukemias with fluorescence in situ hybridization and molecular analysis. Leukemia 1995, 9: 1299-1304.
19. Morgan GJ et al Breakpoints at 11q23 in infant leukemias with the t(11;19)(q23;p13) are clustered. Blood 1992; 80: 2172-2175.
20. Pui C-H et al. 11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia. J Clin Oncol 1994; 12: 909-915.
21. Pui C-H, Kane JR, Crist WM. Biology and treatment of infant leukemias. Leukemia 1995; 9: 762-769.
22. Ridge SA et al. Rapid intraclonal switch of lineage dominance in congenital leukaemia with a MLL gene rearrangement. Leukemia 1995; 9: 2023-2026.
23. Raimondi SC et al. Acute lymphoblastic leukemias with deletion of 11q23 or a novel inversion (11)(p13q23) lack MLL gene rearrangements and have favorable clinical features. Blood 1995; 86: 1881-1886
24. Ridge SA, Wiedemann LM. Chromosome 11q23 abnormalities in leukaemia. Leuk Lymphoma 1994; 14: 11-17.
25. Ross JA, Potter JD, Robison LL. Infant leukemia, topoisomerase II inhibitors, and the MLL gene. J Natl Cancer Inst 1994; 86: 1678-1680.
26. Saha V et al. A novel cysteine-rich motif, the LAP domain, is present in a wide range of proteins including the leukaemia associated proteins HRX, AF10 and AF17. Proc Natl Acad Sci USA 1995; 92: 9737-9741.
27. Schichman SA et al. ALL-1 partial duplication in acute leukemia. Proc Natl Acad Sci USA 1994; 91: 6236-6239.
28. Schichman SA et al. ALL-1 tandem duplication in acute myebid leukemia with a normal karyotype involves homologous recombination between Alu elements. Cancer Res 1994; 54: 4277-4280.
29. Schichman SA, Canaani E, Croce CM. Self-fusion of the ALL-1 gene: a new genetic mechanism for acute leukemia. J Am Med Assoc 1995; 273: 571-576.
30. Stong RC et al. Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics. Blood 1985; 65: 21-31.
31. Thirman MJ et al. Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. New Engl J Med 1993; 329: 909-914.
32. Thirman MJ et al. Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia. Proc Natl Acad Sci USA 1994; 91: 12110-12114.