Estrogen-like effect of a Cimicifuga racemosa extract sub-fraction as assessed by in vivo, ex vivo and in vitro assays

Journal of Steroid Biochemistry and Molecular Biology

Volumn 107, Issue 3-5, 2007, Pages 262-269

  Bolle, P ^a   Mastrangelo, S ^b   Perrone, F ^a   Evandri, M G ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

Cimicifuga racemosa; Oxytocics; Rat uterus; Yeast estrogenicity assay

Indexed keywords

4 HYDROXYTAMOXIFEN; BRADYKININ; CIMICIFUGA RACEMOSA EXTRACT; ESTRADIOL; ESTRADIOL VALERATE; ESTROGEN; ESTROGEN RECEPTOR ALPHA; OXYTOCIN; PROSTAGLANDIN F2 ALPHA; RALOXIFENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; DRUG POTENCY; ESTROGEN ACTIVITY; FEMALE; HYDROPHILICITY; LIPOPHILICITY; NONHUMAN; RAT; UTERUS;

ANIMALS; CIMICIFUGA; ESTROGENS; FEMALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; CIMICIFUGA DAHURICA; CIMICIFUGA RACEMOSA; RATTUS;

EID: 34548473586     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2007.03.044     Document Type: Article

References (46)

1. S. Foster, Black cohosh: Cimicifuga racemosa. A literature review, vol. 45, Herbal Gram Index American Botanical Council, Austin, Texas, 1999, pp. 37-49.
2. Winterhoff H., Spengler B., Christoffel V., Butterweck V., and Lohning A. Cimicifuga extract BNO 1055: reduction of hot flushes and hints on antidepressant activity. Maturitas 44 Suppl. 1 (2003) S51-S58
3. McKenna D.J., Jones K., Humphrey S., and Hughes K. Black cohosh: efficacy, safety, and use in clinical and preclinical applications. Altern. Ther. Health Med. 7 3 (2001) 93-100
4. Jarry H., Harnischfeger G., and Duker E.M. Studies on the endocrine effects of the contents of Cimicifuga racemosa 2. In vitro binding of compounds to estrogen receptors. Planta Med. 4 (1985) 316-319
5. Kennelly E.J., Baggett S., Nuntanakorn P., Ososki A.L., Mori S.A., Duke J., Coleton M., and Kronenberg F. Analysis of thirteen populations of black cohosh for formononetin. Phytomedicine 9 5 (2002) 461-467
6. Jiang B., Kronenberg F., Nuntanakorn P., Qiu M.-H., and Kennelly E.J. Evaluation of the botanical authenticity and phytochemical profile of black cohosh products by high-performance liquid chromatography with selected ion monitoring liquid chromatography-mass spectrometry. J. Agric. Food Chem. 54 (2006) 3242-3253
7. Jarry H., and Harnischfeger G. Endocrine effects of constituents of Cimicifuga racemosa. 1. The effect on serum levels of pituitary hormones in ovariectomized rats. Planta Med. 1 (1985) 46-49
8. Duker E.M., Kopanski L., Jarry H., and Wuttke W. Effects of extracts from Cimicifuga racemosa on gonadotropin release in menopausal women and ovariectomized rats. Planta Med. 57 (1991) 420-424
9. Fitzpatrick L.A. Alternatives to estrogen. Med. Clin. North Am. 87 5 (2003) 1091-1113
10. Wuttke W., Jarry H., Becker T., Schultens A., Christoffel V., Gorkow C., and Seidovlà-Wuttke D. Phytoestrogens: endocrine disrupters or replacement for hormone replacement therapy?. Maturitas 44 Suppl. 1 (2003) S9-S20
11. Seidlovà-Wuttke D., Hesse O., Jarry H., Christoffel V., Spengler B., Becker T., and Wuttke W. Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17 beta. Eur. J. Endocrinol. 149 Oct (4) (2003) 351-362
12. Zierau O., Bodinet C., Kolba S., Wulf M., and Vollmer G. Antiestrogenic activity of Cimicifuga racemosa extracts. J. Steroid Biochem. Mol. Biol. 80 1 (2002) 125-130
13. Beck V., Unterrieder E., Krenn L., Kubelka W., and Jungbauer A. Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapy. J. Steroid Biochem. Mol. Biol. 84 2-3 (2003) 259-268
14. Jarry H., Thelen P., Christoffel V., Spengler B., and Wuttke W. Cimicifuga racemosa extract BNO 1055 inhibits proliferation of the human prostate cancer cell line LNCaP. Phytomedicine 12 3 (2005) 178-182
15. Jacobson J.S., Troxel A.B., Evans J., Klaus L., Vahdat L., Kinne D., Lo K.M., Moore A., Rosenman P.J., Kaufman E.L., Neugut A.I., and Grann V.R. Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. J. Clin. Oncol. 19 10 (2001) 2739-2745
16. Liske E., Hanggi W., Henneicke von Zepelin H.H., Boblitz N., Wustenberg P., and Rahlfs V.W. Physiological investigation of a unique extract of black cohosh (Cimicifuga racemosae rhizoma): a 6-month clinical study demonstrates no systemic estrogenic effect. J. Womens Health Gend. Based Med. 11 2 (2002) 163-174
17. Wuttke W., Seidovlà-Wuttke D., and Gorkow C. The cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas 44 Suppl. 1 (2003) S67-S77
18. Pockaj B.A., Loprinzi C.L., Sloan J.A., Novotny P.J., Barton D.L., Hagenmaier A., Zhang H., Lambert G.H., Reeser K.A., and Wisbey J.A. Pilot evaluation of black cohosh for the treatment of hot flashes in women. Cancer Invest. 22 4 (2004) 515-521
19. Routledge E.J., and Sumpter J.P. Estrogenic activity of surfactants and some of their degradation products assessed using a recombinant yeast screen. Environ. Toxicol. Chem. 15 3 (1996) 241-248
20. Tinwell H., and Ashby J. Sensitivity of the immature rat uterotrophic assay to mixtures of estrogens. Environ. Health Perspect. 112 5 (2004) 575-582
21. Odum J., Lefevre P.A., Tittensor S., Paton D., Routledge E.J., Beresford N.A., Sumpter J.P., and Ashby J. The rodent uterotrophic assay: critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay. Regul. Toxicol. Pharmacol. 25 2 (1997) 176-188
22. Ostad S.N., Soodi M., Shariffzadeh M., Khorshidi N., and Marzban H. The effect of fennel essential oil on uterine contraction as a model for dysmenorrhea, pharmacology and toxicology study. J. Ethnopharmacol. 76 3 (2001) 299-304
23. Kretzschmar G., Nisslein T., Zierau O., and Vollmer G. No estrogen-like effects of an isopropanolic extract of Rhizoma Cimicifugae racemosae on uterus and vena cava of rats after 17 day treatment. J. Steroid Biochem. Mol. Biol. 97 3 (2005) 271-277
24. Kang K.S., Kim H.S., Ryu D.Y., Che J.H., and Lee Y.S. Immature uterotrophic assay is more sensitive than ovariectomized uterotrophic assay for the detection of estrogenicity of p-nonylphenol in Sprague-Dawley rats. Toxicol. Lett. 118 1-2 (2000) 109-115
25. Murone C., Chai S.Y., Muller-Esterl W., Mendelsohn F.A., and Clements J. Localization of bradykinin B2 receptors in the endometrium and myometrium of rat uterus and the effects of estrogen and progesterone. Endocrinology 140 7 (1999) 3372-3382
26. Soloff M.S., Fernstrom M.A., Peryasamy S., Soloff S., Baldwin S., and Wieder M. Regulation of oxytocin receptor concentration in rat uterine explants by estrogen and progesterone. Can. J. Biochem. Cell Biol. 61 7 (1983) 625-630
27. Maggi M., Fantoni G., Peri A., Giannini S., Brandi M.L., Orlando C., and Serio M. Steroid modulation of oxytocin/vasopressin receptors in the uterus. J. Steroid Biochem. Mol. Biol. 40 4-6 (1991) 481-491
28. Maggi M., Magini A., Fiscella A., Giannini S., Fantoni G., Toffoletti F., Massi G., and Serio M. Sex steroid modulation of neurohypophysial hormone receptors in human non pregnant myometrium. J. Clin. Endocrinol. Metab. 74 2 (1992) 385-392
29. Orlicky D.J., Lieberman R., and Gerschenson L.E. A role for prostaglandins in estrogen growth regulation. Med. Hypotheses 25 1 (1988) 1-5
30. Gordan P.L., Jenkins S.L., Wentworth R.A., and Nathanielsz P.W. Effect of in vivo estradiol administration to bilaterally ovariectomized rats on in vitro myometrial responsiveness to prostaglandin F2 alpha and oxytocin. Biol. Reprod. 57 3 (1997) 597-601
31. Oropeza M.V., Ponce-Monter H., Villanueva-Tello T., Palma-Aguirre J.A., and Campos M.G. Anatomical differences in uterine sensitivity to prostaglandin F(2alpha) and serotonin in non-pregnant rats. Eur. J. Pharmacol. 446 1-3 (2002) 161-166
32. Vedernikov Y.P., Hartke J.R., de Long M.A., Saade G.R., and Garfield R.E. Sex hormone effects in non-pregnant rat and human myometrium. Eur. J. Obstet. Gynecol. Reprod. Biol. 108 1 (2003) 59-66
33. Chaud M., Gonzalez E.T., Franchi A.M., Gimeno M.F., and Gimeno A.L. Sex hormones and the motility of and prostaglandin output from, uterine horns of immature rats. Prostaglandins Leukot. Med. 15 1 (1984) 35-44
34. Ramondt J., Zijlstra F., and Wallenburg H.C. Sensitivity of ovine myometrial tissue to various eicosanoids in vitro. Prostaglandins 49 1 (1995) 63-68
35. Osa T., and Ogasawara T. Effects in vitro of progesterone and estradiol-17 beta on the contractile and electrical responses in rat myometrium. Jpn. J. Physiol. 34 3 (1984) 427-441
36. Takayama T. Effects of highly concentrated estrogen and progesterone on the contractile mechanism of the uterine smooth muscles. Nippon Heikatsukin Gakkai Zasshi 22 1 (1986) 43-51
37. 2+ release induced by thromboxane A2 in porcine coronary artery. Circulation 91 10 (1995) 2619-2626
38. Kostrzewska A., Laudanski T., and Batra S. Effect of ovarian steroids and diethylstilbestrol on the contractile responses of the human myometrium and intramyometrial arteries. Eur. J. Pharmacol. 233 1 (1993) 127-134
39. Wassdal I., Nicolaysen G., and Iversen J.G. Bradykinin causes contraction in rat uterus through the same signal pathway as oxytocin. Acta Physiol. Scand. 164 1 (1998) 47-52
40. Clements J., Mukhtar A., Yan S., and Holland A. Kallikreins and kinins in inflammatory-like events in the reproductive tract. Pharmacol. Res. 35 6 (1997) 537-540
41. Borrelli F., and Ernst E. Cimicifuga racemosa: a systematic review of its clinical efficacy. Eur. J. Clin. Pharmacol. 58 4 (2002) 235-241
42. Viereck V., Grundker C., Friess S.C., Frosch K.H., Raddatz D., Schoppet M., Nisslein T., Emons G., and Hofbauer L.C. Isopropanolic extract of black cohosh stimulates osteoprotegerin production by human osteoblasts. J. Bone Miner. Res. 20 11 (2005) 2036-2043
43. Kligler B. Black cohosh. Am. Fam. Physician 68 1 (2003) 114-116
44. Jarry H., Metten M., Spengler B., Christoffel V., and Wuttke W. In vitro effects of the Cimicifuga racemosa extract BNO 1055. Maturitas 44 Suppl. 1 (2003) S31-S38
45. Blumenthal M. German Federal Institute for Drugs and Medical Devices. Commission E. The Complete German Commission E monographs: therapeutic guide to herbal medicines (1998), American Botanical Council, Austin, Texas
46. AADRB. Hepatotoxicity with black cohosh. Aust. Adverse Drug React. Bull. 25 2 (2006) 6-8