Temporal variation in estrogen receptor-α protein turnover in the presence of estrogen

Journal of Molecular Endocrinology

Volumn 40, Issue 1-2, 2008, Pages 23-34

  Valley, Christopher C ^a   Solodin, Natalia M ^a   Powers, Ginny L ^a   Ellison, Stephanie J ^a   Alarid, Elaine T ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; PROTEASOME; PROTEASOME INHIBITOR;

ARTICLE; CONTROLLED STUDY; ESTROGEN THERAPY; GENITAL SYSTEM; HALF LIFE TIME; HORMONE RESPONSE; HUMAN; HUMAN CELL; LIGAND BINDING; LONG TERM CARE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN STABILITY; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; STEADY STATE; STIMULATION;

CELL LINE, TUMOR; ESTROGEN RECEPTOR ALPHA; ESTROGENS; HUMANS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN ISOFORMS; TIME FACTORS;

EID: 39549095617     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/JME-07-0067     Document Type: Article

References (44)

1. Alarid ET 2006 Lives and times of nuclear receptors. Molecular Endocrinology 20 1972-1981.
2. Alarid ET, Bakopoulos N & Solodin N 1999 Proteasome-mediated protcolysis of estrogen receptor: a novel component in autologous down-regulation. Molecular Endocrinology 13 1522-1534.
3. Alarid ET, Preisler-Mashek MT & Solodin NM 2003 Thyroid hormone is an inhibitor of estrogen-induced degradation of estrogen receptor-α protein: estrogen dependent proteolysis is not essential for receptor transactivation function in the pituitary. Endocrinology 144 3469-3476.
4. Blanquart C, Barbier O, Fruchart J-C, Staels B & Glineur C 2002 Peroxisome proliferator-activated receptor α (PPARα) turnover by the ubiquitin-proteasome system controls the ligand-induced expression level of its target genes. Journal of Biological Chemistry 227 37254-37259.
5. Borras M, Hardy L, Lempereur F, El Khissiin AH, Legros N, Gol-Winkler R & Leclercq G 1994 Estradiol-induced down-regulation of estrogen receptor. Effect of various modulators of protein synthesis and expression. Journal of Steroid Biochemistry and Molecular Biology 48 325-336.
6. Calligé M, Kieffer I & Richard-Foy H 2005 CSN5/Jab1 is involved in ligand-dependent degradation of estrogen receptor α by the proteasome. Molecular and Cellular Biology 25 4349-4358.
7. Chen D, Riedl T, Washbrook E, Pace PE, Coombes RC, Egly J-M & Ali S 2000 Activation of estrogen receptor a by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of cdk7. Molecular Cell 6 127-137.
8. Cidlowski JA & Muldoon TG 1978 The dynamics of intracellular estrogen receptor regulation as influenced by 17β-estradiol. Biology of Reproduction 18 234-246.
9. Connell P, Ballinger CA, Jiang J, Wu Y, Thompson LJ, Yin LY & Patterson C 1999 Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Nature Cell Biology 3 93-96.
10. Eckert RL, Mullick A, Rorke EA & Katzenellenbogen BS 1984 Estrogen receptor synthesis and turnover in MCF-7 breast cancer cells measured by a density shift technique. Endocrinology 114 629-637.
11. El Khissiin A & Leclercq G 1999 Implication of proteasome in estrogen receptor degradation. FEBS Letters 448 160-166.
12. Fan M, Park A & Nephew KP 2005 CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha. Molecular Endocrinology 12 2901-2914.
13. Fowler AM, Solodin N, Preisler-Mashek MT, Zhang P, Lee AV & Alarid ET 2004 Increases in estrogen receptor-α concentration in breast cancer cells promote serine 118/104/106-independent AF-1 transactivation and growth in the absence of estrogen. FASEB Journal 118 81-93.
14. Fowler AM, Solodin NM, Valley CC & Alarid ET 2006 Altered target gene regulation controlled by estrogen receptor-α concentration. Molecular Endocrinology 20 291-301.
15. Frasor J, Danes JM, Komm B, Chang KCN, Lyttle CR & Katzenellenbogen BS 2003 Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology, 144 4562-4574.
16. Frech MS, Halama ED, Tilli MT, Singh B, Gunther EJ, Chodosh LA, Flaws JA & Furth PA 2005 Deregulated estrogen receptor α expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ. Cancer Research 65 681-685.
17. Gossen M, Greundlieb S, Bender G, Muller G, Hillen W & Bujard H 1995 Transcriptional activation by tetracyclines in mammalian cells. Science 268 1766-1769.
18. Henrich LM, Smith JA, Kitt D, Errington TM, Nguyen B, Traish AM & Lannigan DA 2003 Extracellular signal-regulated kinase 7, a regulator of hormone-dependent estrogen receptor destruction. Molecular and Cellular Biology 23 5979-5988.
19. Hewitt SC, Deroo BJ, Hansen K, Collins J, Grissom S, Afshari CA & Korach KS 2003 Estrogen receptor-dependent genomic responses in the uterus mirror the biphasic physiological response to estrogen. Molecular Endocrinology 17 2070-2083.
20. Horigome T, Ogata F, Golding TS & Korach KS 1988 Estradiol-stimulated proteolytic cleavage of the estrogen receptor in mouse uterus. Endocrinology 123 2540-2548.
21. Kaneko K, Furlow JD & Gorski J 1993 Involvement of the coding sequence for the estrogen receptor gene in autologous ligand-dependent down-regulation. Molecular Endocrinology 7 879-888.
22. Kato S, Endoh H, Masuhiro Y, Kitamoto T, Uchiyama S, Sasaki H, Masushige S, Gotoh Y, Nishida E, Kawashima H et al. 1995 Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270 1491-1494.
23. Keaveney M, Parker MG & Gannon F 1993 Identification of a functional role for thc 3′ region of the human oestrogen receptor gene. Journal of Molecular Endocrinology 10 143-152.
24. Khan SA, Sachdeva A, Naim S, Meguid MM, Marx W, Simon H, Halverson JD & Numann PJ 1999 The normal breast epithelium of women with breast cancer displays an aberrant response to estradiol. Cancer Epidemiology, Biomarkers and Prevention 8 867-872.
25. Kopf E, Plassat J-L, Vivat V, de The H, Chambon P & Rochette-Egly C 2000 Dimerization with retinoid X receptors and phosphorylation modulate the retinoic acid-induced degradation of retinoic acid receptors alpha and gamma through the ubiquitin-proteasome pathway. Journal of Biological Chemistry 275 33280-33288.
26. Lange CA, Shen T & Horwitz KB 2000 Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 268 proteasome. PNAS 97 1032-1037.
27. LeGoff P, Montano MM, Schodin DJ & Katzenellenbogen BS 1994 Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity. Journal of Biological Chemistry 1994 4458-4466.
28. Lessey BA, Metzger DA, Haney AF & McCarty KS 1989 Immunohistochemical analysis of estrogen and progesterone receptors in endometriosis: comparison with normal endometrium during the menstrual cycle and the effect of medical therapy. Fertility and Sterility 51 409-415.
29. -ΔΔC1 method. Methods 25 402-408.
30. Lonard DM, Nawaz Z, Smith CL & O'Malley BW 2000 The 26S proteasome is required for estrogen receptor-a and coactivator turnover and for efficient estrogen receptor-α transactivation. Molecular Cell 5 939-948.
31. Marsaud V, Gougelet A, Maillard S & Renoir J-M 2003 Various phosphorylation pathways, depending on agonist and antagonist binding to endogenous estrogen receptor a (ERα) differentially affect ERα extractability, proteasome-mediated stability, and transcriptional activity in human breast cancer cells. Molecular Endocrinology 17 2013-2027.
32. Métivier R, Penot G, Hübner MR, Reid G, Brand H, Koš M & Gannon F 2003 Estrogen receptor-α directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115 751-763.
33. Monsma FJ Jr, Katzenellenbogen BS, Miller MA, Ziegler YS & Katzenellenbogen JA 1984 Characterization of the estrogen receptor and its dynamics in MCF-7 human breast cancer cells using a covalently attaching antiestrogen. Endocrinology 115 143-153.
34. Nawaz Z, Lonard DM, Dennis AP, Smith CL & O'Malley BW 1999 Proteasome-dependent degradation of the human estrogen receptor. PNAS 96 1858-1862.
35. Pakdel F, Le Goff P & Katzenellenbogen BS 1993 An assessment of the role of domain F and PEST sequences in estrogen receptor half-life and bioactivity. Journal of Steroid Biochemistry and Molecular Biology 46 663-672.
36. Pink JJ & Jordan VC 1996 Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines. Cancer Research 56 2321-2330.
37. Preisler-Mashek MT, Solodin N, Stark BL, Tyriver MK & Alarid ET 2002 Ligand-specific regulation of proteasome-mediated proteolysis of estrogen receptor-α. American Journal of Physiology. Endocrinology and Metabolism 282 E891-E898.
38. Read LD, Greene GL & Katzenellenbogen BS 1989 Regulation of estrogen receptor messenger ribonucleic acid and protein levels in human breast cancer cell lines by sex steroid hormones, their antagonists, and growth factors. Molecular Endocrinology 3 295-304.
39. Reid G, Hubner MR, Metivier R, Heike B, Denger S, Manu D, Beaudouin J, Ellenberg J & Gannon F 2003 Cyclic, proteasome-mediated turnover of unliganded and liganded ERα on responsive promoters is an integral feature of estrogen signaling. Molecular Cell 11 695-707.
40. Saceda M, Lippman ME, Lindsey RK, Puente M & Martin MB 1989 Role of an estrogen receptor-dependent mechanism in the regulation of estrogen receptor mRNA in MCF-7 cells. Molecular Endocrinology 3 1782-1787.
41. Shang Y, Hu X, DiRenzo J, Lazar MA & Brown M 2000 Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103 843-852.
42. Tateishi Y, Kawabe Y, Chiba T, Murata S, Ichikawa K, Murayama A, Tanaka K, Baba T, Kato S & Yanagisawa J 2004 Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor. EMBO Journal 23 4813-4823.
43. Valley CC, Metivier R, Solodin NM, Fowler AM, Mashek MT, Hill L & Alarid ET 2005 Differential regulation of estrogen-inducible proteolysis and transcription by the estrogen receptor α N-terminus. Molecular and Cellular Biology 25 5417-5428.
44. Wijayaratne AL & McDonnell DP 2001 The human estrogen receptor-α is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists and selective estrogen receptor modulators. Journal of Biological Chemistry, 276 35684-35692.