Thyroglobulin (Tg) activates MAPK pathway to induce thyroid cell growth in the absence of TSH, insulin and serum

Biochemical and Biophysical Research Communications

Volumn 420, Issue 3, 2012, Pages 611-615

  Sue, Mariko ^a   Hayashi, Moyuru ^a   Kawashima, Akira ^a   Akama, Takeshi ^a   Tanigawa, Kazunari ^a   Yoshihara, Aya ^a   Hara, Takeshi ^a   Ishido, Yuko ^a   Ito, Tetsuhide ^b   Takahashi, Shin Ichiro ^c   Ishii, Norihisa ^a   Suzuki, Koichi ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

FRTL 5 cells; Growth; Thyroglobulin; Thyroid gland; TSH

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BROXURIDINE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYC PROTEIN; PROTEIN C FOS; PROTEIN C JUN; RAF PROTEIN; RETINOBLASTOMA PROTEIN; THYROGLOBULIN; THYROTROPIN;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; INSULIN BLOOD LEVEL; MOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SERUM; SIGNAL TRANSDUCTION; THYROID CELL; THYROTROPIN BLOOD LEVEL;

ANIMALS; CELL LINE; CELL PROLIFERATION; CULTURE MEDIA, SERUM-FREE; DNA REPLICATION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; GENE EXPRESSION; INSULIN; MAP KINASE KINASE KINASES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; PROTO-ONCOGENE PROTEINS C-RAF; RATS; THYROGLOBULIN; THYROID GLAND; THYROTROPIN;

EID: 84859617043     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.03.046     Document Type: Article

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