Thyroglobulin Autoregulation of Thyroid-Specific Gene Expression and Follicular Function

Reviews in Endocrine and Metabolic Disorders

Volumn 1, Issue 3, 2000, Pages 217-224

  Suzuki, Koichi ^a,b   Nakazato, Minoru ^a   Ulianich, Luca ^a   Mori Aoki, Atsumi ^a,c   Moriyama, Emiko ^a,b   Chung, Hyun Kyung ^a   Pietrarelli, Michelle ^a   Grassadonia, Antonino ^a   Matoba, Hana ^a   Kohn, Leonard D ^a,d  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b MEDSTAR RESEARCH INSTITUTE   (United States)

^c TOTTORI UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Asialoglycoprotein receptor; Feed back regulation; Follicular heterogeneity; Pax 8; TTF 1; TTF 2

Indexed keywords

THYROGLOBULIN; THYROTROPIN;

ANIMAL; DRUG EFFECT; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; HUMAN; PHYSIOLOGY; REVIEW; THYROID GLAND;

ANIMALS; FEEDBACK; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; THYROGLOBULIN; THYROID GLAND; THYROTROPIN;

EID: 0034173524     PISSN: 13899155     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010035200212     Document Type: Article

References (32)

1. Kohn LD, Saji M, Kosugi M, Ban T, Giuliani C, Hidaka A, Shimura H, Shimura Y, Okajima F. The Synthesis and Secretion of Thyroid Hormones Regulation by Multiple Hormones and Signals which can be Subverted by Autoantibodies to the Thyrotropin Receptor. Boca Raton: CRC Press, 1993;59-118.
2. Santisteban P, Kohn LD, Di Lauro R. Thyroglobulin gene expression is regulated by insulin and insulin-like-growth factor I, as well as thyrotropin, in FRTL-5 thyroid cells. J Biol Chem 1987;262:4048-4052.
3. Dai G, Levy O, Carrasco N. Cloning and characterization of the thyroid iodide transporter. Nature 1996;379:458-460.
4. Suzuki K, Mori A, Ulianich L, Everett LA, Royaux I, Green ED, Kohn LD. Follicular Thyroglobulin (TG) Regulates Expression of Basal and Apical Iodide Transporters the Sodium/Iodide Symporter (NIS) and Pendrin (PDS) Genes ENDO '99. 81st Annual Meeting of The Endocrine Society 1999 Abstract P1-335.
5. Field JB. Mechanism of Action of Thyrotropin. Philadelphia: JB Lippincott Co, 1986;288-303.
6. Damante G, Di Lauro R. Thyroid-specific gene expression. Biochim Biophys Acta 1994;1218:255-266.
7. Ortiz L, Zannini M, Di Lauro R, Santisteban P. Transcriptional control of the forkhead thyroid transcription factor TTF-2 by thyrotropin, insulin, and insulin-like growth factor 1. J Biol Chem 1997;272:23334-23339.
8. Kohn LD, Shimura H, Shimura Y, Hidaka A, Giuliani C, Napolitano G, Ohmori M, Laglia G, Saji M. The thyrotropin receptor. Vitam Horm 1995;50:287-384.
9. Kohn LD, Giuliani C, Montani V, Napolitano G, Ohmori M, Ohta M, Saji M, Schuppert F, Shong M-H, Suzuki K, Taniguchi S-I, Yano K, Singer DS. Antireceptor Immunity. Austin/Georgetown: RG Landes Biomedical Publishers, 1995;115-170.
10. Kohn LD, De Luca ML, Santisteban P, Shifrin S, Yeh HJC, Formisano S, Consiglio E. Thyroglobulin interactions with thyroid membranes implications for regulation of thyroid hormone formation in thyroglobulin. Progress in Endocrine Research and Therapy 1985;2:171-190.
11. Miquelis R, Alquier C, Monsigny M. The N-acetylglucosamine-specific receptor of the thyroid Binding characteristics, partial characterization, and potential role. J Biol Chem 1987;262:15291-15298.
12. Consiglio E, Salvatore G, Rail JE, Kohn LD. Thyroglobulin interactions with thyroid plasma membranes. The existence of specific receptors and their potential role. J Biol Chem 1979;254:5065-5076.
13. Consiglio E, Shifrin S, Yavin Z, Ambesi-Impiombato FS, Rail JE, Salvatore G, Kohn LD. Thyroglobulin interactions with thyroid membranes. Relationship between receptor recognition of N-acetylglucosamine residues and the iodine content of thyroglobulin preparations. J Biol Chem 1981;256:10592-10599.
14. Shifrin S, Kohn LD. Binding of thyroglobulin to bovine thyroid membranes. Role of specific amino acids in receptor recognition. J Biol Chem 1981;256:10600-10605.
15. Zheng G, Marino M, Zhao J, McCluskey RT. Megalin (gp330) a putative endocytic receptor for thyroglobulin (Tg). Endocrinology 1998;139:1462-1465.
16. Pacifico F, Liguoro D, Ulianich L, Montuori N, Cali G, Nitsch L, Kohn LD, Formisano S, Consiglio E. Expression and localization of the RHL-1 subunit of the asialoglycoprotein receptor on thyroid cells a receptor for thyroglobulin endocytosis? J Biol Chem 2000, in press.
17. van den Hove MF, Couvreur M, de Visscher M, Salvatore G. A new mechanism for the reabsorption of thyroid iodoproteins selective fluid endocytosis. Eur J Biochem 1982;122:415-422.
18. Aeschimann S, Kopp PA, Kimura ET, Zbaeren J, Tobler A, Fey MF, Studer H. Morphological and functional polymorphism within clonal thyroid nodules. J Clin Endocrinol Metab 1993;77:846-851.
19. Suzuki K, Matsumoto H, Kobayashi M, Kawaoi A, Asayama K, Moriyama S. Immunohistochemical localization of copper-zinc and manganese superoxide dismutases in diisopropanolnitrosamine-induced rat thyroid lesions. Acta Histochem Cytochem 1991;24:69-73.
20. Yamamoto K, Xue R, Katoh R, Kawaoi A. Differential immunolocalization of thyroglobulin (Tg) in the follicular epithelium of rat thyroid gland and its kinetics under thyrotropin (TSH) stimulation - A quantitative immunoelectron microscopic analysis using post-embedding immunogold technique. Acta Histochem Cytochem 1997;30:147-155.
21. Suzuki K, Mori A, Lavaroni S, Miyagi E, Ulianich L, Katoh R, Kawaoi A, Kohn LD. In vivo expression of thyroid transcription factor-1 RNA and its relation to thyroid function and follicular heterogeneity. Identification of follicular thyroglobulin as a feedback suppressor of thyroid transcription factor-1 RNA levels and thyroglobulin synthesis. Thyroid 1999;9:319-331.
22. Gerber H, Peter HJ, Studer H. Diffusion of thyroglobulin in the follicular colloid. Endocrinol Exp 1986;20:23-33.
23. Yi X, Yamamoto K, Shu L, Katoh R, Kawaoi A. Effect of Propylthiouracil (PTU) administration on the synthesis and secretion of thyroglobulin in the rat thyroid gland a quantitative immunoelectronmicroscopic study using immunogold technique. Endocr Pathol 1997;8:315-325.
24. Suzuki K, Lavaroni S, Mori A, Ohta M, Saito J, Pietrarelli M, Kimura S, Katoh R, Kawaoi A, Kohn LD. Autoregulation of thyroid-specific gene transcription by thyroglobulin. Proc Natl Acad Sci USA 1998;95:8251-8256.
25. Suzuki K, Mori A, Saito J, Moriyama E, Ulianich L, Kohn LD. Follicular thyroglobulin suppresses iodide uptake by suppressing expression of the sodium iodide symporter gene. Endocrinology 1999, in press.
26. Ulianich L, Suzuki K, Mori A, Nakazato M, Pietrarelli M, Goldsmith P, Pacifico F, Consiglio E, Formisano S, Kohn LD. Follicular thyroglobulin (TG) suppression of thyroid-restricted genes involves the apical membrane asialoglycoprotein receptor and TG phosphorylation. J Biol Chem 1999, in press.
27. Suzuki K, Lavaroni S, Mori A, Yamamoto K, Yi X, Miyagi E, Katoh R, Kohn LD, Kawaoi A. Thyroglobulin a master regulator of follicular function via transcriptional suppression of thyroid specific genes. Acta Histochem Cytochem 1999;32:111-119.
28. Nakazato M, Suzuki K, Mori A, Ulianich L, Pietrarelli M, Kohn LD. Regulation of Thyroid Transcription Factor-1 (TTF-1) by Thyroglobulin (TG) Involves a Novel Regulatory Element and Elimination of an Activator of TTF-1 Gene Expression. 81st Annual Meeting of The Endocrine Society, 1999, Abstract OR-8-3.
29. Salabe GB, Corvo L, Lotz H. Thyroglobulin determined in thyroid fine needle aspiration biopsies by radial immunodiffusion and electroimmunodiffusion. Eur J Clin Chem Clin Biochem 1996;34:43-47.
30. Herzog V, Berndorfer U, Saber Y. Isolation of insoluble secretory product from bovine thyroid: extracellular storage of thyroglobulin in covalently cross-linked form. J Cell Biol 1992;118:1071-1083.
31. Schuppert F, Ehrenthal D, Frilling A, Suzuki K, Napolitano G, Kohn LD. Increased major histocompatibility complex (MHC) expression in non-toxic goiters is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies. J Clin Endocrinol Metab 2000;85:858-867.
32. Huang SS, Cerullo MA, Huang FW, Huang JS. Activated thyroglobulin possesses a transforming growth factor-beta activity. J Biol Chem 1998;273:26036-26041.