Delayed onset of paralysis and slowed tumor growth following in situ placement of recombinant human bone morphogenetic protein 2 within spine tumors in a rat model of metastatic breast cancer: Presented at the 2011 Spine Section Meeting - Laboratory investigation

Journal of Neurosurgery: Spine

Volumn 16, Issue 4, 2012, Pages 365-372

  Molina, Camilo A ^a   Sarabia Estrada, Rachel ^a   Gokaslan, Ziya L ^a   Witham, Timothy F ^a   Bydon, Ali ^a   Wolinsky, Jean Paul ^a   Sciubba, Daniel M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Animal model; Bone morphogenetic protein 2; Metastatic spine disease; Oncology; Recombinant human bone morphogenetic protein; Spine tumor

Indexed keywords

COLLAGEN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BONE DESTRUCTION; BONE GROWTH; BREAST CANCER; CANCER GROWTH; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LUMBAR SPINE; METASTASIS; MORBIDITY; MOTOR PERFORMANCE; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PARALYSIS; PARESIS; SPINE TUMOR;

ADENOCARCINOMA; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; CELL LINE, TUMOR; FEMALE; MAMMARY NEOPLASMS, EXPERIMENTAL; NEOPLASM TRANSPLANTATION; PARALYSIS; RATS; RATS, NUDE; RECOMBINANT PROTEINS; SPINAL NEOPLASMS; SPINE; SURVIVAL ANALYSIS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84859601279     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/2011.12.SPINE11496     Document Type: Conference Paper

References (59)

1. Alarmo EL, Kuukasjärvi T, Karhu R, Kallioniemi A: A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7. Breast Cancer Res Treat 103:239-246, 2007
2. Alarmo EL, Pärssinen J, Ketolainen JM, Savinainen K, Karhu R, Kallioniemi A: BMP7 influences proliferation, migration, and invasion of breast cancer cells. Cancer Lett 275:35-43, 2009
3. Anderson E: The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis. Breast Cancer Res 4:197-201, 2002
4. Bach F, Larsen BH, Rohde K, Børgesen SE, Gjerris F, Bøge- Rasmussen T, et al: Metastatic spinal cord compression. Occurrence, symptoms, clinical presentations and prognosis in 398 patients with spinal cord compression. Acta Neurochir (Wien) 107:37-43, 1990
5. Bagley CA, Bookland MJ, Pindrik JA, Ozmen T, Gokaslan ZL, Witham TF: Local delivery of oncogel delays paresis in rat metastatic spinal tumor model. J Neurosurg Spine 7:194-198, 2007
6. Bagley CA, Bookland MJ, Pindrik JA, Ozmen T, Gokaslan ZL, Wolinsky JP, et al: Fractionated, single-port radiotherapy delays paresis in a metastatic spinal tumor model in rats. J Neurosurg Spine 7:323-327, 2007
7. Bartels RH, Feuth T, van der Maazen R, Verbeek AL, Kappelle AC, André Grotenhuis J, et al: Development of a model with which to predict the life expectancy of patients with spinal epidural metastasis. Cancer 110:2042-2049, 2007
8. Bartels RH, van der Linden YM, van der Graaf WT: Spinal extradural metastasis: review of current treatment options. CA Cancer J Clin 58:245-259, 2008
9. Basso DM, Beattie MS, Bresnahan JC: A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21, 1995
10. Bellizzi KM, Mustian KM, Palesh OG, Diefenbach M: Cancer survivorship and aging: moving the science forward. Cancer 113 (12 Suppl):3530-3539, 2008
11. Bilsky MH, Lis E, Raizer J, Lee H, Boland P: The diagnosis and treatment of metastatic spinal tumor. Oncologist 4:459-469, 1999
12. Buijs JT, Henriquez NV, van Overveld PG, van der Horst G, Que I, Schwaninger R, et al: Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer. Cancer Res 67:8742-8751, 2007
13. Burkus JK, Sandhu HS, Gornet MF, Longley MC: Use of rh- BMP-2 in combination with structural cortical allografts: clinical and radiographic outcomes in anterior lumbar spinal surgery. J Bone Joint Surg Am 87:1205-1212, 2005
14. Burkus JK, Transfeldt EE, Kitchel SH, Watkins RG, Balderston RA: Clinical and radiographic outcomes of anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2. Spine (Phila Pa 1976) 27:2396-2408, 2002
15. Cahill KS, Chi JH, Groff MW, McGuire K, Afendulis CC, Claus EB: Outcomes for single-level lumbar fusion: The role of bone morphogenetic protein. Spine (Phila Pa 1976) 36:2354- 2362, 2011
16. Chang H, Brown CW, Matzuk MM: Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocr Rev 23:787-823, 2002
17. Cho SK, Stoker GE, Bridwell KH: Spinal reconstruction with pedicle screw-based instrumentation and rhBMP-2 in patients with neurofibromatosis and severe dural ectasia and spinal deformity: report of two cases and a review of the literature. J Bone Joint Surg Am 93:e86, 2011
18. Clement JH, Marr N, Meissner A, Schwalbe M, Sebald W, Kliche KO, et al: Bone morphogenetic protein 2 (BMP-2) induces sequential changes of Id gene expression in the breast cancer cell line MCF-7. J Cancer Res Clin Oncol 126:271-279, 2000
19. Clement JH, Raida M, Sänger J, Bicknell R, Liu J, Naumann A, et al: Bone morphogenetic protein 2 (BMP-2) induces in vitro invasion and in vivo hormone independent growth of breast carcinoma cells. Int J Oncol 27:401-407, 2005
20. Cole JS, Patchell RA: Metastatic epidural spinal cord compression. Lancet Neurol 7:459-466, 2008
21. Flynn DF, Shipley WU: Management of spinal cord compression secondary to metastatic prostatic carcinoma. Urol Clin North Am 18:145-152, 1991
22. Fujibayashi S, Neo M, Miyaki K, Nakayama T, Nakamura T: The value of palliative surgery for metastatic spinal disease: satisfaction of patients and their families. Spine J 10:42-49, 2010
23. Ganz PA: Survivorship: adult cancer survivors. Prim Care 36: 721-741, 2009
24. Ganz PA, Lee JJ, Siau J: Quality of life assessment. An independent prognostic variable for survival in lung cancer. Cancer 67:3131-3135, 1991
25. Ghosh-Choudhury N, Abboud SL, Nishimura R, Celeste A, Mahimainathan L, Choudhury GG: Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP- 2 gene transcription. J Biol Chem 277:33361-33368, 2002
26. Gok B, McGirt M, Sciubba DM, Ayhan S, Bydon A, Witham TF, et al: Surgical resection plus adjuvant radiotherapy is superior to surgery or radiotherapy alone in the prevention of neurological decline in a rat metastatic spinal tumor model. Neurosurgery 63:346-351, 2008
27. Gok B, McGirt MJ, Sciubba DM, Garces-Ambrossi G, Nelson C, Noggle J, et al: Adjuvant treatment with locally delivered OncoGel delays the onset of paresis after surgical resection of experimental spinal column metastasis. Neurosurgery 65: 193-200, 2009
28. Harel R, Angelov L: Spine metastases: current treatments and future directions. Eur J Cancer 46:2696-2707, 2010
29. Hayat MJ, Howlader N, Reichman ME, Edwards BK: Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) Program. Oncologist 12:20-37, 2007
30. Helweg-Larsen S, Sørensen PS: Symptoms and signs in metastatic spinal cord compression: a study of progression from first symptom until diagnosis in 153 patients. Eur J Cancer 30A: 396-398, 1994
31. Hespanhol V, Queiroga H, Magalhães A, Santos AR, Coelho M, Marques A: Survival predictors in advanced non-small cell lung cancer. Lung Cancer 13:253-267, 1995
32. Iacovou JW, Marks JC, Abrams PH, Gingell JC, Ball AJ: Cord compression and carcinoma of the prostate: is laminectomy justified? Br J Urol 57:733-736, 1985
33. Ibrahim A, Crockard A, Antonietti P, Boriani S, Bünger C, Gasbarrini A, et al: Does spinal surgery improve the quality of life for those with extradural (spinal) osseous metastases? An international multicenter prospective observational study of 223 patients. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2007. J Neurosurg Spine 8:271-278, 2008
34. Jacobs WB, Perrin RG: Evaluation and treatment of spinal metastases: an overview. Neurosurg Focus 11(6):e10, 2001
35. Janjan N: Bone metastases: approaches to management. Semin Oncol 28 (4 Suppl 11):28-34, 2001
36. Kawabata M, Imamura T, Miyazono K: Signal transduction by bone morphogenetic proteins. Cytokine Growth Factor Rev 9:49-61, 1998
37. Kohler BA, Ward E, McCarthy BJ, Schymura MJ, Ries LA, Eheman C, et al: Annual report to the nation on the status of cancer, 1975-2007, featuring tumors of the brain and other nervous system. J Natl Cancer Inst 103:714-736, 2011
38. Lad SP, Nathan JK, Boakye M: Trends in the use of bone morphogenetic protein as a substitute to autologous iliac crest bone grafting for spinal fusion procedures in the United States. Spine (Phila Pa 1976) 36:E274-E281, 2011
39. Loblaw DA, Laperriere NJ, Mackillop WJ: A populationbased study of malignant spinal cord compression in Ontario. Clin Oncol (R Coll Radiol) 15:211-217, 2003
40. Luhmann SJ, Bridwell KH, Cheng I, Imamura T, Lenke LG, Schootman M: Use of bone morphogenetic protein-2 for adult spinal deformity. Spine (Phila Pa 1976) 30 (17 Suppl):S110- S117, 2005
41. Maeda T, Buchowski JM, Kim YJ, Mishiro T, Bridwell KH: Long adult spinal deformity fusion to the sacrum using rh- BMP-2 versus autogenous iliac crest bone graft. Spine (Phila Pa 1976) 34:2205-2212, 2009
42. Mantha A, Legnani FG, Bagley CA, Gallia GL, Garonzik I, Pradilla G, et al: A novel rat model for the study of intraosseous metastatic spine cancer. J Neurosurg Spine 2:303-307, 2005
43. McGirt MJ, Gok B, Shepherd S, Noggle J, Garcés Ambrossi GL, Bydon A, et al: Effect of hyperglycemia on progressive paraparesis in a rat etastatic spinal tumor model. Laboratory investigation. J Neurosurg Spine 10:9-15, 2009
44. Montazeri A: Quality of life data as prognostic indicators of survival in cancer patients: an overview of the literature from 1982 to 2008. Health Qual Life Outcomes 7:102, 2009
45. Montesano R: Bone morphogenetic protein-4 abrogates lumen C. A. Molina et al. formation by mammary epithelial cells and promotes invasive growth. Biochem Biophys Res Commun 353:817-822, 2007
46. Mulconrey DS, Bridwell KH, Flynn J, Cronen GA, Rose PS: Bone morphogenetic protein (RhBMP-2) as a substitute for iliac crest bone graft in multilevel adult spinal deformity surgery: minimum two-year evaluation of fusion. Spine (Phila Pa 1976) 33:2153-2159, 2008
47. Nagata M, Ueda T, Komiya A, Suzuki H, Akakura K, Ishihara M, et al: Treatment and prognosis of patients with paraplegia or quadriplegia because of metastatic spinal cord compression in prostate cancer. Prostate Cancer Prostatic Dis 6:169-173, 2003
48. Parry C, Kent EE, Mariotto AB, Alfano CM, Rowland JH: Cancer survivors: a booming population. Cancer Epidemiol Biomarkers Prev 20:1996-2005, 2011
49. Pouliot F, Labrie C: Role of Smad1 and Smad4 proteins in the induction of p21WAF1,Cip1 during bone morphogenetic protein-induced growth arrest in human breast cancer cells. J Endocrinol 172:187-198, 2002
50. Raida M, Clement JH, Ameri K, Han C, Leek RD, Harris AL: Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death. Int J Oncol 26:1465-1470, 2005
51. Reinholz MM, Iturria SJ, Ingle JN, Roche PC: Differential gene expression of TGF-beta family members and osteopontin in breast tumor tissue: analysis by real-time quantitative PCR. Breast Cancer Res Treat 74:255-269, 2002
52. Sasagawa I, Gotoh H, Miyabayashi H, Yamaguchi O, Shiraiwa Y: Hormonal treatment of symptomatic spinal cord compression in advanced prostatic cancer. Int Urol Nephrol 23:351- 356, 1991
53. Sciubba DM, Gokaslan ZL: Diagnosis and management of metastatic spine disease. Surg Oncol 15:141-151, 2006
54. Sciubba DM, Petteys RJ, Dekutoski MB, Fisher CG, Fehlings MG, Ondra SL, et al: Diagnosis and management of metastatic spine disease. A review. J Neurosurg Spine 13:94-108, 2010
55. Steinmetz MP, Mekhail A, Benzel EC: Management of metastatic tumors of the spine: strategies and operative indications. Neurosurg Focus 11(6):e2, 2001
56. Thawani JP, Wang AC, Than KD, Lin CY, La Marca F, Park P: Bone morphogenetic proteins and cancer: review of the literature. Neurosurgery 66:233-246, 2010
57. van der Linden YM, Dijkstra SP, Vonk EJ, Marijnen CA, Leer JW: Prediction of survival in patients with metastases in the spinal column: results based on a randomized trial of radiotherapy. Cancer 103:320-328, 2005
58. Witham TF, Khavkin YA, Gallia GL, Wolinsky JP, Gokaslan ZL: Surgery insight: current management of epidural spinal cord compression from metastatic spine disease. Nat Clin Pract Neurol 2:87-94, 116, 2006
59. Yang S, Zhong C, Frenkel B, Reddi AH, Roy-Burman P: Diverse biological effect and Smad signaling of bone morphogenetic protein 7 in prostate tumor cells. Cancer Res 65:5769- 5777, 2005