Spinal reconstruction with pedicle screw-based instrumentation and rhBMP-2 in patients with neurofibromatosis and severe dural ectasia and spinal deformity: Report of two cases and a review of the literature

Journal of Bone and Joint Surgery

Volumn 93, Issue 15, 2011, Pages

  Cho, Samuel K ^a   Stoker, Geoffrey E ^b   Bridwell, Keith H ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ADOLESCENT; ADULT; ARTICLE; BACKACHE; BONE ALLOGRAFT; CAFE AU LAIT SPOT; CASE REPORT; DIAGNOSTIC IMAGING; DURAL ECTASIA; FEMALE; FIBROUS DYSPLASIA; HUMAN; KYPHOSCOLIOSIS; KYPHOSIS; LORDOSIS; MALE; NEUROFIBROMATOSIS; PATIENT SATISFACTION; PEDICLE SCREW; PRIORITY JOURNAL; SPINE FUSION; VERTEBRA DISLOCATION;

EID: 80052833674     PISSN: 00219355     EISSN: 15351386     Source Type: Journal    
DOI: 10.2106/JBJS.J.01659     Document Type: Article

References (59)

1. Crawford AH Jr, Bagamery N. Osseous manifestations of neurofibromatosis in childhood. J Pediatr Orthop. 1986;6:72-88. (Pubitemid 16178104)
2. Williams VC, Lucas J, Babcock MA, Gutmann DH, Korf B, Maria BL. Neurofibromatosis type 1 revisited. Pediatrics. 2009;123:124-33.
3. Shen MH, Harper PS, Upadhyaya M. Molecular genetics of neurofibromatosis type 1 (NF1). J Med Genet. 1996;33:2-17. (Pubitemid 26025089)
4. Tsirikos AI, Saifuddin A, Noordeen MH. Spinal deformity in neurofibromatosis type-1: diagnosis and treatment. Eur Spine J. 2005;14:427-39. (Pubitemid 40931907)
5. Maertens O, De Schepper S, Vandesompele J, Brams H, Heyns I, Janssens S, Speleman F, Legius E, Messiaen L. Molecular dissection of isolated disease features in mosaic neurofibromatosis type 1. Am J Hum Genet. 2007;81:243-51. (Pubitemid 47236073)
6. Muir D, Neubauer D, Lim IT, Yachnis AT, Wallace MR. Tumorigenic properties of neurofibromin-deficient neurofibroma Schwann cells. Am J Pathol. 2001;158:501-13. (Pubitemid 32158611)
7. Ferner RE, Huson SM, Thomas N, Moss C, Willshaw H, Evans DG, Upadhyaya M, Towers R, Gleeson M, Steiger C, Kirby A. Guidelines for the diagnosis and management of individuals with neurofibromatosis 1. J Med Genet. 2007;44:81-8.
8. Akbarnia BA, Gabriel KR, Beckman E, Chalk D. Prevalence of scoliosis in neurofibromatosis. Spine (Phila Pa 1976). 1992;17(8 Suppl):S244-8.
9. Rezaian SM. The incidence of scoliosis due to neurofibromatosis. Acta Orthop Scand. 1976;47:534-9.
10. Stone JW, Bridwell KH, Shackelford GD, Abramson CL. Dural ectasia associated with spontaneous dislocation of the upper part of the thoracic spine in neurofibromatosis. A case report and review of the literature. J Bone Joint Surg Am. 1987;69:1079-83. (Pubitemid 18004706)
11. Funasaki H, Winter RB, Lonstein JB, Denis F. Pathophysiology of spinal deformities in neurofibromatosis. An analysis of seventy-one patients who had curves associated with dystrophic changes. J Bone Joint Surg Am. 1994;76:692-700. (Pubitemid 24180979)
12. Kim HW, Weinstein SL. Spine update. The management of scoliosis in neurofibromatosis. Spine (Phila Pa 1976). 1997;22:2770-6.
13. Crawford AH, Herrera-Soto J. Scoliosis associated with neurofibromatosis. Orthop Clin North Am. 2007;38:553-62, vii.
14. Eichhorn C, Wendt G, Staudte HW, Gilsbach JM. Dural ectasia in von Recklinghausen's disease of the lumbar spine: a case report. J Bone Joint Surg Br. 1995;77:834-5.
15. Durrani AA, Crawford AH, Chouhdry SN, Saifuddin A, Morley TR. Modulation of spinal deformities in patients with neurofibromatosis type 1. Spine (Phila Pa 1976). 2000;25:69-75.
16. Wilde PH, Upadhyay SS, Leong JC. Deterioration of operative correction in dystrophic spinal neurofibromatosis. Spine (Phila Pa 1976). 1994;19:1264-70.
17. Hsu LC, Lee PC, Leong JC. Dystrophic spinal deformities in neurofibromatosis. Treatment by anterior and posterior fusion. J Bone Joint Surg Br. 1984;66:495-9. (Pubitemid 14003913)
18. Rockower S, McKay D, Nason S. Dislocation of the spine in neurofibromatosis. A report of two cases. J Bone Joint Surg Am. 1982;64:1240-2. (Pubitemid 13244018)
19. Winter RB, Lovell WW, Moe JH. Excessive thoracic lordosis and loss of pulmonary function in patients with idiopathic scoliosis. J Bone Joint Surg Am. 1975;57:972-7.
20. Curtis BH, Fisher RL, Butterfield WL, Saunders FP. Neurofibromatosis with paraplegia. Report of eight cases. J Bone Joint Surg Am. 1969;51:843-61.
21. Betz RR, Iorio R, Lombardi AV, Clancy M, Steel HH. Scoliosis surgery in neurofibromatosis. Clin Orthop Relat Res. 1989;245:53-6.
22. Savini R, Parisini P, Cervellati S, Gualdrini G. Surgical treatment of vertebral deformities in neurofibromatosis. Ital J Orthop Traumatol. 1983;9:13-24. (Pubitemid 13008410)
23. Calvert PT, Edgar MA, Webb PJ. Scoliosis in neurofibromatosis. The natural history with and without operation. J Bone Joint Surg Br. 1989;71:246-51. (Pubitemid 19081403)
24. Winter RB, Lonstein JE, Anderson M. Neurofibromatosis hyperkyphosis: a review of 33 patients with kyphosis of 80 degrees or greater. J Spinal Disord. 1988;1:39-49. (Pubitemid 19152626)
25. Winter RB, Moe JH, Bradford DS, Lonstein JE, Pedras CV, Weber AH. Spine deformity in neurofibromatosis. A review of one hundred and two patients. J Bone Joint Surg Am. 1979;61:677-94. (Pubitemid 9232023)
26. Crawford AH. Pitfalls of spinal deformities associated with neurofibromatosis in children. Clin Orthop Relat Res. 1989;245:29-42.
27. Sirois JL 3rd, Drennan JC. Dystrophic spinal deformity in neurofibromatosis. J Pediatr Orthop. 1990;10:522-6. (Pubitemid 20315721)
28. Winter RB. Spontaneous dislocation of a vertebra in a patient who had neuro-fibromatosis. Report of a case with dural ectasia. J Bone Joint Surg Am. 1991;73:1402-4.
29. Isu T, Miyasaka K, Abe H, Ito T, Iwasaki Y, Tsuru M, Kitaoka K, Tsunoda M. Atlantoaxial dislocation associated with neurofibromatosis. Report of three cases. J Neurosurg. 1983;58:451-3. (Pubitemid 13149557)
30. Kim K-T, Lee S-H, Suk K-S, Lee J-H, Seo E-M, Jeong B- O. Spontaneous vertebral column dislocation in neurofibromatosis. A Case report. J Korean Orthop Assoc. 2007;42:822-7.
31. Dimar JR, Glassman SD, Burkus KJ, Carreon LY. Clinical outcomes and fusion success at 2 years of single-level instrumented posterolateral fusions with recombinant human bone morphogenetic protein-2/compression resistant matrix versus iliac crest bone graft. Spine (Phila Pa 1976). 2006;31:2534-40.
32. Cho SK, Lenke LG, Hanson D. Traumatic noncontiguous double fracturedislocation of the lumbosacral spine. Spine J. 2006;6:534-8. (Pubitemid 44268942)
33. Vialle R, Court C. Traumatic lateral lumbosacral dislocation: one case and review of literature. J Spinal Disord Tech. 2005;18:286-9. (Pubitemid 43085868)
34. Illés T, Halmai V, de Jonge T, Dubousset J. Decreased bone mineral density in neurofibromatosis-1 patients with spinal deformities. Osteoporos Int. 2001;12:823-7. (Pubitemid 33086269)
35. Bess RS, Lenke LG, Bridwell KH, Cheh G, Mandel S, Sides B. Comparison of thoracic pedicle screw to hook instrumentation for the treatment of adult spinal deformity. Spine (Phila Pa 1976). 2007;32:555-61.
36. Sun E, Alkalay R, Vader D, Snyder BD. Preventing distal pullout of posterior spine instrumentation in thoracic hyperkyphosis: a biomechanical analysis. J Spinal Disord Tech. 2009;22:270-7.
37. McLain RF. The biomechanics of long versus short fixation for thoracolumbar spine fractures. Spine (Phila Pa 1976). 2006;31(11 Suppl):S70-9, S104.
38. Krag MH. Biomechanics of thoracolumbar spinal fixation. A review. Spine (Phila Pa 1976). 1991;16:S84-99.
39. Maeda T, Buchowski JM, Kim YJ, Mishiro T, Bridwell KH. Long adult spinal deformity fusion to the sacrum using rhBMP-2 versus autogenous iliac crest bone graft. Spine (Phila Pa 1976). 2009;34:2205-12.
40. Mulconrey DS, Bridwell KH, Flynn J, Cronen GA, Rose PS. Bone morphogenetic protein (RhBMP-2) as a substitute for iliac crest bone graft in multilevel adult spinal deformity surgery: minimum two-year evaluation of fusion. Spine (Phila Pa 1976). 2008;33:2153-9.
41. Papakostidis C, Kontakis G, Bhandari M, Giannoudis PV. Efficacy of autologous iliac crest bone graft and bone morphogenetic proteins for posterolateral fusion of lumbar spine: ameta-analysis of the results. Spine (Phila Pa 1976). 2008;33:E680-92.
42. Rogozinski A, Rogozinski C, Cloud G. Accelerating autograft maturation in instrumented posterolateral lumbar spinal fusions without donor site morbidity. Orthopedics. 2009;32:809.
43. Slosar PJ, Josey R, Reynolds J. Accelerating lumbar fusions by combining rhBMP-2 with allograft bone: a prospective analysis of interbody fusion rates and clinical outcomes. Spine J. 2007;7:301-7. (Pubitemid 46667736)
44. Boden SD, Kang J, Sandhu H, Heller JG. Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies. Spine (Phila Pa 1976). 2002;27:2662-73.
45. Lovell TP, Dawson EG, Nilsson OS, Urist MR. Augmentation of spinal fusion with bone morphogenetic protein in dogs. Clin Orthop Relat Res. 1989:266-74. (Pubitemid 19165395)
46. Holt RT, Johnson JR. Cotrel-Dubousset instrumentation in neurofibromatosis spine curves. A preliminary report. Clin Orthop Relat Res. 1989;245:19-23.
47. Thawani JP, Wang AC, Than KD, Lin CY, La Marca F, Park P. Bone morphogenetic proteins and cancer: review of the literature. Neurosurgery. 2010;66:233-46.
48. Kleeff J, Maruyama H, Ishiwata T, Sawhney H, Friess H, Büchler MW, Korc M. Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo. Gastroenterology. 1999;116:1202-16. (Pubitemid 29203031)
49. Laitinen M, Jortikka L, Halttunen T, Nevalainen J, Aho AJ, Marttinen A, Lindholm TS. Measurement of total and local bone morphogenetic protein concentration in bone tumours. Int Orthop. 1997;21:188-93. (Pubitemid 27371123)
50. Yoshikawa H, Rettig WJ, Lane JM, Takaoka K, Alderman E, Rup B, Rosen V, Healey JH, Huvos AG, Garin-Chesa P. Immunohistochemical detection of bone morphogenetic proteins in bone and soft-tissue sarcomas. Cancer. 1994;74:842-7. (Pubitemid 24237463)
51. Uludag H, Gao T, Porter TJ, Friess W, Wozney JM. Delivery systems for BMPs: factors contributing to protein retention at an application site. J Bone Joint Surg Am. 2001;83 Suppl 1 (Pt 2):S128-35.
52. Geiger M, Li RH, Friess W. Collagen sponges for bone regeneration with rhBMP-2. Adv Drug Deliv Rev. 2003;55:1613-29. (Pubitemid 37420006)
53. Benglis D, Wang MY, Levi AD. A comprehensive review of the safety profile of bone morphogenetic protein in spine surgery. Neurosurgery. 2008;62(5 Suppl 2): ONS423-31, ONS431.
54. Ong KL, Villarraga ML, Lau E, Carreon LY, Kurtz SM, Glassman SD. Off-label use of bone morphogenetic proteins in the United States using administrative data. Spine (Phila Pa 1976). 2010;35:1794-800.
55. Ackerman SJ, Mafilios MS, Polly DW Jr. Economic evaluation of bone morphogenetic protein versus autogenous iliac crest bone graft in single-level anterior lumbar fusion: an evidence-based modeling approach. Spine (Phila Pa 1976). 2002;27(16 Suppl 1):S94-9.
56. Glassman SD, Carreon LY, Campbell MJ, Johnson JR, Puno RM, Djurasovic M, Dimar JR. The perioperative cost of Infuse bone graft in posterolateral lumbar spine fusion. Spine J. 2008;8:443-8. (Pubitemid 351608965)
57. Polly DW Jr, Ackerman SJ, Shaffrey CI, Ogilvie JW, Wang JC, Stralka SW, Mafilios MS, Heim SE, Sandhu HS. A cost analysis of bone morphogenetic protein versus autogenous iliac crest bone graft in single-level anterior lumbar fusion. Orthopedics. 2003;26:1027-37. (Pubitemid 37304414)
58. Asher M, Min Lai S, Burton D, Manna B. Scoliosis Research Society-22 patient questionnaire: responsiveness to change associated with surgical treatment. Spine (Phila Pa 1976). 2003;28:70-3.
59. Smith JS, Shaffrey CI, Berven S, Glassman S, Hamill C, Horton W, Ondra S, Schwab F, Shainline M, Fu KM, Bridwell K; Spinal Deformity Study Group. Improvement of back pain with operative and nonoperative treatment in adults with scoliosis. Neurosurgery. 2009;65:86-93; discussion 93-4.