Use of bone morphogenetic protein-2 for adult spinal deformity

Spine

Volumn 30, Issue 17 SUPPL., 2005, Pages

  Luhmann, Scott J ^a   Bridwell, Keith H ^a   Cheng, Ivan ^a   Imamura, Toshihiro ^a   Lenke, Lawrence G ^a   Schootman, Mario ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adult spinal deformity; Bone morphogenetic protein; Fusion assessment

Indexed keywords

RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; TITANIUM;

ADULT; ARTICLE; BONE GRAFT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG INDICATION; FOLLOW UP; HUMAN; ILIAC BONE; MAJOR CLINICAL STUDY; MORBIDITY; PRIORITY JOURNAL; RIB; SPINE FUSION; SPINE MALFORMATION; SPINE RADIOGRAPHY; SURGICAL EQUIPMENT; TREATMENT OUTCOME;

EID: 24744432908     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/01.brs.0000175184.27407.6a     Document Type: Article

References (35)

1. Boden SF, Schimandle JH. Biologic enhancement of spinal fusion. Spine 1995;20(suppl):113-23.
2. Akamaru T, Suh D, Boden SD, et al. Simple carrier matrix modifications can enhance delivery of recombinant human bone morphogenetic protein-2 for posterolateral spine fusion. Spine 2003;28:429-34.
3. Aspenberg P, Turek T. BMP-2 for intramuscular bone induction: effect in squirrel monkeys is dependent on implantation site. Acta Orthop Scand 1996;67:3-6.
4. Urist MR. Bone formation by autoinduction. Science 1965;150:893-9.
5. Urist MR, Strates BS. Bone morphogenetic protein. J Dent Res Suppl 1971; 50:1392-406.
6. Cheng H, Jiang W, Phillips FM, et al. Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMP). J Bone Joint Surg Am 2003;85:1544-52.
7. Wozney JM. Overview of bone morphogenetic protein. Spine 2002; 27(suppl):2-8.
8. Boden SD, Moskovitz PA, Morone MA, et al. Video-assisted lateral intertransverse process arthrodesis: validation of a new minimally invasive lumbar spinal fusion technique in the rabbit and nonhuman primate (rhesus) models. Spine 1996;21:2689-97.
9. David SM, Murakami T, Tabor OB, et al. Lumbar spinal fusion using recombinant human bone morphogenetic protein-2 (rhBMP-2): a randomized, blinded and controlled study. Transactions of the International Society for Study of the Lumbar Spine 1995;22:14.
10. Fischgrund JS, James SB, Chabot MC, et al. Augmentation of autograft using rhBMP-2 and different carrier media in the canine spine fusion model. J Spinal Disord 1997;10:467-72.
11. Hollinger EH, Trawick RH, Boden SD, et al. Morphology of the lumbar inter-transverse process fusion mass in the rabbit model: a comparison between two bone graft materialsrhBMP-2 and autograft. J Spinal Disord 1996;9:125-8.
12. Martin GJ, Boden SD, Morone MA, et al. Posterolateral intertransverse process spinal fusion arthrodesis with rhBMP-2 in a non-human primate: important lessons learned regarding dose, carrier, and safety. J Spinal Disord 1999;12:179-86.
13. Sandhu HS, Kanim LEA, Kabo JM, et al. Effective doses of recombinant bone morphogenetic protein-2 in experimental spinal fusion. Spine 1996;21: 2115-22.
14. Sandhu HS, Kanim LE, Kabo JM, et al. Evaluation of rhBMP-2 with an OPLA carrier in a canine posterolateral (transverse process) spinal fusion model. Spine 1996;20:2669-82.
15. Schimandle JH, Boden SD, Hutton WC. Experimental spinal fusion with recombinant human bone morphogenetic protein-2 (rhBMP-2). Spine 1995; 20:1326-37.
16. Damien CJ, Grob D, Boden SD, et al. Purified bovine BMP extract and collagen for spine arthrodesis: preclinical safety and efficacy. Spine 2002; 27(suppl):50-8.
17. Boden SD, Zdeblick TA, Sandhu HS, et al. The use of rhBMP-2 in interbody fusion cages. Spine 2000;25:376-81.
18. Burkus JK, Transfeldt EE, Kitchel SH, et al. Clinical and radiographic outcomes of anterior lumbar interbody fusion using recombinant human bone morphogenetic protein-2. Spine 2002;27:2396-408.
19. Boden SD, Schimandle JH, Hutton WC. Volvo Award Winner in Basic Sciences. The use of an osteoinductive growth factor for lumbar spinal fusion: II. Study of dose, carrier, and species. Spine 1995;20:2633-44.
20. Boden SD, Kang J, Sandhu H, et al. Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans. Spine 2002;23:2662-73.
21. Boden SD, Zdeblick TA, Sandhu HS, et al. The use of rhBMP-2 in interbody fusion cages: definite evidence of osteoinduction in humans: a preclinical report. Spine 2000;25:376-81.
22. Burkus JK, Gornet MF, Dickman CA, et al. Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages. J Spinal Disord 2002;15: 337-49.
23. Burkus JK, Heim SE, Gornet MF, et al. Is INFUSE bone graft superior to autograft bone? An integrated analysis of clinical trials using the LT-CAGE lumbar tapered fusion device. J Spinal Disord 2003;16:113-22.
24. Burkus JK, Dorchak JD, Sanders DL. Radiographic assessment of interbody fusion using recombinant human bone morphogenetic protein type 2. Spine 2003;28:372-7.
25. Arrington ED, Smith WJ, Chambers HG, et al. Complications of iliac crest bone graft harvesting. Clin Orthop 1996;329:300-9.
26. Banwart JC, Asher MA, Hassanein RS. Iliac crest bone graft harvest donor site morbidity, a statistical evaluation. Spine 1995;20:1055-60.
27. Fernyhough JC, Schimandle JH, Weigel MC, et al. Chronic donor site pain complicating bone graft harvesting from the posterior iliac crest for spinal fusion. Spine 1992;17:1474-80.
28. Boden SD. Overview of the biology of lumbar spine fusion and principles for selecting a bone graft substitute. Spine 2002;27(suppl):26-31.
29. Kim YJ, Bridwell KH, Lenke LG, et al. Pseudarthrosis in long adult spinal deformity instrumentation and fusions: risk factor and clinical outcome analysis of 232 cases. Spine In press.
30. Peterson B, Whang PG, Iglesiasa R, et al. Osteoinductivity of commercially available demineralized bone matrix: preparations in a spine fusion model. J Bone Joint Surg Am 2004;86:2243-50.
31. Cammisa FP, Lowery G, Garfin SR, et al. Two-year fusion rate equivalency between Grafton DBM gel and autograft in posterolateral spine fusion. Spine 2004;29:660-6.
32. Shah RR, Mohammed S, Saifuddin A, et al. Comparison of plain radiographs with CT scan to evaluate interbody fusion following the use of titanium interbody cages and transpedicular instrumentation. Eur Spine J 2003; 12:378-85.
33. Eck KR, Lenke LG, Bridwell KH, et al. Radiographic assessment of anterior titanium mesh cages. J Spinal Disord 2000;13:501-9.
34. Lenke LG, Bridwell KH, Bullis D, et al. Results of in situ fusion for isthmic spondylolisthesis. J Spinal Disord 1992;5:433-42.
35. Eck KR, Bridwell KH, Ungacta FF, et al. Analysis of titanium mesh cages in adults with minimum two-year follow-up. Spine 2000;25:2407-15.