Bone morphogenetic protein 2 (BMP-2) induces in vitro invasion and in vivo hormone independent growth of breast carcinoma cells

International Journal of Oncology

Volumn 27, Issue 2, 2005, Pages 401-407

  Clement, Joachim H ^a   Raida, Martin ^b   Sänger, Jörg ^c   Bicknell, Roy ^d   Liu, Jingwen ^e   Naumann, Anke ^a   Geyer, Annette ^a   Waldau, Anja ^a   Hortschansky, Peter ^f   Schmidt, Andreas ^c   Höffken, Klaus ^a   Wölfl, Stefan ^a   Harris, Adrian L ^d  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^c Central Hospital Bad Berka   (Germany)

^d JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f HANS KNÖLL INSTITUTE   (Germany)

Author keywords

BMP 2; Breast cancer; Invasion; Metastasis; Tumorigenicity

Indexed keywords

ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; CHEMOTACTIC FACTOR; MESSENGER RNA; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTICLE; BREAST TUMOR; CANCER INVASION; CELL MOTION; CELL STRAIN 3T3; DOSE RESPONSE; DRUG EFFECT; EXPERIMENTAL NEOPLASM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; TIME; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEINS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CHEMOTACTIC FACTORS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NIH 3T3 CELLS; RNA, MESSENGER; TAMOXIFEN; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 22144465176     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.27.2.401     Document Type: Article

References (20)

1. Hahn SA. Schütte M. Hoque AT. Moskaluk CA, Da Costa LT. Rozenblum E. Weinstein CL. Fischer A. Yeo CJ. Hruban RH and Kern SE: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271: 350-353. 1996.
2. Xie W. Mertens JC. Reiss DJ. Rimm DL. Camp RL. Haffty BG and Reiss M: Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study. Cancer Res 62: 497-505. 2002.
3. Pouliot F. Blais A and Labric C: Overexpression of a dominant negative type II bone morphogenetic protein receptor inhibits the growth of human breast cancer cells. Cancer Res 63: 277-281. 2003.
4. Bentley H. Hamdy FC. Hart KA. Scid JM. Williams JL. Johnstone D and Russell RG: Expression of bone morphogenetic proteins in human prostatic adenocarcinoma and benign prostatic hyperplasia. Br J Cancer 66: 1159-1163. 1992.
5. Clement JH. Sanger J and Höffken K: Expression of bone morphogenetic protein 6 in normal mammary tissue and breast cancer cell lines and its regulation by epidermal growth factor. Int J Cancer 80: 250-256. 1999.
6. Schwalbe M. Säinger J. Eggers R. Naumann A. Schmidt A. Höflken K and Clement JH: Differential expression and regulation of bone morphogenetic protein 7 in breast cancer. Int J Oncol 23: 89-95. 2003.
7. Clement JH. Marr N. Meissner A. Schwalbe M. Scbald W. Kliche KO. Höffken K and Wölfl S: Bone morphogenetic protein 2 (BMP-2) induces sequential changes of Id gene expression in the breast cancer cell line MCF-7. J Cancer Res Clin Oncol 126: 271-279. 2000.
8. Ogata T. Wozney JM. Benezra R and Noda M: Bone morphogenetic protein 2 transiently enhances expression of a gene. Id (inhibitor of differentiation), encoding a helix-loop-helix molecule in ostcoblast-like cells: Proc Natl Acad Sci USA 90: 9219-9222. 1993.
9. Desprez PY. Hara E. Bissell MJ and Campisi J: Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1. Mol Cell Biol 15: 3398-3404. 1995.
10. Cunningham NS. Paralkar V and Rcddi AH: Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor B, mRNA expression. Proc Natl Acad Sci USA 89: 11740-11744. 1992.
11. Zhang HT. Craft P. Scott PAE, Ziche M. Weich HA. Harris AL and Bicknell R: Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells. J Natl Cancer Inst 87: 213-219, 1995.
12. Jia T. Liu YE, Liu J and Shi YE: Stimulation of breast cancer invasion and metastasis by synuclein gamma. Cancer Res 59: 742-747. 1999.
13. Lind M, Eriksen EF and Bünger C: Bone morphogenetic protein-2 but not bone morphogenetic protein-4 and -6 stimulates chemotactic migration of human osteoblasts, human marrow osteoblasts, and U2-OS cells. Bone 18: 53-57, 1996.
14. Arnold SF. Tims E and McGrath BE: Identification of bone morphogenetic proteins and their receptors in human breast cancer cell lines: importance of Bmp2. Cytokine 11: 1031-1037. 1999.
15. Dumont N and Arteaga CL: A kinase-inactive type II TGF beta receptor impairs BMP signaling in human breast cancer cells. Biochem Biophys Res Commun 301: 108-112.2003.
16. Noel A. De Pauw-Gillet MC. Purnell G. Nusgens B. LapiereCM and Foidart JM: Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts. Br J Cancer 68: 909-915. 1993.
17. Tokunaga K. Ogose A. Endo N. Nomura S and Takahashi HE: Human osteosarcoma (OST) induces mouse reactive bone formation in xenograft system. Bone 19: 447-454. 1996.
18. Imai N. Iwai A. Hatakeyama S. Matsuzaki K. Kitagawa Y. Kato S. Hokari R. Kawaguchi A. Nagao S. Miyahara T. Itoh K and Miura S: Expression of hone morphogenetic proteins in colon carcinoma with heterotopic ossification. Pathol Int 51: 643-648. 2001.
19. Kypson AP. Morphew E. Jones R. Gottfried MR and Seigler HF: Heterotopic ossification in rectal cancer: rare finding with a novel proposed mechanism. J Surg Oncol 82: 132-136. 2003.
20. Langenfeld EM. Calvano SE. Lowry SF. Amenta P and Langenfeld J: The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. Carcinogenesis 24: 14 45-1454. 2003.