Trends in the use of bone morphogenetic protein as a substitute to autologous iliac crest bone grafting for spinal fusion procedures in the United States

Spine

Volumn 36, Issue 4, 2011, Pages

  Lad, Shivanand P ^a   Nathan, Jay K ^a   Boakye, Maxwell ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BMP; iliac crest bone graft; spinal fusion; trends.

Indexed keywords

RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ADOLESCENT; ADULT; AGED; ARTICLE; BONE GRAFT; CHILD; CONTROLLED STUDY; COST BENEFIT ANALYSIS; DATA BASE; DEMOGRAPHY; FEMALE; FOOD AND DRUG ADMINISTRATION; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; ILIAC CREST; INTERNATIONAL CLASSIFICATION OF DISEASES; MAJOR CLINICAL STUDY; MALE; PATIENT CARE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SOCIOECONOMICS; SPINE FUSION; TREATMENT INDICATION; UNITED STATES;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BONE MORPHOGENETIC PROTEINS; BONE TRANSPLANTATION; CHILD; CHILD, PRESCHOOL; DATABASES, FACTUAL; FEMALE; HUMANS; ILIUM; INFANT; MALE; MIDDLE AGED; SPINAL FUSION; TREATMENT OUTCOME; UNITED STATES; YOUNG ADULT;

EID: 79951735711     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3182055a6b     Document Type: Article

References (16)

1. Agency for Healthcare Research and Quality. http://www.hcup-us.ahrq.gov/ nisoverview.jsp. Published 2002. Accessed December 2009.
2. Dimar JR, Glassman SD, Burkus KJ, et al. Clinical outcomes and fusion success at 2 years of single-level instrumented posterolateral fusions with recombinant human bone morphogenetic protein-2/compression resistant matrix versus iliac crest bone graft. Spine 2006;31:2534-9; discussion: 40. (Pubitemid 44632234)
3. Burkus JK. Bone morphogenetic proteins in anterior lumbar interbody fusion: old techniques and new technologies. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004. J Neurosurg Spine 2004; 1:254-60.
4. Mulconrey DS, Bridwell KH, Flynn J, et al. Bone morphogenetic pro-tein (RhBMP-2) as a substitute for iliac crest bone graft in multilevel adult spinal deformity surgery: minimum two-year evaluation of fusion. Spine 2008;33:2153-9.
5. Boakye M, Mummaneni PV, Garrett M, et al. Anterior cervical discectomy and fusion involving a polyetheretherketone spacer and bone morphogenetic protein. J Neurosurg Spine 2005;2:521-5.
6. Benglis D, Wang MY, Levi AD. A comprehensive review of the safety profile of bone morphogenetic protein in spine surgery. Neurosurgery 2008;62:ONS423-31; discussion: ONS31.
7. Boden SD, Kang J, Sandhu H, et al. Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies. Spine 2002;27: 2662-73. (Pubitemid 35425320)
8. Villavicencio AT, Burneikiene S, Nelson EL, et al. Safety of trans-foraminal lumbar interbody fusion and intervertebral recombi-nant human bone morphogenetic protein-2. J Neurosurg Spine 2005;3:436-43.
9. Boden SD. Overview of the biology of lumbar spine fusion and prin-ciples for selecting a bone graft substitute. Spine 2002;27:S26-31.
10. Polly DW, Jr., Ackerman SJ, Shaffrey CI, et al. A cost analysis of bone morphogenetic protein versus autogenous iliac crest bone graft in single-level anterior lumbar fusion. Orthopedics 2003;26:1027-37. (Pubitemid 37304414)
11. Papakostidis C, Kontakis G, Bhandari M, et al. Efficacy of autolo-gous iliac crest bone graft and bone morphogenetic proteins for posterolateral fusion of lumbar spine: a meta-analysis of the results. Spine 2008;33:E680-92.
12. Perri B, Cooper M, Lauryssen C, et al. Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion: a case study. Spine J 2007;7:235-9.
13. Baskin DS, Ryan P, Sonntag V, et al. A prospective, random-ized, controlled cervical fusion study using recombinant human bone morphogenetic protein-2 with the CORNERSTONE-SR allograft ring and the ATLANTIS anterior cervical plate. Spine 2003;28:1219-24; discussion: 25. (Pubitemid 36734609)
14. Rengachary SS. Bone morphogenetic proteins: basic concepts. Neu-rosurg Focus 2002;13:e2.
15. Glassman SD, Carreon LY, Campbell MJ, et al. The perioperative cost of infuse bone graft in posterolateral lumbar spine fusion. Spine J 2008;8:443-8. (Pubitemid 351608965)
16. Singh K, Smucker JD, Gill S, et al. Use of recombinant human bone morphogenetic protein-2 as an adjunct in posterolateral lumbar spine fusion: a prospective CTscan analysis at one and two years. J Spinal Disord Tech 2006;19:416-23. (Pubitemid 44197593)