PIM1 gene cooperates with human BCL6 gene to promote the development of lymphomas

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 15, 2012, Pages 5735-5739

  Baron, Beverly W ^a   Anastasi, John ^a   Hyjek, Elizabeth M ^a   Bies, Juraj ^b   Reddy, Poluru L ^a   Dong, Jingfang ^a   Joseph, Loren ^a   Thirman, Michael J ^a   Wroblewski, Kristen ^a   Wolff, Linda ^b   Baron, Joseph M ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN BCL 6; PROTEIN KINASE PIM 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B CELL LYMPHOMA; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE IDENTIFICATION; GENE INSERTION; GENE SEQUENCE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; RETROVIRUS; T CELL LYMPHOMA; TUMOR PROMOTION;

ANIMALS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LYMPHOMA; MICE; MICE, TRANSGENIC; MUTAGENESIS, INSERTIONAL; PRECANCEROUS CONDITIONS; PROTO-ONCOGENE PROTEINS C-PIM-1; RETROVIRIDAE; RNA, MESSENGER; SURVIVAL ANALYSIS;

MURINAE; MUS MUSCULUS;

EID: 84859576043     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1201168109     Document Type: Article

References (45)

1. Pasqualucci L, et al. (2003) Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma. Blood 101:2914-2923. (Pubitemid 36857975)
2. Baron BW, et al. (2004) The human BCL6 transgene promotes the development of lymphomas in the mouse. Proc Natl Acad Sci USA 101:14198-14203. (Pubitemid 39305053)
3. Cattoretti G, et al. (2005) Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice. Cancer Cell 7:445-455. (Pubitemid 40719128)
4. Pasqualucci L, et al. (2011) Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Genet 43:830-837.
5. Felsher DW, Bishop JM (1999) Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell 4:199-207. (Pubitemid 29456888)
6. Wolff L, Koller R, Hu X, Anver MR (2003) A Moloney murine leukemia virus-based retrovirus with 4070A long terminal repeat sequences induces a high incidence of myeloid as well as lymphoid neoplasms. J Virol 77:4965-4971. (Pubitemid 36402845)
7. Morse HC, 3rd, et al.; Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium (2002) Bethesda proposals for classification of lymphoid neoplasms in mice. Blood 100:246-258.
8. Selten G, Cuypers HT, Berns A (1985) Proviral activation of the putative oncogene Pim- 1 in MuLV induced T-cell lymphomas. EMBO J 4:1793-1798.
9. Ionov Y, et al. (2003) Pim-1 protein kinase is nuclear in Burkitt's lymphoma: Nuclear localization is necessary for its biologic effects. Anticancer Res 23(1A):167-178. (Pubitemid 36358514)
10. Saris CJM, Domen J, Berns A (1991) The pim-1 oncogene encodes two related proteinserine/ threonine kinases by alternative initiation at AUG and CUG. EMBO J 10: 655-664. (Pubitemid 21905520)
11. Ye BH, et al. (1995) Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma. EMBO J 14:6209-6217. (Pubitemid 26007307)
12. Akasaka T, et al. (2000) Nonimmunoglobulin (non-Ig)/BCL6 gene fusion in diffuse large B-cell lymphoma results in worse prognosis than Ig/BCL6. Blood 96:2907-2909.
13. Shen HM, Peters A, Baron B, Zhu X, Storb U (1998) Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science 280:1750-1752. (Pubitemid 28283498)
14. Pasqualucci L, et al. (2001) Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 412:341-346. (Pubitemid 32691848)
15. Allman D, et al. (1996) BCL-6 expression during B-cell activation. Blood 87:5257-5268. (Pubitemid 26189869)
16. Mahadevan D, et al. (2005) Transcript profiling in peripheral T-cell lymphoma, not otherwise specified, and diffuse large B-cell lymphoma identifies distinct tumor profile signatures. Mol Cancer Ther 4:1867-1879. (Pubitemid 43056970)
17. Roh M, et al. (2003) Overexpression of the oncogenic kinase Pim-1 leads to genomic instability. Cancer Res 63:8079-8084. (Pubitemid 37549449)
18. van Lohuizen M, et al. (1989) Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors. Cell 56:673-682.
19. Hyjek E, Chadburn A, Liu YF, Cesarman E, Knowles DM (2001) BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus. Blood 97:270-276. (Pubitemid 32061270)
20. Johnston RJ, et al. (2009) Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325:1006-1010.
21. Nurieva RI, et al. (2009) Bcl6 mediates the development of T follicular helper cells. Science 325:1001-1005.
22. Yu D, et al. (2009) The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31:457-468.
23. Chang CC, et al. (2010) BCL6 is required for differentiation of Ig-like transcript 3-Fcinduced CD8+ T suppressor cells. J Immunol 185:5714-5722.
24. Crotty S, Johnston RJ, Schoenberger SP (2010) Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation. Nat Immunol 11:114-120.
25. Mondal A, Sawant D, Dent AL (2010) Transcriptional repressor BCL6 controls Th17 responses by controlling gene expression in both T cells and macrophages. J Immunol 184:4123-4132.
26. Baumjohann D, Okada T, Ansel KM (2011) Cutting edge: Distinct waves of BCL6 expression during T follicular helper cell development. J Immunol 187:2089-2092.
27. Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM (1997) Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276:589-592. (Pubitemid 27193682)
28. Ye BH, et al. (1997) The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet 16:161-170.
29. Wang Z, et al. (2001) Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells. Arch Biochem Biophys 390:9-18. (Pubitemid 32493565)
30. Hu XF, et al. (2009) PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis. J Clin Invest 119:362-375.
31. Zippo A, De Robertis A, Bardelli M, Galvagni F, Oliviero S (2004) Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro. Blood 103:4536-4544. (Pubitemid 38745981)
32. Amson R, et al. (1989) The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias. Proc Natl Acad Sci USA 86:8857-8861. (Pubitemid 20010324)
33. Eichmann A, Yuan L, Bréant C, Alitalo K, Koskinen PJ (2000) Developmental expression of pim kinases suggests functions also outside of the hematopoietic system. Oncogene 19:1215-1224. (Pubitemid 30157552)
34. Wang J, et al. (2010) Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma. Oncogene 29:2477-2487.
35. Chen CN, et al. (2005) Gene expression profile predicts patient survival of gastric cancer after surgical resection. J Clin Oncol 23:7286-7295.
36. Reiser-Erkan C, et al. (2008) Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma. Cancer Biol Ther 7:1352-1359.
37. Chiang WF, et al. (2006) Up-regulation of a serine-threonine kinase proto-oncogene Pim-1 in oral squamous cell carcinoma. Int J Oral Maxillofac Surg 35:740-745.
38. Laird PW, et al. (1993) In vivo analysis of Pim-1 deficiency. Nucleic Acids Res 21: 4750-4755. (Pubitemid 23312750)
39. Chen LS, Redkar S, Taverna P, Cortes JE, Gandhi V (2011) Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia. Blood 118:693-702.
40. Slape C, et al. (2007) Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation. Cancer Res 67: 5148-5155. (Pubitemid 46997251)
41. Lazo PA, Lee JS, Tsichlis PN (1990) Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas. Proc Natl Acad Sci USA 87:170-173.
42. Zeidler R, et al. (1994) Breakpoints of Burkitt's lymphoma t(8;22) translocations map within a distance of 300 kb downstream of MYC. Genes Chromosomes Cancer 9: 282-287.
43. Mikkers H, et al. (2002) High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat Genet 32:153-159. (Pubitemid 34977211)
44. Caudell D, et al. (2010) Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice. Blood 115: 1194-1203.
45. Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3:1101-1108. (Pubitemid 351818697)