Synthesis of antifungal glucan synthase inhibitors from enfumafungin

Journal of Organic Chemistry

Volumn 77, Issue 7, 2012, Pages 3297-3310

  Zhong, Yong Li ^a   Gauthier, Donald R ^a   Shi, Yao Jun ^a   McLaughlin, Mark ^a   Chung, John Y L ^a   Dagneau, Philippe ^a   Marcune, Benjamin ^a   Krska, Shane W ^a   Ball, Richard G ^a   Reamer, Robert A ^a   Yasuda, Nobuyoshi ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYLIC OXIDATION; ANTI-FUNGAL; BOND-FORMING REACTIONS; CHEMOSELECTIVE; DRUG CANDIDATES; FERMENTATION PRODUCTS; GLUCAN SYNTHASE; GRAM QUANTITIES; ISOLATED YIELD; SEMISYNTHESIS;

SYNTHESIS (CHEMICAL);

PALLADIUM COMPOUNDS;

ANTIFUNGAL AGENT; ENFUMAFUNGIN; ENFUMAFUNGIN DERIVATIVE; ENZYME INHIBITOR; GLUCAN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION;

ALCOHOLS; ANTIFUNGAL AGENTS; CATALYSIS; CHRYSENES; ECHINOCANDINS; GLUCOSYLTRANSFERASES; GLYCOSIDES; MOLECULAR STRUCTURE; PALLADIUM; STEREOISOMERISM; TRITERPENES;

EID: 84859569474     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo300046v     Document Type: Article

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