The discovery of enfumafungin, a novel antifungal compound produced by an endophytic Hormonema species biological activity and taxonomy of the producing organisms

Systematic and Applied Microbiology

Volumn 23, Issue 3, 2000, Pages 333-343

  Pelaez, Fernando ^a   Cabello, Angeles ^a   Platas, Gonzalo ^a   Díez, María ^a   Del Val, Antonio González ^a   Basilio, Angela ^a   Martán, Isabel ^a   Vicente, Francisca ^a   Bills, Gerald F ^b   Giacobbe, Robert A ^b   Schwartz, Robert E ^b   Onishi, Janet C ^b   Meinz, María S ^b   Abruzzo, George K ^b   Flattery, Amy M ^b   Kong, Li ^b   Kurtz, Myra B ^b  

^a Medical affairs Merck sharp and Dohme ltd   (Spain)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antifungal compound; Enfumafungin; Hormonema; Kabatina; Triterpene glycoside

Indexed keywords

ANTIFUNGAL AGENT; CASPOFUNGIN; DNA; ENFUMAFUNGIN; GLUCAN SYNTHASE; GLYCOSIDE; NATURAL PRODUCT; PNEUMOCANDIN DERIVATIVE; RIBOSOME DNA; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA; CANDIDIASIS; DNA FINGERPRINTING; DNA SEQUENCE; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; ENZYME INHIBITION; JUNIPERUS; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE; TAXONOMY;

ASPERGILLUS; ASPERGILLUS FUMIGATUS; CANDIDA; FUNGI; HORMONEMA; JUNIPERUS; JUNIPERUS COMMUNIS; KABATINA;

EID: 0033678540     PISSN: 07232020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0723-2020(00)80062-4     Document Type: Article

References (45)

1. Glucan synthesis and its inhibition by cilofungin in susceptible and resistant strains of Candida albicans
2. ITS sequencing supports that Epicoccum nigrum and Phoma epicoccina are the same biological species
3. In vitro antifungal activities and in vivo efficacies of 1,3-β-D-glucan synthesis inhibitors L-671,329; L-646,991; tetrahydroechinocandin B, and L-687, 781, a papulacandin
4. Tremorgenic mycotoxins, paspalistrem A and C, from a tropical Phomopsis
5. Distribution of Zaragozic Acids (Squalestatins) among filamentous ascomycetes
6. Antifungal agents
7. Reclassification of a pneumocandin-producing anamorph, Glarea lozoyensis gen. et sp. nov., previously identified as Zalerion arboricola
8. Fungal endophytes of twigs, leaves and bark of Quercus ilex from Central Spain
9. Survey of the black yeasts and allied fungi
10. Potential of fungi in the discovery of novel, low-molecular weight pharmaceuticals
11. Confidence intervals on phylogenies: An approach using the bootstrap
12. ITS primers with enhanced specificity of basidiomycetes: Application to the identification of mycorrhizae and rusts
13. Aureobasidium and allied genera
14. Zaragozic acids production from discomycetes
15. Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-β-D-glucan synthase
16. Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase
17. Molecular identification of mycorrhizal fungi by direct amplification of microsatellite regions
18. The discovery of australifungin, a novel inhibitor of sphinganine N-acyltransferase from Sporormiella australis
19. Khafrefungin, a novel inhibitor of sphingolipid synthesis
20. Rhizosphaera oudemansii (Sphaeropsidales) associated with a needle cast of Spanish Abies pinsapo
21. An echinocandin from an endophytic Cryptosporiopsis sp. and Pezicula sp. in Pinus sylvestris and Fagus sylvatica
22. Antimicrobial activity of viridiofungins
23. Discovery of novel antifungal β-(1,3)-glucan synthase inhibitors
24. A new Delitschia from West Africa
25. Infraspecific variation in two species of aquatic hyphomycetes, assessed by RAPD analyses
26. Endophytic fungi from plants living on gypsum soils as a source of secondary metabolites with antimicrobial activity
27. In vitro activity of two echinocandin derivatives, LY303366 and MK-0991 (L-743, 792), against clinical isolates of Aspergillus, Fusarium, Rhizopus and other filamentous fungi
28. Antifungal chemotherapy. Are we winning?
29. L-741,494, a fungal metabolite that is an inhibitor of interleukin- 1beta converting enzyme
30. Pramanicin, a novel antimicrobial agent from a fungal fermentation
31. The isolation and structural determination of enfumafungin, a triterpene glycoside antifugal agent from the fermentation of a Hormonema sp
32. Organic acid, a potent inhibitor of ras farnesyl-protein transfrase
33. Discovery of an angiotensin II binding inhibitor from a Cytospora sp. using semi-automated screening procedures
34. A novel antiviral agent which inhibits the endonuclease of influenza viruses
35. Emerging fungal pathogens in immunocompromised patients: Classification, diagnosis and management
36. Genomic fingerprints produced by PCR with consensus tRNA gene primers
37. Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics