Taste masked lipid pellets with enhanced release of hydrophobic active ingredient

International Journal of Pharmaceutics

Volumn 429, Issue 1-2, 2012, Pages 99-103

  Vaassen, Jonathan ^a   Bartscher, Kathrin ^b   Breitkreutz, Joerg ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b Pharbil Waltrop GmbH   (Germany)

Author keywords

Immediate release; Lipid extrusion; Pellets; Taste masking

Indexed keywords

COPOLYMER; CROSPOVIDONE; DYNASAN; GLYCEROL PALMITOSTEARATE; LIPID; MACROGOL; NONSTEROID ANTIINFLAMMATORY AGENT; NXP 1210; POLYVINYL ALCOHOL; UNCLASSIFIED DRUG; WITOCAN;

ARTICLE; DRUG DOSE; DRUG SOLUBILITY; HYDROPHOBICITY; PRIORITY JOURNAL;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DRUG COMPOUNDING; EXCIPIENTS; FEASIBILITY STUDIES; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPIDS; POLYVINYLS; POVIDONE; SOLUBILITY; TASTE; TEMPERATURE; TIME FACTORS;

EID: 84859568797     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.03.013     Document Type: Article

References (25)

1. S.L. Ali Phenylbutazone Anal. Profiles Drug Subst. 11 1982 483 521
2. Z. Ayenew, V. Puri, L. Kumar, and A.K. Bansal Trends in pharmaceutical taste masking technologies: a patent review Recent Pat. Drug Deliv. Formul. 3 2009 26 39
3. H. Bechgaard, and G. Hegermann Nielsen Controlled-release multiple-units and single-unit doses. A literature review Drug Dev. Ind. Pharm. 4 1978 53 67
4. D. Bora, P. Borude, and K. Bhise Taste masking by spray-drying technique AAPS PharmSciTech 9 2008 1159 1164
5. J. Breitkreutz, F. El-Saleh, C. Kiera, P. Kleinebudde, and W. Widey Pediatric drug formulations of sodium benzoate: II. Coated granules with lipophilic binder Eur. J. Pharm. Biopharm. 56 2003 255 260 (Pubitemid 37072110)
6. J. Breitkreutz, and J. Boos Paediatric and geriatric drug delivery Expert Opin. Drug Deliv. 4 2007 37 45 (Pubitemid 46117485)
7. M. Callies, and D. Quéré On water repellency J. Mater. Chem. 15 2005 55 61
8. G. Caron, P. Gaillard, P.A. Carrut, and B. Testa Lipophilicity behavior of model and medicinal compounds containing a sulfide, sulfoxide, or sulfone moiety Helv. Chim. Acta 80 1997 449 462
9. D.D. Douroumis, A. Gryczke, and S. Schminke Development and evaluation of cetirizine HCl taste-masked oral disintegrating tablets AAPS PharmSciTech 12 2011 141 151
10. A. Dukic-Ott, M. Thommes, J.P. Remon, P. Kleinebudde, and C. Vervaet Production of pellets via extrusion-spheronisation without the incorporation of microcrystalline cellulose: a critical review Eur. J. Pharm. Biopharm. 71 2009 38 46
11. Ghebre Sellassie Pellets: a general overview I. Ghebre Sellassie, Pharmaceutical Pelletization Technology 1989 Marcel Dekker New York 1 14
12. A.G. Gilman, L.S. Goodman, and A. Gilman The Pharmacological Basis of Therapeutics 6th ed. 1980 Macmillan Publishing New York
13. S. Gueres, and P. Kleinebudde Dissolution from solid lipid extrudates containing release modifiers Int. J. Pharm. 412 2011 77 84
14. J. Krause, T. Thommes, and J. Breitkreutz Immediate release pellets with lipid binders obtained by solvent free cold extrusion Eur. J. Pharm. Biopharm. 71 2009 138 144
15. R.F. Menegon, L. Blau, N.S. Janzantti, A.C. Pizzolitto, M.A. Corrêa, M. Monteiro, and M.C. Chung A nonstaining and tasteless hydrophobic salt of chlorhexidine J. Pharm. Sci. 100 2011 3130 3138
16. A. Michalk, V.R. Kanikanti, H.J. Hamann, and P. Kleinebudde Controlled release of active as a consequence oft the die diameter in solid lipid extrusion J. Control. Release 132 2008 35 41
17. N. Ono, Y. Miyamoto, T. Ishiguro, K. Motoyama, F. Hirayama, D. Iohara, H. Seo, S. Tsuruta, H. Arima, and K. Uekama Reduction of bitterness of antihistaminic drugs by complexation with ß-cyclodextrins J. Pharm. Sci. 100 2010 1935 1943
18. C.J.H. Porter, N.L. Trevaskis, and W.N. Charman Lipids and lipid based formulations: optimizing the oral delivery of lipophilic drugs Nat. Rev. Drug Discov. 6 2007 231 248 (Pubitemid 46344627)
19. C. Reitz, and P. Kleinebudde Spheronization of solid lipid extrudates Powder Technol. 189 2009 238 244
20. A.D. Reynolds A new technique for the production of spherical particles Manuf. Chem. 41 1970 40 43
21. A.M. Suthar, and M.M. Patel Formulation and evaluation of taste masked suspension of metronidazole Int. J. Appl. Pharm. 3 2011 16 19
22. Y. Tanigawara, Y. Yamaoka, T. Nakagawa, M. Nakagawa, and T. Uno Correlation between in vivo mean dissolution time and in vitro mean dissolution time of ampicillin products J. Pharm. Dyn. 5 1982 370 372 (Pubitemid 12021829)
23. M.R. Thompson, and J. Sun Wet granulation in a twin-screw extruder: implication of screw design J. Pharm. Sci. 99 2009 2090 2103
24. M. Windbergs, C.J. Strachan, and P. Kleinebudde Tailor-made dissolution profiles by extruded matrices based on lipid polyethylene glycol mixtures J. Control. Release 137 2009 211 216
25. K. Woertz, C. Tissen, P. Kleinebudde, and J. Breitkreutz Rational development of taste masked oral liquids guided by an electronic tongue Int. J. Pharm. 400 2010 114 123