Tailor-made dissolution profiles by extruded matrices based on lipid polyethylene glycol mixtures

Journal of Controlled Release

Volumn 137, Issue 3, 2009, Pages 211-216

  Windbergs, Maike ^a,b   Strachan, Clare J ^b,c   Kleinebudde, Peter ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Controlled release; Dissolution; Matrix release; Polyethylene glycol lipid ratio; Solid lipid extrusion

Indexed keywords

ANHYDRATE; CONTROLLED RELEASE; DISSOLUTION PROFILES; DISSOLUTION RATES; DOSAGE FORMS; EXTRUDATES; HYDROPHILIC POLYMERS; INTERCONNECTED PORE NETWORKS; MATRIX; MATRIX COMPOSITION; MATRIX MATERIALS; MATRIX RELEASE; MELTING TEMPERATURES; MODEL DRUGS; POLYMORPHIC TRANSFORMATION; POLYMORPHIC TRANSITIONS; SOLID LIPID EXTRUSION; STABILITY TESTING;

DISSOLUTION; ETHYLENE GLYCOL; EXTRUSION; MELTING POINT; POLYETHYLENE OXIDES; THERMOPLASTICS;

POLYETHYLENE GLYCOLS;

MACROGOL; THEOPHYLLINE; TRIPALMITIN;

ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG CONFORMATION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; HYDROPHILICITY; PRIORITY JOURNAL; SOLID STATE;

CALORIMETRY, DIFFERENTIAL SCANNING; DRUG CARRIERS; DRUG STABILITY; DRUG STORAGE; POLYETHYLENE GLYCOLS; POWDER DIFFRACTION; SOLUBILITY; TEMPERATURE; THEOPHYLLINE; TRIGLYCERIDES; X-RAY DIFFRACTION;

EID: 67649132600     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.04.002     Document Type: Article

References (29)

1. Porter C.J.H., and Charman W.N. In vitro assessment of oral lipid based formulations. Adv. Drug Deliv. Rev. 50 (2001) 127-147
2. Humberstone A.J., and Charman W.N. Lipid based vehicles for the oral delivery of poorly water soluble drugs. Adv. Drug Deliv. Rev. 25 (1997) 103-128
3. Mehnert W., and Mäder K. Solid lipid nanoparticles - production, characterization and applications. Adv. Drug Deliv. Rev. 47 (2001) 165-196
4. Prabhu S., Ortega M., and Ma C. Novel lipid-based formulations enhancing the in vitro dissolution and permeability characteristics of a poorly water-soluble model drug, piroxicam. Int. J. Pharm. 301 1-2 (2005) 209-216
5. Sato K. Crystallization behaviour of fats and lipids - a review. Chem. Eng. Sci. 56 (2001) 2255-2265
6. Sato K., Ueno S., and Yano J. Molecular interactions and kinetic properties of fats. Prog. Lipid Res. 38 (1999) 91-116
7. Hagemann J.W. Thermal behaviour and polymorphism of acylglycerides. In: Garti N., and Sato K. (Eds). Crystallization and Polymorphism of Fats and Fatty Acids (1988), Marcel Dekker, New York 9-95
8. Hamdani J., Moes A.J., and Amighi K. Development and evaluation of prolonged release pellets obtained by the melt pelletization process. Int. J. Pharm. 245 1-2 (2002) 167-177
9. Zhang Y.E., and Schwartz J.B. Melt granulation and heat treatment for wax matrix-controlled drug release. Drug Dev. Ind. Pharm. 29 2 (2003) 131-138
10. Chauhan B., Shimpi S., and Paradkar A. Preparation and characterization of etoricoxib solid dispersions using lipid carriers by spray drying technique. AAPS PharmSciTech 6 3 (2005) E405-12
11. Bunjes H., Westensen K., and Koch M.H.J. Crystallization tendency and polymorphic transitions in triglyceride nanoparticles. Int. J. Pharm. 129 (1996) 159-173
12. Choy Y.W., Khan N., and Yuen K.H. Significance of lipid matrix aging on in vitro release and in vitro bioavailability. Int. J. Pharm. 299 (2005) 55-64
13. Khan N., and Craig D.Q.M. Role of blooming in determining the storage stability of lipid-based dosage forms. J. Pharm. Sci. 93 12 (2004) 2962-2971
14. Breitkreutz J., El Saleh F., Kiera C., Kleinebudde P., and Wiedey W. Pediatric drug formulations of sodium benzoate: II. Coated granules with a lipophilic binder. Eur. J. Pharm. Biopharm. 56 (2003) 255-260
15. Pinto J.F., and Silverio N.P. Assessment of the extrudability of three different mixtures of saturated polyglycolysed glycerides by determination of the "specific work of extrusion" and cappillar rheometry. Pharm. Dev. Technol. 6 (2001) 117-128
16. Michalk A., Kanikanti V.-R., Hamann H.-J., and Kleinebudde P. Controlled release of active as a consequence of the die diameter in solid lipid extrusion. J. Control. Release 132 (2008) 35-41
17. Reitz C., and Kleinebudde P. Solid lipid extrusion of sustained release dosage forms. Eur. J. Pharm. Biopharm. 67 (2007) 440-448
18. Windbergs M., Strachan C.J., and Kleinebudde P. Understanding the solid-state behaviour of triglyceride solid lipid extrudates and its influence on dissolution. Eur. J. Pharm. Biopharm. 71 (2009) 80-87
19. M. Windbergs, C.J. Strachan, P. Kleinebudde, Influence of the composition of glycerides on the solid-state behaviour and the dissolution profiles of solid lipid extrudates, Int. J. Pharm. (in press), doi:10.1016/j.ipharm.2009.03.002.
20. In: Rowe R.C., Sheskey P.J., and Weller P.J. (Eds). Handbook of Pharmaceutical Excipients. 4th ed. (2003), Pharmaceutical press, London, UK 460-461
21. Schmidt P. J. Prochazka Über die Entwicklung von Retardgranulaten durch Granulatformung. Pharm. Ind. 38 10 (1976) 921-926
22. Herrmann S., Winter G., Mohl S., and Siepmann F. J. Siepmann mechanisms controlling protein release from lipidic implants: effect of PEG addition. J. Control. Release 118 (2007) 161-168
23. Herrmann S., Mohl S., Siepmann F., Siepmann J., and Winter G. New insight into the role of polyethylene glycol acting as protein release modifier in lipidic implants. Pharm. Res. 24 8 (2007) 1527-1537
24. Craig D.Q.M., and Newton J.M. Characterisation of polyethylene glycol solid dispersions using differential scanning calorimetry and solution calorimetry. Int. J. Pharm. 76 (1991) 17-24
25. Crowley M.M., Zhang F., Koleng J.J., and McGinity J.W. Stability of polyethylene oxide in matrix tablets prepared by hot-melt extrusion. Biomaterials 23 (2002) 4241-4248
26. Craig D.Q.M., and Newton J.M. Characterisation of polyethylene glycols using differential scanning calorimetry. Int. J. Pharm. 74 (1991) 33-41
27. Chen W., Zhang X., Shan B., and You X. Methylxanthines. I. Anhydrous theophylline. Acta Crystallogr. C53 (1997) 777-779
28. Windbergs M., Jurna M., Offerhaus H.L., Herek J.L., Kleinebudde P., and Strachan C.J. Chemical imaging of oral solid dosage forms and changes upon dissolution using coherent anti-Stokes Raman scattering microscopy. Anal. Chem. 81 (2009) 2085-2091
29. Fang W., Mayama H., and Tsujii K. Spontanous formation of fractal structures on triglyceride surfaces with reference to their water-repellent properties. J. Phys. Chem. B 111 (2007) 564-571