Rational development of taste masked oral liquids guided by an electronic tongue

International Journal of Pharmaceutics

Volumn 400, Issue 1-2, 2010, Pages 114-123

  Woertz, Katharina ^a   Tissen, Corinna ^a   Kleinebudde, Peter ^a   Breitkreutz, Jörg ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Electronic taste sensing system; Formulation development; Quinine hydrochloride; Sulfobutyl ether cyclodextrin; Taste assessment; Taste masking

Indexed keywords

ACESULFAME POTASSIUM; BETA CYCLODEXTRIN SULFOBUTYL ETHER; DOMIPHEN BROMIDE; FRUCTOSE; GAMMA CYCLODEXTRIN; GLUCOSE; MALTODEXTRIN; MANNITOL; MONOAMMONIUM GLYCYRRHIZINATE; POLACRILIN; QUININE; SACCHARIN SODIUM; SUCRALOSE; SUCROSE; SWEETENING AGENT; UNCLASSIFIED DRUG;

ARTICLE; DRUG FORMULATION; ION EXCHANGE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; TASTE;

BIOSENSING TECHNIQUES; CATION EXCHANGE RESINS; CHEMISTRY, PHARMACEUTICAL; CYCLODEXTRINS; ELECTRICAL EQUIPMENT AND SUPPLIES; HUMANS; PRINCIPAL COMPONENT ANALYSIS; QUININE; SWEETENING AGENTS; TASTE; TECHNOLOGY, PHARMACEUTICAL; TONGUE;

EID: 77957686851     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.08.042     Document Type: Article

References (25)

1. Ayenew Z., Puri V., Kumar L., Bansal A.K. Trends in pharmaceutical taste masking technologies: a patent review. Recent Pat. Drug Deliv. Formul. 2009, 3:26-39.
2. Ciosek P., Wróblewski W. Sensor arrays for liquid sensing - electronic tongue systems. Analyst 2007, 132:963-978.
3. Cram A., Breitkreutz J., Desset-Brèthes S., Nunn T., Tuleu C. Challenges of developing palatable oral paediatric formulations. Int. J. Pharm. 2009, 365:1-3.
4. Daniels R. Elektronische Nasen und Zungen in Entwicklung und Qualitätskontrolle: Part 1. Pharm. Ind. 2005, 67:945-949.
5. Daniels R. Elektronische Nasen und Zungen in Entwicklung und Qualitätskontrolle: Part 2. Pharm. Ind. 2005, 67:1096-1100.
6. Davies E.H., Tuleu C. Medicines for children: a matter of taste. J. Pediatr. 2008, 153:599-604.
7. European Pharmacopoeia, 6th edition (6.7), 2010. Strasbourg Cedex, France, pp. 255-256, 2800-2801.
8. Fan Z., Diao C.-H., Song H.-B., Jing Z.-L., Yu M., Chen X., Guo M.-J. Encapsulation of quinine by β-cyclodextrin: excellent model for mimicking enzyme - substrate interactions. J. Org. Chem. 2006, 71:1244-1246.
9. Hamashita T., Matsuzaki M., Ono T., Ono M., Tsunenari Y., Aketo T., Watano S. Granulation of core particles suitable for film coating by agitation fluidized bed II. A proposal of a rapid dissolution test for evaluation of bitter taste of ibuprofen. Chem. Pharm. Bull. 2008, 56:883-887.
10. Hesse M., Meier H., Zeeh B. Spektroskopische Methoden in der organischen Chemie 2002, Thieme, Stuttgart/New York. 6th ed.
11. Kayumba P.C., Huyghebaert N., Cordella C., Ntawukuliryayo J.D., Vervaet C., Remon J.P. Quinine sulphate pellets for flexible pediatric drug dosing: formulation development and evaluation of taste-masking efficiency using the electronic tongue. Eur. J. Pharm. Biopharm. 2007, 66:460-465.
12. Kobayashi Y., Habara M., Ikezazki H., Chen R., Naito Y., Toko K. Advanced taste sensors based on artificial lipids with global selectivity to basic taste qualities and high correlation to sensory scores. Sensors 2010, 10:3411-3443.
13. Lyall V., Phan T.-H.T., Ren Z., Mummalaneni S., Melone P., Mahavadi S., Murthy K.S., DeSimone J.A. Regulation of the putative TRPV 1t salt taste receptor by phosphatidylinositol 4, 5-bisphosphate. J. Neurophysiol. 2010, 103:1337-1349.
14. Mennella J.A., Beauchamp G.K. Optimizing oral medications for children. Clin. Ther. 2008, 30:2120-2132.
15. Nakamura T., Tanigake A., Miyanaga Y., Ogawa T., Akiyoshi T., Matsuyama K., Uchida T. The effect of various substances on the suppression of the bitterness of quinine-human gustatory sensation, binding, and taste sensor studies. Chem. Pharm. Bull. 2002, 50:1589-1593.
16. Rao C.G.G., Motiwale A.V., Satyanarayana D., Subrahmanyam E.V.S. Formulation of taste masked oral suspension of quinine sulphate by complexation. Indian J. Pharm. Sci. 2004, 66:329-331.
17. Sato T., Nishishita K., Okada Y., Toda K. Effect of gap junction blocker β-glycyrrhetinic acid on taste disk cells in frog. Cell. Mol. Neurobiol. 2009, 29:503-512.
18. Saunders L., Srivastava R. The absorption of quinine by a carboxylic acid ion-exchange resin. J. Chem. Soc. 1950, 2915-2919.
19. Schiffman S.S., Gatlin C.A. Sweeteners: state of knowledge review. Neurosci. Biobehav. Rev. 1993, 17:313-345.
20. Stevens J.C. Detection of tastes in mixtures with other tastes: issues of masking and aging. Chem. Senses 1996, 21:211-221.
21. Toko K. Electronic tongue. Biosens. Bioelectron. 1998, 13:701-709.
22. Turner, R.M., 2009. Cyclodextrins for oral liquid paediatric drug delivery: application to corticosteroids. Ph.D. Thesis, School of Pharmacy, University of London, United Kingdom.
23. Wagh V.D., Ghadlinge Y.B. Taste masking methods and techniques in oral pharmaceuticals: current perspectives. J. Pharm. Res. 2009, 2:1049-1054.
24. Woertz K., Tissen C., Kleinebudde P., Breitkreutz J. Performance qualification of an electronic tongue based on ICH guideline Q2. J. Pharm. Biomed. Anal. 2010, 51:497-506.
25. World Health Organization Guidelines for the Treatment of Malaria 2010, Geneva, Switzerland. http://whqlibdoc.who.int/publications/2010/9789241547925_eng.pdf, 2nd ed.