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Volumn 25, Issue 5, 2011, Pages 749-760

Optimizing the use of lenalidomide in relapsed or refractory multiple myeloma: Consensus statement

(16)  Dimopoulos, M A a   Palumbo, A b   Attal, M c   Beksac M d   Davies, F E e   Delforge, M f   Einsele, H g   Hajek, R h   Harousseau, J L i   Da Costa, F Leal j   Ludwig, H k   Mellqvist, U H l   Morgan, G J e   San Miguel, J F m   Zweegman, S n   Sonneveld, P o  


Author keywords

dexamethasone; Lenalidomide; multiple myeloma; refractory; relapsed

Indexed keywords

ACETYLSALICYLIC ACID; ANTIBIOTIC AGENT; ANTIHISTAMINIC AGENT; BORTEZOMIB; CORTICOSTEROID; COTRIMOXAZOLE; CREATININE; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DOXORUBICIN; ERYTHROPOIETIN; GRANULOCYTE COLONY STIMULATING FACTOR; LENALIDOMIDE; LOW MOLECULAR WEIGHT HEPARIN; MAGNESIUM; MELPHALAN; PENICILLIN G; PREDNISONE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; THALIDOMIDE;

EID: 79955855079     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.3     Document Type: Review
Times cited : (103)

References (79)
  • 2
    • 67349240834 scopus 로고    scopus 로고
    • Improved survival of patients with multiple myeloma after the introduction of novel agents and the applicability of the International Staging System (ISS): An analysis of the Greek Myeloma Study Group (GMSG)
    • Kastritis E, Zervas K, Symeonidis A, Terpos E, Delimbassi S, Anagnostopoulos N et al. Improved survival of patients with multiple myeloma after the introduction of novel agents and the applicability of the International Staging System (ISS): an analysis of the Greek Myeloma Study Group (GMSG). Leukemia 2009; 23: 1152-1157.
    • (2009) Leukemia , vol.23 , pp. 1152-1157
    • Kastritis, E.1    Zervas, K.2    Symeonidis, A.3    Terpos, E.4    Delimbassi, S.5    Anagnostopoulos, N.6
  • 3
    • 54049133274 scopus 로고    scopus 로고
    • Treatment of myeloma: Cure vs control
    • Rajkumar SV. Treatment of myeloma: cure vs control. Mayo Clinic Proc 2008; 83: 1142-1145.
    • (2008) Mayo Clinic Proc , vol.83 , pp. 1142-1145
    • Rajkumar, S.V.1
  • 4
    • 77950644007 scopus 로고    scopus 로고
    • Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function
    • Gandhi AK, Kang J, Capone L, Parton A, Wu L, Zhang LH et al. Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function. Curr Cancer Drug Targets 2010; 10: 155-167.
    • (2010) Curr Cancer Drug Targets , vol.10 , pp. 155-167
    • Gandhi, A.K.1    Kang, J.2    Capone, L.3    Parton, A.4    Wu, L.5    Zhang, L.H.6
  • 5
    • 0035412366 scopus 로고    scopus 로고
    • Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
    • Davies FE, Raje N, Hideshima T, Lentzsch S, Young G, Tai YT et al. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood 2001; 98: 210-216.
    • (2001) Blood , vol.98 , pp. 210-216
    • Davies, F.E.1    Raje, N.2    Hideshima, T.3    Lentzsch, S.4    Young, G.5    Tai, Y.T.6
  • 7
    • 51649123319 scopus 로고    scopus 로고
    • Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells
    • Wu L, Adams M, Carter T, Chen R, Muller G, Stirling D et al. Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells. Clin Cancer Res 2008; 14: 4650-4657.
    • (2008) Clin Cancer Res , vol.14 , pp. 4650-4657
    • Wu, L.1    Adams, M.2    Carter, T.3    Chen, R.4    Muller, G.5    Stirling, D.6
  • 8
    • 36849024949 scopus 로고    scopus 로고
    • Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumour activity of rituximab in vivo
    • DOI 10.1111/j.1365-2141.2007.06841.x
    • Reddy N, Hernandez-Ilizaliturri FJ, Deeb G, Roth M, Vaughn M, Knight J et al. Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumour activity of rituximab in vivo. Br J Haematol 2008; 140: 36-45. (Pubitemid 350233246)
    • (2008) British Journal of Haematology , vol.140 , Issue.1 , pp. 36-45
    • Reddy, N.1    Hernandez-Ilizaliturri, F.J.2    Deeb, G.3    Roth, M.4    Vaughn, M.5    Knight, J.6    Wallace, P.7    Czuczman, M.S.8
  • 10
    • 79955866911 scopus 로고    scopus 로고
    • Lenalidomide is able to restore immune system in multiple myeloma patients
    • (abstract 4909)
    • Chiarenza A, Parrinello N, La Cava P, Spina E, Tibullo D, Giallongo C et al. Lenalidomide is able to restore immune system in multiple myeloma patients. Blood 2009; 114: (abstract 4909).
    • (2009) Blood , vol.114
    • Chiarenza, A.1    Parrinello, N.2    La Cava, P.3    Spina, E.4    Tibullo, D.5    Giallongo, C.6
  • 11
    • 77957774888 scopus 로고    scopus 로고
    • Better quality of response to lenalidomide plus dexamethasone is associated with improved clinical outcomes in patients with relapsed or refractory multiple myeloma
    • Harousseau JL, Dimopoulos MA, Wang M, Corso A, Chen C, Attal M et al. Better quality of response to lenalidomide plus dexamethasone is associated with improved clinical outcomes in patients with relapsed or refractory multiple myeloma. Haemato-logica 2010; 95: 1738-1744.
    • (2010) Haemato-logica , vol.95 , pp. 1738-1744
    • Harousseau, J.L.1    Dimopoulos, M.A.2    Wang, M.3    Corso, A.4    Chen, C.5    Attal, M.6
  • 12
    • 79955865545 scopus 로고    scopus 로고
    • Effects of lenalidomide and dexametha-sone treatment duration on survival in patients with relapsed or refractory multiple myeloma treated with lenalidomide and dexamethasone
    • E-pub ahead of print 26 October 2010
    • San Miguel JF, Dimopoulos MA, Stadtmauer AE, Rajkumar SV, Siegel D, Bravo ML et al. Effects of lenalidomide and dexametha-sone treatment duration on survival in patients with relapsed or refractory multiple myeloma treated with lenalidomide and dexamethasone. Clinl Lymphoma Myeloma Leuk 2010; E-pub ahead of print 26 October 2010.
    • (2010) Clinl Lymphoma Myeloma Leuk
    • San Miguel, J.F.1    Dimopoulos, M.A.2    Stadtmauer, A.E.3    Rajkumar, S.V.4    Siegel, D.5    Bravo, M.L.6
  • 14
    • 78650303638 scopus 로고    scopus 로고
    • Phase III intergroup study of lenalidomide versus placebo maintenance therapy following single autologous stem cell transplant (ASCT) for multiple myeloma (MM): CALGB 100104
    • (abstract 8017)
    • McCarthy PL, Owzar K, Anderson KC, Hofmeister CC, Hassoun H, Hurd DD et al. Phase III intergroup study of lenalidomide versus placebo maintenance therapy following single autologous stem cell transplant (ASCT) for multiple myeloma (MM): CALGB 100104. J Clin Oncol (ASCO Ann Meet Proc) 2010; 28(Suppl): (abstract 8017).
    • (2010) J Clin Oncol (ASCO Ann Meet Proc) , vol.28 , Issue.SUPPL.
    • McCarthy, P.L.1    Owzar, K.2    Anderson, K.C.3    Hofmeister, C.C.4    Hassoun, H.5    Hurd, D.D.6
  • 15
    • 78649686966 scopus 로고    scopus 로고
    • A phase 3 study to determine the efficacy and safety of lenalidomide combined with melphalan and prednisone in patients X65 years with newly diagnosed multiple myeloma (NDMM)
    • (abstract 0566)
    • Palumbo A, Dimopoulos M, Delforge M, Hajek R, Kropff M, Petrucci MT et al. A phase 3 study to determine the efficacy and safety of lenalidomide combined with melphalan and prednisone in patients X65 years with newly diagnosed multiple myeloma (NDMM). Haematol (EHA Annu Meet Abstr) 2010; 95(Suppl 2): 234 (abstract 0566).
    • (2010) Haematol (EHA Annu Meet Abstr) , vol.95 , Issue.SUPPL. 2 , pp. 234
    • Palumbo, A.1    Dimopoulos, M.2    Delforge, M.3    Hajek, R.4    Kropff, M.5    Petrucci, M.T.6
  • 17
    • 33750607347 scopus 로고    scopus 로고
    • A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma
    • Richardson PG, Blood E, Mitsiades CS, Jagannath S, Zeldenrust SR, Alsina M et al. A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma. Blood 2006; 108: 3458-3464.
    • (2006) Blood , vol.108 , pp. 3458-3464
    • Richardson, P.G.1    Blood, E.2    Mitsiades, C.S.3    Jagannath, S.4    Zeldenrust, S.R.5    Alsina, M.6
  • 18
    • 68249135722 scopus 로고    scopus 로고
    • Safety and efficacy of single-agent lenalidomide in patients with relapsed and refractory multiple myeloma
    • Richardson P, Jagannath S, Hussein M, Berenson J, Singhal S, Irwin D et al. Safety and efficacy of single-agent lenalidomide in patients with relapsed and refractory multiple myeloma. Blood 2009; 114: 772-778.
    • (2009) Blood , vol.114 , pp. 772-778
    • Richardson, P.1    Jagannath, S.2    Hussein, M.3    Berenson, J.4    Singhal, S.5    Irwin, D.6
  • 19
    • 77952118055 scopus 로고    scopus 로고
    • European Medicines Agency European Public Assessment Report: Revlimid Accessed July 2010
    • European Medicines Agency. Revlimid summary of product characteristics. European Public Assessment Report: Revlimid. Available from: http://www.emea.europa.eu. Accessed July 2010.
    • Revlimid Summary of Product Characteristics
  • 20
    • 77953766954 scopus 로고    scopus 로고
    • Celgene Corporation Summit NJ Accessed July 2010
    • Celgene Corporation. Revlimid Package Insert. Summit, NJ, Available at: http://www.revlimid.com/pdf/REVLIMID-PI.pdf. Accessed July 2010.
    • Revlimid Package Insert
  • 23
    • 70450230539 scopus 로고    scopus 로고
    • Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma
    • Dimopoulos MA, Chen C, Spencer A, Niesvizky R, Attal M, Stadtmauer EA et al. Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myeloma. Leukemia 2009; 23: 2147-2152.
    • (2009) Leukemia , vol.23 , pp. 2147-2152
    • Dimopoulos, M.A.1    Chen, C.2    Spencer, A.3    Niesvizky, R.4    Attal, M.5    Stadtmauer, E.A.6
  • 24
    • 65349097489 scopus 로고    scopus 로고
    • Lenalidomide in combination with dexa-methasone at first relapse in comparison with its use as later salvage therapy in relapsed or refractory multiple myeloma
    • Stadtmauer EA, Weber DM, Niesvizky R, Belch A, Prince MH, San Miguel JF et al. Lenalidomide in combination with dexa-methasone at first relapse in comparison with its use as later salvage therapy in relapsed or refractory multiple myeloma. Eur J Haematol 2009; 82: 426-432.
    • (2009) Eur J Haematol , vol.82 , pp. 426-432
    • Stadtmauer, E.A.1    Weber, D.M.2    Niesvizky, R.3    Belch, A.4    Prince, M.H.5    San Miguel, J.F.6
  • 25
    • 42649116903 scopus 로고    scopus 로고
    • Lenalidomide (L) in combination with dexamethasone (D) significantly improves time to progression (TTP) in non-stem cell transplant patients (pts) with relapsed or refractory (rel/ref) multiple myeloma (MM): Analysis from MM-009 and MM-010 randomized phase III clinical trials
    • (abstract 3554)
    • Chanan-Khan AA, Yu Z, Weber D, Chen C, Niesvizky R, Spencer A et al. Lenalidomide (L) in combination with dexamethasone (D) significantly improves time to progression (TTP) in non-stem cell transplant patients (pts) with relapsed or refractory (rel/ref) multiple myeloma (MM): Analysis from MM-009 and MM-010 randomized phase III clinical trials. Blood (ASH Annu Meet Abstr) 2006; 108: (abstract 3554).
    • (2006) Blood (ASH Annu Meet Abstr) , vol.108
    • Chanan-Khan, A.A.1    Yu, Z.2    Weber, D.3    Chen, C.4    Niesvizky, R.5    Spencer, A.6
  • 26
    • 58149384555 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone is more effective than dexamethasone alone in patients with relapsed or refractory multiple myeloma regardless of prior thalidomide exposure
    • Wang M, Dimopoulos MA, Chen C, Cibeira MT, Attal M, Spencer A et al. Lenalidomide plus dexamethasone is more effective than dexamethasone alone in patients with relapsed or refractory multiple myeloma regardless of prior thalidomide exposure. Blood 2008; 112: 4445-4451.
    • (2008) Blood , vol.112 , pp. 4445-4451
    • Wang, M.1    Dimopoulos, M.A.2    Chen, C.3    Cibeira, M.T.4    Attal, M.5    Spencer, A.6
  • 27
    • 77953862198 scopus 로고    scopus 로고
    • The efficacy and safety of lenalidomide plus dexamethasone in relapsed and/or refractory multiple myeloma patients with impaired renal function
    • Dimopoulos M, Alegre A, Stadtmauer EA, Goldschmidt H, Zonder JA, de Castro CM et al. The efficacy and safety of lenalidomide plus dexamethasone in relapsed and/or refractory multiple myeloma patients with impaired renal function. Cancer 2010; 116: 3807-3814.
    • (2010) Cancer , vol.116 , pp. 3807-3814
    • Dimopoulos, M.1    Alegre, A.2    Stadtmauer, E.A.3    Goldschmidt, H.4    Zonder, J.A.5    De Castro, C.M.6
  • 28
    • 79955824056 scopus 로고    scopus 로고
    • Lenalidomide plus dexamethasone has similar tolerability and efficacy in treatment of relapsed/refractory multiple myeloma patients with or without history of neuropathy
    • (abstract 3873)
    • Delforge M, Facon T, Bravo M-L, Dimopoulos MA. Lenalidomide plus dexamethasone has similar tolerability and efficacy in treatment of relapsed/refractory multiple myeloma patients with or without history of neuropathy. Blood (ASH Annu Meet Abstr) 2009; 114: (abstract 3873).
    • (2009) Blood (ASH Annu Meet Abstr) , vol.114
    • Delforge, M.1    Facon, T.2    Bravo, M.-L.3    Dimopoulos, M.A.4
  • 30
    • 79955644443 scopus 로고    scopus 로고
    • Safety and efficacy outcomes with lenalidomide plus dexamethasone in relapsed or refractory multiple myeloma were not significantly different for the treatment of patients with or without high-risk disease or elderly status
    • (abstract 3701)
    • Chanan-Khan AA, Dimopoulos MA, Weber DM, Spencer A, Attal M, Belch A et al. Safety and efficacy outcomes with lenalidomide plus dexamethasone in relapsed or refractory multiple myeloma were not significantly different for the treatment of patients with or without high-risk disease or elderly status. Blood (ASH Annu Meet Abstr) 2008; 112: (abstract 3701).
    • (2008) Blood (ASH Annu Meet Abstr) , vol.112
    • Chanan-Khan, A.A.1    Dimopoulos, M.A.2    Weber, D.M.3    Spencer, A.4    Attal, M.5    Belch, A.6
  • 31
    • 77957777556 scopus 로고    scopus 로고
    • Full dose of lenalidomide for 12 months followed by a lower maintenance dose improves progression-free survival in patients with relapsed/ refractory multiple myeloma
    • (abstract 2874)
    • Dimopoulos MA, Hussein M, Swern AS, Weber D. Full dose of lenalidomide for 12 months followed by a lower maintenance dose improves progression-free survival in patients with relapsed/ refractory multiple myeloma. Blood (ASH Annu Meet Abstr) 2009; 114: (abstract 2874).
    • (2009) Blood (ASH Annu Meet Abstr) , vol.114
    • Dimopoulos, M.A.1    Hussein, M.2    Swern, A.S.3    Weber, D.4
  • 32
    • 41649097366 scopus 로고    scopus 로고
    • Dexamethasone dose adjustments seem to result in better efficacy and improved tolerability in patients with relapsed/ refractory multiple myeloma who are treated with lenalidomide/ dexamethasone (MM009/010 sub-analysis)
    • (abstract 2712)
    • San Miguel JF, Dimopoulos M, Weber D, Olesnyckyj M, Yu Z, Zeldis J et al. Dexamethasone dose adjustments seem to result in better efficacy and improved tolerability in patients with relapsed/ refractory multiple myeloma who are treated with lenalidomide/ dexamethasone (MM009/010 sub-analysis). Blood (ASH Annu Meet Abstr) 2007; 110: (abstract 2712).
    • (2007) Blood (ASH Annu Meet Abstr) , vol.110
    • San Miguel, J.F.1    Dimopoulos, M.2    Weber, D.3    Olesnyckyj, M.4    Yu, Z.5    Zeldis, J.6
  • 33
    • 77954681332 scopus 로고    scopus 로고
    • Analysis of efficacy and prognostic factors of lenalidomide treatment as part of a Dutch compassionate use program
    • Kneppers E, Lokhorst HM, Eeltink CM, Huls G, Kersten MJ, Koedam J et al. Analysis of efficacy and prognostic factors of lenalidomide treatment as part of a Dutch compassionate use program. Clin Lymphoma Myeloma Leuk2010; 10: 138-143.
    • (2010) Clin Lymphoma Myeloma Leuk , vol.10 , pp. 138-143
    • Kneppers, E.1    Lokhorst, H.M.2    Eeltink, C.M.3    Huls, G.4    Kersten, M.J.5    Koedam, J.6
  • 34
    • 77949423941 scopus 로고    scopus 로고
    • Impact of high-risk cytogenetics and prior therapy on outcomes in patients with advanced relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone
    • Avet-Loiseau H, Soulier J, Fermand JP, Yakoub-Agha I, Attal M, Hulin C et al. Impact of high-risk cytogenetics and prior therapy on outcomes in patients with advanced relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone. Leukemia 2010; 24: 623-628.
    • (2010) Leukemia , vol.24 , pp. 623-628
    • Avet-Loiseau, H.1    Soulier, J.2    Fermand, J.P.3    Yakoub-Agha, I.4    Attal, M.5    Hulin, C.6
  • 35
    • 77957996812 scopus 로고    scopus 로고
    • Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: Prospective evaluation of the impact of cytogenetic abnormalities and of previous therapies
    • Dimopoulos MA, Kastritis E, Christoulas D, Migkou M, Gavriatopoulou M, Gkotzamanidou M et al. Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: prospective evaluation of the impact of cytogenetic abnormalities and of previous therapies. Leukemia 2010; 24: 1769-1778.
    • (2010) Leukemia , vol.24 , pp. 1769-1778
    • Dimopoulos, M.A.1    Kastritis, E.2    Christoulas, D.3    Migkou, M.4    Gavriatopoulou, M.5    Gkotzamanidou, M.6
  • 36
    • 70149113290 scopus 로고    scopus 로고
    • Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone: Adverse effect of deletion 17p13
    • Reece D, Song KW, Fu T, Roland B, Chang H, Horsman DE et al. Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone: adverse effect of deletion 17p13. Blood 2009; 114: 522-525.
    • (2009) Blood , vol.114 , pp. 522-525
    • Reece, D.1    Song, K.W.2    Fu, T.3    Roland, B.4    Chang, H.5    Horsman, D.E.6
  • 37
    • 77952310929 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone compared with melphalan and prednisone in previously untreated multiple myeloma: Updated follow-up and impact of subsequent therapy in the phase III VISTA Trial
    • Mateos MV, Richardson PG, Schlag R, Khuageva NK, Dimopoulos MA, Shpilberg O et al. Bortezomib plus melphalan and prednisone compared with melphalan and prednisone in previously untreated multiple myeloma: updated follow-up and impact of subsequent therapy in the phase III VISTA Trial. J Clin Oncol 2010; 28: 2259-2266.
    • (2010) J Clin Oncol , vol.28 , pp. 2259-2266
    • Mateos, M.V.1    Richardson, P.G.2    Schlag, R.3    Khuageva, N.K.4    Dimopoulos, M.A.5    Shpilberg, O.6
  • 38
    • 77954592430 scopus 로고    scopus 로고
    • The addition of cyclophosphamide to lenalidomide and dexamethasone in multiply relapsed/refractory myeloma patients; A phase I/II study
    • Schey SA, Morgan GJ, Ramasamy K, Hazel B, Ladon D, Corderoy S et al. The addition of cyclophosphamide to lenalidomide and dexamethasone in multiply relapsed/refractory myeloma patients; a phase I/II study. BrJ Haematol 2010; 150: 326-333.
    • (2010) BrJ Haematol , vol.150 , pp. 326-333
    • Schey, S.A.1    Morgan, G.J.2    Ramasamy, K.3    Hazel, B.4    Ladon, D.5    Corderoy, S.6
  • 39
    • 77957996812 scopus 로고    scopus 로고
    • Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: Prospective evaluation of the impact of cytogenetic abnormalities and of previous therapies
    • Dimopoulos MA, Kastritis E, Christoulas D, Migkou M, Gavriatopoulou M, Gkotzamanidou M et al. Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: prospective evaluation of the impact of cytogenetic abnormalities and of previous therapies. Leukemia 2010; 24: 1769-1778.
    • (2010) Leukemia , vol.24 , pp. 1769-1778
    • Dimopoulos, M.A.1    Kastritis, E.2    Christoulas, D.3    Migkou, M.4    Gavriatopoulou, M.5    Gkotzamanidou, M.6
  • 40
    • 66149109580 scopus 로고    scopus 로고
    • Lenalidomide adriamycin and dexamethasone (RAD) in patients with relapsed and refractory multiple myeloma: A report from the German Myeloma Study Group DSMM (Deutsche Studiengruppe Multiples Myelom)
    • Knop S, Gerecke C, Liebisch P, Topp MS, Platzbecker U, Sezer O et al. Lenalidomide, adriamycin, and dexamethasone (RAD) in patients with relapsed and refractory multiple myeloma: a report from the German Myeloma Study Group DSMM (Deutsche Studiengruppe Multiples Myelom). Blood 2009; 113: 4137-4143.
    • (2009) Blood , vol.113 , pp. 4137-4143
    • Knop, S.1    Gerecke, C.2    Liebisch, P.3    Topp, M.S.4    Platzbecker, U.5    Sezer, O.6
  • 41
    • 49449107318 scopus 로고    scopus 로고
    • Pathogenesis and treatment of renal failure in multiple myeloma
    • Dimopoulos MA, Kastritis E, Rosinol L, Blade J, Ludwig H et al. Pathogenesis and treatment of renal failure in multiple myeloma. Leukemia 2008; 22: 1485-1493.
    • (2008) Leukemia , vol.22 , pp. 1485-1493
    • Dimopoulos, M.A.1    Kastritis, E.2    Rosinol, L.3    Blade, J.4    Ludwig, H.5
  • 42
    • 79955861880 scopus 로고    scopus 로고
    • Dosing of drugs in renal failure
    • Koda-Kimble AM, Young L, Kradjan W, Guglielmo BJ, Aldredge B, Corelli R, Williams B (eds) 8th ed, Lipponcott, Williams & Wilkins: Vancouver, WA
    • Quan DJ, Aweeka FT. Dosing of drugs in renal failure. In: Koda-Kimble AM, Young L, Kradjan W, Guglielmo BJ, Aldredge B, Corelli R, Williams B (eds). Applied Therapeutics-The clinical use of drugs, Vol. 34, 8th ed, Lipponcott Williams & Wilkins: Vancouver, WA, 2005, pp 1-25.
    • (2005) Applied Therapeutics-The Clinical Use of Drugs , vol.34 , pp. 1-25
    • Quan, D.J.1    Aweeka, F.T.2
  • 43
    • 36148973115 scopus 로고    scopus 로고
    • Pharmacokinetics of lenalidomide in subjects with various degrees of renal impairment and in subjects on hemodialysis
    • DOI 10.1177/0091270007309563
    • Chen N, Lau H, Kong L, Kumar G, Zeldis JB, Knight R et al. Pharmacokinetics of lenalidomide in subjects with various degrees of renal impairment and in subjects on hemodialysis. J Clin Pharmacol 2007; 47: 1466-1475. (Pubitemid 350115306)
    • (2007) Journal of Clinical Pharmacology , vol.47 , Issue.12 , pp. 1466-1475
    • Nianhang Chen1    Lau, H.2    Linghui Kong3    Kumar, G.4    Zeldis, J.B.5    Knight, R.6    Laskin, O.L.7
  • 44
    • 77956949045 scopus 로고    scopus 로고
    • Activity and safety of lenalidomide and dexamethasone in multiple myeloma patients requiring dialysis: A Spanish multicenter retrospective study
    • de la Rubia J, Roig M, Ibañez A, García I, Vera JA, Aguilar C et al. Activity and safety of lenalidomide and dexamethasone in multiple myeloma patients requiring dialysis: a Spanish multicenter retrospective study. EurJ Haematol 2010; 85: 363-365.
    • (2010) EurJ Haematol , vol.85 , pp. 363-365
    • De La Rubia, J.1    Roig, M.2    Ibañez, A.3    García, I.4    Vera, J.A.5    Aguilar, C.6
  • 45
    • 34547625141 scopus 로고    scopus 로고
    • Use of lenalidomide (Revlimid® +/- corticosteroids in relapsed/ refractory multiple myeloma patients with elevated baseline serum creatinine levels
    • (abstract 3548)
    • Reece DE, Masih-Khan E, Chen C, Wang L, Dean S, Kukreti V et al. Use of lenalidomide (Revlimid® +/- corticosteroids in relapsed/ refractory multiple myeloma patients with elevated baseline serum creatinine levels. Blood (ASH Annu Meet Abstr) 2006; 108: (abstract 3548).
    • (2006) Blood (ASH Annu Meet Abstr) , vol.108
    • Reece, D.E.1    Masih-Khan, E.2    Chen, C.3    Wang, L.4    Dean, S.5    Kukreti, V.6
  • 46
    • 77953826186 scopus 로고    scopus 로고
    • Lenalidomide and dexamethasone for the treatment of refractory/relapsed multiple myeloma: Dosing of lenalidomide according to renal function and effect on renal impairment
    • Dimopoulos MA, Christoulas D, Roussou M, Kastritis E, Migkou M, Gavriatopoulou M et al. Lenalidomide and dexamethasone for the treatment of refractory/relapsed multiple myeloma: dosing of lenalidomide according to renal function and effect on renal impairment. Eur J Haematol 2010; 85: 1-5.
    • (2010) Eur J Haematol , vol.85 , pp. 1-5
    • Dimopoulos, M.A.1    Christoulas, D.2    Roussou, M.3    Kastritis, E.4    Migkou, M.5    Gavriatopoulou, M.6
  • 47
    • 77951880822 scopus 로고    scopus 로고
    • Renal recovery with lenalidomide in a patient with bortezomib-resistant multiple myeloma
    • Ludwig H, Zojer N. Renal recovery with lenalidomide in a patient with bortezomib-resistant multiple myeloma. Nat Rev Clin Oncol 2010; 7: 289-294.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 289-294
    • Ludwig, H.1    Zojer, N.2
  • 48
    • 38349124445 scopus 로고    scopus 로고
    • Should prophylactic granulocyte-colony stimulating factor be used in multiple myeloma patients developing neutropenia under lenalidomide-based therapy?
    • Mateos MV, García-Sanz R, Colado E, Olazábal J, San-Miguel J. Should prophylactic granulocyte-colony stimulating factor be used in multiple myeloma patients developing neutropenia under lenalidomide-based therapy? Br J Haematol 2008; 140: 324-326.
    • (2008) Br J Haematol , vol.140 , pp. 324-326
    • Mateos, M.V.1    García-Sanz, R.2    Colado, E.3    Olazábal, J.4    San-Miguel, J.5
  • 49
    • 73249146496 scopus 로고    scopus 로고
    • Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: An open-label randomised controlled trial
    • Rajkumar SV, Jacobus S, Callander NS, Fonseca R, Vesole DH, Williams ME et al. Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial. Lancet Oncol 2010; 11: 29-37.
    • (2010) Lancet Oncol , vol.11 , pp. 29-37
    • Rajkumar, S.V.1    Jacobus, S.2    Callander, N.S.3    Fonseca, R.4    Vesole, D.H.5    Williams, M.E.6
  • 50
    • 57049113927 scopus 로고    scopus 로고
    • Effective prophylaxis of thromboembolic complications with low molecular weight heparin in relapsed multiple myeloma patients treated with lenalidomide and dexamethasone
    • Klein U, Kosely F, Hillengass J, Hundemer M, Schmitt S, Neben K et al. Effective prophylaxis of thromboembolic complications with low molecular weight heparin in relapsed multiple myeloma patients treated with lenalidomide and dexamethasone. Ann Hematol 2009; 88: 67-71.
    • (2009) Ann Hematol , vol.88 , pp. 67-71
    • Klein, U.1    Kosely, F.2    Hillengass, J.3    Hundemer, M.4    Schmitt, S.5    Neben, K.6
  • 51
    • 77955450608 scopus 로고    scopus 로고
    • Phase Ib multicenter dose escalation study of carfilzomib plus lenalidomide and low dose dexamethasone (CRd) in relapsed and refractory multiple myeloma (MM)
    • (abstract 304)
    • Niesvizky R, Wang L, Orlowski RZ, Bensinger W, Alsina M, Gabrail N et al. Phase Ib multicenter dose escalation study of carfilzomib plus lenalidomide and low dose dexamethasone (CRd) in relapsed and refractory multiple myeloma (MM). Blood (ASH Annu Meet Abstr) 2009; 114: (abstract 304).
    • (2009) Blood (ASH Annu Meet Abstr) , vol.114
    • Niesvizky, R.1    Wang, L.2    Orlowski, R.Z.3    Bensinger, W.4    Alsina, M.5    Gabrail, N.6
  • 52
    • 72649087729 scopus 로고    scopus 로고
    • Lenalidomide (Revlimid) combined with continuous oral cyclo-phosphamide (endoxan) and prednisone (REP) is effective in lenalidomide/dexamethasone- refractory myeloma
    • Van de Donk NW, Wittebol S, Minnema MC, Lokhorst HM. Lenalidomide (Revlimid) combined with continuous oral cyclo-phosphamide (endoxan) and prednisone (REP) is effective in lenalidomide/dexamethasone-refractory myeloma. Br J Haematol 2010; 148: 335-337.
    • (2010) Br J Haematol , vol.148 , pp. 335-337
    • Van De Donk, N.W.1    Wittebol, S.2    Minnema, M.C.3    Lokhorst, H.M.4
  • 53
    • 70249097029 scopus 로고    scopus 로고
    • Phase II study of thalidomide plus dexamethasone induction followed by tandem melphalan-based autotransplanta-tion and thalidomide-plus-prednisone maintenance for untreated multiple myeloma: A southwest oncology group trial (S0204)
    • Hussein MA, Bolejack V, Zonder JA, Durie BG, Jakubowiak AJ, Crowley JJ et al. Phase II study of thalidomide plus dexamethasone induction followed by tandem melphalan-based autotransplanta-tion and thalidomide-plus-prednisone maintenance for untreated multiple myeloma: a southwest oncology group trial (S0204). J Clin Oncol 2009; 27: 3510-3517.
    • (2009) J Clin Oncol , vol.27 , pp. 3510-3517
    • Hussein, M.A.1    Bolejack, V.2    Zonder, J.A.3    Durie, B.G.4    Jakubowiak, A.J.5    Crowley, J.J.6
  • 55
    • 77649215631 scopus 로고    scopus 로고
    • Bortezomib as induction before autologous transplantation, followed by lenalidomide as consolidation-maintenance in untreated multiple myeloma patients
    • Palumbo A, Gay F, Falco P, Crippa C, Montefusco V, Patriarca F et al. Bortezomib as induction before autologous transplantation, followed by lenalidomide as consolidation-maintenance in untreated multiple myeloma patients. J Clin Oncol 2010; 28: 800-807.
    • (2010) J Clin Oncol , vol.28 , pp. 800-807
    • Palumbo, A.1    Gay, F.2    Falco, P.3    Crippa, C.4    Montefusco, V.5    Patriarca, F.6
  • 56
    • 79955845333 scopus 로고    scopus 로고
    • Post-approval safety study (PASS) of lenalidomide compared with other treatments in patients with relapsed or refractory multiple myeloma: First report on 518 patients
    • (abstract 383)
    • Blau I, Gimsing P, Drenou B, Masini L, Lokhorst H, Waage A et al. Post-approval safety study (PASS) of lenalidomide compared with other treatments in patients with relapsed or refractory multiple myeloma: first report on 518 patients. Haematol (EHA Annu Meet Abstr) 2010; 95(Suppl 2): 154 (abstract 383).
    • (2010) Haematol (EHA Annu Meet Abstr) , vol.95 , Issue.SUPPL. 2 , pp. 154
    • Blau, I.1    Gimsing, P.2    Drenou, B.3    Masini, L.4    Lokhorst, H.5    Waage, A.6
  • 58
    • 74049162897 scopus 로고    scopus 로고
    • International Myeloma Working Group molecular classification of multiple myeloma: Spotlight review
    • Fonseca R, Bergsagel PL, Drach J, Shaughnessy J, Gutierrez N, Stewart AK et al. International Myeloma Working Group molecular classification of multiple myeloma: spotlight review. Leukemia 2009; 23: 2210-2221.
    • (2009) Leukemia , vol.23 , pp. 2210-2221
    • Fonseca, R.1    Bergsagel, P.L.2    Drach, J.3    Shaughnessy, J.4    Gutierrez, N.5    Stewart, A.K.6
  • 61
    • 70349320472 scopus 로고    scopus 로고
    • Complete remission in multiple myeloma examined as time-dependent variable in terms of both onset and duration in total therapy protocols
    • Hoering A, Crowley J, Shaughnessy Jr JD, Hollmig K, Alsayed Y, Szymonifka J et al. Complete remission in multiple myeloma examined as time-dependent variable in terms of both onset and duration in total therapy protocols. Blood 2009; 114: 1299-1305.
    • (2009) Blood , vol.114 , pp. 1299-1305
    • Hoering, A.1    Crowley, J.2    Shaughnessy Jr., J.D.3    Hollmig, K.4    Alsayed, Y.5    Szymonifka, J.6
  • 63
    • 70449472463 scopus 로고    scopus 로고
    • Risky business in myeloma
    • Lonial S. Risky business in myeloma. Blood 2009; 114: 496-497.
    • (2009) Blood , vol.114 , pp. 496-497
    • Lonial, S.1
  • 64
    • 54949106553 scopus 로고    scopus 로고
    • A randomized Southwest Oncology Group study comparing dexamethasone (D) to lenalidomide + dexa-methasone (LD) as treatment of newly-diagnosed multiple myeloma (NDMM): Impact of cytogenetic abnormalities on efficacy of LD, and updated overall study results
    • (abstract 8521)
    • Zonder JA, Crowley JJ, Bolejack V, Hussein MA, Moore Sr DF, Whittenberger BF et al. A randomized Southwest Oncology Group study comparing dexamethasone (D) to lenalidomide + dexa-methasone (LD) as treatment of newly-diagnosed multiple myeloma (NDMM): Impact of cytogenetic abnormalities on efficacy of LD, and updated overall study results. J Clin Oncol (ASCO Annu Meet Proc) 2008; 26(Suppl): (abstract 8521).
    • (2008) J Clin Oncol (ASCO Annu Meet Proc) , vol.26 , Issue.SUPPL.
    • Zonder, J.A.1    Crowley, J.J.2    Bolejack, V.3    Hussein, M.A.4    Moore Sr., D.F.5    Whittenberger, B.F.6
  • 65
    • 70149107680 scopus 로고    scopus 로고
    • Impact of risk stratification on outcome among patients with multiple myeloma receiving initial therapy with lenalidomide and dexamethasone
    • Kapoor P, Kumar S, Fonseca R, Lacy MQ, Witzig TE, Hayman SR et al. Impact of risk stratification on outcome among patients with multiple myeloma receiving initial therapy with lenalidomide and dexamethasone. Blood 2009; 114: 518-521.
    • (2009) Blood , vol.114 , pp. 518-521
    • Kapoor, P.1    Kumar, S.2    Fonseca, R.3    Lacy, M.Q.4    Witzig, T.E.5    Hayman, S.R.6
  • 66
    • 70349296572 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma (MM): Encouraging response rates and tolerability with correlation of outcome and adverse cytogenetics in a phase II study
    • (abstract 1742)
    • Richardson P, Jagannath S, Jakubowiak A, Lonial S, Raje N, Alsina M et al. Lenalidomide, bortezomib, and dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma (MM): encouraging response rates and tolerability with correlation of outcome and adverse cytogenetics in a phase II study. Blood (ASH Annu Meet Abstr) 2008; 112: (abstract 1742).
    • (2008) Blood (ASH Annu Meet Abstr) , vol.112
    • Richardson, P.1    Jagannath, S.2    Jakubowiak, A.3    Lonial, S.4    Raje, N.5    Alsina, M.6
  • 67
    • 77950530986 scopus 로고    scopus 로고
    • Superior rate of complete response with up-front Velcade-thalidomide- dexamethasone versus thalidomide-dexamethasone in newly diagnosed multiple myeloma is not affected by adverse prognostic factors, including high-risk cyto-genetic abnormalities
    • (abstract 1662)
    • Cavo M, Testoni N, Terragna C, Marzocchi G, Durante S, Zambello R et al. Superior rate of complete response with up-front Velcade-thalidomide- dexamethasone versus thalidomide-dexamethasone in newly diagnosed multiple myeloma is not affected by adverse prognostic factors, including high-risk cyto-genetic abnormalities. Blood (ASH Annu Meet Abstr) 2008; 112: (abstract 1662).
    • (2008) Blood (ASH Annu Meet Abstr) , vol.112
    • Cavo, M.1    Testoni, N.2    Terragna, C.3    Marzocchi, G.4    Durante, S.5    Zambello, R.6
  • 68
    • 78049501226 scopus 로고    scopus 로고
    • Bortezomib plus dexamethasone induction improves outcome of patients with t(4;14) myeloma but not outcome of patients with del(17p)
    • Avet-Loiseau H, Leleu X, Roussel M, Moreau P, Guerin-Charbonnel C, Caillot D et al. Bortezomib plus dexamethasone induction improves outcome of patients with t(4;14) myeloma but not outcome of patients with del(17p). J Clin Oncol 2010; 28: 4630-4634.
    • (2010) J Clin Oncol , vol.28 , pp. 4630-4634
    • Avet-Loiseau, H.1    Leleu, X.2    Roussel, M.3    Moreau, P.4    Guerin-Charbonnel, C.5    Caillot, D.6
  • 69
    • 67649985917 scopus 로고    scopus 로고
    • Expanded safety experience with lenalidomide plus dexa-methasone in relapsed or refractory multiple myeloma
    • Chen C, Reece DE, Siegel D, Niesvizky R, Boccia RV, Stadtmauer EA et al. Expanded safety experience with lenalidomide plus dexa-methasone in relapsed or refractory multiple myeloma. Br J Haematol 2009; 146: 164-170.
    • (2009) Br J Haematol , vol.146 , pp. 164-170
    • Chen, C.1    Reece, D.E.2    Siegel, D.3    Niesvizky, R.4    Boccia, R.V.5    Stadtmauer, E.A.6
  • 70
    • 77949463293 scopus 로고    scopus 로고
    • Declining rates of adverse events and dose modifications with lenalidomide in combination with dexamethasone
    • (abstract 3708)
    • Ishak J, Dimopoulos MA, Weber D, Knight RD, Shearer A, Caro JJ. Declining rates of adverse events and dose modifications with lenalidomide in combination with dexamethasone. Blood (ASH Annu Meet Abstr) 2008; 112: (abstract 3708).
    • (2008) Blood (ASH Annu Meet Abstr) , vol.112
    • Ishak, J.1    Dimopoulos, M.A.2    Weber, D.3    Knight, R.D.4    Shearer, A.5    Caro, J.J.6
  • 71
    • 79955803480 scopus 로고    scopus 로고
    • Neutropenia is a predictable and early event in affected patients with relapsed/refractory multiple myeloma treated with lenalido-mide in combination with dexamethasone
    • (abstract 2879)
    • Lonial S, Baz R, Swern AS, Weber D, Dimopoulos MA. Neutropenia is a predictable and early event in affected patients with relapsed/refractory multiple myeloma treated with lenalido-mide in combination with dexamethasone. Blood (ASH Annu Meet Abstr) 2009; 114: (abstract 2879).
    • (2009) Blood (ASH Annu Meet Abstr) , vol.114
    • Lonial, S.1    Baz, R.2    Swern, A.S.3    Weber, D.4    Dimopoulos, M.A.5
  • 73
    • 33748094595 scopus 로고    scopus 로고
    • Increased risk of thrombosis with lenalidomide in combination with dexamethasone and erythropoietin
    • (abstract 7506)
    • Niesvizky R, Spencer A, Wang M, Weber D, Chen C, Dimopoulos MA et al. Increased risk of thrombosis with lenalidomide in combination with dexamethasone and erythropoietin. J Clin Oncol (ASCO Annu Meet Proc) 2006; 24(Suppl): (abstract 7506).
    • (2006) J Clin Oncol (ASCO Annu Meet Proc) , vol.24 , Issue.SUPPL.
    • Niesvizky, R.1    Spencer, A.2    Wang, M.3    Weber, D.4    Chen, C.5    Dimopoulos, M.A.6
  • 74
    • 37849003198 scopus 로고    scopus 로고
    • Use of epoetin and darbepoetin in patients with cancer: 2007 American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update
    • Rizzo JD, Somerfield MR, Hagerty KL, Seidenfeld J, Bohlius J, Bennett CL et al. Use of epoetin and darbepoetin in patients with cancer: 2007 American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update. J Clin Oncol 2008; 26: 132-149.
    • (2008) J Clin Oncol , vol.26 , pp. 132-149
    • Rizzo, J.D.1    Somerfield, M.R.2    Hagerty, K.L.3    Seidenfeld, J.4    Bohlius, J.5    Bennett, C.L.6
  • 76
    • 33745590139 scopus 로고    scopus 로고
    • Thrombotic complications in patients with newly diagnosed multiple myeloma treated with lenalidomide and dexamethasone: Benefit of aspirin prophylaxis [5]
    • DOI 10.1182/blood-2006-01-0154
    • Zonder JA, Barlogie B, Durie BG, McCoy J, Crowley J, Hussein MA. Thrombotic complications in patients with newly diagnosed multiple myeloma treated with lenalidomide and dexamethasone: benefit of aspirin prophylaxis. Blood 2006; 108: 403. (Pubitemid 43990659)
    • (2006) Blood , vol.108 , Issue.1 , pp. 403
    • Zonder, J.A.1    Barlogie, B.2    Durie, B.G.M.3    McCoy, J.4    Crowley, J.5    Hussein, M.A.6
  • 77
    • 73949154067 scopus 로고    scopus 로고
    • Survival effect of venous thromboembolism in patients with multiple myeloma treated with lenalidomide and high-dose dexamethasone
    • Zangari M, Tricot G, Polavaram L, Zhan F, Finlayson A, Knight R et al. Survival effect of venous thromboembolism in patients with multiple myeloma treated with lenalidomide and high-dose dexamethasone. J Clin Oncol 2010; 28: 132-135.
    • (2010) J Clin Oncol , vol.28 , pp. 132-135
    • Zangari, M.1    Tricot, G.2    Polavaram, L.3    Zhan, F.4    Finlayson, A.5    Knight, R.6
  • 78
    • 33750074147 scopus 로고    scopus 로고
    • Dermatologic adverse effects of lenalidomide therapy for amyloidosis and multiple myeloma
    • Sviggum HP, Davis MD, Rajkumar SV, Dispenzieri A. Dermato-logic adverse effects of lenalidomide therapy for amyloidosis and multiple myeloma. Arch Dermatol 2006; 142: 1298-1302. (Pubitemid 44583279)
    • (2006) Archives of Dermatology , vol.142 , Issue.10 , pp. 1298-1302
    • Sviggum, H.P.1    Davis, M.D.P.2    Rajkumar, S.V.3    Dispenzieri, A.4
  • 79
    • 61349118005 scopus 로고    scopus 로고
    • Lenalidomide in combination with dexametha-sone for the treatment of relapsed or refractory multiple myeloma
    • Palumbo A, Dimopoulos M, San Miguel J, Harousseau JL, Attal M, Hussein M et al. Lenalidomide in combination with dexametha-sone for the treatment of relapsed or refractory multiple myeloma. Blood Rev 2009; 23: 87-93.
    • (2009) Blood Rev , vol.23 , pp. 87-93
    • Palumbo, A.1    Dimopoulos, M.2    San Miguel, J.3    Harousseau, J.L.4    Attal, M.5    Hussein, M.6


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