메뉴 건너뛰기




Volumn 232, Issue 1, 2012, Pages 13-19

Growth hormone secretagogue receptor (GHS-R1a) knockout mice exhibit improved spatial memory and deficits in contextual memory

Author keywords

Behavioral characterization; Dopamine; Fear conditioning; Ghrelin; GHS R1a knockout mouse; Growth hormone secretagogue receptor (GHS R1a); Hot plate test; Morris water maze; Open field; Rotarod

Indexed keywords

GHRELIN RECEPTOR;

EID: 84859516159     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.03.012     Document Type: Article
Times cited : (53)

References (52)
  • 3
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402:656-660.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 4
    • 33748560432 scopus 로고    scopus 로고
    • Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
    • Abizaid A., Liu Z.W., Andrews Z.B., Shanabrough M., Borok E., Elsworth J.D., et al. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest 2006, 116:3229-3239.
    • (2006) J Clin Invest , vol.116 , pp. 3229-3239
    • Abizaid, A.1    Liu, Z.W.2    Andrews, Z.B.3    Shanabrough, M.4    Borok, E.5    Elsworth, J.D.6
  • 8
    • 33746583963 scopus 로고    scopus 로고
    • Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers
    • Jiang H., Betancourt L., Smith R.G. Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers. Mol Endocrinol 2006, 20:1772-1785.
    • (2006) Mol Endocrinol , vol.20 , pp. 1772-1785
    • Jiang, H.1    Betancourt, L.2    Smith, R.G.3
  • 9
    • 1842480284 scopus 로고    scopus 로고
    • Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    • Sun Y., Wang P., Zheng H., Smith R.G. Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci USA 2004, 101:4679-4684.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4679-4684
    • Sun, Y.1    Wang, P.2    Zheng, H.3    Smith, R.G.4
  • 10
    • 19944427023 scopus 로고    scopus 로고
    • Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity
    • Baessler A., Hasinoff M.J., Fischer M., Reinhard W., Sonnenberg G.E., Olivier M., et al. Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity. Diabetes 2005, 54:259-267.
    • (2005) Diabetes , vol.54 , pp. 259-267
    • Baessler, A.1    Hasinoff, M.J.2    Fischer, M.3    Reinhard, W.4    Sonnenberg, G.E.5    Olivier, M.6
  • 11
    • 79951684312 scopus 로고    scopus 로고
    • Identification and functional analysis of novel human growth hormone secretagogue receptor (GHSR) gene mutations in Japanese subjects with short stature
    • Inoue H., Kangawa N., Kinouchi A., Sakamoto Y., Kimura C., Horikawa R., et al. Identification and functional analysis of novel human growth hormone secretagogue receptor (GHSR) gene mutations in Japanese subjects with short stature. J Clin Endocrinol Metab 2011, 96:E373-E378.
    • (2011) J Clin Endocrinol Metab , vol.96
    • Inoue, H.1    Kangawa, N.2    Kinouchi, A.3    Sakamoto, Y.4    Kimura, C.5    Horikawa, R.6
  • 12
    • 34548093246 scopus 로고    scopus 로고
    • Four missense mutations in the ghrelin receptor result in distinct pharmacological abnormalities
    • Liu G., Fortin J.P., Beinborn M., Kopin A.S. Four missense mutations in the ghrelin receptor result in distinct pharmacological abnormalities. J Pharmacol Exp Ther 2007, 322:1036-1043.
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 1036-1043
    • Liu, G.1    Fortin, J.P.2    Beinborn, M.3    Kopin, A.S.4
  • 13
    • 51449100773 scopus 로고    scopus 로고
    • Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance
    • Mager U., Degenhardt T., Pulkkinen L., Kolehmainen M., Tolppanen A.M., Lindstrom J., et al. Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance. PLoS One 2008, 3:e2941.
    • (2008) PLoS One , vol.3
    • Mager, U.1    Degenhardt, T.2    Pulkkinen, L.3    Kolehmainen, M.4    Tolppanen, A.M.5    Lindstrom, J.6
  • 14
    • 84863010954 scopus 로고    scopus 로고
    • Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism
    • Kern A., A-ZR, Walsh H.E., Smith R.G. Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism. Neuron 2012, 73(2):317-332.
    • (2012) Neuron , vol.73 , Issue.2 , pp. 317-332
    • Kern, A.1    A-ZR2    Walsh, H.E.3    Smith, R.G.4
  • 15
    • 70349744089 scopus 로고    scopus 로고
    • Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis
    • de la Monte S.M., Longato L., Tong M., Wands J.R. Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis. Curr Opin Investig Drugs 2009, 10:1049-1060.
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 1049-1060
    • de la Monte, S.M.1    Longato, L.2    Tong, M.3    Wands, J.R.4
  • 18
    • 48849085723 scopus 로고    scopus 로고
    • The blood-brain barrier: connecting the gut and the brain
    • Banks W.A. The blood-brain barrier: connecting the gut and the brain. Regul Pept 2008, 149:11-14.
    • (2008) Regul Pept , vol.149 , pp. 11-14
    • Banks, W.A.1
  • 19
    • 0020653896 scopus 로고
    • Neuropeptides and the blood-brain barrier
    • Pardridge W.M. Neuropeptides and the blood-brain barrier. Annu Rev Physiol 1983, 45:73-82.
    • (1983) Annu Rev Physiol , vol.45 , pp. 73-82
    • Pardridge, W.M.1
  • 20
    • 51449084843 scopus 로고    scopus 로고
    • Pulsatile cerebrospinal fluid and plasma ghrelin in relation to growth hormone secretion and food intake in the sheep
    • Grouselle D., Chaillou E., Caraty A., Bluet-Pajot M.T., Zizzari P., Tillet Y., et al. Pulsatile cerebrospinal fluid and plasma ghrelin in relation to growth hormone secretion and food intake in the sheep. J Neuroendocrinol 2008, 20:1138-1146.
    • (2008) J Neuroendocrinol , vol.20 , pp. 1138-1146
    • Grouselle, D.1    Chaillou, E.2    Caraty, A.3    Bluet-Pajot, M.T.4    Zizzari, P.5    Tillet, Y.6
  • 21
    • 0242330291 scopus 로고    scopus 로고
    • High constitutive signaling of the ghrelin receptor-identification of a potent inverse agonist
    • Holst B., Cygankiewicz A., Jensen T.H., Ankersen M., Schwartz T.W. High constitutive signaling of the ghrelin receptor-identification of a potent inverse agonist. Mol Endocrinol 2003, 17:2201-2210.
    • (2003) Mol Endocrinol , vol.17 , pp. 2201-2210
    • Holst, B.1    Cygankiewicz, A.2    Jensen, T.H.3    Ankersen, M.4    Schwartz, T.W.5
  • 22
    • 79851510132 scopus 로고    scopus 로고
    • Learning and memory consolidation: linking molecular and behavioral data
    • Morgado-Bernal I. Learning and memory consolidation: linking molecular and behavioral data. Neuroscience 2011, 176:12-19.
    • (2011) Neuroscience , vol.176 , pp. 12-19
    • Morgado-Bernal, I.1
  • 23
    • 0032448684 scopus 로고    scopus 로고
    • Deficits in memory tasks of mice with CREB mutations depend on gene dosage
    • Gass P., Wolfer D.P., Balschun D., Rudolph D., Frey U., Lipp H.P., et al. Deficits in memory tasks of mice with CREB mutations depend on gene dosage. Learn Mem 1998, 5:274-288.
    • (1998) Learn Mem , vol.5 , pp. 274-288
    • Gass, P.1    Wolfer, D.P.2    Balschun, D.3    Rudolph, D.4    Frey, U.5    Lipp, H.P.6
  • 26
    • 44049088846 scopus 로고    scopus 로고
    • Models of nociception: hot-plate, tail-flick, and formalin tests in rodents
    • Chapter 8:Unit 8 9
    • Bannon A.W., Malmberg A.B. Models of nociception: hot-plate, tail-flick, and formalin tests in rodents. Curr Protoc Neurosci 2007, Chapter 8:Unit 8 9.
    • (2007) Curr Protoc Neurosci
    • Bannon, A.W.1    Malmberg, A.B.2
  • 28
    • 84861454257 scopus 로고    scopus 로고
    • Anxiety-Related Behaviors in Mice
    • Bailey KR, Crawley JN. Anxiety-Related Behaviors in Mice; 2009.
    • (2009)
    • Bailey, K.R.1    Crawley, J.N.2
  • 29
    • 33846461062 scopus 로고    scopus 로고
    • Morris water maze: procedures for assessing spatial and related forms of learning and memory
    • Vorhees C.V., Williams M.T. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 2006, 1:848-858.
    • (2006) Nat Protoc , vol.1 , pp. 848-858
    • Vorhees, C.V.1    Williams, M.T.2
  • 30
    • 30844471550 scopus 로고    scopus 로고
    • Assessment of spatial memory using the radial arm maze and Morris water maze
    • Chapter 8:Unit 8 5A
    • Wenk G.L. Assessment of spatial memory using the radial arm maze and Morris water maze. Curr Protoc Neurosci 2004, Chapter 8:Unit 8 5A.
    • (2004) Curr Protoc Neurosci
    • Wenk, G.L.1
  • 31
    • 60749098727 scopus 로고    scopus 로고
    • Automated scoring of fear-related behavior using EthoVision software
    • Pham J., Cabrera S.M., Sanchis-Segura C., Wood M.A. Automated scoring of fear-related behavior using EthoVision software. J Neurosci Methods 2009, 178:323-326.
    • (2009) J Neurosci Methods , vol.178 , pp. 323-326
    • Pham, J.1    Cabrera, S.M.2    Sanchis-Segura, C.3    Wood, M.A.4
  • 32
    • 34249087808 scopus 로고    scopus 로고
    • Strain differences in lithium attenuation of d-amphetamine-induced hyperlocomotion: a mouse model for the genetics of clinical response to lithium
    • Gould T.D., O'Donnell K.C., Picchini A.M., Manji H.K. Strain differences in lithium attenuation of d-amphetamine-induced hyperlocomotion: a mouse model for the genetics of clinical response to lithium. Neuropsychopharmacology 2007, 32:1321-1333.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 1321-1333
    • Gould, T.D.1    O'Donnell, K.C.2    Picchini, A.M.3    Manji, H.K.4
  • 33
    • 0002427760 scopus 로고    scopus 로고
    • Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice
    • Holmes A., Wrenn C.C., Harris A.P., Thayer K.E., Crawley J.N. Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice. Genes Brain Behav 2002, 1:55-69.
    • (2002) Genes Brain Behav , vol.1 , pp. 55-69
    • Holmes, A.1    Wrenn, C.C.2    Harris, A.P.3    Thayer, K.E.4    Crawley, J.N.5
  • 34
    • 0033578272 scopus 로고    scopus 로고
    • Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests
    • Crawley J.N. Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests. Brain Res 1999, 835:18-26.
    • (1999) Brain Res , vol.835 , pp. 18-26
    • Crawley, J.N.1
  • 35
    • 84897366749 scopus 로고    scopus 로고
    • Age sensitivity of behavioral tests and brain substrates of normal aging in mice
    • Kennard J.A., Woodruff-Pak D.S. Age sensitivity of behavioral tests and brain substrates of normal aging in mice. Front Aging Neurosci 2011, 3:9.
    • (2011) Front Aging Neurosci , vol.3 , pp. 9
    • Kennard, J.A.1    Woodruff-Pak, D.S.2
  • 36
    • 81755186376 scopus 로고    scopus 로고
    • Impact of food restriction and cocaine on locomotion in ghrelin- and ghrelin-receptor knockout mice
    • Clifford S., Zeckler R.A., Buckman S., Thompson J., Hart N., Wellman P.J., et al. Impact of food restriction and cocaine on locomotion in ghrelin- and ghrelin-receptor knockout mice. Addict Biol 2010.
    • (2010) Addict Biol
    • Clifford, S.1    Zeckler, R.A.2    Buckman, S.3    Thompson, J.4    Hart, N.5    Wellman, P.J.6
  • 37
    • 31044451759 scopus 로고    scopus 로고
    • Mice lacking ghrelin receptors resist the development of diet-induced obesity
    • Zigman J.M., Nakano Y., Coppari R., Balthasar N., Marcus J.N., Lee C.E., et al. Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest 2005, 115:3564-3572.
    • (2005) J Clin Invest , vol.115 , pp. 3564-3572
    • Zigman, J.M.1    Nakano, Y.2    Coppari, R.3    Balthasar, N.4    Marcus, J.N.5    Lee, C.E.6
  • 38
    • 79952483790 scopus 로고    scopus 로고
    • Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in mice
    • Davis J.F., Choi D.L., Clegg D.J., Benoit S.C. Signaling through the ghrelin receptor modulates hippocampal function and meal anticipation in mice. Physiol Behav 2011, 103:39-43.
    • (2011) Physiol Behav , vol.103 , pp. 39-43
    • Davis, J.F.1    Choi, D.L.2    Clegg, D.J.3    Benoit, S.C.4
  • 39
    • 38549133092 scopus 로고    scopus 로고
    • Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance
    • Sun Y., Butte N.F., Garcia J.M., Smith R.G. Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance. Endocrinology 2008, 149:843-850.
    • (2008) Endocrinology , vol.149 , pp. 843-850
    • Sun, Y.1    Butte, N.F.2    Garcia, J.M.3    Smith, R.G.4
  • 40
    • 0034044741 scopus 로고    scopus 로고
    • Strain-dependent differences in LTP and hippocampus-dependent memory in inbred mice
    • Nguyen P.V., Abel T., Kandel E.R., Bourtchouladze R. Strain-dependent differences in LTP and hippocampus-dependent memory in inbred mice. Learn Mem 2000, 7:170-179.
    • (2000) Learn Mem , vol.7 , pp. 170-179
    • Nguyen, P.V.1    Abel, T.2    Kandel, E.R.3    Bourtchouladze, R.4
  • 41
    • 0037112316 scopus 로고    scopus 로고
    • Differential learning abilities of 129T2/Sv and C57BL/6J mice as assessed in three water maze protocols
    • Wolff M., Savova M., Malleret G., Segu L., Buhot M.C. Differential learning abilities of 129T2/Sv and C57BL/6J mice as assessed in three water maze protocols. Behav Brain Res 2002, 136:463-474.
    • (2002) Behav Brain Res , vol.136 , pp. 463-474
    • Wolff, M.1    Savova, M.2    Malleret, G.3    Segu, L.4    Buhot, M.C.5
  • 42
    • 33846482062 scopus 로고    scopus 로고
    • Feeling strained? Influence of genetic background on depression-related behavior in mice: a review
    • Jacobson L.H., Cryan J.F. Feeling strained? Influence of genetic background on depression-related behavior in mice: a review. Behav Genet 2007, 37:171-213.
    • (2007) Behav Genet , vol.37 , pp. 171-213
    • Jacobson, L.H.1    Cryan, J.F.2
  • 43
    • 9644252997 scopus 로고    scopus 로고
    • The individuality of mice
    • Lathe R. The individuality of mice. Genes Brain Behav 2004, 3:317-327.
    • (2004) Genes Brain Behav , vol.3 , pp. 317-327
    • Lathe, R.1
  • 44
    • 0027772145 scopus 로고
    • The aged mouse as a model of cognitive decline with special emphasis on studies in NMRI mice
    • Gower A.J., Lamberty Y. The aged mouse as a model of cognitive decline with special emphasis on studies in NMRI mice. Behav Brain Res 1993, 57:163-173.
    • (1993) Behav Brain Res , vol.57 , pp. 163-173
    • Gower, A.J.1    Lamberty, Y.2
  • 45
    • 34547734523 scopus 로고    scopus 로고
    • Age-related changes in visual acuity, learning and memory in C57BL/6J and DBA/2J mice
    • Wong A.A., Brown R.E. Age-related changes in visual acuity, learning and memory in C57BL/6J and DBA/2J mice. Neurobiol Aging 2007, 28:1577-1593.
    • (2007) Neurobiol Aging , vol.28 , pp. 1577-1593
    • Wong, A.A.1    Brown, R.E.2
  • 46
    • 33750036683 scopus 로고    scopus 로고
    • Subicular place cells generate the same map for different environments: comparison with hippocampal cells
    • Sharp P.E. Subicular place cells generate the same map for different environments: comparison with hippocampal cells. Behav Brain Res 2006, 174:206-214.
    • (2006) Behav Brain Res , vol.174 , pp. 206-214
    • Sharp, P.E.1
  • 47
    • 79952401018 scopus 로고    scopus 로고
    • Reduced spine density in specific regions of CA1 pyramidal neurons in two transgenic mouse models of Alzheimer's disease
    • Perez-Cruz C., Nolte M.W., van Gaalen M.M., Rustay N.R., Termont A., Tanghe A., et al. Reduced spine density in specific regions of CA1 pyramidal neurons in two transgenic mouse models of Alzheimer's disease. J Neurosci 2011, 31:3926-3934.
    • (2011) J Neurosci , vol.31 , pp. 3926-3934
    • Perez-Cruz, C.1    Nolte, M.W.2    van Gaalen, M.M.3    Rustay, N.R.4    Termont, A.5    Tanghe, A.6
  • 48
    • 34249933552 scopus 로고    scopus 로고
    • Anatomical and physiological plasticity of dendritic spines
    • Alvarez V.A., Sabatini B.L. Anatomical and physiological plasticity of dendritic spines. Annu Rev Neurosci 2007, 30:79-97.
    • (2007) Annu Rev Neurosci , vol.30 , pp. 79-97
    • Alvarez, V.A.1    Sabatini, B.L.2
  • 50
    • 77956794197 scopus 로고    scopus 로고
    • Associative learning and CA3-CA1 synaptic plasticity are impaired in D1R null, Drd1a-/- mice and in hippocampal siRNA silenced Drd1a mice
    • Ortiz O., Delgado-Garcia J.M., Espadas I., Bahi A., Trullas R., Dreyer J.L., et al. Associative learning and CA3-CA1 synaptic plasticity are impaired in D1R null, Drd1a-/- mice and in hippocampal siRNA silenced Drd1a mice. J Neurosci 2010, 30:12288-12300.
    • (2010) J Neurosci , vol.30 , pp. 12288-12300
    • Ortiz, O.1    Delgado-Garcia, J.M.2    Espadas, I.3    Bahi, A.4    Trullas, R.5    Dreyer, J.L.6
  • 51
    • 33645873908 scopus 로고    scopus 로고
    • Under the curve: critical issues for elucidating D1 receptor function in working memory
    • Williams G.V., Castner S.A. Under the curve: critical issues for elucidating D1 receptor function in working memory. Neuroscience 2006, 139:263-276.
    • (2006) Neuroscience , vol.139 , pp. 263-276
    • Williams, G.V.1    Castner, S.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.