The blood-brain barrier: Connecting the gut and the brain

Regulatory Peptides

Volumn 149, Issue 1-3, 2008, Pages 11-14

  Banks, William A ^a  

^a SAINT LOUIS UNIVERSITY   (United States)

Author keywords

Blood brain barrier; Central nervous system; Ghrelin; Gut brain interactions; Insulin; Leptin

Indexed keywords

AMINO ACID; AMYLIN; CYTOKINE; GASTROINTESTINAL HORMONE; GHRELIN; INSULIN; LEPTIN; NITRIC OXIDE; PANCREAS POLYPEPTIDE; SECRETIN; TRIACYLGLYCEROL;

AMINO ACID TRANSPORT; APPETITE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN; BRAIN FUNCTION; CYTOKINE RELEASE; ENDOTHELIUM CELL; ENZYME ACTIVITY; FEEDING; FOOD INTAKE; GASTROINTESTINAL TRACT; HORMONE METABOLISM; HUMAN; MOLECULAR DYNAMICS; NONHUMAN; PERICYTE; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVIEW;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CENTRAL NERVOUS SYSTEM; GASTROINTESTINAL TRACT; GHRELIN; HUMANS; INSULIN; LEPTIN; MODELS, BIOLOGICAL; PEPTIDE HORMONES;

EID: 48849085723     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2007.08.027     Document Type: Review

References (46)

1. Smith G.P., Gibbs J., Jerome C., Pi-Sunyer F.X., Kissileff H.R., and Thornton J. The satiety effect of cholecystokinin: a progress report. Peptides 2 Suppl 2 (1981) 57-59
2. Kelley K.W., Bluthe R.M., Dantzer R., Zhou J.H., Shen W.H., Johnson R.W., and Broussard S.R. Cytokine-induced sickness behavior. Brain Behav Immun 17 (2003) S112-S118
3. Romeo H.E., Tio D.L., Rahman S.U., Chiappelli F., and Taylor A.N. The glossopharyngeal nerve as a novel pathway in immune-to-brain communication: relevance to neuroimmune surveillance of the oral cavity. J Neuroimmunol 115 (2001) 91-100
4. Watkins L.R., Maier S.F., and Goehler L.E. Cytokine-to-brain communication: a review & analysis of alternative mechanisms. Life Sci 57 (1995) 1011-1026
5. Davson H., and Segal M.B. Physiology of the CSF and blood-brain barriers (1996), CRC Press, Boca Raton
6. Reese T.S., and Karnovsky M.J. Fine structural localization of a blood-brain barrier to exogenous peroxidase. J Cell Biol 34 (1967) 207-217
7. Gross P.M., and Weindl A. Peering through the windows of the brain. J Cereb Blood Flow Metab 7 (1987) 663-672
8. Johnson A.K. The neuroendocrinology of thirst and salt appetite-visceral sensory signals and mechanisms of central integration. Front Neuroendocrinol 18 (1997) 292-353
9. Morley J.E., Morley P.M.K., and Flood J.F. Anorectic effects of amylin in rats over the life span. Pharmacol Biochem Behav 44 (1993) 577-580
10. Riediger T., Schmid H.A., Lutz T., and Simon E. Amylin potently activates AP neurons possibly via formation of the excitatory second messenger cGMP. Am J Physiol 281 (2001) R1833-R1843
11. Mutt V., Carlquist M., and Tatemoto K. Secretin-like bioactivity in extracts of porcine brain. Life Sci 25 (1979) 1703-1707
12. Florant G.L., Singer L., Scheurink A.J.W., Park C.R., Richardson R.D., and Woods S.C. Intraventricular insulin reduces food intake and body weight of marmots during the summer feeding period. Physiol Behav 49 (1991) 335-338
13. Woods S.C., Seeley R.J., Baskin D.G., and Schwartz M.W. Insulin and the blood-brain barrier. Curr Pharm Des 9 (2003) 795-800
14. Banks W.A., and Kastin A.J. Physiological consequences of the passage of peptides across the blood-brain barrier. Rev Neurosci 4 (1993) 365-372
15. Banks W.A., Kastin A.J., Huang W., Jaspan J.B., and Maness L.M. Leptin enters the brain by a saturable system independent of insulin. Peptides 17 (1996) 305-311
16. Banks W.A., and Kastin A.J. Differential permeability of the blood-brain barrier to two pancreatic peptides: insulin and amylin. Peptides 19 (1998) 883-889
17. Banks W.A., Tschop M., Robinson S.M., and Heiman M.L. Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. J Pharmacol Exp Ther 302 (2002) 822-827
18. Grill H.J., Schwartz M.W., Kaplan J.M., Foxhall J.S., Breininger J., and Baskin D.G. Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake. Endocrinology 143 (2002) 239-246
19. Diano S., Farr S.A., Benoit S.E., McNay E.C., da Silva I., Horvath B., Gaskin F.S., Nonaka N., Jaeger J.B., Banks W.A., Morley J.E., Pinto S., Sherwin R.S., Xu L., Yamada K.A., Sleeman M.W., Tschop M.H., and Horvath T.L. Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci 9 (2006) 381-388
20. Gupta G., Azam M., and Baquer N.Z. Modulation of rat brain insulin receptor kinase activity in diabetes. Neurochem Int 20 (1992) 487-492
21. Banks W.A., Jaspan J.B., and Kastin A.J. Selective, physiological transport of insulin across the blood-brain barrier: novel demonstration by species-specific enzyme immunoassays. Peptides 18 (1997) 1257-1262
22. Banks W.A., Jaspan J.B., Huang W., and Kastin A.J. Transport of insulin across the blood-brain barrier: saturability at euglycemic doses of insulin. Peptides 18 (1997) 1423-1429
23. Xaio H., Banks W.A., Niehoff M.L., and Morley J.E. Effect of LPS on the permeability of the blood-brain barrier to insulin. Brain Res 896 (2001) 36-42
24. Dahn M.S., Lange M.P., Mitchell R.A., Lobdell K., and Wilson R.F. Insulin production following injury and sepsis. J Trauma Inj Infect Crit Care 27 (1987) 1031-1038
25. Vanhorebeck I., Langouche L., and Van den Berghe G. Glycemic and nonglycemic effects of insulin: how do they contribute to a better outcome of critical illness?. Curr Opin Crit Care 11 (2005) 304-344
26. Banks W.A., DiPalma C.R., and Farrell C.L. Impaired transport of leptin across the blood-brain barrier in obesity. Peptides 20 (1999) 1341-1345
27. Banks W.A., Clever C.M., and Farrell C.L. Partial saturation and regional variation in the blood to brain transport of leptin in normal weight mice. Am J Physiol 278 (2000) E1158-E1165
28. Banks W.A., Phillips-Conroy J.E., Jolly C.J., and Morley J.E. Serum leptin levels in wild and captive populations of baboons (Papio): implications for the ancestral role of leptin. J Clin Endocrinol Metab 86 (2001) 4315-4320
29. Banks W.A. Is obesity a disease of the blood-brain barrier? Physiological, pathological, and evolutionary considerations. Curr Pharm Des 9 (2003) 801-809
30. Banks W.A., Coon A.B., Robinson S.M., Moinuddin A., Shultz J.M., Nakaoke R., and Morley J.E. Triglycerides induce leptin resistance at the blood-brain barrier. Diabetes 53 (2004) 1253-1260
31. Cangiano C., Cardelli-Cangiano P., Cascino A., Patrizi M.A., Barberini F., Rossi F., Capocaccia L., and Strom R. On the stimulation by insulin of tryptophan transport across the blood-brain barrier. Biochem Int 7 (1983) 617-627
32. Ayre S.G., Skaletski B., and Mosnaim A.D. Blood-brain barrier passage of azidothymidine in rats: effect of insulin. Res Commun Chem Pathol Pharmacol 63 (1989) 45-52
33. Kastin A.J., and Akerstrom V. Glucose and insulin increase the transport of leptin through the blood-brain barrier in normal mice but not in streptozotocin-diabetic mice. Neuroendocrinology 73 (2001) 237-242
34. Catalan R.E., Martinez A.M., Aragones M.D., Miguel B.G., and Robles A. Insulin action on brain microvessels; effect on alkaline phosphatase. Biochem Biophys Res Commun 150 (1988) 583-590
35. Mandi Y., Ocsovszki I., Szabo D., Nagy Z., Nelson J., and Molnar J. Nitric oxide production and MDR expression by human brain endothelial cells. Anticancer Res 18 (1998) 3049-3052
36. Kis B., Kaiya H., Nishi R., Deli M.A., Abraham C.S., Yanagita T., Isse T., Gotoh S., Kobayashi H., Wada A., Niwa M., Kangawa K., Greenwood J., Yamashita H., and Ueta Y. Cerebral endothelial cells are a major source of adrenomedullin. J Neuroendocrinol 14 (2002) 283-293
37. Vadeboncoeur N., Segura M., Al-Numani D., Vanier G., and Gottschalk M. Proinflammatory cytokine and chemokine release by human brain microvascular endothelial cells stimulated by Streptococcus suis serotype 2. FEMS Immunol Med Microbiol 35 (2003) 49-58
38. Didier N., Banks W.A., Creminon C., Dereuddre-Bosquet N., and Mabondzo A. Endothelin-1 production at the in-vitro blood-brain barrier during HIV infection. Neuroreport 13 (2002) 1179-1183
39. Reyes T.M., Fabry Z., and Coe C.L. Brain endothelial cell production of a neuroprotective cytokine, interleukin-6, in response to noxious stimuli. Brain Res 851 (1999) 215-220
40. Verma S., Nakaoke R., Dohgu S., and Banks W.A. Release of cytokines by brain endothelial cells: a polarized response to lipopolysaccharide. Brain Behav Immun 20 (2006) 449-455
41. Fasshauer M., Kralisch S., Klier M., Lossner U., Bluher M., Klein J., and Paschke R. Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun 301 (2003) 1045-1050
42. Goldstein B.J., and Scalia R. Adiponectin: a novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metab 89 (2004) 2563-2568
43. Hattori Y., Suzuki M., Hattori S., and Kasai K. Globular adiponectin upregulates nitric oxide production in vascular endothelial cells. Diabetologia 46 (2003) 1543-1549
44. Ouchi N., Nihara S., Arita Y., Okamoto Y., Maeda K., Kuriyama H., Hotta K., Nishida M., Takahashi M., Muraguchi M., Ohmoto Y., Nakamura T., Yamashita S., Funahashi T., and Matsuzawa Y. Adiponectin, and adipocytes-derived plasma protein, inhibits endothelial NF-kappaß signaling through a cAMP-dependent pathway. Circulation 102 (2000) 1296-1301
45. Qi Y., Takahashi N., Hileman S.M., Patel H.R., Berg A.H., Pajvani U.B., Scherer P.E., and Ahima R.S. Adiponectin acts in the brain to decrease body weight. Nat Med 10 (2004) 524-529
46. Spranger J., Verma S., Gohring I., Bobbert T., Seifert J., Sindler A.L., Pfeiffer A., Hileman S.M., Tschop M., and Banks W.A. Adiponectin does not cross the blood-brain barrier, but modifies cytokine expression of brain endothelial cells. Diabetes 55 (2006) 141-147