Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers

Human Molecular Genetics

Volumn 14, Issue 8, 2005, Pages 997-1007

  Izumi, Hiroyuki ^a   Inoue, Jun ^a,b   Yokoi, Sana ^a,b   Hosoda, Hiroshi ^c   Shibata, Tatsuhiro ^d   Sunamori, Makoto ^a   Hirohashi, Setsuo ^d   Inazawa, Johji ^a,b   Imoto, Issei ^a,b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TOKYO KYOSAI HOSPITAL   (Japan)

^d NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGE; AGED; ARTICLE; CANCER STAGING; CELL GROWTH; CELL LINE; CHROMOSOME 9Q; CHROMOSOME ABERRATION; CIGARETTE SMOKING; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CPG ISLAND; EPIGENETICS; EXON; FEMALE; FREQUENCY ANALYSIS; GENE DELETION; GENE FREQUENCY; GENE OVEREXPRESSION; GENE SILENCING; GENOME ANALYSIS; GROWTH INHIBITION; HISTOLOGY; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; LUNG PARENCHYMA; MAJOR CLINICAL STUDY; MALE; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METHYLATION; SEX DIFFERENCE; TISSUE DISTRIBUTION;

AGED; ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; CARCINOMA, NON-SMALL-CELL LUNG; CHROMOSOMES, HUMAN, PAIR 9; CPG ISLANDS; DNA; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENE DELETION; GENE SILENCING; HUMANS; MALE; PROMOTER REGIONS (GENETICS); TUMOR SUPPRESSOR PROTEINS;

EID: 17744373486     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddi092     Document Type: Article

References (30)

1. Jemal, A., Tiwari, R.C., Murray, T., Ghafoor, A., Samuels, A., Ward, E., Feuer, E.J. and Thun, M.J. (2004) Cancer statistics, 2004. CA - Cancer J. Clin., 54, 8-29.
2. Statistics and Information Department, Minister's Secretariat. (2003) Vital Statistics of Japan 2001. Ministry of Health, Labour and Welfare, Tokyo, Vol. 3, pp. 384-411.
3. Snijders, A.M., Nowak, N., Segraves, R., Blackwood, S., Brown, N., Conroy, J., Hamilton, G., Hindle, A.K., Huey, B., Kimura, K. et al. (2001) Assembly of microarrays for genome-wide measurement of DNA copy number. Nat. Genet., 29, 263-264.
4. Albertson, D.G. and Pinkel, D. (2003) Genomic microarrays in human genetic disease and cancer. Hum. Mol. Genet., 12, 145-152.
5. Inazawa, J., Inoue, J. and Imoto, I. (2004) Comparative genomic hybridization (CGH)-arrays pave the way for identification of novel cancer-related genes. Cancer Sci., 95, 559-563.
6. Sonoda, I., Imoto, I., Inoue, J., Shibata, T., Shimada, Y., Chin, K., Imamura, M., Amagasa, T., Gray, J.W., Hirohashi, S. et al. (2004) Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma. Cancer Res., 64, 3741-3747.
7. Habuchi, T., Luscombe, M., Elder, P.A. and Knowles, M.A. (1998) Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33. Genomics, 48, 277-288.
8. Nishiyama, H., Hornigold, N., Davies, A.M. and Knowles, M.A. (1999) A sequence-ready 840-kb PAC config spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33. Genomics, 59 335-338.
9. Habuchi, T., Takahashi, T., Kakinuma, H., Wang, L., Tsuchiya, N., Satoh, S., Akao, T., Sato, K., Ogawa, O., Knowles, M.A. et al. (2001) Hypermethylation at 9q32-33 tumour suppressor region is age-related in normal urothelium and an early and frequent alteration in bladder cancer. Oncogene, 20, 531-537.
10. Merlo, A., Gabrielson, E., Mabry, M., Vollmer, R., Baylin, S.B. and Sidransky, D. (1994) Homozygous deletion on chromosome 9p and loss of heterozygosity on 9q, 6p, and 6q in primary human small cell lung cancer. Cancer Res., 54, 2322-2326.
11. Petersen, I., Bujard, M., Petersen, S., Wolf, G., Goeze, A., Schwendel, A., Langreck, H., Gellert, K., Reichel, M., Just, K. et al. (1997) Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung. Cancer Res., 57, 2331-2335.
12. Goeze, A., Schluns, K., Wolf, G., Thasler, Z., Petersen, S. and Petersen, I. (2002) Chromosomal imbalances of primary and metastatic lung adenocarcinomas. J. Pathol., 196, 8-16.
13. Balsara, B.R. and Testa, J.R. (2002) Chromosomal imbalances in human lung cancer. Oncogene, 21, 6877-6883.
14. Baylin, S.B., Herman, J.G., Graff, J.R., Vertino, P.M. and Issa, J.P. (1998) Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv. Cancer Res., 72, 141-196.
15. Esteller, M., Corn, P.G., Baylin, S.B. and Herman, J.G. (2001) A gene hypermethylation profile of human cancer. Cancer Res. 61, 3225-3229.
16. Bird, A.P. and Wolffe, A.P. (1999) Methylation-induced repression - belts, braces, and chromatin. Cell, 99, 451-454.
17. Cameron, E.E., Bachman, K.E., Myohanen, S., Herman, J.G. and Baylin, S.B. (1999) Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat. Genet., 21, 103-107.
18. Nguyen, C.T., Gonzales, F.A. and Jones, P.A. (2001) Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation. Nucleic Acids Res., 29, 4598-4606.
19. Imoto, I., Yuki, Y., Sonoda, I., Ito, T., Shimada, Y., Imamura, M. and Inazawa, J. (2003) Identification of ZASC1 encoding a Kruppel-like zinc finger protein as a novel target for 3q26 amplification in esophageal squamous cell carcinomas. Cancer Res., 63, 5691-5696.
20. Wright, K.O., Messing, E.M. and Reeder, J.E. (2004) DBCCR1 mediates death in cultured bladder tumor cells. Oncogene, 23, 82-90.
21. Yokoi, S., Yasui, K., Iizasa, T., Imoto, I., Fujisawa, T. and Inazawa, J. (2003) TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers. Clin. Cancer Res., 9, 4705-4713.
22. Gao, S., Worm, J., Guldberg, P., Eiberg, H., Krogdahl, A., Sorensen, J.A., Liu, C.J., Reibel, J. and Dabelsteen, E. (2004) Loss of heterozygosity at 9q33 and hypermethylation of the DBCCR1 gene in oral squamous cell carcinoma. Br. J. Cancer, 91, 760-764.
23. INK4a and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer. Cancer Res. 61, 3419-3424.
24. Belinsky, S.A., Palmisano, W.A., Gilliland, F.D., Crooks, L.A., Divine, K.K., Winters, S.A., Grimes, M.J., Harms, H.J., Tellez, C.S., Smith, T.M. et al. (2002) Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers. Cancer Res., 62, 2370-2377.
25. Kim, H., Kwon, Y.M., Kim, J.S., Lee, H., Park, J.H., Shim, Y.M., Han, J., Park, J. and Kim, D.H. (2004) Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer. J. Clin. Oncol., 22, 2363-2370.
26. Belinsky, S.A. (2004) Gene-promoter hypermethylation as a biomarker in lung cancer. Nat. Rev. Cancer, 4, 707-717.
27. Nishiyama, H., Gill, J.H., Pitt, E., Kennedy, W. and Knowles, M.A. (2001) Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1. Oncogene, 20, 2956-2964.
28. Noguchi, M., Furuya, S., Takeuchi, T. and Hirohashi, S. (1997) Modified formalin and methanol fixation methods for molecular biological and morphological analyses. Pathol. Int., 47, 685-691.
29. Yuki, Y., Imoto, I., Imaizumi, M., Hibi, S., Kaneko, Y., Amagasa, T. and Inazawa J. (2004) Identification of a novel fusion gene in a pre-B acute lymphoblastic leukemia with t(1;19)(q23;p13). Cancer Sci., 95, 503-507.
30. Tanabe, C., Aoyagi, K., Sakiyama, T., Kohno, T., Yanagitani, N., Akimoto, S., Sakamoto, M., Sakamoto, H., Yokota, J., Ohki, M. et al. (2003) Evaluation of a whole-genome amplification method based on adaptor-ligation PCR of randomly sheared genomic DNA. Genes Chromosomes Cancer, 38, 168-176.