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Volumn 13, Issue 1, 2003, Pages 9-14

Transformation of ginsenosides to compound K (IH-901) by lactic acid bacteria of human intestine

Author keywords

Compound K; Cytotoxicity; Ginsenosides; Lactic acid bacteria

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; GINSENG EXTRACT; GINSENOSIDE; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; PRODRUG; PROTOPANAXADIOL 20 GLUCOSIDE; UNCLASSIFIED DRUG; WATER;

EID: 0037300761     PISSN: 10177825     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (56)

References (17)
  • 1
    • 85009708837 scopus 로고    scopus 로고
    • Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration measurement of compound K by enzyme immunoassay
    • Akao, T., M. Kanaoka, and K. Kobashi. 1998. Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration measurement of compound K by enzyme immunoassay. Biol. Pharm. Bull. 21: 245-249.
    • (1998) Biol. Pharm. Bull. , vol.21 , pp. 245-249
    • Akao, T.1    Kanaoka, M.2    Kobashi, K.3
  • 2
    • 0031736410 scopus 로고    scopus 로고
    • Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng
    • Akao, T., H. Kida, M. Kanaoka, M. Hattori, and K. Kobashi. 1998. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J. Pharm. Pharmacol. 50: 1155-1160.
    • (1998) J. Pharm. Pharmacol. , vol.50 , pp. 1155-1160
    • Akao, T.1    Kida, H.2    Kanaoka, M.3    Hattori, M.4    Kobashi, K.5
  • 3
    • 0034536269 scopus 로고    scopus 로고
    • Constitutive β-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria
    • Bae, E.-A., S.-Y. Park, and D.-H. Kim. 2000. Constitutive β-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol. Pharm. Bull. 23: 1481-1485.
    • (2000) Biol. Pharm. Bull. , vol.23 , pp. 1481-1485
    • Bae, E.-A.1    Park, S.-Y.2    Kim, D.-H.3
  • 4
    • 0036370799 scopus 로고    scopus 로고
    • Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities
    • Bae, E. A., M. J. Han, M.-K. Choo, S.-Y. Park, and D.-H. Kim. 2002. Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol. Pharm. Bull. 25: 58-63.
    • (2002) Biol. Pharm. Bull. , vol.25 , pp. 58-63
    • Bae, E.A.1    Han, M.J.2    Choo, M.-K.3    Park, S.-Y.4    Kim, D.-H.5
  • 5
    • 0023130372 scopus 로고
    • Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing
    • Carmichael, J., W. G. DeGreff, A. F. Gazdar, J. D. Minna, and J. B. Mitchell. 1987. Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing. Cancer Res. 47: 936-940.
    • (1987) Cancer Res. , vol.47 , pp. 936-940
    • Carmichael, J.1    DeGreff, W.G.2    Gazdar, A.F.3    Minna, J.D.4    Mitchell, J.B.5
  • 6
    • 0030864673 scopus 로고    scopus 로고
    • Role of human intestinal Prevotella oris in hydrolyzing Ginseng saponis
    • Hasegawa, H., J.-W. Sung, and Y. Benno. 1997. Role of human intestinal Prevotella oris in hydrolyzing Ginseng saponis. Planta Medica 63: 436-440.
    • (1997) Planta Medica , vol.63 , pp. 436-440
    • Hasegawa, H.1    Sung, J.-W.2    Benno, Y.3
  • 7
    • 0026516250 scopus 로고
    • Studies on the enzyme immunoassay of bioactive constituents contained in oriental medicinal drugs. VI. Enzyme immunoassay of ginsenoside Rb1 from Panax ginseng
    • Kanaoka, M., H. Kato, F. Shimada, and S. Yano. 1992. Studies on the enzyme immunoassay of bioactive constituents contained in oriental medicinal drugs. VI. Enzyme immunoassay of ginsenoside Rb1 from Panax ginseng. Chem. Pharm. Bull. 40: 314-317.
    • (1992) Chem. Pharm. Bull. , vol.40 , pp. 314-317
    • Kanaoka, M.1    Kato, H.2    Shimada, F.3    Yano, S.4
  • 8
    • 0000370568 scopus 로고
    • Metabolism of ginseng saponins, ginsenosides, by human intestinal bacteria
    • Kanaoka, M., T. Akao, and K. Kobashi. 1994. Metabolism of ginseng saponins, ginsenosides, by human intestinal bacteria. J. Tradit. Med. 11: 241-245.
    • (1994) J. Tradit. Med. , vol.11 , pp. 241-245
    • Kanaoka, M.1    Akao, T.2    Kobashi, K.3
  • 9
    • 0025946582 scopus 로고
    • Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside Rb1 and Rb2 in the digestive tract of rats
    • Karikura, M., T. Miyaze, H. Tanizawa, T. Taniyzma, and Y. Takino. 1991. Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside Rb1 and Rb2 in the digestive tract of rats. Chem. Pharm. Bull. 38: 2357-2361.
    • (1991) Chem. Pharm. Bull. , vol.38 , pp. 2357-2361
    • Karikura, M.1    Miyaze, T.2    Tanizawa, H.3    Taniyzma, T.4    Takino, Y.5
  • 10
    • 0034928571 scopus 로고    scopus 로고
    • Physiological responses of oxygen-tolerant anaerobic Bifidobacterium longum under oxygen
    • Kim, D.-W., H.-J. Hwang, and K.-H. Park. 2001. Physiological responses of oxygen-tolerant anaerobic Bifidobacterium longum under oxygen. J. Microbiol. Biotechnol. 11: 443-451.
    • (2001) J. Microbiol. Biotechnol. , vol.11 , pp. 443-451
    • Kim, D.-W.1    Hwang, H.-J.2    Park, K.-H.3
  • 11
    • 0032782069 scopus 로고    scopus 로고
    • Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin
    • Lee, S. J., J. H. Sung, S. J. Lee, C. K. Moon, and B. H. Lee. 1999. Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin. Cancer Lett. 144: 39-43.
    • (1999) Cancer Lett. , vol.144 , pp. 39-43
    • Lee, S.J.1    Sung, J.H.2    Lee, S.J.3    Moon, C.K.4    Lee, B.H.5
  • 13
    • 0029098678 scopus 로고
    • Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside Rb2, 20(R)- and 20(S)-ginsenoside Rg3, of Red ginseng
    • Mochizuki, M., C. Y. Yoo, K. Matsuzawa, K. Sato, I. Saiki, S. Tono-oka, K. Samukawa, and I. Azuma. 1995. Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside Rb2, 20(R)- and 20(S)-ginsenoside Rg3, of Red ginseng. Biol. Pharm. Bull. 18: 1197-1202.
    • (1995) Biol. Pharm. Bull. , vol.18 , pp. 1197-1202
    • Mochizuki, M.1    Yoo, C.Y.2    Matsuzawa, K.3    Sato, K.4    Saiki, I.5    Tono-oka, S.6    Samukawa, K.7    Azuma, I.8
  • 14
    • 85008118525 scopus 로고
    • Chemical studies on the oriental plant drugs. XXVIII. Saponins and sapogenins of ginseng; Stereochemistry of sapogenin of ginsenoside Rb1, Rb2 and Rc
    • Tanaka, N., O. Tanaka, and S. Shibata. 1972. Chemical studies on the oriental plant drugs. XXVIII. Saponins and sapogenins of ginseng; Stereochemistry of sapogenin of ginsenoside Rb1, Rb2 and Rc. Chem. Pharm. Bull. 20: 1212-1216.
    • (1972) Chem. Pharm. Bull. , vol.20 , pp. 1212-1216
    • Tanaka, N.1    Tanaka, O.2    Shibata, S.3
  • 15
    • 0028340930 scopus 로고
    • Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng - Ginsenoside Rb2
    • Sato, K., M. Mochizuki, I. Saiki, Y. C. Yoo, K. Samukawa, and I. Azuma. 1994. Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng - ginsenoside Rb2. Biol. Pharm. Bull. 17: 635-639.
    • (1994) Biol. Pharm. Bull. , vol.17 , pp. 635-639
    • Sato, K.1    Mochizuki, M.2    Saiki, I.3    Yoo, Y.C.4    Samukawa, K.5    Azuma, I.6
  • 16
    • 0031303557 scopus 로고    scopus 로고
    • In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration
    • Wakabayashi, C., H. Hasegawa, J. Murata, and I. Saiki. 1998. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol. Res. 9: 411-417.
    • (1998) Oncol. Res. , vol.9 , pp. 411-417
    • Wakabayashi, C.1    Hasegawa, H.2    Murata, J.3    Saiki, I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.