Studies on absorption, distribution and metabolism of ginseng in humans after oral administration

Journal of Ethnopharmacology

Volumn 122, Issue 1, 2009, Pages 143-148

  Lee, Jayeul ^a   Lee, Euiju ^a   Kim, Donghyun ^b   Lee, Junhee ^a   Yoo, Junghee ^a   Koh, Byunghee ^a  

^a Kyung Hee University College of Medicine   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

ADME; Compound K; Ginseng; Ginsenoside Rb1

Indexed keywords

20 O BETA DEXTRO GLUCOPYRANOSYL 20 PROTOPANAXADIOL; GINSENG EXTRACT; GINSENOSIDE RB 1; PROTOPANAXADIOL; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CORRELATION ANALYSIS; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG TRANSFORMATION; HUMAN; INTESTINE FLORA; MALE; MAXIMUM PLASMA CONCENTRATION; QUANTITATIVE ASSAY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; FECES; GINSENOSIDES; HUMANS; INTESTINES; PANAX; PLANT EXTRACTS;

PANAX GINSENG;

EID: 59849098283     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.12.012     Document Type: Article

References (28)

1. Akao T., Kanaoka M., and Kobashi K. Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral administration-measurement of compound K by enzyme immunoassay. Biological & Pharmaceutical Bulletin 21 (1998) 245-249
2. Akao T., Kida H., Kanaoka M., Hattori M., and Kobashi K. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. Journal of Pharmacokinetics and Pharmacodynamics 50 (1998) 1155-1160
3. Bae E.A., Park S.Y., and Kim D.H. Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biological & Pharmaceutical Bulletin 23 (2000) 1481-1485
4. Chi H., Kim D.H., and Ji G.E. Transformation of ginsenosides Rb2 and Rc from Panax ginseng by food microorganisms. Biological & Pharmaceutical Bulletin 28 (2005) 2102-2105
5. Cui J.F., Bjorkhem I., and Eneroth P. Gas chromatographic-mass spectrometric determination of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol for study on human urinary excretion of ginsenosides after ingestion of ginseng preparations. Journal of Chromatography B: Biomedical Sciences and Applications 689 (1997) 349-435
6. Eliason B.C., Kruger J., Mark D., and Rasman D.N. Dietary supplement users: demographic, product use and medical system interaction. Journal of the American Board of Family Practice 10 (1997) 265-271
7. Gruenwald J., and Buettel K. The European phytomedicines market-figures, trends, analyses. Drugs made in Germany 39 (1996) 6-11
8. Harnack L.J., Rydall S.A., and Stang J. Prevalence of use of herbal products by adults in the Minneapolis/St. Paul, Minn, metropolitan area. Mayo Clinic Proceedings 76 (2001) 688-694
9. Hasegawa H., and Uchiyama M. Antimetastatic efficacy of orally administered ginsenoside Rb1 in dependence on intestinal bacterial hydrolyzing potential and significance of treatment with an active bacterial metabolite. Planta Medicine 64 (1998) 696-700
10. Hasegawa H., Sung J.H., Matsumiya S., and Uchiyama M. Main ginseng metabolites formed by intestinal bacteria. Planta Medicine 63 (1996) 453-455
11. Hasegawa H., Sung J.H., and Benno Y. Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins. Planta Medicine 63 (1997) 436-440
12. Karikura M., Miyase T., Tanizawa H., Takino Y., Taniyama T., and Hayashi T. Studies on absorption, distribution, excretion and metabolism of ginsengsaponins. V. The decomposition products of ginsenoside Rb2 in the large intestine of rats. Chemical & Pharmaceutical Bulletin 38 (1990) 2859-3286
13. Karikura M., Miyase T., Tanizawa H., Taniyama T., and Takino Y. Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VI. The decomposition products of ginsenoside Rb2 in the stomach of rats. Chemical & Pharmaceutical Bulletin 39 (1991) 400-404
14. Karikura M., Miyase T., Tanizawa H., Taniyama T., and Takino Y. Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats. Chemical & Pharmaceutical Bulletin 39 (1991) 2357-2361
15. Lee S.J., Sung J.H., Lee S.J., Moon C.K., and Lee B.H. Antitumor activity of a novel ginseng saponin metabolite in human pulmonary adenocarcinoma cells resistant to cisplatin. Cancer Letters 144 (1999) 39-44
16. Lee D.K., Kim Y.S., Ko C.N., Cho K.H., Bae H.S., Lee K.S., Kim J.J., Park E.K., and Kim D.H. Fecal metabolic activities of herbal components to bioactive compounds. Archives of Pharmacal Research 25 (2002) 165-169
17. Lee H.U., Bae E.A., Han M.J., Kim N.J., and Kim D.H. Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury. Liver International 25 (2005) 1069-1073
18. Li L., Sheng Y., Zhang J., Wang C., and Guo D. HPLC determination of four active saponins from Panax notoginseng in rat serum and its application to pharmacokinetic studies. Biomedical Chromatography 18 (2004) 849-856
19. Li K., Chen X., Xu J., Li X., and Zhong D. Liquid chromatography tandem/mass spectrometry for pharmacokinetic studies of 20(R)-ginsenoside Rg3 in dog. Communication Mass Spectrometry 19 (2005) 813-817
20. Mochizuki M., Yoo Y.C., Matsuzawa K., Sato K., Saiki I., Tono-oka S., Samukawa K., and Azuma I. Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng. Biological & Pharmaceutical Bulletin 18 (1995) 1197-1202
21. Odani T., Tanizawa H., and Takino Y. Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. II. The absorption, distribution and excretion of ginsenoside Rg1 in the rat. Chemical & Pharmaceutical Bulletin 31 (1983) 292-298
22. Shibata S. Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds. Journal of Korean Medical Science 16 (2001) S28-S37
23. Shibata S., Fujita M., Itokawa H., and Tanaka O. Studies on the constituents of Japanese and Chinese crude drugs. XI. Panaxadiol, A Sapogenin of ginseng roots. Chemical & Pharmaceutical Bulletin 11 (1963) 759-764
24. Stömbom J., Sandberg F., and Dencker L. Studies on absorption, distribution and excretion of ginsenoside Rg1 by whole-body autoradiography and chromatography. Acta Pharmaceutica Suecica 22 (1985) 113-122
25. Tawab M.A., Bahr U., Karas M., Wurglics M., and Schubert-Zsilavecz M. Degradation of ginsenosides in humans after oral administration. Journal of Immunology 148 (2003) 2357-2362
26. Wakabayashi C., Hasegawa H., Murata J., and Saiki I. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncology Research 9 (1997) 411-417
27. Xie H.T., Wang G.J., Sun J.G., Tucker I., Zhao X.C., Xie Y.Y., Li H., Jiang X.L., Wang R., Xu M.J., and Wang W. High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase ion for pharmacokinetic studies. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 818 (2005) 167-173
28. Yim J.S., Kim Y.S., Moon S.K., Cho K.H., Bae H.S., Kim J.J., Park E.K., and Kim D.H. Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora. Biological & Pharmaceutical Bulletin 27 (2004) 1580-1583