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Volumn 18, Issue 2, 2012, Pages 117-123

Molecular testing in melanoma

Author keywords

BRAF; copy number; direct sequencing; KIT; Melanoma; molecular testing; next generation sequencing; NRAS; single nucleotide extension; somatic mutation testing

Indexed keywords

B RAF KINASE; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN GNA11; PROTEIN GNAQ; PROTEIN KIT; PROTEIN NRAS; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

EID: 84859471285     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0b013e31824f11bf     Document Type: Review
Times cited : (20)

References (93)
  • 1
    • 79958043675 scopus 로고    scopus 로고
    • Bethesda, MD: National Cancer Institute Accessed on December 1, 2011
    • Howlader NA, Krapcho M, Neyman N, et al, eds. SEER Cancer Statistics Review 1975-2008. Bethesda, MD: National Cancer Institute; 2011. Available at: http://seer.cancer.gov/csr/1975-2008/. Accessed on December 1, 2011.
    • (2011) SEER Cancer Statistics Review 1975-2008
    • Howlader, N.A.1    Krapcho, M.2    Neyman, N.3
  • 2
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A, Robert C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;364:2507-2516.
    • (2011) N Engl J Med. , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 3
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363:711-723.
    • (2010) N Engl J Med. , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 4
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011; 364:2517-2526.
    • (2011) N Engl J Med. , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 6
    • 0033848628 scopus 로고    scopus 로고
    • High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: Long-term survival update
    • Atkins MB, Kunkel L, Sznol M, et al. High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: long-term survival update. Cancer J Sci Am 6 Suppl. 2000;1:S11-S14.
    • (2000) Cancer J Sci Am 6 Suppl. , vol.1
    • Atkins, M.B.1    Kunkel, L.2    Sznol, M.3
  • 9
    • 77951464173 scopus 로고    scopus 로고
    • Molecular therapeutic approaches to melanoma
    • Ji Z, Flaherty KT, Tsao H. Molecular therapeutic approaches to melanoma. Mol Aspects Med. 2010;31:194-204.
    • (2010) Mol Aspects Med. , vol.31 , pp. 194-204
    • Ji, Z.1    Flaherty, K.T.2    Tsao, H.3
  • 10
    • 65649090993 scopus 로고    scopus 로고
    • BRAF signaling and targeted therapies in melanoma
    • ix
    • Dhomen N, Marais R. BRAF signaling and targeted therapies in melanoma. Hematol Oncol Clin North Am. 2009;23:529-545, ix.
    • (2009) Hematol Oncol Clin North Am. , vol.23 , pp. 529-545
    • Dhomen, N.1    Marais, R.2
  • 15
    • 68849120567 scopus 로고    scopus 로고
    • KRAS mutation testing in colorectal cancer
    • Plesec TP, Hunt JL. KRAS mutation testing in colorectal cancer. Adv Anat Pathol. 2009;16:196-203.
    • (2009) Adv Anat Pathol. , vol.16 , pp. 196-203
    • Plesec, T.P.1    Hunt, J.L.2
  • 16
    • 79958066836 scopus 로고    scopus 로고
    • KIT as a therapeutic target in metastatic melanoma
    • Carvajal RD, Antonescu CR, Wolchok JD, et al. KIT as a therapeutic target in metastatic melanoma. JAMA. 2011;305:2327-2334.
    • (2011) JAMA. , vol.305 , pp. 2327-2334
    • Carvajal, R.D.1    Antonescu, C.R.2    Wolchok, J.D.3
  • 17
    • 84856009717 scopus 로고    scopus 로고
    • Phase II, open-label, randomized trial of the MEK 1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma
    • Kirkwood JM, Bastholt L, Robert C, et al. Phase II, open-label, randomized trial of the MEK 1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma. Clin Cancer Res. 2012;18:555-567.
    • (2012) Clin Cancer Res. , vol.18 , pp. 555-567
    • Kirkwood, J.M.1    Bastholt, L.2    Robert, C.3
  • 18
    • 78650008177 scopus 로고    scopus 로고
    • Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
    • Villanueva J, Vultur A, Lee JT, et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell. 2010; 18:683-695.
    • (2010) Cancer Cell. , vol.18 , pp. 683-695
    • Villanueva, J.1    Vultur, A.2    Lee, J.T.3
  • 19
    • 34548682537 scopus 로고    scopus 로고
    • Pyrosequencing applications
    • Marsh S. Pyrosequencing applications. Methods Mol Biol. 2007;373: 15-24.
    • (2007) Methods Mol Biol. , vol.373 , pp. 15-24
    • Marsh, S.1
  • 20
    • 67449158731 scopus 로고    scopus 로고
    • Pyrosequencing method to detect KRAS mutation in formalin-fixed and paraffin-embedded tumor tissues
    • Dufort S, Richard MJ, de Fraipont F. Pyrosequencing method to detect KRAS mutation in formalin-fixed and paraffin-embedded tumor tissues. Anal Biochem. 2009;391:166-168.
    • (2009) Anal Biochem. , vol.391 , pp. 166-168
    • Dufort, S.1    Richard, M.J.2    De Fraipont, F.3
  • 22
    • 67649382929 scopus 로고    scopus 로고
    • AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
    • Vasudevan KM, Barbie DA, Davies MA, et al. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell. 2009;16:21-32.
    • (2009) Cancer Cell. , vol.16 , pp. 21-32
    • Vasudevan, K.M.1    Barbie, D.A.2    Davies, M.A.3
  • 23
    • 62249112106 scopus 로고    scopus 로고
    • Personalized cancer therapy gets closer
    • Hayden EC. Personalized cancer therapy gets closer. Nature. 2009; 458:131-132.
    • (2009) Nature. , vol.458 , pp. 131-132
    • Hayden, E.C.1
  • 24
    • 70350064529 scopus 로고    scopus 로고
    • A SNaPshot assay for the rapid and simple detection of four common hotspot codon mutations in the PIK3CA gene
    • Hurst CD, Zuiverloon TC, Hafner C, et al. A SNaPshot assay for the rapid and simple detection of four common hotspot codon mutations in the PIK3CA gene. BMC Res Notes. 2009;2:66.
    • (2009) BMC Res Notes. , vol.2 , pp. 66
    • Hurst, C.D.1    Zuiverloon, T.C.2    Hafner, C.3
  • 25
    • 33746610267 scopus 로고    scopus 로고
    • Matrix-assisted laser desorption/ionisation, time-of-flight mass spectrometry in genomics research
    • Ragoussis J, Elvidge GP, Kaur K, et al. Matrix-assisted laser desorption/ionisation, time-of-flight mass spectrometry in genomics research. PLoS Genet. 2006;2:e100.
    • (2006) PLoS Genet. , vol.2
    • Ragoussis, J.1    Elvidge, G.P.2    Kaur, K.3
  • 26
    • 70849116358 scopus 로고    scopus 로고
    • Profiling critical cancer gene mutations in clinical tumor samples
    • MacConaill LE, Campbell CD, Kehoe SM, et al. Profiling critical cancer gene mutations in clinical tumor samples. PLoS One. 2009;4:e7887.
    • (2009) PLoS One. , vol.4
    • MacConaill, L.E.1    Campbell, C.D.2    Kehoe, S.M.3
  • 27
    • 84856260422 scopus 로고    scopus 로고
    • Defining the prognosis of early stage chronic lymphocytic leukaemia patients
    • Pepper C, Majid A, Lin TT, et al. Defining the prognosis of early stage chronic lymphocytic leukaemia patients. Br J Haematol. 2012; 156:499-507.
    • (2012) Br J Haematol. , vol.156 , pp. 499-507
    • Pepper, C.1    Majid, A.2    Lin, T.T.3
  • 28
    • 82355181581 scopus 로고    scopus 로고
    • Acute myeloid leukemia: Conventional cytoge-netics FISH and moleculocentric methodologies
    • x
    • Morrissette JJ, Bagg A. Acute myeloid leukemia: conventional cytoge-netics, FISH, and moleculocentric methodologies. Clin Lab Med. 2011; 31:659-686, x.
    • (2011) Clin Lab Med. , vol.31 , pp. 659-686
    • Morrissette, J.J.1    Bagg, A.2
  • 29
    • 84860766821 scopus 로고    scopus 로고
    • Histologic subtypes, immuno-histochemistry, FISH or molecular screening for the accurate diagnosis of ALK-rearrangement in lung cancer: A comprehensive study of Caucasian non-smokers. [Epub ahead of print December 6, 2011.]
    • Just PA, Cazes A, Audebourg A, et al. Histologic subtypes, immuno-histochemistry, FISH or molecular screening for the accurate diagnosis of ALK-rearrangement in lung cancer: a comprehensive study of Caucasian non-smokers. [Epub ahead of print December 6, 2011.] Lung Cancer. 2011.
    • (2011) Lung Cancer.
    • Just, P.A.1    Cazes, A.2    Audebourg, A.3
  • 30
    • 84355162843 scopus 로고    scopus 로고
    • Genomic gains and losses in malignant mesothelioma demonstrated by FISH analysis of paraffin-embedded tissues
    • Takeda M, Kasai T, Enomoto Y, et al. Genomic gains and losses in malignant mesothelioma demonstrated by FISH analysis of paraffin-embedded tissues. J Clin Pathol. 2012;65:77-82.
    • (2012) J Clin Pathol. , vol.65 , pp. 77-82
    • Takeda, M.1    Kasai, T.2    Enomoto, Y.3
  • 31
    • 84859459321 scopus 로고    scopus 로고
    • Fluorescence in-situ hybridization analysis for melanoma diagnosis. [published online ahead of print October 18, 2011]
    • Senetta R, Paglierani M, Massi D. Fluorescence in-situ hybridization analysis for melanoma diagnosis. [published online ahead of print October 18, 2011] Histopathology.
    • Histopathology
    • Senetta, R.1    Paglierani, M.2    Massi, D.3
  • 32
    • 80052655057 scopus 로고    scopus 로고
    • Differentiation of melanoma and benign nevi by fluorescence in-situ hybridization
    • Hossain D, Qian J, Adupe J, et al. Differentiation of melanoma and benign nevi by fluorescence in-situ hybridization. Melanoma Res. 2011; 21:426-430.
    • (2011) Melanoma Res. , vol.21 , pp. 426-430
    • Hossain, D.1    Qian, J.2    Adupe, J.3
  • 33
    • 0036463808 scopus 로고    scopus 로고
    • Cancer genomics
    • DOI 10.1016/S1535-6108(02)00026-0
    • Weber BL. Cancer genomics. Cancer Cell. 2002;1:37-47. (Pubitemid 41039174)
    • (2002) Cancer Cell , vol.1 , Issue.1 , pp. 37-47
    • Weber, B.L.1
  • 34
    • 0025979843 scopus 로고
    • Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: A Pediatric Oncology Group study
    • Look AT, Hayes FA, Shuster JJ, et al. Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a Pediatric Oncology Group study. J Clin Oncol. 1991;9:581-591.
    • (1991) J Clin Oncol. , vol.9 , pp. 581-591
    • Look, A.T.1    Hayes, F.A.2    Shuster, J.J.3
  • 36
    • 34047258036 scopus 로고    scopus 로고
    • Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays
    • DOI 10.1158/0008-5472.CAN-06-4152
    • Stark M, Hayward N. Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays. Cancer Res. 2007;67:2632-2642. (Pubitemid 46548950)
    • (2007) Cancer Research , vol.67 , Issue.6 , pp. 2632-2642
    • Stark, M.1    Hayward, N.2
  • 37
    • 77953500573 scopus 로고    scopus 로고
    • Somatic alterations in the melanoma genome: A high-resolution array-based comparative genomic hybridization study
    • Gast A, Scherer D, Chen B, et al. Somatic alterations in the melanoma genome: a high-resolution array-based comparative genomic hybridization study. Genes Chromosomes Cancer. 2010;49:733-745.
    • (2010) Genes Chromosomes Cancer. , vol.49 , pp. 733-745
    • Gast, A.1    Scherer, D.2    Chen, B.3
  • 40
    • 3543023204 scopus 로고    scopus 로고
    • Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification
    • Schouten JP, McElgunn CJ, Waaijer R, et al. Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification. Nucleic Acids Res. 2002;30:e57.
    • (2002) Nucleic Acids Res. , vol.30
    • Schouten, J.P.1    McElgunn, C.J.2    Waaijer, R.3
  • 41
    • 59449105394 scopus 로고    scopus 로고
    • New applications and developments in the use of multiplex ligation-dependent probe amplification
    • Kozlowski P, Jasinska AJ, Kwiatkowski DJ. New applications and developments in the use of multiplex ligation-dependent probe amplification. Electrophoresis. 2008;29:4627-4636.
    • (2008) Electrophoresis. , vol.29 , pp. 4627-4636
    • Kozlowski, P.1    Jasinska, A.J.2    Kwiatkowski, D.J.3
  • 42
    • 52049088505 scopus 로고    scopus 로고
    • The relative contribution of point mutations and genomic rearrangements in BRCA1 and BRCA2 in high-risk breast cancer families
    • Palma MD, Domchek SM, Stopfer J, et al. The relative contribution of point mutations and genomic rearrangements in BRCA1 and BRCA2 in high-risk breast cancer families. Cancer Res. 2008;68:7006-7014.
    • (2008) Cancer Res. , vol.68 , pp. 7006-7014
    • Palma, M.D.1    Domchek, S.M.2    Stopfer, J.3
  • 43
    • 70349792450 scopus 로고    scopus 로고
    • Clinical genetic testing for familial melanoma in Italy: A cooperative study
    • Bruno W, Ghiorzo P, Battistuzzi L, et al. Clinical genetic testing for familial melanoma in Italy: a cooperative study. J Am Acad Dermatol. 2009;61:775-782.
    • (2009) J Am Acad Dermatol. , vol.61 , pp. 775-782
    • Bruno, W.1    Ghiorzo, P.2    Battistuzzi, L.3
  • 44
    • 70949098730 scopus 로고    scopus 로고
    • Identification of chromosomal abnormalities relevant to prognosis in chronic lymphocytic leukemia using multiplex ligation-dependent probe amplification
    • Stevens-Kroef M, Simons A, Gorissen H, et al. Identification of chromosomal abnormalities relevant to prognosis in chronic lymphocytic leukemia using multiplex ligation-dependent probe amplification. Cancer Genet Cytogenet. 2009;195:97-104.
    • (2009) Cancer Genet Cytogenet. , vol.195 , pp. 97-104
    • Stevens-Kroef, M.1    Simons, A.2    Gorissen, H.3
  • 45
    • 80053508491 scopus 로고    scopus 로고
    • Whole cancer genome sequencing by next-generation methods
    • Ross JS, Cronin M. Whole cancer genome sequencing by next-generation methods. Am J Clin Pathol. 2011;136:527-539.
    • (2011) Am J Clin Pathol. , vol.136 , pp. 527-539
    • Ross, J.S.1    Cronin, M.2
  • 46
    • 74449093973 scopus 로고    scopus 로고
    • A comprehensive catalogue of somatic mutations from a human cancer genome
    • Pleasance ED, Cheetham RK, Stephens PJ, et al. A comprehensive catalogue of somatic mutations from a human cancer genome. Nature. 2010;463:191-196.
    • (2010) Nature. , vol.463 , pp. 191-196
    • Pleasance, E.D.1    Cheetham, R.K.2    Stephens, P.J.3
  • 48
    • 67349149403 scopus 로고    scopus 로고
    • Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma
    • Palavalli LH, Prickett TD, Wunderlich JR, et al. Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma. Nat Genet. 2009;41:518-520.
    • (2009) Nat Genet. , vol.41 , pp. 518-520
    • Palavalli, L.H.1    Prickett, T.D.2    Wunderlich, J.R.3
  • 49
    • 0025264931 scopus 로고
    • Isolation by polymerase chain reaction of a cDNA whose product partially complements the ultraviolet sensivity of xeroderma pigmentosum group C cells
    • DOI 10.1016/0378-1119(90)90316-J
    • Teitz T, Penner M, Eli D, et al. Isolation by polymerase chain reaction of a cDNA whose product partially complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells. Gene. 1990;87: 295-298. (Pubitemid 20146053)
    • (1990) Gene , vol.87 , Issue.2 , pp. 295-298
    • Teitz, T.1    Penner, M.2    Eli, D.3    Stark, M.4    Bakhanashvili, M.5    Naiman, T.6    Canaani, D.7
  • 50
    • 33745751085 scopus 로고    scopus 로고
    • Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
    • Liang C, Feng P, Ku B, et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol. 2006; 8:688-699.
    • (2006) Nat Cell Biol. , vol.8 , pp. 688-699
    • Liang, C.1    Feng, P.2    Ku, B.3
  • 51
    • 85027946522 scopus 로고    scopus 로고
    • Exome sequencing identifies GRIN2A as frequently mutated in melanoma
    • Wei X, Walia V, Lin JC, et al. Exome sequencing identifies GRIN2A as frequently mutated in melanoma. Nat Genet. 2011;43:442-446
    • (2011) Nat Genet. , vol.43 , pp. 442-446
    • Wei, X.1    Walia, V.2    Lin, J.C.3
  • 53
    • 33845592531 scopus 로고    scopus 로고
    • NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: A study based on mutation screening by pyrosequencing
    • DOI 10.1097/01.cmr.0000232300.22032.86, PII 0000839020061200000001
    • Edlundh-Rose E, Egyhazi S, Omholt K, et al. NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: a study based on mutation screening by pyrosequencing. Melanoma Res. 2006; 16:471-478. (Pubitemid 44934704)
    • (2006) Melanoma Research , vol.16 , Issue.6 , pp. 471-478
    • Edlundh-Rose, E.1    Egyhazi, S.2    Omholt, K.3    Mansson-Brahme, E.4    Platz, A.5    Hansson, J.6    Lundeberg, J.7
  • 55
    • 84856268319 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma
    • Nikolaev SI, Rimoldi D, Iseli C, et al. Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. Nat Genet. 2011;44:133-139.
    • (2011) Nat Genet. , vol.44 , pp. 133-139
    • Nikolaev, S.I.1    Rimoldi, D.2    Iseli, C.3
  • 56
    • 0028178840 scopus 로고
    • Ras mutations in human melanoma: A marker of malignant progression
    • Ball NJ, Yohn JJ, Morelli JG, et al. Ras mutations in human melanoma: a marker of malignant progression. J Invest Dermatol. 1994; 102:285-290.
    • (1994) J Invest Dermatol. , vol.102 , pp. 285-290
    • Ball, N.J.1    Yohn, J.J.2    Morelli, J.G.3
  • 58
    • 67649415934 scopus 로고    scopus 로고
    • Melanoma: Molecular path-ogenesis and emerging target therapies [review]
    • Russo AE, Torrisi E, Bevelacqua Y, et al. Melanoma: molecular path-ogenesis and emerging target therapies [review]. Int J Oncol. 2009; 34:1481-1489.
    • (2009) Int J Oncol. , vol.34 , pp. 1481-1489
    • Russo, A.E.1    Torrisi, E.2    Bevelacqua, Y.3
  • 59
    • 33748053013 scopus 로고    scopus 로고
    • Cutaneous melanoma subtypes show different BRAF and NRAS mutation frequencies
    • DOI 10.1158/1078-0432.CCR-05-2447
    • Saldanha G, Potter L, Daforno P, et al. Cutaneous melanoma subtypes show different BRAF and NRAS mutation frequencies. Clin Cancer Res. 2006;12:4499-4505. (Pubitemid 44297798)
    • (2006) Clinical Cancer Research , vol.12 , Issue.15 , pp. 4499-4505
    • Saldanha, G.1    Potter, L.2    DaForno, P.3    Pringle, J.H.4
  • 60
    • 79953723136 scopus 로고    scopus 로고
    • Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: A meta-analysis
    • Lee JH, Choi JW, Kim YS. Frequencies of BRAF and NRAS mutations are different in histological types and sites of origin of cutaneous melanoma: a meta-analysis. Br J Dermatol. 2011;164:776-784.
    • (2011) Br J Dermatol. , vol.164 , pp. 776-784
    • Lee, J.H.1    Choi, J.W.2    Kim, Y.S.3
  • 61
    • 80051873884 scopus 로고    scopus 로고
    • Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma
    • Devitt B, Liu W, Salemi R, et al. Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma. Pigment Cell Melanoma Res. 2011;24:666-672.
    • (2011) Pigment Cell Melanoma Res. , vol.24 , pp. 666-672
    • Devitt, B.1    Liu, W.2    Salemi, R.3
  • 62
    • 33747332544 scopus 로고    scopus 로고
    • Malignant melanoma: Genetics and therapeutics in the genomic era
    • Chin L, Garraway LA, Fisher DE. Malignant melanoma: genetics and therapeutics in the genomic era. Genes Dev. 2006;20:2149-2182.
    • (2006) Genes Dev. , vol.20 , pp. 2149-2182
    • Chin, L.1    Garraway, L.A.2    Fisher, D.E.3
  • 64
    • 0348223934 scopus 로고    scopus 로고
    • NRAS and BRAF Mutations Arise Early during Melanoma Pathogenesis and Are Preserved throughout Tumor Progression
    • Omholt K, Platz A, Kanter L, et al. NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Clin Cancer Res. 2003;9:6483-6488. (Pubitemid 38031837)
    • (2003) Clinical Cancer Research , vol.9 , Issue.17 , pp. 6483-6488
    • Omholt, K.1    Platz, A.2    Kanter, L.3    Ringborg, U.4    Hansson, J.5
  • 65
    • 10344258041 scopus 로고    scopus 로고
    • Targeting the mitogen-activated protein kinase cascade to treat cancer
    • DOI 10.1038/nrc1503
    • Sebolt-Leopold JS, Herrera R. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer. 2004;4:937-947. (Pubitemid 39626217)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.12 , pp. 937-947
    • Sebolt-Leopold, J.S.1    Herrera, R.2
  • 66
    • 84978034236 scopus 로고    scopus 로고
    • Prognostic and clinicopath-ologic associations of oncogenic BRAF in metastatic melanoma
    • Long GV, Menzies AM, Nagrial AM, et al. Prognostic and clinicopath-ologic associations of oncogenic BRAF in metastatic melanoma. J Clin Oncol. 2011;29:1239-1246.
    • (2011) J Clin Oncol. , vol.29 , pp. 1239-1246
    • Long, G.V.1    Menzies, A.M.2    Nagrial, A.M.3
  • 67
    • 65349136425 scopus 로고    scopus 로고
    • Distinct patterns of DNA copy number alterations associate with BRAF mutations in melanomas and melanoma-derived cell lines
    • Greshock J, Nathanson K, Medina A, et al. Distinct patterns of DNA copy number alterations associate with BRAF mutations in melanomas and melanoma-derived cell lines. Genes Chromosomes Cancer. 2009; 48:419-428.
    • (2009) Genes Chromosomes Cancer. , vol.48 , pp. 419-428
    • Greshock, J.1    Nathanson, K.2    Medina, A.3
  • 69
    • 33646155553 scopus 로고    scopus 로고
    • Kit and melanocyte migration
    • Grichnik JM. Kit and melanocyte migration. J Invest Dermatol. 2006; 126:945-947.
    • (2006) J Invest Dermatol. , vol.126 , pp. 945-947
    • Grichnik, J.M.1
  • 70
    • 33749021085 scopus 로고    scopus 로고
    • Somatic activation of KIT in distinct subtypes of melanoma
    • DOI 10.1200/JCO.2006.06.2984
    • Curtin JA, Busam K, Pinkel D, et al. Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol. 2006;24:4340-4346. (Pubitemid 46630793)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.26 , pp. 4340-4346
    • Curtin, J.A.1    Busam, K.2    Pinkel, D.3    Bastian, B.C.4
  • 71
    • 0032518262 scopus 로고    scopus 로고
    • MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes
    • DOI 10.1038/34681
    • Hemesath TJ, Price ER, Takemoto C, et al. MAP kinase links the transcription factor microphthalmia to c-Kit signalling in melanocytes. Nature. 1998;391:298-301. (Pubitemid 28099019)
    • (1998) Nature , vol.391 , Issue.6664 , pp. 298-301
    • Hemesath, T.J.1    Price, E.R.2    Takemoto, C.3    Badalian, T.4    Fisher, D.E.5
  • 72
    • 49749122255 scopus 로고    scopus 로고
    • Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumours
    • Lasota J, Miettinen M. Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumours. Histopathology. 2008;53:245-266.
    • (2008) Histopathology. , vol.53 , pp. 245-266
    • Lasota, J.1    Miettinen, M.2
  • 73
    • 34447121280 scopus 로고    scopus 로고
    • Improved insight into resistance mechanisms to imatinib in gastrointestinal stromal tumors: A basis for novel approaches and individualization of treatment
    • DOI 10.1634/theoncologist.12-6-719
    • Sleijfer S, Wiemer E, Seynaeve C, et al. Improved insight into resistance mechanisms to imatinib in gastrointestinal stromal tumors: a basis for novel approaches and individualization of treatment. Oncologist. 2007;12:719-726. (Pubitemid 47036206)
    • (2007) Oncologist , vol.12 , Issue.6 , pp. 719-726
    • Sleijfer, S.1    Wiemer, E.2    Seynaeve, C.3    Verweij, J.4
  • 74
    • 0033816156 scopus 로고    scopus 로고
    • Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
    • Buchdunger E, Cioffi CL, Law N, et al. Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther. 2000;295:139-145.
    • (2000) J Pharmacol Exp Ther. , vol.295 , pp. 139-145
    • Buchdunger, E.1    Cioffi, C.L.2    Law, N.3
  • 75
    • 33645405597 scopus 로고    scopus 로고
    • Analysis of protein tyrosine kinases expression in the melanoma metastases of patients treated with imatinib mesylate (STI571, Gleevec)
    • Ivan D, Niveiro M, Diwan AH, et al. Analysis of protein tyrosine kinases expression in the melanoma metastases of patients treated with imatinib mesylate (STI571, Gleevec). J Cutan Pathol. 2006;33: 280-285.
    • (2006) J Cutan Pathol. , vol.33 , pp. 280-285
    • Ivan, D.1    Niveiro, M.2    Diwan, A.H.3
  • 76
    • 50249141632 scopus 로고    scopus 로고
    • Phase II trial of imatinib mesylate in patients with metastatic melanoma
    • Kim KB, Eton O, Davis DW, et al. Phase II trial of imatinib mesylate in patients with metastatic melanoma. Br J Cancer. 2008;99:734-740.
    • (2008) Br J Cancer. , vol.99 , pp. 734-740
    • Kim, K.B.1    Eton, O.2    Davis, D.W.3
  • 77
    • 42949128595 scopus 로고    scopus 로고
    • Major response to imatinib mesylate in KIT-mutated melanoma
    • Hodi FS, Friedlander P, Corless CL, et al. Major response to imatinib mesylate in KIT-mutated melanoma. J Clin Oncol. 2008;26:2046-2051.
    • (2008) J Clin Oncol. , vol.26 , pp. 2046-2051
    • Hodi, F.S.1    Friedlander, P.2    Corless, C.L.3
  • 78
    • 47249099056 scopus 로고    scopus 로고
    • Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation
    • DOI 10.1111/j.1755-148X.2008.00475.x
    • Lutzky J, Bauer J, Bastian BC. Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation. Pigment Cell Melanoma Res. 2008;21:492-493. (Pubitemid 351990966)
    • (2008) Pigment Cell and Melanoma Research , vol.21 , Issue.4 , pp. 492-493
    • Lutzky, J.1    Bauer, J.2    Bastian, B.C.3
  • 79
    • 79960708519 scopus 로고    scopus 로고
    • Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification
    • Guo J, Si L, Kong Y, et al. Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. J Clin Oncol. 2011;29:2904-2909.
    • (2011) J Clin Oncol. , vol.29 , pp. 2904-2909
    • Guo, J.1    Si, L.2    Kong, Y.3
  • 80
    • 68849093078 scopus 로고    scopus 로고
    • Activity of dasatinib against L576P KIT mutant melanoma: Molecular, cellular, and clinical correlates
    • Woodman SE, Trent JC, Stemke-Hale K, et al. Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates. Mol Cancer Ther. 2009;8:2079-2085.
    • (2009) Mol Cancer Ther. , vol.8 , pp. 2079-2085
    • Woodman, S.E.1    Trent, J.C.2    Stemke-Hale, K.3
  • 81
    • 0038456399 scopus 로고    scopus 로고
    • PTEN signaling pathways in melanoma
    • DOI 10.1038/sj.onc.1206451, Melanoma
    • Wu H, Goel V, Haluska FG. PTEN signaling pathways in melanoma. Oncogene. 2003;22:3113-3122. (Pubitemid 36713763)
    • (2003) Oncogene , vol.22 , Issue.20 , pp. 3113-3122
    • Wu, H.1    Goel, V.2    Haluska, F.G.3
  • 83
    • 0142244844 scopus 로고    scopus 로고
    • PTEN expression in normal skin, acquired melanocytic nevi, and cutaneous melanoma
    • DOI 10.1016/S0190-9622(03)02473-3
    • Tsao H, Mihm MC Jr, Sheehan C. PTEN expression in normal skin, acquired melanocytic nevi, and cutaneous melanoma. J Am Acad Dermatol. 2003;49:865-872. (Pubitemid 37314875)
    • (2003) Journal of the American Academy of Dermatology , vol.49 , Issue.5 , pp. 865-872
    • Tsao, H.1    Mihm Jr., M.C.2    Sheehan, C.3
  • 87
    • 1442274619 scopus 로고    scopus 로고
    • Genetic Interaction between NRAS and BRAF Mutations and PTEN/MMAC1 Inactivation in Melanoma
    • DOI 10.1046/j.0022-202X.2004.22243.x
    • Tsao H, Goel V, Wu H, et al. Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. J Invest Dermatol. 2004;122:337-341. (Pubitemid 38281053)
    • (2004) Journal of Investigative Dermatology , vol.122 , Issue.2 , pp. 337-341
    • Tsao, H.1    Goel, V.2    Wu, H.3    Yang, G.4    Haluska, F.G.5
  • 89
    • 0033819340 scopus 로고    scopus 로고
    • Epigenetic PTEN silencing in malignant melanomas without PTEN mutation
    • Zhou XP, Gimm O, Hampel H, et al. Epigenetic PTEN silencing in malignant melanomas without PTEN mutation. Am J Pathol. 2000; 157:1123-1128.
    • (2000) Am J Pathol. , vol.157 , pp. 1123-1128
    • Zhou, X.P.1    Gimm, O.2    Hampel, H.3
  • 91
    • 59049107421 scopus 로고    scopus 로고
    • Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
    • Van Raamsdonk CD, Bezrookove V, Green G, et al. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature. 2009; 457:599-602.
    • (2009) Nature. , vol.457 , pp. 599-602
    • Van Raamsdonk, C.D.1    Bezrookove, V.2    Green, G.3


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