메뉴 건너뛰기




Volumn 31, Issue 4, 2011, Pages 659-686

Acute myeloid leukemia: Conventional cytogenetics, FISH, and moleculocentric methodologies

Author keywords

AML; Classification; Cytogenetics; FISH; Molecular genetic

Indexed keywords

ALKYLATING AGENT; CBL PROTEIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CHLORAMBUCIL; DNA METHYLTRANSFERASE 3A; FLT3 LIGAND; GYRASE INHIBITOR; MELPHALAN; MIXED LINEAGE LEUKEMIA PROTEIN; NUCLEOPHOSMIN; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN P53; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR RUNX1; WT1 PROTEIN;

EID: 82355181581     PISSN: 02722712     EISSN: 15579832     Source Type: Journal    
DOI: 10.1016/j.cll.2011.08.006     Document Type: Review
Times cited : (14)

References (93)
  • 2
    • 77955914238 scopus 로고    scopus 로고
    • Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials
    • National Cancer Research Institute Adult Leukaemia Working Group
    • Grimwade D., Hills R.K., Moorman A.V., et al. Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials. Blood 2010, 116:354-365. National Cancer Research Institute Adult Leukaemia Working Group.
    • (2010) Blood , vol.116 , pp. 354-365
    • Grimwade, D.1    Hills, R.K.2    Moorman, A.V.3
  • 4
    • 0034890863 scopus 로고    scopus 로고
    • Hematologic malignancies
    • Gilliland D.G. Hematologic malignancies. Curr Opin Hematol 2001, 8:189-191.
    • (2001) Curr Opin Hematol , vol.8 , pp. 189-191
    • Gilliland, D.G.1
  • 5
    • 12744253468 scopus 로고    scopus 로고
    • Pathogenesis of acute myeloid leukaemia and inv(16)(p13;q22): a paradigm for understanding leukaemogenesis?
    • Reilly J.T. Pathogenesis of acute myeloid leukaemia and inv(16)(p13;q22): a paradigm for understanding leukaemogenesis?. Br J Haematol 2005, 128:18-34.
    • (2005) Br J Haematol , vol.128 , pp. 18-34
    • Reilly, J.T.1
  • 6
    • 34248547644 scopus 로고    scopus 로고
    • The prognostic significance of cytogenetic aberrations in childhood acute myeloid leukaemia: a study of the Swiss Paediatric Oncology Group (SPOG)
    • Betts D.R., Ammann R.A., Hirt A., et al. The prognostic significance of cytogenetic aberrations in childhood acute myeloid leukaemia: a study of the Swiss Paediatric Oncology Group (SPOG). Eur J Haematol 2007, 78:468-476.
    • (2007) Eur J Haematol , vol.78 , pp. 468-476
    • Betts, D.R.1    Ammann, R.A.2    Hirt, A.3
  • 7
    • 77954949832 scopus 로고    scopus 로고
    • Prognostic impact of specific chromosomal aberrations in a large group of pediatric patients with acute myeloid leukemia treated uniformly according to trial AML-BFM 98
    • von Neuhoff C., Reinhardt D., Sander A., et al. Prognostic impact of specific chromosomal aberrations in a large group of pediatric patients with acute myeloid leukemia treated uniformly according to trial AML-BFM 98. J Clin Oncol 2010, 28:2682-2689.
    • (2010) J Clin Oncol , vol.28 , pp. 2682-2689
    • von Neuhoff, C.1    Reinhardt, D.2    Sander, A.3
  • 8
    • 0023471245 scopus 로고    scopus 로고
    • Prognostic significance of chromosomal abnormalities in acute nonlymphocytic leukemia: a study of 343 patients
    • Berger R, Bernheim A, Ochoa-Noguera ME, et al. Prognostic significance of chromosomal abnormalities in acute nonlymphocytic leukemia: a study of 343 patients. Cancer Genet Cytogenet 987;28:293-9.
    • Cancer Genet Cytogenet. , vol.987 , Issue.28 , pp. 293-9
    • Berger, R.1    Bernheim, A.2    Ochoa-Noguera, M.E.3
  • 9
    • 0023838176 scopus 로고
    • Specific chromosomal abnormalities in acute nonlymphocytic leukemia correlate with drug susceptibility in vivo
    • Samuels B.L., Larson R.A., Le Beau M.M., et al. Specific chromosomal abnormalities in acute nonlymphocytic leukemia correlate with drug susceptibility in vivo. Leukemia 1988, 2:79-83.
    • (1988) Leukemia , vol.2 , pp. 79-83
    • Samuels, B.L.1    Larson, R.A.2    Le Beau, M.M.3
  • 10
    • 0023711896 scopus 로고
    • Cytogenetic pattern in acute myelogenous leukemia: a major reproducible determinant of outcome
    • Keating M.J., Smith T.L., Kantarjian H., et al. Cytogenetic pattern in acute myelogenous leukemia: a major reproducible determinant of outcome. Leukemia 1988, 2:403-412.
    • (1988) Leukemia , vol.2 , pp. 403-412
    • Keating, M.J.1    Smith, T.L.2    Kantarjian, H.3
  • 11
    • 0024469383 scopus 로고
    • Cytogenetics and their prognostic significance in acute myeloid leukaemia: a report on 283 cases
    • Fenaux P., Preudhomme C., Lai J.L., et al. Cytogenetics and their prognostic significance in acute myeloid leukaemia: a report on 283 cases. Br J Haematol 1989, 73:61-67.
    • (1989) Br J Haematol , vol.73 , pp. 61-67
    • Fenaux, P.1    Preudhomme, C.2    Lai, J.L.3
  • 12
    • 0026765375 scopus 로고
    • Prognostic impact of karyotype and immunologic phenotype in 125 adult patients with de novo AML
    • Marosi C., Köller U., Koller-Weber E., et al. Prognostic impact of karyotype and immunologic phenotype in 125 adult patients with de novo AML. Cancer Genet Cytogenet 1992, 61:14-25.
    • (1992) Cancer Genet Cytogenet , vol.61 , pp. 14-25
    • Marosi, C.1    Köller, U.2    Koller-Weber, E.3
  • 13
    • 0028979666 scopus 로고
    • Prognostic significance of karyotype in de novo adult myeloid leukemia
    • Dastugue N., Payen C., Lafage-Pochitaloff M., et al. Prognostic significance of karyotype in de novo adult myeloid leukemia. Leukemia 1995, 9:1491-1498.
    • (1995) Leukemia , vol.9 , pp. 1491-1498
    • Dastugue, N.1    Payen, C.2    Lafage-Pochitaloff, M.3
  • 14
    • 79955973367 scopus 로고    scopus 로고
    • Integrative prognostic risk score in acute myeloid leukemia with normal karyotype
    • [Epub ahead of print]
    • Damm F., Heuser M., Morgan M., et al. Integrative prognostic risk score in acute myeloid leukemia with normal karyotype. Blood 2011, [Epub ahead of print].
    • (2011) Blood
    • Damm, F.1    Heuser, M.2    Morgan, M.3
  • 15
    • 79953218064 scopus 로고    scopus 로고
    • Predictive value of TP53 fluorescence in situ hybridization in cytogenetic subgroups of acute myeloid leukemia
    • Tavor S., Rothman R., Golan T., et al. Predictive value of TP53 fluorescence in situ hybridization in cytogenetic subgroups of acute myeloid leukemia. Leuk Lymphoma 2011, 52:642-647.
    • (2011) Leuk Lymphoma , vol.52 , pp. 642-647
    • Tavor, S.1    Rothman, R.2    Golan, T.3
  • 16
    • 14344259132 scopus 로고    scopus 로고
    • Diagnostic value of fluorescence in situ hybridization for the detection of genomic aberrations in older patients with acute myeloid leukemia
    • AML Study Group Ulm
    • Fröhling S., Kayser S., Mayer C., et al. Diagnostic value of fluorescence in situ hybridization for the detection of genomic aberrations in older patients with acute myeloid leukemia. Haematologica 2005, 90:194-199. AML Study Group Ulm.
    • (2005) Haematologica , vol.90 , pp. 194-199
    • Fröhling, S.1    Kayser, S.2    Mayer, C.3
  • 17
    • 34147121394 scopus 로고    scopus 로고
    • Utility of interphase FISH to stratify patients into cytogenetic risk categories at diagnosis of AML in an Eastern Cooperative Oncology Group (ECOG) clinical trial (E1900)
    • Vance G.H., Kim H., Hicks G.A., et al. Utility of interphase FISH to stratify patients into cytogenetic risk categories at diagnosis of AML in an Eastern Cooperative Oncology Group (ECOG) clinical trial (E1900). Leuk Res 2007, 31:605-609.
    • (2007) Leuk Res , vol.31 , pp. 605-609
    • Vance, G.H.1    Kim, H.2    Hicks, G.A.3
  • 18
    • 55949117662 scopus 로고    scopus 로고
    • FISH glossary: an overview of the fluorescence in situ hybridization technique
    • Volpi E.V., Bridger J.M. FISH glossary: an overview of the fluorescence in situ hybridization technique. Biotechniques 2008, 45:385-386.
    • (2008) Biotechniques , vol.45 , pp. 385-386
    • Volpi, E.V.1    Bridger, J.M.2
  • 19
    • 79957701784 scopus 로고    scopus 로고
    • A comparative analysis of molecular genetic and conventional cytogenetic detection of diagnostically important translocations in over 400 cases of acute leukemia, highlighting the frequency of false negative conventional cytogenetics
    • King R.L., Naghashpour M., Watt C.D., et al. A comparative analysis of molecular genetic and conventional cytogenetic detection of diagnostically important translocations in over 400 cases of acute leukemia, highlighting the frequency of false negative conventional cytogenetics. Am J Clinic Path 2011, 135:921-928.
    • (2011) Am J Clinic Path , vol.135 , pp. 921-928
    • King, R.L.1    Naghashpour, M.2    Watt, C.D.3
  • 20
    • 0036636857 scopus 로고    scopus 로고
    • Core-binding factors in haematopoiesis and leukaemia
    • Speck N.A., Gilliland D.G. Core-binding factors in haematopoiesis and leukaemia. Nat Rev Cancer 2002, 2:502-513.
    • (2002) Nat Rev Cancer , vol.2 , pp. 502-513
    • Speck, N.A.1    Gilliland, D.G.2
  • 21
    • 77954933160 scopus 로고    scopus 로고
    • Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12
    • Harrison C.J., Hills R.K., Moorman A.V., et al. Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12. J Clin Oncol 2010, 28:2674-2681.
    • (2010) J Clin Oncol , vol.28 , pp. 2674-2681
    • Harrison, C.J.1    Hills, R.K.2    Moorman, A.V.3
  • 22
    • 0025059007 scopus 로고
    • Acute myelogenous leukemia with an 8;21 translocation; a report on 148 cases from the Groupe Francais de Cytogenetique Hematologique
    • Groupe Francais de Cytogenetique Hematologique
    • Acute myelogenous leukemia with an 8;21 translocation; a report on 148 cases from the Groupe Francais de Cytogenetique Hematologique. Cancer Genet Cytogenet 1990, 44:169-179. Groupe Francais de Cytogenetique Hematologique.
    • (1990) Cancer Genet Cytogenet , vol.44 , pp. 169-179
  • 23
    • 31544433933 scopus 로고    scopus 로고
    • Acute myeloid leukemia associated with variant t(8;21) detected by conventional cytogenetic and molecular studies: a report of four cases and review of the literature
    • Huang L., Abruzzo L.V., Valbuena J.R., et al. Acute myeloid leukemia associated with variant t(8;21) detected by conventional cytogenetic and molecular studies: a report of four cases and review of the literature. Am J Clin Pathol 2006, 125:267-272.
    • (2006) Am J Clin Pathol , vol.125 , pp. 267-272
    • Huang, L.1    Abruzzo, L.V.2    Valbuena, J.R.3
  • 24
    • 34247602991 scopus 로고    scopus 로고
    • Oncogenic pathways of AML1-ETO in acute myeloid leukemia: multifaceted manipulation of marrow maturation
    • Elagib K.E., Goldfarb A.N. Oncogenic pathways of AML1-ETO in acute myeloid leukemia: multifaceted manipulation of marrow maturation. Cancer Lett 2007, 251:179-186.
    • (2007) Cancer Lett , vol.251 , pp. 179-186
    • Elagib, K.E.1    Goldfarb, A.N.2
  • 25
    • 0037092955 scopus 로고    scopus 로고
    • In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia
    • Wiemels J.L., Xiao Z., Buffler P.A., et al. In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia. Blood 2002, 99:3801-3805.
    • (2002) Blood , vol.99 , pp. 3801-3805
    • Wiemels, J.L.1    Xiao, Z.2    Buffler, P.A.3
  • 26
    • 9544257262 scopus 로고    scopus 로고
    • Persistence of the AML1/ETO fusion transcript in patients treated with allogeneic bone marrow transplantation for t(8;21) leukemia
    • Jurlander J., Caligiuri M.A., Ruutu T., et al. Persistence of the AML1/ETO fusion transcript in patients treated with allogeneic bone marrow transplantation for t(8;21) leukemia. Blood 1996, 88:2183-2191.
    • (1996) Blood , vol.88 , pp. 2183-2191
    • Jurlander, J.1    Caligiuri, M.A.2    Ruutu, T.3
  • 27
    • 9344257318 scopus 로고    scopus 로고
    • Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia
    • Miyamoto T., Nagafuji K., Akashi K., et al. Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia. Blood 1996, 87:4789-4796.
    • (1996) Blood , vol.87 , pp. 4789-4796
    • Miyamoto, T.1    Nagafuji, K.2    Akashi, K.3
  • 28
    • 74049159886 scopus 로고    scopus 로고
    • Persistent altered fusion transcript splicing identifies RUNX1-RUNX1T1+ AML patients likely to relapse
    • Ommen H.B., Ostergaard M., Yan M., et al. Persistent altered fusion transcript splicing identifies RUNX1-RUNX1T1+ AML patients likely to relapse. Eur J Haematol 2010, 84:128-132.
    • (2010) Eur J Haematol , vol.84 , pp. 128-132
    • Ommen, H.B.1    Ostergaard, M.2    Yan, M.3
  • 29
    • 33748467435 scopus 로고    scopus 로고
    • Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study
    • Paschka P., Marcucci G., Ruppert A.S., et al. Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study. J Clin Oncol 2006, 24:3904-3911.
    • (2006) J Clin Oncol , vol.24 , pp. 3904-3911
    • Paschka, P.1    Marcucci, G.2    Ruppert, A.S.3
  • 30
    • 33344465478 scopus 로고    scopus 로고
    • KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival
    • Schnittger S., Kohl T.M., Haferlach T., et al. KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival. Blood 2006, 107:1791-1799.
    • (2006) Blood , vol.107 , pp. 1791-1799
    • Schnittger, S.1    Kohl, T.M.2    Haferlach, T.3
  • 31
    • 77950612017 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML
    • Pollard J.A., Alonzo T.A., Gerbing R.B., et al. Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML. Blood 2010, 115:2372-2379.
    • (2010) Blood , vol.115 , pp. 2372-2379
    • Pollard, J.A.1    Alonzo, T.A.2    Gerbing, R.B.3
  • 32
    • 0038170400 scopus 로고    scopus 로고
    • Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias
    • Care R.S., Valk P.J., Goodeve A.C., et al. Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias. Br J Haematol 2003, 121:775-777.
    • (2003) Br J Haematol , vol.121 , pp. 775-777
    • Care, R.S.1    Valk, P.J.2    Goodeve, A.C.3
  • 33
    • 33748467435 scopus 로고    scopus 로고
    • Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study
    • Cancer and Leukemia Group B
    • Paschka P., Marcucci G., Ruppert A.S., et al. Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study. J Clin Oncol 2006, 24:3904-3911. Cancer and Leukemia Group B.
    • (2006) J Clin Oncol , vol.24 , pp. 3904-3911
    • Paschka, P.1    Marcucci, G.2    Ruppert, A.S.3
  • 34
    • 33744487375 scopus 로고    scopus 로고
    • Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML)
    • Boissel N., Leroy H., Brethon B., et al. Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML). Leukemia 2006, 20:965-970.
    • (2006) Leukemia , vol.20 , pp. 965-970
    • Boissel, N.1    Leroy, H.2    Brethon, B.3
  • 35
    • 48749121814 scopus 로고    scopus 로고
    • Core binding factor acute myeloid leukemia
    • Paschka P. Core binding factor acute myeloid leukemia. Semin Oncol 2008, 35:410-417.
    • (2008) Semin Oncol , vol.35 , pp. 410-417
    • Paschka, P.1
  • 36
    • 1842474806 scopus 로고    scopus 로고
    • Molecular basis for a dominant inactivation of RUNX1/AML1 by the leukemogenic inversion 16 chimera
    • Huang G., Shigesada K., Wee H.J., et al. Molecular basis for a dominant inactivation of RUNX1/AML1 by the leukemogenic inversion 16 chimera. Blood 2004, 103:3200-3207.
    • (2004) Blood , vol.103 , pp. 3200-3207
    • Huang, G.1    Shigesada, K.2    Wee, H.J.3
  • 37
    • 0015694741 scopus 로고
    • Identification of a translocation with quinacrine fluorescence in a patient with acute leukaemia
    • Rowley J.D. Identification of a translocation with quinacrine fluorescence in a patient with acute leukaemia. Ann. Genet 1973, 16:109-112.
    • (1973) Ann. Genet , vol.16 , pp. 109-112
    • Rowley, J.D.1
  • 38
    • 0036079158 scopus 로고    scopus 로고
    • The human genome browser at UCSC
    • Accessed August 15, 2011
    • Kent W.J., Sugnet C.W., Furey T.S., et al. The human genome browser at UCSC. Genome Res 2002, 12:996-1006. Accessed August 15, 2011. http://genome.ucsc.edu/cgi-bin/hgTracks?hgHubConnect.destUrl=%2Fcgi-%09bin%2FhgTracks%26clade=mammal%26org=Human%26db=hg19%26position=chr15%3A74287014-%0974340153%26hgt.suggest=PML%26hgt.suggestTrack=knownGene%26Submit=submit%26hgsid=21192596%095%26hgt.newJQuery=1%26knownGene=pack.
    • (2002) Genome Res , vol.12 , pp. 996-1006
    • Kent, W.J.1    Sugnet, C.W.2    Furey, T.S.3
  • 39
    • 77952954175 scopus 로고    scopus 로고
    • Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations in acute promyelocytic leukemia: a systematic review
    • Beitinjaneh A., Jang S., Roukoz H., et al. Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations in acute promyelocytic leukemia: a systematic review. Leuk Res 2010, 34:831-836.
    • (2010) Leuk Res , vol.34 , pp. 831-836
    • Beitinjaneh, A.1    Jang, S.2    Roukoz, H.3
  • 40
    • 67649992737 scopus 로고    scopus 로고
    • Prognostic factors in adult patients up to 60 years old with acute myeloid leukemia and translocations of chromosome band 11q23: individual patient data-based meta-analysis of the German Acute Myeloid Leukemia Intergroup
    • Krauter J., Wagner K., Schäfer I., et al. Prognostic factors in adult patients up to 60 years old with acute myeloid leukemia and translocations of chromosome band 11q23: individual patient data-based meta-analysis of the German Acute Myeloid Leukemia Intergroup. J Clin Oncol 2009, 27:3000-3006.
    • (2009) J Clin Oncol , vol.27 , pp. 3000-3006
    • Krauter, J.1    Wagner, K.2    Schäfer, I.3
  • 41
    • 0033485565 scopus 로고    scopus 로고
    • Chromosomal abnormalities in 478 children with acute myeloid leukemia: clinical characteristics and treatment outcome in a cooperative pediatric oncology group study-POG 8821
    • Raimondi S.C., Chang M.N., Ravindranath Y., et al. Chromosomal abnormalities in 478 children with acute myeloid leukemia: clinical characteristics and treatment outcome in a cooperative pediatric oncology group study-POG 8821. Blood 1999, 94:3707-3716.
    • (1999) Blood , vol.94 , pp. 3707-3716
    • Raimondi, S.C.1    Chang, M.N.2    Ravindranath, Y.3
  • 42
    • 77956247735 scopus 로고    scopus 로고
    • Clinical, molecular, and prognostic significance of WHO type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and various other 3q abnormalities in acute myeloid leukemia
    • Lugthart S., Gröschel S., Beverloo H.B., et al. Clinical, molecular, and prognostic significance of WHO type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and various other 3q abnormalities in acute myeloid leukemia. J Clin Oncol 2010, 28:3890-3898.
    • (2010) J Clin Oncol , vol.28 , pp. 3890-3898
    • Lugthart, S.1    Gröschel, S.2    Beverloo, H.B.3
  • 43
    • 3442887156 scopus 로고    scopus 로고
    • Classical and molecular cytogenetic abnormalities and outcome of childhood acute myeloid leukaemia: report from a referral centre in Israel
    • Stark B., Jeison M., Gabay L.G., et al. Classical and molecular cytogenetic abnormalities and outcome of childhood acute myeloid leukaemia: report from a referral centre in Israel. Br J Haematol 2004, 126:320-337.
    • (2004) Br J Haematol , vol.126 , pp. 320-337
    • Stark, B.1    Jeison, M.2    Gabay, L.G.3
  • 44
    • 33745184051 scopus 로고    scopus 로고
    • A retrospective study of 69 patients with t(6;9)(p23;q34) AML emphasizes the need for a prospective, multicenter initiative for rare 'poor prognosis' myeloid malignancies
    • Slovak M.L., Gundacker H., Bloomfield C.D., et al. A retrospective study of 69 patients with t(6;9)(p23;q34) AML emphasizes the need for a prospective, multicenter initiative for rare 'poor prognosis' myeloid malignancies. Leukemia 2006, 20:1295-1297.
    • (2006) Leukemia , vol.20 , pp. 1295-1297
    • Slovak, M.L.1    Gundacker, H.2    Bloomfield, C.D.3
  • 45
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C., Steudel C., Mohr B., et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood 2002, 12:4326-4335.
    • (2002) Blood , vol.12 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 46
    • 0037100420 scopus 로고    scopus 로고
    • Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Français de Cytogénétique Hématologique (GFCH)
    • Dastugue N., Lafage-Pochitaloff M., Pagès M.P., et al. Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Français de Cytogénétique Hématologique (GFCH). Blood 2002, 100:618-626.
    • (2002) Blood , vol.100 , pp. 618-626
    • Dastugue, N.1    Lafage-Pochitaloff, M.2    Pagès, M.P.3
  • 48
    • 77952578145 scopus 로고    scopus 로고
    • Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1)
    • Falini B., Macijewski K., Weiss T., et al. Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1). Blood 2010, 115:3776-3786.
    • (2010) Blood , vol.115 , pp. 3776-3786
    • Falini, B.1    Macijewski, K.2    Weiss, T.3
  • 49
    • 78649920418 scopus 로고    scopus 로고
    • Genetic deletions in AML and MDS
    • Ebert B.L. Genetic deletions in AML and MDS. Best Pract Res Clin Haematol 2010, 23:457-461.
    • (2010) Best Pract Res Clin Haematol , vol.23 , pp. 457-461
    • Ebert, B.L.1
  • 50
    • 38949123096 scopus 로고    scopus 로고
    • Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML
    • Gondek L.P., Tiu R., O'Keefe C.L., et al. Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML. Blood 2008, 111:1534-1542.
    • (2008) Blood , vol.111 , pp. 1534-1542
    • Gondek, L.P.1    Tiu, R.2    O'Keefe, C.L.3
  • 51
    • 73849121794 scopus 로고    scopus 로고
    • Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype
    • Starczynowski D.T., Kuchenbauer F., Argiropoulos B., et al. Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nat Med 2009, 16:49-58.
    • (2009) Nat Med , vol.16 , pp. 49-58
    • Starczynowski, D.T.1    Kuchenbauer, F.2    Argiropoulos, B.3
  • 52
    • 84886341711 scopus 로고    scopus 로고
    • Acute myeloid leukemia
    • Heim S, Mitelman F, editors. Cancer cytogenetics, chromosomal and molecular genetic aberrations in tumor cells. Hoboken (NJ):.
    • Johansson B, Harrison CJ. Acute myeloid leukemia. In: Heim S, Mitelman F, editors. Cancer cytogenetics, chromosomal and molecular genetic aberrations in tumor cells. Hoboken (NJ): John Wiley & Sons; p. 45-139.
    • John Wiley & Sons. , pp. 45-139
    • Johansson, B.1    Harrison, C.J.2
  • 53
    • 16244417494 scopus 로고    scopus 로고
    • Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22
    • Curtiss N.P., Bonifas J.M., Lauchle J.O., et al. Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22. Genomics 2005, 85:600-607.
    • (2005) Genomics , vol.85 , pp. 600-607
    • Curtiss, N.P.1    Bonifas, J.M.2    Lauchle, J.O.3
  • 55
    • 65349103909 scopus 로고    scopus 로고
    • Therapy-related acute myeloid leukemia with t(8;21) (q22;q22) shares many features with de novo acute myeloid leukemia with t(8;21)(q22;q22) but does not have a favorable outcome
    • Gustafson S.A., Lin P., Chen S.S., et al. Therapy-related acute myeloid leukemia with t(8;21) (q22;q22) shares many features with de novo acute myeloid leukemia with t(8;21)(q22;q22) but does not have a favorable outcome. Am J Clin Pathol 2009, 131:647-655.
    • (2009) Am J Clin Pathol , vol.131 , pp. 647-655
    • Gustafson, S.A.1    Lin, P.2    Chen, S.S.3
  • 56
    • 77950629000 scopus 로고    scopus 로고
    • Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia
    • Qian Z., Joslin J.M., Tennant T.R., et al. Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia. Chem Biol Interact 2010, 184:50-57.
    • (2010) Chem Biol Interact , vol.184 , pp. 50-57
    • Qian, Z.1    Joslin, J.M.2    Tennant, T.R.3
  • 58
    • 54349092877 scopus 로고    scopus 로고
    • Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype
    • Breems D.A., Van Putten W.L., De Greef G.E., et al. Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype. J Clin Oncol 2008, 26:4791-4797.
    • (2008) J Clin Oncol , vol.26 , pp. 4791-4797
    • Breems, D.A.1    Van Putten, W.L.2    De Greef, G.E.3
  • 59
    • 77957715843 scopus 로고    scopus 로고
    • Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experience
    • Medeiros B.C., Othus M., Fang M., et al. Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experience. Blood 2010, 116:2224-2228.
    • (2010) Blood , vol.116 , pp. 2224-2228
    • Medeiros, B.C.1    Othus, M.2    Fang, M.3
  • 60
    • 79953878823 scopus 로고    scopus 로고
    • Acute myeloid leukemia with monosomal karyotype at the far end of the unfavorable prognostic spectrum
    • Breems D.A., Löwenberg B. Acute myeloid leukemia with monosomal karyotype at the far end of the unfavorable prognostic spectrum. Haematologica 2011, 96:491-493.
    • (2011) Haematologica , vol.96 , pp. 491-493
    • Breems, D.A.1    Löwenberg, B.2
  • 61
    • 0030041634 scopus 로고    scopus 로고
    • Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites
    • Broeker P.L., Super H.G., Thirman M.J., et al. Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites. Blood 1996, 87:1912-1922.
    • (1996) Blood , vol.87 , pp. 1912-1922
    • Broeker, P.L.1    Super, H.G.2    Thirman, M.J.3
  • 62
    • 0141816710 scopus 로고    scopus 로고
    • AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases
    • Schoch C., Schnittger S., Klaus M., et al. AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases. Blood 2003, 102:2395-2402.
    • (2003) Blood , vol.102 , pp. 2395-2402
    • Schoch, C.1    Schnittger, S.2    Klaus, M.3
  • 63
    • 70350497118 scopus 로고    scopus 로고
    • Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study
    • Balgobind B.V., Raimondi S.C., Harbott J., et al. Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study. Blood 2009, 114:2489-2496.
    • (2009) Blood , vol.114 , pp. 2489-2496
    • Balgobind, B.V.1    Raimondi, S.C.2    Harbott, J.3
  • 64
    • 67349225649 scopus 로고    scopus 로고
    • AML with translocation t(8;16)(p11;p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features
    • Haferlach T., Kohlmann A., Klein H.U., et al. AML with translocation t(8;16)(p11;p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features. Leukemia 2009, 23:934-943.
    • (2009) Leukemia , vol.23 , pp. 934-943
    • Haferlach, T.1    Kohlmann, A.2    Klein, H.U.3
  • 65
    • 78649905124 scopus 로고    scopus 로고
    • Independent prognostic variables in acute myeloid leukaemia
    • Smith M.L., Hills R.K., Grimwade D. Independent prognostic variables in acute myeloid leukaemia. Blood Rev 2011, 25:39-51.
    • (2011) Blood Rev , vol.25 , pp. 39-51
    • Smith, M.L.1    Hills, R.K.2    Grimwade, D.3
  • 67
    • 79952078495 scopus 로고    scopus 로고
    • Biology, risk stratification, and therapy of pediatric acute leukemias: an update
    • Pui C.H., Carroll W.L., Meshinchi S., et al. Biology, risk stratification, and therapy of pediatric acute leukemias: an update. J Clin Oncol 2011, 29:551-565.
    • (2011) J Clin Oncol , vol.29 , pp. 551-565
    • Pui, C.H.1    Carroll, W.L.2    Meshinchi, S.3
  • 68
    • 78649293176 scopus 로고    scopus 로고
    • Molecular diagnosis of acute myeloid leukemia
    • Watt C.D., Bagg A. Molecular diagnosis of acute myeloid leukemia. Expert Rev Mol Diagn 2010, 10:993-1012.
    • (2010) Expert Rev Mol Diagn , vol.10 , pp. 993-1012
    • Watt, C.D.1    Bagg, A.2
  • 69
    • 79952092487 scopus 로고    scopus 로고
    • Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications
    • Marcucci G., Haferlach T., Döhner H. Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications. J Clin Oncol 2011, 29:475-486.
    • (2011) J Clin Oncol , vol.29 , pp. 475-486
    • Marcucci, G.1    Haferlach, T.2    Döhner, H.3
  • 70
    • 79251556241 scopus 로고    scopus 로고
    • Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?
    • Falini B., Martelli M.P., Bolli N. Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?. Blood 2011, 117:1109-1120.
    • (2011) Blood , vol.117 , pp. 1109-1120
    • Falini, B.1    Martelli, M.P.2    Bolli, N.3
  • 71
    • 43749118762 scopus 로고    scopus 로고
    • Nucleophosmin (NPM1) mutations in acute myeloid leukemia: an ongoing (cytoplasmic) tale of dueling mutations and duality of molecular genetic testing methodologies
    • Wertheim G., Bagg A. Nucleophosmin (NPM1) mutations in acute myeloid leukemia: an ongoing (cytoplasmic) tale of dueling mutations and duality of molecular genetic testing methodologies. J Mol Diagn 2008, 10:198-202.
    • (2008) J Mol Diagn , vol.10 , pp. 198-202
    • Wertheim, G.1    Bagg, A.2
  • 72
    • 79952122978 scopus 로고    scopus 로고
    • Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity
    • Taskesen E., Bullinger L., Corbacioglu A. Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity. Blood 2011, 117:2469-2475.
    • (2011) Blood , vol.117 , pp. 2469-2475
    • Taskesen, E.1    Bullinger, L.2    Corbacioglu, A.3
  • 73
    • 28444473100 scopus 로고    scopus 로고
    • Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations
    • Döhner K., Schlenk R.F., Habdank M., et al. Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood 2005, 106:3740-3746.
    • (2005) Blood , vol.106 , pp. 3740-3746
    • Döhner, K.1    Schlenk, R.F.2    Habdank, M.3
  • 74
    • 65449180371 scopus 로고    scopus 로고
    • Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor
    • Breitenbuecher F., Schnittger S., Grundler R. Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor. Blood 2009, 113:4074-4077.
    • (2009) Blood , vol.113 , pp. 4074-4077
    • Breitenbuecher, F.1    Schnittger, S.2    Grundler, R.3
  • 75
    • 28444485658 scopus 로고    scopus 로고
    • Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia
    • Gale R.E., Hills R., Pizzey A.R., et al. Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia. Blood 2005, 106:3768-3776.
    • (2005) Blood , vol.106 , pp. 3768-3776
    • Gale, R.E.1    Hills, R.2    Pizzey, A.R.3
  • 76
    • 33344465478 scopus 로고    scopus 로고
    • KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival
    • Schnittger S., Kohl T.M., Haferlach T., et al. KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival. Blood 2006, 107:1791-1799.
    • (2006) Blood , vol.107 , pp. 1791-1799
    • Schnittger, S.1    Kohl, T.M.2    Haferlach, T.3
  • 77
    • 33750087521 scopus 로고    scopus 로고
    • The MLL partial tandem duplication in acute myeloid leukaemia
    • Basecke J., Whelan J.T., Griesinger F., et al. The MLL partial tandem duplication in acute myeloid leukaemia. Br J Haematol 2006, 135:438-449.
    • (2006) Br J Haematol , vol.135 , pp. 438-449
    • Basecke, J.1    Whelan, J.T.2    Griesinger, F.3
  • 78
    • 77951899709 scopus 로고    scopus 로고
    • Acute myeloid leukemia with t(9;11)(p21-22;q23): common properties of dysregulated ras pathway signaling and genomic progression characterize de novo and therapy-related cases
    • Chandra P., Luthra R., Zuo Z., et al. Acute myeloid leukemia with t(9;11)(p21-22;q23): common properties of dysregulated ras pathway signaling and genomic progression characterize de novo and therapy-related cases. Am J Clin Pathol 2010, 133:686-693.
    • (2010) Am J Clin Pathol , vol.133 , pp. 686-693
    • Chandra, P.1    Luthra, R.2    Zuo, Z.3
  • 79
    • 50949113696 scopus 로고    scopus 로고
    • Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia
    • Raghavan M., Smith L.L., Lillington D.M., et al. Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia. Blood 2008, 112:814-821.
    • (2008) Blood , vol.112 , pp. 814-821
    • Raghavan, M.1    Smith, L.L.2    Lillington, D.M.3
  • 80
    • 78649753896 scopus 로고    scopus 로고
    • Acquired genomic copy number aberrations and survival in adult acute myelogenous leukemia
    • Parkin B., Erba H., Ouillette P., et al. Acquired genomic copy number aberrations and survival in adult acute myelogenous leukemia. Blood 2010, 116:4958-4967.
    • (2010) Blood , vol.116 , pp. 4958-4967
    • Parkin, B.1    Erba, H.2    Ouillette, P.3
  • 81
    • 70449715477 scopus 로고    scopus 로고
    • New lesions detected by single nucleotide polymorphism array-based chromosomal analysis have important clinical impact in acute myeloid leukemia
    • Tiu R.V., Gondek L.P., O'Keefe C.L., et al. New lesions detected by single nucleotide polymorphism array-based chromosomal analysis have important clinical impact in acute myeloid leukemia. J Clin Oncol 2009, 27:5219-5226.
    • (2009) J Clin Oncol , vol.27 , pp. 5219-5226
    • Tiu, R.V.1    Gondek, L.P.2    O'Keefe, C.L.3
  • 82
    • 76749153827 scopus 로고    scopus 로고
    • Identification of acquired copy number alterations and uniparental disomies in cytogenetically normal acute myeloid leukemia using high-resolution single nucleotide polymorphism analysis
    • Bullinger L., Kronke J., Schon C., et al. Identification of acquired copy number alterations and uniparental disomies in cytogenetically normal acute myeloid leukemia using high-resolution single nucleotide polymorphism analysis. Leukemia 2010, 24:438-449.
    • (2010) Leukemia , vol.24 , pp. 438-449
    • Bullinger, L.1    Kronke, J.2    Schon, C.3
  • 83
    • 34548018092 scopus 로고    scopus 로고
    • Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia
    • Bullinger L., Rücker F.G., Kurz S., et al. Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia. Blood 2007, 110:1291-1300.
    • (2007) Blood , vol.110 , pp. 1291-1300
    • Bullinger, L.1    Rücker, F.G.2    Kurz, S.3
  • 84
    • 57449103508 scopus 로고    scopus 로고
    • An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia
    • Cancer and Leukemia Group B; German AML Cooperative Group
    • Metzeler K.H., Hummel M., Bloomfield C.D., et al. An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia. Blood 2008, 112:4193-4201. Cancer and Leukemia Group B; German AML Cooperative Group.
    • (2008) Blood , vol.112 , pp. 4193-4201
    • Metzeler, K.H.1    Hummel, M.2    Bloomfield, C.D.3
  • 85
    • 33747420007 scopus 로고    scopus 로고
    • Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B study
    • Radmacher M.D., Marcucci G., Ruppert A.S., et al. Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B study. Blood 2006, 108:1677-1683.
    • (2006) Blood , vol.108 , pp. 1677-1683
    • Radmacher, M.D.1    Marcucci, G.2    Ruppert, A.S.3
  • 86
    • 72949114887 scopus 로고    scopus 로고
    • Leukaemogenesis: more than mutant genes
    • Chen J., Odenike O., Rowley J.D. Leukaemogenesis: more than mutant genes. Nat Rev Cancer 2008, 10:23-36.
    • (2008) Nat Rev Cancer , vol.10 , pp. 23-36
    • Chen, J.1    Odenike, O.2    Rowley, J.D.3
  • 87
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley T.J., Ding L., Walter M.J., et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med 2010, 363:2424-2433.
    • (2010) N Engl J Med , vol.363 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.J.3
  • 88
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia [Epub ahead of print]
    • Yan X.J., Xu J., Gu Z.H., et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia [Epub ahead of print]. Nat Genet 2011.
    • (2011) Nat Genet
    • Yan, X.J.1    Xu, J.2    Gu, Z.H.3
  • 89
    • 42449141513 scopus 로고    scopus 로고
    • MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukaemia
    • Garzon R., Volinia S., Liu C.G., et al. MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukaemia. Blood 2008, 111:3183-3189.
    • (2008) Blood , vol.111 , pp. 3183-3189
    • Garzon, R.1    Volinia, S.2    Liu, C.G.3
  • 90
    • 79251585937 scopus 로고    scopus 로고
    • The prognostic and functional role of microRNAs in acute myeloid leukemia
    • Marcucci G., Mrózek K., Radmacher M.D., et al. The prognostic and functional role of microRNAs in acute myeloid leukemia. Blood 2011, 117:1121-1129.
    • (2011) Blood , vol.117 , pp. 1121-1129
    • Marcucci, G.1    Mrózek, K.2    Radmacher, M.D.3
  • 91
    • 55549101623 scopus 로고    scopus 로고
    • DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
    • Ley T.J., Mardis E.R., Ding L., et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature 2008, 456:66-72.
    • (2008) Nature , vol.456 , pp. 66-72
    • Ley, T.J.1    Mardis, E.R.2    Ding, L.3
  • 92
    • 79955854144 scopus 로고    scopus 로고
    • Identification of recurring tumor-specific somatic mutations in acute myeloid leukemia by transcriptome sequencing [Epub ahead of print]
    • Greif P.A., Eck S.H., Konstandin N.P., et al. Identification of recurring tumor-specific somatic mutations in acute myeloid leukemia by transcriptome sequencing [Epub ahead of print]. Leukemia 2011.
    • (2011) Leukemia
    • Greif, P.A.1    Eck, S.H.2    Konstandin, N.P.3
  • 93
    • 70249111091 scopus 로고    scopus 로고
    • Targeted capture and massively parallel sequencing of 12 human exomes
    • Ng S.B., Turner E.H., Robertson P.D., et al. Targeted capture and massively parallel sequencing of 12 human exomes. Nature 2009, 461:272-276.
    • (2009) Nature , vol.461 , pp. 272-276
    • Ng, S.B.1    Turner, E.H.2    Robertson, P.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.