Involvement of PGE 2and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages

Biochemical Journal

Volumn 443, Issue 2, 2012, Pages 451-461

  Díaz Muñoz, Manuel D ^a,b   Osma García, Inés C ^a   Fresno, Manuel ^a   Iñiguez, Miguel A ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

Cyclo oxygenase 2 (COX 2); E prostanoid (EP) receptor; Gene regulation; Inflammation; Lipid mediator; Microsomal prostaglandin E synthase 1 (mPGES 1)

Indexed keywords

BUCLADESINE; CAY10399; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOOXYGENASE 2; FORSKOLIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR AFFECTING AGENT; UNCLASSIFIED DRUG; ISOMERASE; PROSTAGLANDIN E SYNTHASE; PTGS2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE DELETION; GENE MUTATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION; ANIMAL; CELL LINE; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; MACROPHAGE; METABOLISM; PROMOTER REGION;

ANIMALS; CELL LINE; CYCLIC AMP; CYCLOOXYGENASE 2; DINOPROSTONE; INTRAMOLECULAR OXIDOREDUCTASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84859459694     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20111052     Document Type: Article

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